Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TSC22 domain family protein 3

Gene

Tsc22d3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • body fluid secretion Source: RGD

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 3
Alternative name(s):
Glucocorticoid-induced leucine zipper protein
Gene namesi
Name:Tsc22d3
Synonyms:Dsipi, Gilz
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621654 Tsc22d3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193731 – 134TSC22 domain family protein 3Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineCombined sources1
Modified residuei125PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EQZ1
PRIDEiQ9EQZ1

PTM databases

iPTMnetiQ9EQZ1
PhosphoSitePlusiQ9EQZ1

Expressioni

Inductioni

By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells. Expression is up-regulated by synthetic glucocorticoid dexamethasone in differentiating myoblasts (By similarity).By similarity

Gene expression databases

BgeeiENSRNOG00000056135 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ9EQZ1 RN

Interactioni

Subunit structurei

Can form homodimers, however it is likely to function as a monomer. Interacts with AP1 and NFKB1. Interacts with MYOD1. Interacts with HDAC1; this interaction affects HDAC1 activity on MYOG promoter and thus inhibits MYOD1 transcriptional activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051018

Structurei

3D structure databases

ProteinModelPortaliQ9EQZ1
SMRiQ9EQZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60AP1-bindingBy similarityAdd BLAST60
Regioni76 – 97Leucine-zipperAdd BLAST22

Domaini

The leucine-zipper is involved in homodimerization.By similarity

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000015349
HOVERGENiHBG075918
InParanoidiQ9EQZ1
OMAiSTEMFAK
OrthoDBiEOG091G06PM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTEMYQTPM EVAVYQLHNF SISFFSSLLG GDVVSVKLDN SASGASVVAL
60 70 80 90 100
DNKIEQAMDL VKNHLMYAVR EEVEVLKEQI RELVEKNSQL ERENTLLKTL
110 120 130
ASPEQLEKFQ SRLSPEEPAP EAPETPEAPG GSAV
Length:134
Mass (Da):14,836
Last modified:March 1, 2001 - v1
Checksum:iC3B6CC1266908342
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025431 mRNA Translation: BAB18679.1
BC061979 mRNA Translation: AAH61979.1
RefSeqiNP_112635.1, NM_031345.1
UniGeneiRn.21970

Genome annotation databases

EnsembliENSRNOT00000085118; ENSRNOP00000072713; ENSRNOG00000056135
GeneIDi83514
KEGGirno:83514
UCSCiRGD:621654 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB025431 mRNA Translation: BAB18679.1
BC061979 mRNA Translation: AAH61979.1
RefSeqiNP_112635.1, NM_031345.1
UniGeneiRn.21970

3D structure databases

ProteinModelPortaliQ9EQZ1
SMRiQ9EQZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051018

PTM databases

iPTMnetiQ9EQZ1
PhosphoSitePlusiQ9EQZ1

Proteomic databases

PaxDbiQ9EQZ1
PRIDEiQ9EQZ1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000085118; ENSRNOP00000072713; ENSRNOG00000056135
GeneIDi83514
KEGGirno:83514
UCSCiRGD:621654 rat

Organism-specific databases

CTDi1831
RGDi621654 Tsc22d3

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000015349
HOVERGENiHBG075918
InParanoidiQ9EQZ1
OMAiSTEMFAK
OrthoDBiEOG091G06PM

Miscellaneous databases

PROiPR:Q9EQZ1

Gene expression databases

BgeeiENSRNOG00000056135 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ9EQZ1 RN

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT22D3_RAT
AccessioniPrimary (citable) accession number: Q9EQZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again