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Protein

Potassium voltage-gated channel subfamily H member 7

Gene

Kcnh7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pore-forming (alpha) subunit of voltage-gated potassium channel (By similarity). Channel properties may be modulated by cAMP and subunit assembly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi745 – 862cNMPAdd BLAST118

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-MMU-1296072 Voltage gated Potassium channels

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily H member 7
Alternative name(s):
Ether-a-go-go-related gene potassium channel 3
Short name:
ERG-3
Short name:
Eag-related protein 3
Short name:
Ether-a-go-go-related protein 3
Voltage-gated potassium channel subunit Kv11.3
Gene namesi
Name:Kcnh7
Synonyms:Erg3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2159566 Kcnh7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 412CytoplasmicSequence analysisAdd BLAST412
Transmembranei413 – 433Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini434 – 449ExtracellularSequence analysisAdd BLAST16
Transmembranei450 – 470Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini471 – 494CytoplasmicSequence analysisAdd BLAST24
Transmembranei495 – 515Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini516 – 521ExtracellularSequence analysis6
Transmembranei522 – 542Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini543 – 549CytoplasmicSequence analysis7
Transmembranei550 – 570Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini571 – 614ExtracellularSequence analysisAdd BLAST44
Intramembranei615 – 635Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Topological domaini636 – 641ExtracellularSequence analysis6
Transmembranei642 – 662Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini663 – 1195CytoplasmicSequence analysisAdd BLAST533

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000540161 – 1195Potassium voltage-gated channel subfamily H member 7Add BLAST1195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphoserineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei319PhosphoserineBy similarity1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei891PhosphoserineBy similarity1
Modified residuei894PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ER47
PRIDEiQ9ER47

PTM databases

iPTMnetiQ9ER47
PhosphoSitePlusiQ9ER47

Expressioni

Gene expression databases

BgeeiENSMUSG00000059742 Expressed in 58 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ9ER47 baseline and differential
GenevisibleiQ9ER47 MM

Interactioni

Subunit structurei

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH2/ERG1 and KCNH6/ERG2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074563

Structurei

3D structure databases

ProteinModelPortaliQ9ER47
SMRiQ9ER47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 70PASAdd BLAST30
Domaini92 – 144PACAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi627 – 632Selectivity filterBy similarity6

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0498 Eukaryota
ENOG410XPSE LUCA
GeneTreeiENSGT00900000140833
HOGENOMiHOG000230793
HOVERGENiHBG052232
InParanoidiQ9ER47
KOiK04910
OMAiQMTTDIQ
OrthoDBiEOG091G024C
TreeFamiTF313130

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR005821 Ion_trans_dom
IPR003938 K_chnl_volt-dep_EAG/ELK/ERG
IPR003967 K_chnl_volt-dep_ERG
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00520 Ion_trans, 1 hit
PF13426 PAS_9, 1 hit
PRINTSiPR01463 EAGCHANLFMLY
PR01470 ERGCHANNEL
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
SSF55785 SSF55785, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q9ER47-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE
60 70 80 90 100
MTGFSRPDVM QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH
110 120 130 140 150
KNGSTFICNT HIIPVKNQEG VAMMFIINFE YVTDEENAAT PERVNPILPV
160 170 180 190 200
KTVNRKLFGF KFPGLRVLTY RKQSLPQEDP DVVVIDSSKH SDDSVAMKHF
210 220 230 240 250
KSPTKESCSP SEADDTKALI QPSQCSPLVN ISGPLDHSSP KRQWDRLYPD
260 270 280 290 300
MLQSSSQLTH SRSRESLCSI RRASSVHDIE GFSVHPKNIF RDRHASEDNG
310 320 330 340 350
RNVKGPFNHI KSSLLGSTSD SNLNKYSTIN KIPQLTLNFS DVKTEKKNTS
360 370 380 390 400
PPSSDKTIIA PKVKERTHNV TEKVTQVLSL GADVLPEYKL QTPRINKFTI
410 420 430 440 450
LHYSPFKAVW DWLILLLVIY TAIFTPYSAA FLLNDREEQK RRECGYSCSP
460 470 480 490 500
LNVVDLIVDI MFIIDILINF RTTYVNQNEE VVSDPAKIAI HYFKGWFLID
510 520 530 540 550
MVAAIPFDLL IFGSGSDETT TLIGLLKTAR LLRLVRVARK LDRYSEYGAA
560 570 580 590 600
VLMLLMCIFA LIAHWLACIW YAIGNVERPY LTDKIGWLDS LGTQIGKRYN
610 620 630 640 650
DSDSSSGPSI KDKYVTALYF TFSSLTSVGF GNVSPNTNSE KIFSICVMLI
660 670 680 690 700
GSLMYASIFG NVSAIIQRLY SGTARYHMQM LRVKEFIRFH QIPNPLRQRL
710 720 730 740 750
EEYFQHAWTY TNGIDMNMVL KGFPECLQAD ICLHLNQTLL QNCKAFRGAS
760 770 780 790 800
KGCLRALAMK FKTTHAPPGD TLVHCGDVLT ALYFLSRGSI EILKDDIVVA
810 820 830 840 850
ILGKNDIFGE MVHLYAKPGK SNADVRALTY CDLHKIQRED LLEVLDMYPE
860 870 880 890 900
FSDHFLTNLE LTFNLRHESA KSQSVNDSEG DTGKLRRRRL SFESEGEKDF
910 920 930 940 950
SKENSANDAD DSTDTIRRYQ SSKKHFEERK SRSSSFISSI DDEQKPLFLG
960 970 980 990 1000
TVDSTPRMVK ATRLHGEETM PHSGRIHTEK RSHSCRDITD THSWEREPAR
1010 1020 1030 1040 1050
AQPEECSPSG LQRAAWGVSE TESDLTYGEV EQRLDLLQEQ LNRLESQMTT
1060 1070 1080 1090 1100
DIQAILQLLQ KQTTVVPPAY SMVTAGAEYQ RPILRLLRTS HPRASIKTDR
1110 1120 1130 1140 1150
SFSPSSQCPE FLDLEKSKLQ SKESLSSGRR LNTASEDNLT SLLKQDSDAS
1160 1170 1180 1190
SELDPRQRKT YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK
Length:1,195
Mass (Da):135,062
Last modified:July 27, 2011 - v2
Checksum:iEC9A541243FED06D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CC38Q8CC38_MOUSE
Potassium voltage-gated channel sub...
Kcnh7
522Annotation score:
Q8C782Q8C782_MOUSE
Potassium voltage-gated channel sub...
Kcnh7
515Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48F → L in CAC14797 (Ref. 1) Curated1
Sequence conflicti511I → V in CAC14797 (Ref. 1) Curated1
Sequence conflicti750S → N in CAC14797 (Ref. 1) Curated1
Sequence conflicti972 – 974HSG → PSP in CAC14797 (Ref. 1) Curated3
Sequence conflicti979E → D in CAC14797 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291608 mRNA Translation: CAC14797.1
AL928663, AL928689, AL929246 Genomic DNA Translation: CAM20556.1
AL929246, AL928663, AL928689 Genomic DNA Translation: CAM21791.1
AL928689, AL928663, AL929246 Genomic DNA Translation: CAM22230.1
CCDSiCCDS38128.1
RefSeqiNP_573470.2, NM_133207.2
UniGeneiMm.242532

Genome annotation databases

EnsembliENSMUST00000075052; ENSMUSP00000074563; ENSMUSG00000059742
GeneIDi170738
KEGGimmu:170738
UCSCiuc008jvq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKCNH7_MOUSE
AccessioniPrimary (citable) accession number: Q9ER47
Secondary accession number(s): A2AUY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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