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Protein

TSC22 domain family protein 4

Gene

Tsc22d4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TSC22 domain family protein 4
Alternative name(s):
TSC22-related-inducible leucine zipper protein 2
Thg-1pit
Gene namesi
Name:Tsc22d4
Synonyms:Thg1pit, Tilz2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926079 Tsc22d4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193751 – 387TSC22 domain family protein 4Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphothreonineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei165PhosphoserineCombined sources1
Modified residuei183PhosphothreonineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei223PhosphothreonineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1
Modified residuei362PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9EQN3
MaxQBiQ9EQN3
PaxDbiQ9EQN3
PRIDEiQ9EQN3

PTM databases

iPTMnetiQ9EQN3
PhosphoSitePlusiQ9EQN3

Expressioni

Developmental stagei

Expression starts at 8.5 dpc and undergoes a second peak of activation at 12.5 dpc. At 12.5 dpc, expression encompasses the entire central nervous system, with highest levels in the dorsal root and trigeminal ganglia.1 Publication

Inductioni

Up-regulated by TGF-beta treatment.1 Publication

Gene expression databases

BgeeiENSMUSG00000029723 Expressed in 297 organ(s), highest expression level in thymus
CleanExiMM_TSC22D4
ExpressionAtlasiQ9EQN3 baseline and differential
GenevisibleiQ9EQN3 MM

Interactioni

Subunit structurei

Forms a homodimer or heterodimer. Can form a heterodimer with TSC22D1 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi219663, 1 interactor
IntActiQ9EQN3, 3 interactors
MINTiQ9EQN3
STRINGi10090.ENSMUSP00000098108

Structurei

3D structure databases

ProteinModelPortaliQ9EQN3
SMRiQ9EQN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni336 – 357Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the TSC-22/Dip/Bun family.Curated

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000253006
HOVERGENiHBG069048
InParanoidiQ9EQN3
OMAiCVDIYER
TreeFamiTF338725

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9EQN3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGKKKSSF QITSVTTDYE GPGSPGASDS PVPPALAGPP PRLPNGDPNP
60 70 80 90 100
DPGGRGTPRN GSPPPGAPAS RFRVVKLPQG LGEPYRRGRW TCVDVYERDL
110 120 130 140 150
EPPSFGRLLE GIRGASGGTG GRSLDSRLEL ASLGISTPIP QPGLSQGPTS
160 170 180 190 200
WLRPPPTSPG PQARSFTGGL GQLAGPGKAK VETPPLSASP PQQRPPGPGT
210 220 230 240 250
GDSAQTLPSL RVEVESGGSA AATPPLSRRR DGAVRLRMEL VAPAETGKVP
260 270 280 290 300
PTDSRPNSPA LYFDASLVHK SPDPFGAAAA QSLSLARSML AISGHLDSDD
310 320 330 340 350
DSGSGSLVGI DNKIEQAMDL VKSHLMFAVR EEVEVLKEQI RDLAERNAAL
360 370 380
EQENGLLRAL ASPEQLAQLP SSGLPRLGPS APNGPSI
Length:387
Mass (Da):39,979
Last modified:July 27, 2011 - v2
Checksum:iD4160FA3AB2DFB90
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZZ4D3YZZ4_MOUSE
TSC22 domain family protein 4
Tsc22d4
168Annotation score:
F6VXN4F6VXN4_MOUSE
TSC22 domain family protein 4
Tsc22d4
96Annotation score:
Q3U1U6Q3U1U6_MOUSE
TSC22 domain family protein 4
Tsc22d4
509Annotation score:
Q9DA18Q9DA18_MOUSE
TSC22 domain family protein 4
Tsc22d4
149Annotation score:
D3Z6V5D3Z6V5_MOUSE
MCG6859, isoform CRA_b
Tsc22d4 mCG_6859
210Annotation score:

Sequence cautioni

The sequence AAK02018 differs from that shown. Reason: Frameshift at positions 222 and 251.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97E → K in AAK02018 (PubMed:11707329).Curated1
Sequence conflicti339Q → H in AAG41219 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315352 mRNA Translation: AAK02018.1 Frameshift.
AF201286 mRNA Translation: AAG41219.1
BC018544 mRNA Translation: AAH18544.1
BC023761 mRNA Translation: AAH23761.1
BC145721 mRNA Translation: AAI45722.1
BC145723 mRNA Translation: AAI45724.1
AK018735 mRNA Translation: BAB31377.1
AK143608 mRNA Translation: BAE25460.1
CH466529 Genomic DNA Translation: EDL19240.1
CCDSiCCDS19776.1
RefSeqiNP_076399.4, NM_023910.6
UniGeneiMm.286399
Mm.486508
Mm.491129

Genome annotation databases

EnsembliENSMUST00000100539; ENSMUSP00000098107; ENSMUSG00000029723
GeneIDi78829
KEGGimmu:78829
UCSCiuc009adu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF315352 mRNA Translation: AAK02018.1 Frameshift.
AF201286 mRNA Translation: AAG41219.1
BC018544 mRNA Translation: AAH18544.1
BC023761 mRNA Translation: AAH23761.1
BC145721 mRNA Translation: AAI45722.1
BC145723 mRNA Translation: AAI45724.1
AK018735 mRNA Translation: BAB31377.1
AK143608 mRNA Translation: BAE25460.1
CH466529 Genomic DNA Translation: EDL19240.1
CCDSiCCDS19776.1
RefSeqiNP_076399.4, NM_023910.6
UniGeneiMm.286399
Mm.486508
Mm.491129

3D structure databases

ProteinModelPortaliQ9EQN3
SMRiQ9EQN3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219663, 1 interactor
IntActiQ9EQN3, 3 interactors
MINTiQ9EQN3
STRINGi10090.ENSMUSP00000098108

PTM databases

iPTMnetiQ9EQN3
PhosphoSitePlusiQ9EQN3

Proteomic databases

EPDiQ9EQN3
MaxQBiQ9EQN3
PaxDbiQ9EQN3
PRIDEiQ9EQN3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100539; ENSMUSP00000098107; ENSMUSG00000029723
GeneIDi78829
KEGGimmu:78829
UCSCiuc009adu.2 mouse

Organism-specific databases

CTDi81628
MGIiMGI:1926079 Tsc22d4

Phylogenomic databases

eggNOGiKOG4797 Eukaryota
ENOG411251N LUCA
GeneTreeiENSGT00530000063062
HOGENOMiHOG000253006
HOVERGENiHBG069048
InParanoidiQ9EQN3
OMAiCVDIYER
TreeFamiTF338725

Miscellaneous databases

PROiPR:Q9EQN3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029723 Expressed in 297 organ(s), highest expression level in thymus
CleanExiMM_TSC22D4
ExpressionAtlasiQ9EQN3 baseline and differential
GenevisibleiQ9EQN3 MM

Family and domain databases

InterProiView protein in InterPro
IPR000580 TSC-22_Dip_Bun
PANTHERiPTHR12348 PTHR12348, 1 hit
PfamiView protein in Pfam
PF01166 TSC22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007152 TSC-22_Dip_Bun, 1 hit
PROSITEiView protein in PROSITE
PS01289 TSC22, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiT22D4_MOUSE
AccessioniPrimary (citable) accession number: Q9EQN3
Secondary accession number(s): Q99PD5, Q9D2V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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