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Protein

Synaptotagmin-13

Gene

Syt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:Syt13
Synonyms:Kiaa1427
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1933945 Syt13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6VesicularSequence analysis6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 426CytoplasmicSequence analysisAdd BLAST397

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839761 – 426Synaptotagmin-13Add BLAST426

Proteomic databases

PaxDbiQ9EQT6
PeptideAtlasiQ9EQT6
PRIDEiQ9EQT6

PTM databases

iPTMnetiQ9EQT6
PhosphoSitePlusiQ9EQT6
SwissPalmiQ9EQT6

Expressioni

Tissue specificityi

Expressed in brain, heart, spleen, lung and testis.1 Publication

Developmental stagei

Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiENSMUSG00000027220 Expressed in 210 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SYT13
GenevisibleiQ9EQT6 MM

Interactioni

Subunit structurei

Interacts with NRXN1.1 Publication

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9EQT6
SMRiQ9EQT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 259C2 1PROSITE-ProRule annotationAdd BLAST85
Domaini289 – 394C2 2PROSITE-ProRule annotationAdd BLAST106

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H Eukaryota
ENOG4110ZXG LUCA
GeneTreeiENSGT00920000148994
HOGENOMiHOG000231448
HOVERGENiHBG098553
InParanoidiQ9EQT6
KOiK19913
OMAiVWNEMIM
OrthoDBiEOG091G0DPW
PhylomeDBiQ9EQT6
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028692 SYT13
PANTHERiPTHR10024:SF250 PTHR10024:SF250, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDREPDPEK
60 70 80 90 100
ARPGVLQAAQ QFNIKKSTEP VQPRPLLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
TLETTEESAA PASPQAQSDS RLKRQVTEEL SIRPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHFRLDYDQ KKAELFVTSL EAVTSDHEGG CDCYIQGSVA
210 220 230 240 250
VKTGSVEAQT ALKKRQLHTT WEEGLALPLG EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVIGELRL GLDGASVPLG AAQWGELKTT AKEPSAGAGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQAQKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLR ASSVELEVLG QGEEGPSCEL GHCSLGLHAS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,870
Last modified:March 1, 2001 - v1
Checksum:i8B67FAF369861CBE
GO

Sequence cautioni

The sequence BAC98167 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52R → G in BAC31748 (PubMed:16141072).Curated1
Sequence conflicti103E → G in BAC98167 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048947 mRNA Translation: BAB19628.1
AK044038 mRNA Translation: BAC31748.1
AK049840 mRNA Translation: BAC33948.1
AK082425 mRNA Translation: BAC38491.1
AK129357 mRNA Translation: BAC98167.1 Different initiation.
BC030907 mRNA Translation: AAH30907.1
CCDSiCCDS16451.1
RefSeqiNP_109650.1, NM_030725.4
UniGeneiMm.33490

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220
GeneIDi80976
KEGGimmu:80976
UCSCiuc008lfn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048947 mRNA Translation: BAB19628.1
AK044038 mRNA Translation: BAC31748.1
AK049840 mRNA Translation: BAC33948.1
AK082425 mRNA Translation: BAC38491.1
AK129357 mRNA Translation: BAC98167.1 Different initiation.
BC030907 mRNA Translation: AAH30907.1
CCDSiCCDS16451.1
RefSeqiNP_109650.1, NM_030725.4
UniGeneiMm.33490

3D structure databases

ProteinModelPortaliQ9EQT6
SMRiQ9EQT6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9EQT6
PhosphoSitePlusiQ9EQT6
SwissPalmiQ9EQT6

Proteomic databases

PaxDbiQ9EQT6
PeptideAtlasiQ9EQT6
PRIDEiQ9EQT6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028648; ENSMUSP00000028648; ENSMUSG00000027220
GeneIDi80976
KEGGimmu:80976
UCSCiuc008lfn.1 mouse

Organism-specific databases

CTDi57586
MGIiMGI:1933945 Syt13
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IT3H Eukaryota
ENOG4110ZXG LUCA
GeneTreeiENSGT00920000148994
HOGENOMiHOG000231448
HOVERGENiHBG098553
InParanoidiQ9EQT6
KOiK19913
OMAiVWNEMIM
OrthoDBiEOG091G0DPW
PhylomeDBiQ9EQT6
TreeFamiTF315600

Miscellaneous databases

ChiTaRSiSyt13 mouse
PROiPR:Q9EQT6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027220 Expressed in 210 organ(s), highest expression level in islet of Langerhans
CleanExiMM_SYT13
GenevisibleiQ9EQT6 MM

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028692 SYT13
PANTHERiPTHR10024:SF250 PTHR10024:SF250, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYT13_MOUSE
AccessioniPrimary (citable) accession number: Q9EQT6
Secondary accession number(s): Q6ZPR2, Q8BRK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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