Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 133 (10 Apr 2019)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Immunoglobulin superfamily DCC subclass member 4

Gene

Igdcc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin superfamily DCC subclass member 4
Alternative name(s):
Neighbor of punc e11
Protein DDM36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Igdcc4
Synonyms:Ddm36, Kiaa1628, Nope
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858497 Igdcc4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 956ExtracellularSequence analysisAdd BLAST934
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei957 – 977HelicalSequence analysisAdd BLAST21
Topological domaini978 – 1252CytoplasmicSequence analysisAdd BLAST275

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030462323 – 1252Immunoglobulin superfamily DCC subclass member 4Add BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 120PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi163 ↔ 211PROSITE-ProRule annotation
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi264 ↔ 311PROSITE-ProRule annotation
Disulfide bondi355 ↔ 404PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei994PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9EQS9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EQS9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EQS9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skeletal muscle, heart and brain. Brain expression is hippocampus-specific.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed from 9.5 dpc. Expression is observed in the developing embryo, especially in the notochord, in developing skeletal muscles, and later in the ventricular zone of the nervous system.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032816 Expressed in 269 organ(s), highest expression level in substantia nigra

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9EQS9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EQS9 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000076878

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9EQS9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EQS9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 136Ig-like 1Add BLAST110
Domaini142 – 228Ig-like 2Add BLAST87
Domaini241 – 329Ig-like 3Add BLAST89
Domaini334 – 420Ig-like 4Add BLAST87
Domaini430 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini526 – 622Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini631 – 742Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST112
Domaini751 – 844Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini849 – 944Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi384 – 387Poly-Gly4
Compositional biasi440 – 443Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159637

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113009

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EQS9

KEGG Orthology (KO)

More...
KOi
K22657

Identification of Orthologs from Complete Genome Data

More...
OMAi
MQHRTPS

Database of Orthologous Groups

More...
OrthoDBi
1010015at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9EQS9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 5 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EQS9-1) [UniParc]FASTAAdd to basket
Also known as: Ddm36

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARADTGRGL LVLTFCLLSA RGELPLPQET TVKLSCDEGP LQVILGPEQA
60 70 80 90 100
VVLDCTLGAT AAGPPTRVTW SKDGDTVLEH ENLHLLPNGS LWLSSPLEQE
110 120 130 140 150
DSDDEEALRI WKVTEGSYSC LAHSPLGVVA SQVAVVKLAT LEDFSLHPES
160 170 180 190 200
QIVEENGTAR FECHTKGLPA PIITWEKDQV TVPEESRLIT LPNGVLQILD
210 220 230 240 250
VQDSDAGSYR CVATNSARQR FSQEASLTVA LRGSLEATRG QDVVIVAAPE
260 270 280 290 300
NTTVVSGQSV VMECVASADP TPFVSWVRQD GKPISTDVIV LGRTNLLIAS
310 320 330 340 350
AQPRHSGVYV CRANKPRTRD FATAAAELRV LAAPAISQAP EALSRTRAST
360 370 380 390 400
ARFVCRASGE PRPALHWLHD GIPLRPNGRV KVQGGGGSLV ITQIGLQDAG
410 420 430 440 450
YYQCVAENSA GTACAAAPLA VVVREGLPSA PTRVTATPLS SSSVLVAWER
460 470 480 490 500
PELHSEQIIG FSLHYQKARG VDNVEYQFAV NNDTTELQVR DLEPNTDYEF
510 520 530 540 550
YVVAYSQLGA SRTSSPALVH TLDDVPSAAP QLTLSSPNPS DIRVAWLPLP
560 570 580 590 600
SSLSNGQVLK YKIEYGLGKE DQVFSTEVPG NETQLTLNSL QPNKVYRVRI
610 620 630 640 650
SAGTGAGYGV PSQWMQHRTP GVHNQSHVPF APAELKVRAK MESLVVSWQP
660 670 680 690 700
PPHPTQISGY KLYWREVGTE EEADGDRPPG GRGDQAWDVG PVRLKKKVKQ
710 720 730 740 750
YELTQLVPGR LYEVKLVAFN KHEDGYAAVW KGKTEKAPTP DLPIQRGPPL
760 770 780 790 800
PPAHVHAESN SSTSIWLRWK KPDFTTVKIV NYTVRFGPWG LRNASLVTYY
810 820 830 840 850
TSSGEDILIG GLKPFTKYEF AVQSHGVDMD GPFGSVVERS TLPDRPSTPP
860 870 880 890 900
SDLRLSPLTP STVRLHWCPP TEPNGEIVEY LILYSNNHTQ PEHQWTLLTT
910 920 930 940 950
EGNIFSAEVH GLESDTRYFF KMGARTEVGP GPFSRLQDVI TLQKTFSDSL
960 970 980 990 1000
DVHAVTGIIV GVCLGLLCLL ACMCAGLRRS SHREALPGLS SSGTPGNPAL
1010 1020 1030 1040 1050
YTRARLGPPS VPAAHELESL VHPRPQDWSP PPSDVEDKAE VHSLMGGSVS
1060 1070 1080 1090 1100
DCRGHSKRKI SWAQAGGPNW AGSWAGCELP QGSGPRPALT RALLPPAGTG
1110 1120 1130 1140 1150
QTLLLQALVY DAIKSNGRKK PSPACRNQVE AEVIVHSDFG ASKGCPDLHL
1160 1170 1180 1190 1200
QDLEPEEPLT AETLPSTSGA VDLSQGADWL GRELGGCQPT TSGPERLTCL
1210 1220 1230 1240 1250
PEAASASCSC SDLQPSTAIE EAPGKSCQPK ALCPLTVSPS LPRAPVSSAQ

VP
Length:1,252
Mass (Da):134,765
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA5292393483AB73
GO
Isoform 2 (identifier: Q9EQS9-2) [UniParc]FASTAAdd to basket
Also known as: Ddm36e

The sequence of this isoform differs from the canonical sequence as follows:
     570-570: E → EE

Show »
Length:1,253
Mass (Da):134,894
Checksum:i2D55B254A42B9AEE
GO
Isoform 3 (identifier: Q9EQS9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     280-377: DGKPISTDVI...LHDGIPLRPN → GDQSKKELGI...CTTGSRCDPM

Note: No experimental confirmation available.
Show »
Length:1,301
Mass (Da):139,524
Checksum:i2C5E7B69D119685A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0JNS2A0JNS2_MOUSE
Igdcc4 protein
Igdcc4 Nope
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QAQ0E9QAQ0_MOUSE
Immunoglobulin superfamily DCC subc...
Igdcc4
1,299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 20GLLVL…CLLSA → EGSQENPSAWHG in BAC65817 (PubMed:10997877).CuratedAdd BLAST12
Sequence conflicti186S → P in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti193 – 195NGV → KWL in AAF65930 (PubMed:10708514).Curated3
Sequence conflicti259S → N in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti317R → L in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti665R → G in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti711L → P in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti944K → E in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti979R → Q in AAF65930 (PubMed:10708514).Curated1
Sequence conflicti1112A → G in AAF65930 (PubMed:10708514).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028047280 – 377DGKPI…PLRPN → GDQSKKELGIQTSGCDAALQ GCSGNLVVGEGVEGTVPASP SSLLLLCHQMESLSPRMSSF WAGPIYSSPARSLGTLESMS AEPTSPARVISPLRLLSSEC LLPQPSRRRPRRSRGRGPAP RASCAGRPGSHGPRCTGCTT GSRCDPM in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_028048570E → EE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF176694 mRNA Translation: AAF65930.1
AB052620 mRNA Translation: BAB19278.1
AB052621 mRNA Translation: BAB19279.1
AK122535 mRNA Translation: BAC65817.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72258.1 [Q9EQS9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001277244.1, NM_001290315.1 [Q9EQS9-2]
NP_064427.2, NM_020043.3 [Q9EQS9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.209041

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000035499; ENSMUSP00000045387; ENSMUSG00000032816 [Q9EQS9-2]
ENSMUST00000213533; ENSMUSP00000150272; ENSMUSG00000032816 [Q9EQS9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:56741

UCSC genome browser

More...
UCSCi
uc009qct.2 mouse [Q9EQS9-1]
uc009qcu.2 mouse [Q9EQS9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176694 mRNA Translation: AAF65930.1
AB052620 mRNA Translation: BAB19278.1
AB052621 mRNA Translation: BAB19279.1
AK122535 mRNA Translation: BAC65817.1
CCDSiCCDS72258.1 [Q9EQS9-2]
RefSeqiNP_001277244.1, NM_001290315.1 [Q9EQS9-2]
NP_064427.2, NM_020043.3 [Q9EQS9-1]
UniGeneiMm.209041

3D structure databases

ProteinModelPortaliQ9EQS9
SMRiQ9EQS9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076878

PTM databases

iPTMnetiQ9EQS9
PhosphoSitePlusiQ9EQS9

Proteomic databases

PRIDEiQ9EQS9

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
56741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035499; ENSMUSP00000045387; ENSMUSG00000032816 [Q9EQS9-2]
ENSMUST00000213533; ENSMUSP00000150272; ENSMUSG00000032816 [Q9EQS9-1]
GeneIDi56741
KEGGimmu:56741
UCSCiuc009qct.2 mouse [Q9EQS9-1]
uc009qcu.2 mouse [Q9EQS9-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57722
MGIiMGI:1858497 Igdcc4

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

GeneTreeiENSGT00940000159637
HOGENOMiHOG000113009
InParanoidiQ9EQS9
KOiK22657
OMAiMQHRTPS
OrthoDBi1010015at2759
PhylomeDBiQ9EQS9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Igdcc4 mouse

Protein Ontology

More...
PROi
PR:Q9EQS9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000032816 Expressed in 269 organ(s), highest expression level in substantia nigra
ExpressionAtlasiQ9EQS9 baseline and differential
GenevisibleiQ9EQS9 MM

Family and domain databases

CDDicd00063 FN3, 5 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 5 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 5 hits
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 3 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 5 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGDC4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQS9
Secondary accession number(s): Q80TB0, Q9EQS8, Q9JLI1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: April 10, 2019
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again