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UniProtKB - Q9EQR2 (ADAS_RAT)
Protein
Alkyldihydroxyacetonephosphate synthase, peroxisomal
Gene
Agps
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalyzes the exchange of the acyl chain in acyl-dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl-dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis.
1 PublicationCatalytic activityi
- a 1-acylglycerone 3-phosphate + a long chain fatty alcohol = 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H+2 PublicationsEC:2.5.1.262 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + H+ + hexadecanoateBy similarityThis reaction proceeds in the forwardBy similarity direction.
- 1-hexadecanoylglycerone 3-phosphate + a long-chain fatty acid = a 1-acylglycerone 3-phosphate + hexadecanoateBy similarityThis reaction proceeds in the forwardBy similarity direction.
Cofactori
FADBy similarity
Activity regulationi
Inhibited by divalent cation Mg2+.1 Publication
Kineticsi
- KM=44 µM for hexadecanol1 Publication
- KM=38 µM for octadecenol1 Publication
- KM=50 µM for palmitoylglycerone phosphate1 Publication
pH dependencei
Optimum pH is 7.5.1 Publication
: ether lipid biosynthesis Pathwayi
This protein is involved in the pathway ether lipid biosynthesis, which is part of Glycerolipid metabolism.View all proteins of this organism that are known to be involved in the pathway ether lipid biosynthesis and in Glycerolipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 405 | Important for enzyme activityBy similarity | 1 | |
Binding sitei | 501 | SubstrateBy similarity | 1 | |
Active sitei | 564 | Proton donor/acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 220 – 226 | FADBy similarity | 7 | |
Nucleotide bindingi | 289 – 295 | FADBy similarity | 7 | |
Nucleotide bindingi | 302 – 305 | FADBy similarity | 4 | |
Nucleotide bindingi | 354 – 360 | FADBy similarity | 7 |
GO - Molecular functioni
- alkylglycerone-phosphate synthase activity Source: UniProtKB
- FAD binding Source: UniProtKB
- oxidoreductase activity Source: InterPro
GO - Biological processi
- ether lipid biosynthetic process Source: UniProtKB
- lipid biosynthetic process Source: RGD
Keywordsi
Molecular function | Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-RNO-75896, Plasmalogen biosynthesis R-RNO-9033241, Peroxisomal protein import |
UniPathwayi | UPA00781 |
Names & Taxonomyi
Protein namesi | Recommended name: Alkyldihydroxyacetonephosphate synthase, peroxisomal (EC:2.5.1.262 Publications)Short name: Alkyl-DHAP synthase Alternative name(s): Alkylglycerone-phosphate synthase |
Gene namesi | Name:Agps Synonyms:Ads |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620364, Agps |
Subcellular locationi
Peroxisome
- Peroxisome membrane By similarity
- Peroxisome 1 Publication
Mitochondrion
- mitochondrion Source: RGD
Peroxisome
- peroxisomal membrane Source: UniProtKB-SubCell
- peroxisome Source: HGNC-UCL
Keywords - Cellular componenti
Membrane, PeroxisomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 44 | PeroxisomeBy similarityAdd BLAST | 44 | |
ChainiPRO_0000231677 | 45 – 644 | Alkyldihydroxyacetonephosphate synthase, peroxisomalAdd BLAST | 600 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | PhosphoserineBy similarity | 1 | |
Modified residuei | 56 | PhosphoserineBy similarity | 1 | |
Modified residuei | 88 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 333 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q9EQR2 |
PaxDbi | Q9EQR2 |
PRIDEi | Q9EQR2 |
PTM databases
iPTMneti | Q9EQR2 |
PhosphoSitePlusi | Q9EQR2 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002111 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 188 – 370 | FAD-binding PCMH-typePROSITE-ProRule annotationAdd BLAST | 183 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 70 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 601 – 603 | Important for enzyme activityBy similarity | 3 | |
Regioni | 640 – 644 | Important for enzyme activityBy similarity | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 23 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the FAD-binding oxidoreductase/transferase type 4 family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG1233, Eukaryota |
InParanoidi | Q9EQR2 |
OrthoDBi | 824020at2759 |
PhylomeDBi | Q9EQR2 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9EQR2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEAAGEAGA SERDPDAVRA RRRLRVLSGH LLGRPQEAPS TNECKARRAA
60 70 80 90 100
SAAGASPAAS PAAPESGTIP KKRQELMKWN GWGYNDSKFL LNKKGQVELT
110 120 130 140 150
GKRYPLSGLA LPTLKDWIQN TLGVNLEHKT TSKPSINPSE APPSIVNEDF
160 170 180 190 200
LQELKEAHIS YSQDADDRVF RAHGHCLHEI FLLREGMFER IPDIVVWPTC
210 220 230 240 250
HDDVVKIVNL ACKYNLCIIP IGGGTSVSYG LMCPADETRT IISLDTSQMN
260 270 280 290 300
RILWVDENNL TAHVEAGITG QDLERQLKES GYCTGHEPDS LEFSIVGGWI
310 320 330 340 350
STRASGMKKN VYGNIEDLVV HMKMVTPRGV IEKSSQGPRM STGPDIHHFI
360 370 380 390 400
MGSEGTLGVI TEATIKIRPT PEYQKYGSVA FPNFEQGVAC LREIAKQRCA
410 420 430 440 450
PASIRLMDNQ QFQFGHALKP QVSSIFTSFL DGFKKFYITK FKGFDPNQIS
460 470 480 490 500
VATLLFEGDR EKVLQHEKQV YDIAAKFGGL AAGEDNGQRG YLLTYVIAYM
510 520 530 540 550
RDLGLEYYVV GESFETSAPW DRVIDLCRNV KERIRRECKE RGVQFAPLST
560 570 580 590 600
CRVTQTYDAG ACIYFYFAFN YRGISDPLTV FEQTEAAARD EILANGGSLS
610 620 630 640
HHHGVGKLRK QWLKESISDV GFGMLKSVKD YVDPSNIFGN RNLL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1M9Q8 | F1M9Q8_RAT | Alkylglycerone-phosphate synthase | Agps | 644 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121052 mRNA Translation: AAG43235.1 |
RefSeqi | NP_445802.2, NM_053350.2 |
Genome annotation databases
GeneIDi | 84114 |
KEGGi | rno:84114 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF121052 mRNA Translation: AAG43235.1 |
RefSeqi | NP_445802.2, NM_053350.2 |
3D structure databases
SMRi | Q9EQR2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002111 |
PTM databases
iPTMneti | Q9EQR2 |
PhosphoSitePlusi | Q9EQR2 |
Proteomic databases
jPOSTi | Q9EQR2 |
PaxDbi | Q9EQR2 |
PRIDEi | Q9EQR2 |
Genome annotation databases
GeneIDi | 84114 |
KEGGi | rno:84114 |
Organism-specific databases
CTDi | 8540 |
RGDi | 620364, Agps |
Phylogenomic databases
eggNOGi | KOG1233, Eukaryota |
InParanoidi | Q9EQR2 |
OrthoDBi | 824020at2759 |
PhylomeDBi | Q9EQR2 |
Enzyme and pathway databases
UniPathwayi | UPA00781 |
Reactomei | R-RNO-75896, Plasmalogen biosynthesis R-RNO-9033241, Peroxisomal protein import |
Miscellaneous databases
PROi | PR:Q9EQR2 |
Family and domain databases
Gene3Di | 1.10.45.10, 1 hit 3.30.43.10, 1 hit 3.30.465.10, 1 hit |
InterProi | View protein in InterPro IPR025650, Alkyl-DHAP_Synthase IPR016166, FAD-bd_PCMH IPR036318, FAD-bd_PCMH-like_sf IPR016167, FAD-bd_PCMH_sub1 IPR016169, FAD-bd_PCMH_sub2 IPR016164, FAD-linked_Oxase-like_C IPR004113, FAD-linked_oxidase_C IPR006094, Oxid_FAD_bind_N IPR016171, Vanillyl_alc_oxidase_C-sub2 |
PANTHERi | PTHR46568, PTHR46568, 1 hit |
Pfami | View protein in Pfam PF02913, FAD-oxidase_C, 1 hit PF01565, FAD_binding_4, 1 hit |
SUPFAMi | SSF55103, SSF55103, 1 hit SSF56176, SSF56176, 1 hit |
PROSITEi | View protein in PROSITE PS51387, FAD_PCMH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAS_RAT | |
Accessioni | Q9EQR2Primary (citable) accession number: Q9EQR2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | June 2, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families