Protein-S-isoprenylcysteine O-methyltransferase

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + S-adenosyl-L-methionine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  + S-adenosyl-L-homocysteine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:O60725 (ICMT_HUMAN)
  EC:2.1.1.100
  • Search proteins in UniProtKB for this EC number.
  • See the description of this EC number in ENZYME.
  • Search reactions for this EC number in Rhea.
  By similarity

  Manual assertion inferred from sequence similarity toⁱ

  • UniProtKB:O60725 (ICMT_HUMAN)
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

  . Show »« Hide
  [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  C-terminal S-[(2E,6E)-farnesyl]-L-cysteine residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  S-adenosyl-L-methionine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  =

  [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.

  

  C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester residue

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

  +

  S-adenosyl-L-homocysteine

  • Search proteins in UniProtKB for this molecule.
  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  zoom

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cAMP response element binding protein binding Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf."
    Bergo M.O., Gavino B.J., Hong C., Beigneux A.P., McMahon M., Casey P.J., Young S.G.
    J Clin Invest 113:539-550(2004) [PubMed] [Europe PMC] [Abstract]
• protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Young S.G.
    J Biol Chem 275:17605-17610(2000) [PubMed] [Europe PMC] [Abstract]
  • "Isoprenylcysteine carboxyl methyltransferase deficiency in mice."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Gomes A.Q., Seabra M.C., Young S.G.
    J Biol Chem 276:5841-5845(2001) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• bone mineralization Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]
• C-terminal protein methylation Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Young S.G.
    J Biol Chem 275:17605-17610(2000) [PubMed] [Europe PMC] [Abstract]
• determination of adult lifespan Source: MGIInferred from genetic interactionⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Isoprenylcysteine carboxyl methyltransferase deficiency in mice."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Gomes A.Q., Seabra M.C., Young S.G.
    J Biol Chem 276:5841-5845(2001) [PubMed] [Europe PMC] [Abstract]
  • "Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice."
    Lin X., Jung J., Kang D., Xu B., Zaret K.S., Zoghbi H.
    Gastroenterology 123:345-351(2002) [PubMed] [Europe PMC] [Abstract]
• liver development Source: MGIInferred from mutant phenotypeⁱ
  • "Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice."
    Lin X., Jung J., Kang D., Xu B., Zaret K.S., Zoghbi H.
    Gastroenterology 123:345-351(2002) [PubMed] [Europe PMC] [Abstract]
• multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • "Isoprenylcysteine carboxyl methyltransferase deficiency in mice."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Gomes A.Q., Seabra M.C., Young S.G.
    J Biol Chem 276:5841-5845(2001) [PubMed] [Europe PMC] [Abstract]
• neuromuscular process Source: MGIInferred from genetic interactionⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf."
    Bergo M.O., Gavino B.J., Hong C., Beigneux A.P., McMahon M., Casey P.J., Young S.G.
    J Clin Invest 113:539-550(2004) [PubMed] [Europe PMC] [Abstract]
• protein localization Source: MGIInferred from mutant phenotypeⁱ
  • "Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Young S.G.
    J Biol Chem 275:17605-17610(2000) [PubMed] [Europe PMC] [Abstract]
• protein methylation Source: MGIInferred from mutant phenotypeⁱ
  • "Isoprenylcysteine carboxyl methyltransferase deficiency in mice."
    Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Gomes A.Q., Seabra M.C., Young S.G.
    J Biol Chem 276:5841-5845(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of cellular senescence Source: MGIInferred from genetic interactionⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of protein localization Source: MGIInferred from mutant phenotypeⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of Ras protein signal transduction Source: MGIInferred from genetic interactionⁱ
  • "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf."
    Bergo M.O., Gavino B.J., Hong C., Beigneux A.P., McMahon M., Casey P.J., Young S.G.
    J Clin Invest 113:539-550(2004) [PubMed] [Europe PMC] [Abstract]
• S-adenosylhomocysteine metabolic process Source: MGI
• S-adenosylmethioninamine metabolic process Source: MGI
• TOR signaling Source: MGIInferred from mutant phenotypeⁱ
  • "Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria."
    Ibrahim M.X., Sayin V.I., Akula M.K., Liu M., Fong L.G., Young S.G., Bergo M.O.
    Science 340:1330-1333(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cAMP response element binding protein binding Source: MGIInferred from mutant phenotypeⁱ
  • "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf."
    Bergo M.O., Gavino B.J., Hong C., Beigneux A.P., McMahon M., Casey P.J., Young S.G.
    J Clin Invest 113:539-550(2004) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAAARRGSAG SEARLSLATF LLGASVLALP LLTRAGLQGR TGLALYVAGL 
        60         70         80         90        100
NALLLLLYRP PRYQIAIRAC FLGFVFGCGV LLSFSQSSWN HFGWYVCSLS 
       110        120        130        140        150
LFHYSEYLVT AVNNPKSLSL DSFLLNHSLE YTVAALSSWI EFTLENIFWP 
       160        170        180        190        200
ELKQITWLSA TGLLMVVFGE CLRKAAMFTA GSNFNHVVQS EKSDTHTLVT 
       210        220        230        240        250
SGVYAWCRHP SYVGWFYWSI GTQVMLCNPI CGVVYALTVW RFFRDRTEEE 
       260        270        280 
EISLIHFFGE EYLDYKKRVP TGLPFIKGVK VEL                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families