UniProtKB - Q9EQR3 (KCNN1_MOUSE)
Small conductance calcium-activated potassium channel protein 1
Kcnn1
Functioni
Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:11557517).
Activation is followed by membrane hyperpolarization (PubMed:11557517).
Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11557517).
1 PublicationActivity regulationi
GO - Molecular functioni
- calmodulin binding Source: MGI
- inward rectifier potassium channel activity Source: MGI
- protein-containing complex binding Source: MGI
- small conductance calcium-activated potassium channel activity Source: MGI
GO - Biological processi
- ion transport Source: GO_Central
- potassium ion transmembrane transport Source: MGI
Keywordsi
Molecular function | Calmodulin-binding, Ion channel |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-1296052, Ca2+ activated K+ channels |
Protein family/group databases
TCDBi | 9.A.48.1.1, the unconventional protein secretion (ups) system |
Names & Taxonomyi
Protein namesi | Recommended name: Small conductance calcium-activated potassium channel protein 1Short name: SK1 Short name: SKCa 1 Short name: SKCa1 Alternative name(s): KCa2.1 |
Gene namesi | Name:Kcnn1 Synonyms:Sk1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1933993, Kcnn1 |
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
- neuron projection Source: GO_Central
- neuronal cell body Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 108 – 128 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 137 – 157 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 225 – 245 | Helical; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 274 – 294 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 314 – 334 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155008 | 1 – 537 | Small conductance calcium-activated potassium channel protein 1Add BLAST | 537 |
Proteomic databases
MaxQBi | Q9EQR3 |
PaxDbi | Q9EQR3 |
PeptideAtlasi | Q9EQR3 |
PRIDEi | Q9EQR3 |
ProteomicsDBi | 269274 [Q9EQR3-1] 269275 [Q9EQR3-2] 269276 [Q9EQR3-3] 269277 [Q9EQR3-4] 269278 [Q9EQR3-5] 269279 [Q9EQR3-6] 269280 [Q9EQR3-7] 269281 [Q9EQR3-8] 269282 [Q9EQR3-9] |
PTM databases
PhosphoSitePlusi | Q9EQR3 |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).
Interacts with calmodulin.
By similarity1 PublicationGO - Molecular functioni
- calmodulin binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 219999, 1 interactor |
STRINGi | 10090.ENSMUSP00000105708 |
Miscellaneous databases
RNActi | Q9EQR3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 90 | DisorderedSequence analysisAdd BLAST | 90 | |
Regioni | 343 – 363 | Segment S6Sequence analysisAdd BLAST | 21 | |
Regioni | 381 – 460 | Calmodulin-bindingBy similarityAdd BLAST | 80 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3684, Eukaryota |
InParanoidi | Q9EQR3 |
OrthoDBi | 907751at2759 |
PhylomeDBi | Q9EQR3 |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSHSHNGSV GQPLGSGPGF LGWEPVDPEA GRPLQPTQGP GLQMVAKGQP
60 70 80 90 100
VRLSPGGSRG HPQEQEEEEE EEEEEDKTGS GKPPTVSHRL GHRRALFEKR
110 120 130 140 150
KRLSDYALIF GMFGIVVMVT ETELSWGVYT KESLCSFALK CLISLSTVIL
160 170 180 190 200
LGLVILYHAR EIQLFLVDNG ADDWRIAMTW ERVSLISLEL VVCAIHPVPG
210 220 230 240 250
HYRFTWTARL AFSLVPSAAE ADLDVLLSIP MFLRLYLLAR VMLLHSRIFT
260 270 280 290 300
DASSRSIGAL NRVTFNTRFV TKTLMTICPG TVLLVFSVSS WIVAAWTVRV
310 320 330 340 350
CERYHDKQEV TSNFLGAMWL ISITFLSIGY GDMVPHTYCG KGVCLLTGIM
360 370 380 390 400
GAGCTALVVA VVARKLELTK AEKHVHNFMM DTQLTKRVKN AAANVLRETW
410 420 430 440 450
LIYKHTRLVK KPDQGRVRKH QRKFLQAIHQ AQKLRSVKIE QGKVNDQANT
460 470 480 490 500
LAELAKAQSI AYEVVSELQA QQEELEARLA ALESRLDVLG ASLQALPGLI
510 520 530
AQAICPLPPP WPGPGHLATA THSPQSHWLP TMGSDCG
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RM38 | A0A1D5RM38_MOUSE | Small conductance calcium-activated... | Kcnn1 | 581 | Annotation score: | ||
A0A140T8Q8 | A0A140T8Q8_MOUSE | Small conductance calcium-activated... | Kcnn1 | 538 | Annotation score: | ||
Z4YL28 | Z4YL28_MOUSE | Small conductance calcium-activated... | Kcnn1 | 539 | Annotation score: | ||
A0A1D5RMB2 | A0A1D5RMB2_MOUSE | Small conductance calcium-activated... | Kcnn1 | 535 | Annotation score: | ||
A0A1D5RLR9 | A0A1D5RLR9_MOUSE | Small conductance calcium-activated... | Kcnn1 | 157 | Annotation score: | ||
A0A1D5RLS4 | A0A1D5RLS4_MOUSE | Small conductance calcium-activated... | Kcnn1 | 113 | Annotation score: | ||
A0A1D5RMF8 | A0A1D5RMF8_MOUSE | Small conductance calcium-activated... | Kcnn1 | 132 | Annotation score: |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 66 | E → EE in strain: C57BL/6J, A/HeJ and SPRET/Ei. 1 Publication | 1 | |
Natural varianti | 66 | E → EEE in strain: SWR/J, AKR/J, RBF/DNJ and P/J. | 1 | |
Natural varianti | 522 | H → Q in strain: C57BL/6J. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002809 | 1 | M → MFWNGQGDVQPLLSPQVHSE ALLRNHAGPQRACCTPSPRR QVAM in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_002810 | 351 – 387 | Missing in isoform 3, isoform 4, isoform 5 and isoform 6. CuratedAdd BLAST | 37 | |
Alternative sequenceiVSP_002811 | 423 – 537 | KFLQA…GSDCG → LRSSEV in isoform 5 and isoform 8. CuratedAdd BLAST | 115 | |
Alternative sequenceiVSP_002812 | 423 – 537 | KFLQA…GSDCG → SEV in isoform 6 and isoform 7. CuratedAdd BLAST | 115 | |
Alternative sequenceiVSP_002813 | 431 – 433 | Missing in isoform 4 and isoform 9. Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116525 mRNA Translation: AAG43216.1 AF297870, AF297869 Genomic DNA Translation: AAK30363.1 AF303461 mRNA Translation: AAK29550.1 AF303462 mRNA Translation: AAK29551.1 AF303463 mRNA Translation: AAK29552.1 AF357239 mRNA Translation: AAK48900.1 AY258143 mRNA Translation: AAP45948.1 BC090622 mRNA Translation: AAH90622.1 |
RefSeqi | NP_115773.2, NM_032397.2 XP_006509870.1, XM_006509807.3 XP_006509871.1, XM_006509808.3 |
Genome annotation databases
GeneIDi | 84036 |
KEGGi | mmu:84036 |
UCSCi | uc012gfj.1, mouse [Q9EQR3-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116525 mRNA Translation: AAG43216.1 AF297870, AF297869 Genomic DNA Translation: AAK30363.1 AF303461 mRNA Translation: AAK29550.1 AF303462 mRNA Translation: AAK29551.1 AF303463 mRNA Translation: AAK29552.1 AF357239 mRNA Translation: AAK48900.1 AY258143 mRNA Translation: AAP45948.1 BC090622 mRNA Translation: AAH90622.1 |
RefSeqi | NP_115773.2, NM_032397.2 XP_006509870.1, XM_006509807.3 XP_006509871.1, XM_006509808.3 |
3D structure databases
SMRi | Q9EQR3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 219999, 1 interactor |
STRINGi | 10090.ENSMUSP00000105708 |
Protein family/group databases
TCDBi | 9.A.48.1.1, the unconventional protein secretion (ups) system |
PTM databases
PhosphoSitePlusi | Q9EQR3 |
Proteomic databases
MaxQBi | Q9EQR3 |
PaxDbi | Q9EQR3 |
PeptideAtlasi | Q9EQR3 |
PRIDEi | Q9EQR3 |
ProteomicsDBi | 269274 [Q9EQR3-1] 269275 [Q9EQR3-2] 269276 [Q9EQR3-3] 269277 [Q9EQR3-4] 269278 [Q9EQR3-5] 269279 [Q9EQR3-6] 269280 [Q9EQR3-7] 269281 [Q9EQR3-8] 269282 [Q9EQR3-9] |
Protocols and materials databases
DNASUi | 84036 |
Genome annotation databases
GeneIDi | 84036 |
KEGGi | mmu:84036 |
UCSCi | uc012gfj.1, mouse [Q9EQR3-2] |
Organism-specific databases
CTDi | 3780 |
MGIi | MGI:1933993, Kcnn1 |
Phylogenomic databases
eggNOGi | KOG3684, Eukaryota |
InParanoidi | Q9EQR3 |
OrthoDBi | 907751at2759 |
PhylomeDBi | Q9EQR3 |
Enzyme and pathway databases
Reactomei | R-MMU-1296052, Ca2+ activated K+ channels |
Miscellaneous databases
BioGRID-ORCSi | 84036, 3 hits in 65 CRISPR screens |
ChiTaRSi | Kcnn1, mouse |
PROi | PR:Q9EQR3 |
RNActi | Q9EQR3, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR004178, CaM-bd_dom IPR036122, CaM-bd_dom_sf IPR015449, K_chnl_Ca-activ_SK IPR013099, K_chnl_dom |
PANTHERi | PTHR10153, PTHR10153, 1 hit |
Pfami | View protein in Pfam PF02888, CaMBD, 1 hit PF07885, Ion_trans_2, 1 hit PF03530, SK_channel, 1 hit |
PRINTSi | PR01451, SKCHANNEL |
SMARTi | View protein in SMART SM01053, CaMBD, 1 hit |
SUPFAMi | SSF81327, SSF81327, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KCNN1_MOUSE | |
Accessioni | Q9EQR3Primary (citable) accession number: Q9EQR3 Secondary accession number(s): Q5CZY7, Q6JXY1, Q99JA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families