Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-12

Gene

Stx12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).By similarity

GO - Molecular functioni

  • SNAP receptor activity Source: GO_Central
  • SNARE binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-12
Gene namesi
Name:Stx12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1931027 Stx12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 250CytoplasmicSequence analysisAdd BLAST249
Transmembranei251 – 271Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini272 – 274VesicularSequence analysis3

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002102242 – 274Syntaxin-12Add BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei139PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei225PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ER00
MaxQBiQ9ER00
PaxDbiQ9ER00
PeptideAtlasiQ9ER00
PRIDEiQ9ER00

PTM databases

iPTMnetiQ9ER00
PhosphoSitePlusiQ9ER00
SwissPalmiQ9ER00

Expressioni

Gene expression databases

BgeeiENSMUSG00000028879 Expressed in 292 organ(s), highest expression level in Ammon's horn
CleanExiMM_STX12
GenevisibleiQ9ER00 MM

Interactioni

Subunit structurei

Associates with the BLOC-1 complex. Interacts with BLOC1S6. Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A (By similarity). Interacts with GRIPAP1 (PubMed:20098723). Forms a complex with GRIP1, GRIA2 and NSG1; controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). Interacts with NSG1 (PubMed:12070131).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221409, 1 interactor
CORUMiQ9ER00
IntActiQ9ER00, 8 interactors
MINTiQ9ER00
STRINGi10090.ENSMUSP00000030698

Structurei

3D structure databases

ProteinModelPortaliQ9ER00
SMRiQ9ER00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 240t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili33 – 130Sequence analysisAdd BLAST98

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00450000040239
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiQ9ER00
KOiK13813
OMAiHQIQHYT
OrthoDBiEOG091G0HKZ
PhylomeDBiQ9ER00
TreeFamiTF315607

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ER00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYGPLDMYR NPGPSGPQPR DFNSIIQTCS GNIQRISQAT AQIKNLMSQL
60 70 80 90 100
GTKQDSSKLQ ENLQQLQHST NQLAKETNEL LKELGSLPLP LSASEQRQQK
110 120 130 140 150
LQKERLMNDF SSALNNFQVV QRKVSEKEKE SIARARAGSR LSAEDRQREE
160 170 180 190 200
QLVSFDSHEE WNQMQSQEEE AAITEQDLEL IKERETAIRQ LEADILDVNQ
210 220 230 240 250
IFKDLAMMIH DQGDLIDSIE ANVESSEVHV ERATDQLQRA AYYQKKSRKK
260 270
MCILVLVLSV IVTVLVVVIW VASK
Length:274
Mass (Da):31,195
Last modified:March 1, 2001 - v1
Checksum:i443A294A1A1E2905
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171A → V in AAH10669 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019211 mRNA Translation: BAB20282.1
AK077678 mRNA Translation: BAC36951.1
AK078948 mRNA Translation: BAC37473.1
AK146544 mRNA Translation: BAE27249.1
AK146735 mRNA Translation: BAE27397.1
AK167087 mRNA Translation: BAE39244.1
BC010669 mRNA Translation: AAH10669.1
CCDSiCCDS18737.1
RefSeqiNP_598648.1, NM_133887.4
UniGeneiMm.28237
Mm.491148

Genome annotation databases

EnsembliENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879
GeneIDi100226
KEGGimmu:100226
UCSCiuc008vbx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019211 mRNA Translation: BAB20282.1
AK077678 mRNA Translation: BAC36951.1
AK078948 mRNA Translation: BAC37473.1
AK146544 mRNA Translation: BAE27249.1
AK146735 mRNA Translation: BAE27397.1
AK167087 mRNA Translation: BAE39244.1
BC010669 mRNA Translation: AAH10669.1
CCDSiCCDS18737.1
RefSeqiNP_598648.1, NM_133887.4
UniGeneiMm.28237
Mm.491148

3D structure databases

ProteinModelPortaliQ9ER00
SMRiQ9ER00
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221409, 1 interactor
CORUMiQ9ER00
IntActiQ9ER00, 8 interactors
MINTiQ9ER00
STRINGi10090.ENSMUSP00000030698

PTM databases

iPTMnetiQ9ER00
PhosphoSitePlusiQ9ER00
SwissPalmiQ9ER00

Proteomic databases

EPDiQ9ER00
MaxQBiQ9ER00
PaxDbiQ9ER00
PeptideAtlasiQ9ER00
PRIDEiQ9ER00

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030698; ENSMUSP00000030698; ENSMUSG00000028879
GeneIDi100226
KEGGimmu:100226
UCSCiuc008vbx.1 mouse

Organism-specific databases

CTDi23673
MGIiMGI:1931027 Stx12

Phylogenomic databases

eggNOGiKOG0811 Eukaryota
COG5325 LUCA
GeneTreeiENSGT00450000040239
HOGENOMiHOG000188453
HOVERGENiHBG053083
InParanoidiQ9ER00
KOiK13813
OMAiHQIQHYT
OrthoDBiEOG091G0HKZ
PhylomeDBiQ9ER00
TreeFamiTF315607

Miscellaneous databases

PROiPR:Q9ER00
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028879 Expressed in 292 organ(s), highest expression level in Ammon's horn
CleanExiMM_STX12
GenevisibleiQ9ER00 MM

Family and domain databases

CDDicd00179 SynN, 1 hit
InterProiView protein in InterPro
IPR010989 SNARE
IPR006012 Syntaxin/epimorphin_CS
IPR006011 Syntaxin_N
IPR000727 T_SNARE_dom
PfamiView protein in Pfam
PF05739 SNARE, 1 hit
PF14523 Syntaxin_2, 1 hit
SMARTiView protein in SMART
SM00503 SynN, 1 hit
SM00397 t_SNARE, 1 hit
SUPFAMiSSF47661 SSF47661, 1 hit
PROSITEiView protein in PROSITE
PS00914 SYNTAXIN, 1 hit
PS50192 T_SNARE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTX12_MOUSE
AccessioniPrimary (citable) accession number: Q9ER00
Secondary accession number(s): Q3UIV9, Q921T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again