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Protein

Toll-like receptor 9

Gene

Tlr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:18931679, PubMed:21402738, PubMed:14993594, PubMed:17474149, PubMed:25686612, PubMed:18820679). Plays a role in defense against systemic mouse cytomegalovirus infection (PubMed:14993594). Controls lymphocyte response to Helicobacter infection (PubMed:17474149). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).By similarity6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei132CpG-DNABy similarity1
Binding sitei208CpG-DNABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-109704 PI3K Cascade
R-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975155 MyD88 dependent cascade initiated on endosome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-like receptor 9
Alternative name(s):
CD_antigen: CD289
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tlr9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932389 Tlr9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 818ExtracellularSequence analysisAdd BLAST793
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei819 – 839HelicalSequence analysisAdd BLAST21
Topological domaini840 – 1032CytoplasmicSequence analysisAdd BLAST193

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced proliferation of lymphocytes, reduced interferon-gamma production by splenocytes and reduced neutrophil numbers following Helicobacter infection.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi47W → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi74R → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi104S → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi108F → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi132Y → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi152H → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi179Y → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi229Y → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi499L → P: Highly susceptible to mouse cytomegalovirus infection. Shows low level of cytokine induction and natural killer activation on viral infection. 1 Publication1
Mutagenesisi642H → A: Loss of NF-kappa-B activation. 1 Publication1
Mutagenesisi668F → A: Significantly decreased NF-kappa-B activation. 1 Publication1
Mutagenesisi695N → A: Significantly decreased NF-kappa-B activation. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6128

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003473826 – 1032Toll-like receptor 9Add BLAST1007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 45Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi98 ↔ 110Combined sources1 Publication
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 184Combined sources1 Publication
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi255 ↔ 268Combined sources1 Publication
Disulfide bondi258 ↔ 265Combined sources1 Publication
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi332N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi340N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi471 ↔ 501Combined sources1 Publication
Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi568N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi700N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi732N-linked (GlcNAc...) asparagineSequence analysisCombined sources1 Publication1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi765 ↔ 791Combined sources1 Publication
Disulfide bondi767 ↔ 810Combined sources1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain (PubMed:18931679, PubMed:18820679). Cleavage requires UNC93B1 (PubMed:18820679). Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling (PubMed:21402738).3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9EQU3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9EQU3

PeptideAtlas

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PeptideAtlasi
Q9EQU3

PRoteomics IDEntifications database

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PRIDEi
Q9EQU3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9EQU3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EQU3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the basolateral region of gastric epithelial cells with high levels detected in antrum and body mucosa (at protein level). Detected in spleen and stomach at higher levels in C57BL/6 mice than BALB/C.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Following Helicobacter infection, down-regulated in C57BL/6 mice and up-regulated in BALB/C mice.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045322 Expressed in 60 organ(s), highest expression level in bone marrow macrophage

CleanEx database of gene expression profiles

More...
CleanExi
MM_TLR9

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EQU3 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Exists as a monomer in the absence of unmethylated cytidine-phosphate-guanosine (CpG) ligand. Proteolytic processing of an insertion loop (Z-loop) is required for homodimerization upon binding to the unmethylated CpG ligand leading to its activation (By similarity). Interacts with MYD88 via their respective TIR domains (PubMed:18820679). Interacts with BTK (By similarity). Interacts (via transmembrane domain) with UNC93B1 (PubMed:17452530, PubMed:18931679). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (PubMed:21940676). Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:18780723, PubMed:20865800). Interacts with SMPDL3B (PubMed:26095358).By similarity7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Atp2a2P115074EBI-9979528,EBI-916319From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
219897, 1 interactor

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9EQU3

Protein interaction database and analysis system

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IntActi
Q9EQU3, 28 interactors

Molecular INTeraction database

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MINTi
Q9EQU3

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000082207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11032
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9EQU3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9EQU3

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 85LRR 1Add BLAST24
Repeati87 – 110LRR 2Add BLAST24
Repeati122 – 147LRR 3Add BLAST26
Repeati150 – 166LRR 4Add BLAST17
Repeati167 – 190LRR 5Add BLAST24
Repeati198 – 221LRR 6Add BLAST24
Repeati223 – 242LRR 7Add BLAST20
Repeati243 – 268LRR 8Add BLAST26
Repeati283 – 306LRR 9Add BLAST24
Repeati308 – 332LRR 10Add BLAST25
Repeati333 – 356LRR 11Add BLAST24
Repeati363 – 386LRR 12Add BLAST24
Repeati390 – 413LRR 13Add BLAST24
Repeati415 – 440LRR 14Add BLAST26
Repeati471 – 495LRR 15Add BLAST25
Repeati497 – 520LRR 16Add BLAST24
Repeati521 – 544LRR 17Add BLAST24
Repeati546 – 573LRR 18Add BLAST28
Repeati575 – 599LRR 19Add BLAST25
Repeati601 – 623LRR 20Add BLAST23
Repeati628 – 651LRR 21Add BLAST24
Repeati653 – 676LRR 22Add BLAST24
Repeati677 – 700LRR 23Add BLAST24
Repeati702 – 724LRR 24Add BLAST23
Repeati725 – 748LRR 25Add BLAST24
Repeati750 – 773LRR 26Add BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini868 – 1016TIRPROSITE-ProRule annotationAdd BLAST149

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 51Interaction with CpG-DNABy similarity5
Regioni72 – 77Interaction with CpG-DNABy similarity6
Regioni95 – 109Interaction with CpG-DNABy similarityAdd BLAST15
Regioni179 – 181Interaction with CpG-DNABy similarity3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4641 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162493

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230468

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018601

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9EQU3

KEGG Orthology (KO)

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KOi
K10161

Identification of Orthologs from Complete Genome Data

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OMAi
RRCDHAR

Database of Orthologous Groups

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OrthoDBi
EOG091G0BWK

TreeFam database of animal gene trees

More...
TreeFami
TF325595

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10140, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR24373:SF37 PTHR24373:SF37, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13855 LRR_8, 3 hits
PF01582 TIR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 15 hits
SM00255 TIR, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52200 SSF52200, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51450 LRR, 16 hits
PS50104 TIR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLRRRTLHP LSLLVQAAVL AETLALGTLP AFLPCELKPH GLVDCNWLFL
60 70 80 90 100
KSVPRFSAAA SCSNITRLSL ISNRIHHLHN SDFVHLSNLR QLNLKWNCPP
110 120 130 140 150
TGLSPLHFSC HMTIEPRTFL AMRTLEELNL SYNGITTVPR LPSSLVNLSL
160 170 180 190 200
SHTNILVLDA NSLAGLYSLR VLFMDGNCYY KNPCTGAVKV TPGALLGLSN
210 220 230 240 250
LTHLSLKYNN LTKVPRQLPP SLEYLLVSYN LIVKLGPEDL ANLTSLRVLD
260 270 280 290 300
VGGNCRRCDH APNPCIECGQ KSLHLHPETF HHLSHLEGLV LKDSSLHTLN
310 320 330 340 350
SSWFQGLVNL SVLDLSENFL YESITHTNAF QNLTRLRKLN LSFNYRKKVS
360 370 380 390 400
FARLHLASSF KNLVSLQELN MNGIFFRLLN KYTLRWLADL PKLHTLHLQM
410 420 430 440 450
NFINQAQLSI FGTFRALRFV DLSDNRISGP STLSEATPEE ADDAEQEELL
460 470 480 490 500
SADPHPAPLS TPASKNFMDR CKNFKFTMDL SRNNLVTIKP EMFVNLSRLQ
510 520 530 540 550
CLSLSHNSIA QAVNGSQFLP LTNLQVLDLS HNKLDLYHWK SFSELPQLQA
560 570 580 590 600
LDLSYNSQPF SMKGIGHNFS FVTHLSMLQS LSLAHNDIHT RVSSHLNSNS
610 620 630 640 650
VRFLDFSGNG MGRMWDEGGL YLHFFQGLSG LLKLDLSQNN LHILRPQNLD
660 670 680 690 700
NLPKSLKLLS LRDNYLSFFN WTSLSFLPNL EVLDLAGNQL KALTNGTLPN
710 720 730 740 750
GTLLQKLDVS SNSIVSVVPA FFALAVELKE VNLSHNILKT VDRSWFGPIV
760 770 780 790 800
MNLTVLDVRS NPLHCACGAA FVDLLLEVQT KVPGLANGVK CGSPGQLQGR
810 820 830 840 850
SIFAQDLRLC LDEVLSWDCF GLSLLAVAVG MVVPILHHLC GWDVWYCFHL
860 870 880 890 900
CLAWLPLLAR SRRSAQTLPY DAFVVFDKAQ SAVADWVYNE LRVRLEERRG
910 920 930 940 950
RRALRLCLED RDWLPGQTLF ENLWASIYGS RKTLFVLAHT DRVSGLLRTS
960 970 980 990 1000
FLLAQQRLLE DRKDVVVLVI LRPDAHRSRY VRLRQRLCRQ SVLFWPQQPN
1010 1020 1030
GQGGFWAQLS TALTRDNRHF YNQNFCRGPT AE
Length:1,032
Mass (Da):116,412
Last modified:December 14, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC13A7888588CE297
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti325T → N in BAB19260 (PubMed:11130078).Curated1
Sequence conflicti325T → N in AAK29625 (PubMed:11470918).Curated1
Sequence conflicti325T → N in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti325T → N in AAU04980 (PubMed:17474149).Curated1
Sequence conflicti378L → S in BAB19260 (PubMed:11130078).Curated1
Sequence conflicti378L → S in AAK29625 (PubMed:11470918).Curated1
Sequence conflicti378L → S in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti378L → S in AAU04980 (PubMed:17474149).Curated1
Sequence conflicti554S → G in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti562M → I in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti573T → A in AAK29625 (PubMed:11470918).Curated1
Sequence conflicti573T → A in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti573T → A in AAU04980 (PubMed:17474149).Curated1
Sequence conflicti579Q → H in AAK29625 (PubMed:11470918).Curated1
Sequence conflicti579Q → H in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti579Q → H in AAU04980 (PubMed:17474149).Curated1
Sequence conflicti867T → A in AAK29625 (PubMed:11470918).Curated1
Sequence conflicti867T → A in AAK28488 (PubMed:11867692).Curated1
Sequence conflicti867T → A in AAU04980 (PubMed:17474149).Curated1
Sequence conflicti897E → G in AAK28488 (PubMed:11867692).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB045181 mRNA Translation: BAB19260.1
AF348140 mRNA Translation: AAK29625.1
AF314224 mRNA Translation: AAK28488.1
AC164430 Genomic DNA No translation available.
AY649790 Genomic DNA Translation: AAU04980.1
AY649791 Genomic DNA Translation: AAU04981.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40755.1

NCBI Reference Sequences

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RefSeqi
NP_112455.2, NM_031178.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.44889

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062241; ENSMUSP00000082207; ENSMUSG00000045322

Database of genes from NCBI RefSeq genomes

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GeneIDi
81897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:81897

UCSC genome browser

More...
UCSCi
uc009rjh.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB045181 mRNA Translation: BAB19260.1
AF348140 mRNA Translation: AAK29625.1
AF314224 mRNA Translation: AAK28488.1
AC164430 Genomic DNA No translation available.
AY649790 Genomic DNA Translation: AAU04980.1
AY649791 Genomic DNA Translation: AAU04981.1
CCDSiCCDS40755.1
RefSeqiNP_112455.2, NM_031178.2
UniGeneiMm.44889

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WPFX-ray1.96A26-818[»]
3WPGX-ray2.25A26-818[»]
3WPHX-ray2.33A26-818[»]
3WPIX-ray2.25A26-818[»]
4QDHX-ray2.40A/B480-753[»]
5ZLNX-ray2.30A/B26-818[»]
ProteinModelPortaliQ9EQU3
SMRiQ9EQU3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219897, 1 interactor
CORUMiQ9EQU3
IntActiQ9EQU3, 28 interactors
MINTiQ9EQU3
STRINGi10090.ENSMUSP00000082207

Chemistry databases

ChEMBLiCHEMBL6128

PTM databases

iPTMnetiQ9EQU3
PhosphoSitePlusiQ9EQU3

Proteomic databases

MaxQBiQ9EQU3
PaxDbiQ9EQU3
PeptideAtlasiQ9EQU3
PRIDEiQ9EQU3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062241; ENSMUSP00000082207; ENSMUSG00000045322
GeneIDi81897
KEGGimmu:81897
UCSCiuc009rjh.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54106
MGIiMGI:1932389 Tlr9

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000162493
HOGENOMiHOG000230468
HOVERGENiHBG018601
InParanoidiQ9EQU3
KOiK10161
OMAiRRCDHAR
OrthoDBiEOG091G0BWK
TreeFamiTF325595

Enzyme and pathway databases

ReactomeiR-MMU-109704 PI3K Cascade
R-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168138 Toll Like Receptor 9 (TLR9) Cascade
R-MMU-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-MMU-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-MMU-975155 MyD88 dependent cascade initiated on endosome

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9EQU3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045322 Expressed in 60 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_TLR9
GenevisibleiQ9EQU3 MM

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR000157 TIR_dom
IPR027181 TLR9
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR24373:SF37 PTHR24373:SF37, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 15 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 16 hits
PS50104 TIR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTLR9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQU3
Secondary accession number(s): F8VPN5
, Q4L0K3, Q4L0K4, Q99MF2, Q99MQ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: December 14, 2011
Last modified: December 5, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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