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Entry version 162 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Regulating synaptic membrane exocytosis protein 2

Gene

Rims2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri126 – 182FYVE-typePROSITE-ProRule annotationAdd BLAST57

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Exocytosis, Neurotransmitter transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulating synaptic membrane exocytosis protein 2
Alternative name(s):
Rab-3-interacting molecule 2
Short name:
RIM 2
Rab-3-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rims2
Synonyms:Rab3ip2, Rim2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152972 Rims2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001902021 – 1530Regulating synaptic membrane exocytosis protein 2Add BLAST1530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei409PhosphoserineCombined sources1
Modified residuei698PhosphothreonineBy similarity1
Modified residuei800PhosphoserineCombined sources1
Modified residuei803PhosphoserineCombined sources1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1175PhosphoserineBy similarity1
Modified residuei1251PhosphoserineBy similarity1
Modified residuei1515PhosphoserineCombined sources1
Modified residuei1518PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9EQZ7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EQZ7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EQZ7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9EQZ7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in testis, pituitary and an insulinoma cell line. Detected at low levels in cerebellar cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037386 Expressed in 206 organ(s), highest expression level in rostral migratory stream

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9EQZ7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EQZ7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TSPOAP1 and RIMBP2.

Interacts with PPFIA3 and PPFIA4.

Interacts via its zinc finger with the first C2 domain of UNC13A.

Forms a complex consisting of UNC13A, RIMS2 and RAB3A (By similarity). Heterodimer with PCLO.

Part of a ternary complex involving PCLO and EPAC2.

Interacts with RAB3A and RAB3B that have been activated by GTP-binding.

Interacts with RAB3C, RAB3D and RAB26.

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228026, 9 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9EQZ7

Protein interaction database and analysis system

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IntActi
Q9EQZ7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048719

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EQZ7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 194RabBDPROSITE-ProRule annotationAdd BLAST169
Domaini677 – 763PDZPROSITE-ProRule annotationAdd BLAST87
Domaini816 – 922C2 1PROSITE-ProRule annotationAdd BLAST107
Domaini1376 – 1478C2 2PROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1169 – 1202Ser-richAdd BLAST34

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri126 – 182FYVE-typePROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155236

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082403

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EQZ7

KEGG Orthology (KO)

More...
KOi
K15297

Database of Orthologous Groups

More...
OrthoDBi
109268at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9EQZ7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030631 RIM2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12157 PTHR12157, 2 hits
PTHR12157:SF15 PTHR12157:SF15, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF17820 PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EQZ7-1) [UniParc]FASTAAdd to basket
Also known as: RIM2-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAPLGPRGR PAPTPAASQP PPQPEMPDLS HLTEEERKII LAVMDRQKKE
60 70 80 90 100
EEKEQSVLKI KEEHKAQPTQ WFPFSGITEL VNNVLQPQQK QPNEKEPQTK
110 120 130 140 150
LHQQFEMYKE QVKKMGEESQ QQQEQKGDAP TCGICHKTKF ADGCGHNCSY
160 170 180 190 200
CQTKFCARCG GRVSLRSNKV MWVCNLCRKQ QEILTKSGAW FYNSGSNTLQ
210 220 230 240 250
QPDQKVPRGL RNEEAPQEKK AKLHEQPQFQ GAPGDLSVPA VEKGRAHGLT
260 270 280 290 300
RQDTIKNGSG VKHQIASDMP SDRKRSPSVS RDQNRRYEQS EEREDYSQYV
310 320 330 340 350
PSDGTMPRSP SDYADRRSQR EPQFYEEPGH LNYRDSNRRG HRHSKEYIVD
360 370 380 390 400
DEDVESRDEY ERQRREEEYQ ARYRSDPNLA RYPVKPQPYE EQMRIHAEVS
410 420 430 440 450
RARHERRHSD VSLANAELED SRISLLRMDR PSRQRSVSER RAAMENQRSY
460 470 480 490 500
SMERTREAQG QSSYPQRTSN HSPPTPRRSP IPLDRPDMRR ADSLRKQHHL
510 520 530 540 550
DPSSAVRKTK REKMETMLRN DSLSSDQSES VRPPPPRPHK SKKGGKMRQV
560 570 580 590 600
SLSSSEEELA STPEYTSCDD VELESESVSE KGDSQKGKRK TSEQGVLSDS
610 620 630 640 650
NTRSERQKKR MYYGGHSLEE DLEWSEPQIK DSGVDTCSST TLNEEHSHSD
660 670 680 690 700
KHPVTWQPSK DGDRLIGRIL LNKRLKDGSV PRDSGAMLGL KVVGGKMTES
710 720 730 740 750
GRLCAFITKV KKGSLADTVG HLRPGDEVLE WNGRLLQGAT FEEVYNIILE
760 770 780 790 800
SKPEPQVELV VSRPIGDIPR IPDSTHAQLE SSSSSFESQK MDRPSISVTS
810 820 830 840 850
PMSPGMLRDV PQFLSGQLSI KLWFDKVGHQ LIVTILGAKD LPSREDGRPR
860 870 880 890 900
NPYVKIYFLP DRSDKNKRRT KTVKKTLEPK WNQTFIYSPV HRREFRERML
910 920 930 940 950
EITLWDQARV REEESEFLGE ILIELETALL DDEPHWYKLQ THDVSSLPLP
960 970 980 990 1000
RPSPYLPRRQ LHGESPTRRL QRSKRISDSE VSDYDCEDGV GVVSDYRHNG
1010 1020 1030 1040 1050
RDLQSSTLSV PEQVMSSNHC SPSGSPHRVD VIGRTRSWSP SAPPPQRNVE
1060 1070 1080 1090 1100
QGHRGTRATG HYNTISRMDR HRVMDDHYSS DRDRSHPRTG SVQTSPSSTP
1110 1120 1130 1140 1150
GTGRRGRQLP QLPPKGTLER SAMDIEERNR QMKLNKYKQV AGSDPRLEQD
1160 1170 1180 1190 1200
YHSKYRSGWD PHRGADTVST KSSDSDVSDV SAVSRTSSAS RFSSTSYMSV
1210 1220 1230 1240 1250
QSERPRGNRK ISVFTSKMQN RQMGVSGKNL TKSTSISGDM CSLEKNDGSQ
1260 1270 1280 1290 1300
SDTAVGALGT SGKKRRSSIG AKMVAIVGLS RKSRSASQLS QTEGGGKKLR
1310 1320 1330 1340 1350
STVQRSTETG LAVEMRNWMT RQASRESTDG SMNSYSSEGN LIFPGVRLAS
1360 1370 1380 1390 1400
DSQFSDFLDG LGPAQLVGRQ TLATPAMGDI QVGMMDKKGQ LEVEIIRARG
1410 1420 1430 1440 1450
LVVKPGSKTL PAPYVKVYLL DNGVCIAKKK TKVARKTLEP LYQQLLSFEE
1460 1470 1480 1490 1500
SPQGRVLQII VWGDYGRMDH KSFMGVAQIL LDELELSNMV IGWFKLFPPS
1510 1520 1530
SLVDPTLAPL TRRASQSSLE SSTGPSYSRS
Length:1,530
Mass (Da):172,863
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58CF11BF7152357D
GO
Isoform 2 (identifier: Q9EQZ7-2) [UniParc]FASTAAdd to basket
Also known as: RIM2-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-1245: Missing.
     1246-1292: NDGSQSDTAV...SRSASQLSQT → MGRQGLGGTG...CMNSLEEDEG

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):30,972
Checksum:iFC17F384B1F97E4E
GO
Isoform 3 (identifier: Q9EQZ7-3) [UniParc]FASTAAdd to basket
Also known as: RIM2-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.
     233-272: PGDLSVPAVE...HQIASDMPSD → MQFETLRQVC...ELFGQTLNNA

Note: No experimental confirmation available.
Show »
Length:1,298
Mass (Da):146,793
Checksum:iC3CC6365227441FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D9HP81D9HP81_MOUSE
Regulating synaptic membrane exocyt...
Rims2
1,572Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0VF51Q0VF51_MOUSE
Regulating synaptic membrane exocyt...
Rims2
1,550Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRM1A0A2I3BRM1_MOUSE
Regulating synaptic membrane exocyt...
Rims2
1,297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I3BRN6A0A2I3BRN6_MOUSE
Regulating synaptic membrane exocyt...
Rims2
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081811 – 1245Missing in isoform 2. 1 PublicationAdd BLAST1245
Alternative sequenceiVSP_0081821 – 232Missing in isoform 3. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_008183233 – 272PGDLS…DMPSD → MQFETLRQVCNSVLSHFHGV FSSPPNILQNELFGQTLNNA in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0081841246 – 1292NDGSQ…QLSQT → MGRQGLGGTGAAGRSMQRSQ SRSSLSASFEALAGYFPCMN SLEEDEG in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB021131 mRNA Translation: BAB18975.1
AK032619 mRNA Translation: BAC27953.1
AK083172 mRNA Translation: BAC38794.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS37067.1 [Q9EQZ7-1]

NCBI Reference Sequences

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RefSeqi
NP_001243313.1, NM_001256384.1 [Q9EQZ7-2]
NP_444501.1, NM_053271.2 [Q9EQZ7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000082054; ENSMUSP00000080711; ENSMUSG00000037386 [Q9EQZ7-1]
ENSMUST00000226410; ENSMUSP00000153868; ENSMUSG00000037386 [Q9EQZ7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
116838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:116838

UCSC genome browser

More...
UCSCi
uc007vod.2 mouse [Q9EQZ7-1]
uc007voh.2 mouse [Q9EQZ7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021131 mRNA Translation: BAB18975.1
AK032619 mRNA Translation: BAC27953.1
AK083172 mRNA Translation: BAC38794.1
CCDSiCCDS37067.1 [Q9EQZ7-1]
RefSeqiNP_001243313.1, NM_001256384.1 [Q9EQZ7-2]
NP_444501.1, NM_053271.2 [Q9EQZ7-1]

3D structure databases

SMRiQ9EQZ7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi228026, 9 interactors
CORUMiQ9EQZ7
IntActiQ9EQZ7, 1 interactor
STRINGi10090.ENSMUSP00000048719

PTM databases

iPTMnetiQ9EQZ7
PhosphoSitePlusiQ9EQZ7
SwissPalmiQ9EQZ7

Proteomic databases

PRIDEiQ9EQZ7

Genome annotation databases

EnsembliENSMUST00000082054; ENSMUSP00000080711; ENSMUSG00000037386 [Q9EQZ7-1]
ENSMUST00000226410; ENSMUSP00000153868; ENSMUSG00000037386 [Q9EQZ7-2]
GeneIDi116838
KEGGimmu:116838
UCSCiuc007vod.2 mouse [Q9EQZ7-1]
uc007voh.2 mouse [Q9EQZ7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9699
MGIiMGI:2152972 Rims2

Phylogenomic databases

GeneTreeiENSGT00940000155236
HOGENOMiHOG000082403
InParanoidiQ9EQZ7
KOiK15297
OrthoDBi109268at2759
PhylomeDBiQ9EQZ7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rims2 mouse

Protein Ontology

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PROi
PR:Q9EQZ7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037386 Expressed in 206 organ(s), highest expression level in rostral migratory stream
ExpressionAtlasiQ9EQZ7 baseline and differential
GenevisibleiQ9EQZ7 MM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR041282 FYVE_2
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR010911 Rab_BD
IPR039032 Rim-like
IPR030631 RIM2
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
PANTHERiPTHR12157 PTHR12157, 2 hits
PTHR12157:SF15 PTHR12157:SF15, 2 hits
PfamiView protein in Pfam
PF00168 C2, 2 hits
PF02318 FYVE_2, 1 hit
PF17820 PDZ_6, 1 hit
SMARTiView protein in SMART
SM00239 C2, 2 hits
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50106 PDZ, 1 hit
PS50916 RABBD, 1 hit
PS50178 ZF_FYVE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIMS2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQZ7
Secondary accession number(s): Q8C433, Q8CCK2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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