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Entry version 132 (07 Oct 2020)
Sequence version 2 (10 Jun 2008)
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Protein

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

Gene

Magi3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi123 – 130ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • frizzled binding Source: MGI
  • molecular adaptor activity Source: InterPro

GO - Biological processi

  • positive regulation of JUN kinase activity Source: MGI
  • signal transduction Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Alternative name(s):
Membrane-associated guanylate kinase inverted 3
Short name:
MAGI-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Magi3
Synonyms:Kiaa1634
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923484, Magi3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003414081 – 1476Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3Add BLAST1476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei236PhosphoserineCombined sources1
Modified residuei598PhosphoserineBy similarity1
Modified residuei702PhosphoserineBy similarity1
Modified residuei833PhosphoserineBy similarity1
Modified residuei916PhosphoserineCombined sources1
Modified residuei1321PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9EQJ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EQJ9

PeptideAtlas

More...
PeptideAtlasi
Q9EQJ9

PRoteomics IDEntifications database

More...
PRIDEi
Q9EQJ9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EQJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EQJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Colocalizes with TGFA in neurons in the cortex and dentate gyrus, as well as in ependymal cells and some astrocytes (at protein level). Present in lens epithelium.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052539, Expressed in dorsal root ganglion and 274 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EQJ9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ADRB1, ADGRB1, LPAR2/EDG4, GRIN2B, PTEN, and PTPRB.

Interacts with unidentified tyrosine phosphorylated proteins (By similarity).

Interacts with FZD4, FZD7, TGFA and VANGL2.

Interacts with DLL1 (PubMed:15509766).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9EQJ9, 7 interactors

Molecular INTeraction database

More...
MINTi
Q9EQJ9

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000112934

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9EQJ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EQJ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 108PDZ 1PROSITE-ProRule annotationAdd BLAST91
Domaini116 – 290Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST175
Domaini296 – 329WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini342 – 375WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini413 – 495PDZ 2PROSITE-ProRule annotationAdd BLAST83
Domaini581 – 657PDZ 3PROSITE-ProRule annotationAdd BLAST77
Domaini729 – 811PDZ 4PROSITE-ProRule annotationAdd BLAST83
Domaini852 – 939PDZ 5PROSITE-ProRule annotationAdd BLAST88
Domaini1022 – 1104PDZ 6PROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni18 – 108Interaction with ADRB1 and TGFA1 PublicationAdd BLAST91
Regioni413 – 495Interaction with PTENBy similarityAdd BLAST83
Regioni729 – 811Interaction with ADGRB1By similarityAdd BLAST83
Regioni852 – 939Interaction with LPAR2 and GRIN2BBy similarityAdd BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 9Poly-Lys4
Compositional biasi240 – 245Poly-Glu6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0707, Eukaryota
KOG3209, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004562_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EQJ9

KEGG Orthology (KO)

More...
KOi
K06112

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANRSRGQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9EQJ9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR030035, MAGI3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10316:SF10, PTHR10316:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 4 hits
PF00397, WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 6 hits
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 6 hits
SSF51045, SSF51045, 2 hits
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 6 hits
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EQJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTLKKKKH WLSKVQECAV SWAGPPGDLG AEIRGGAERG EFPYLGRLRD
60 70 80 90 100
EAGGGGGTCC VVSGKAPSPG DVLLEVNGTP VSGLTNRDTL AVIRHFREPI
110 120 130 140 150
RLKTVKPGKV INKDLRHYLS LQFQKGSIDH KLQQVIRDNL YLRTIPCTTR
160 170 180 190 200
APRDGEVPGV DYNFISVEQF KALEESGALL ESGTYDGNFY GTPKPPAEPS
210 220 230 240 250
PFQPDPVDQV LFDNEFDTES QRKRTTSVSK MERMDSSLPE EEEDEDKEAV
260 270 280 290 300
NGSGSMETRE MHSETSDCWM KTVPSYNQTN SSMDFRNYMM RDENLEPLPK
310 320 330 340 350
NWEMAYTDTG MIYFIDHNTK TTTWLDPRLC KKAKAPEDCE DGELPYGWEK
360 370 380 390 400
IEDPQYGTYY VDHLNQKTQF ENPVEEAKRK KQLGQAEIHS AKTDVERAHF
410 420 430 440 450
TRDPSQLKGV LVRASLKKST MGFGFTIIGG DRPDEFLQVK NVLKDGPAAQ
460 470 480 490 500
DGKIAPGDVI VDINGNCVLG HTHADVVQMF QLVPVNQYVN LTLCRGYPLP
510 520 530 540 550
DDSEDPVVDI VAATPVINGQ SLTKGETCMN TQDFKLGAMV LDQNGKSGQI
560 570 580 590 600
LASDRLNGPS ESSEQRASLA SSGSSQPELV TIPLIKGPKG FGFAIADSPT
610 620 630 640 650
GQKVKMILDS QWCQGLQKGD IIKEIYHQNV QNLTHLQVVE VLKQFPVGAD
660 670 680 690 700
VPLLILRGGP CSPTKTAKTK TDTKENSGSL ETINEPIPQP MPFPPSIIRS
710 720 730 740 750
GSPKLDPSEV YLKSKTLYED KPPNTKDLDV FLRKQESGFG FRVLGGDGPD
760 770 780 790 800
QSIYIGAIIP LGAAEKDGRL RAADELMCID GIPVKGKSHK QVLDLMTTAA
810 820 830 840 850
RNGHVLLTVR RKIFYGEKQP EDESHQAFSQ NGSPRLNRAE LPTRSAPQEA
860 870 880 890 900
YDVTLQRKEN EGFGFVILTS KSKPPPGVIP HKIGRVIDGS PADRCGGLKV
910 920 930 940 950
GDHISAVNGQ SIVDLSHDNI VQLIKDAGVT VTLTVVAEEE HHGPPSGTNS
960 970 980 990 1000
ARQSPALQHR PMGQAQANHI PGDRIALEGE IGRDVCSSYR HSWSDHKHLA
1010 1020 1030 1040 1050
QPDTAVISVV GSRHNQSLGC YPVELERGPR GFGFSLRGGK EYNMGLFILR
1060 1070 1080 1090 1100
LAEDGPAIKD GRIHVGDQIV EINGEPTQGI THTRAIELIQ AGGNKVLLLL
1110 1120 1130 1140 1150
RPGTGLIPDH GDWDTNSPSS SNVIYDEQPP PLPSSHSAST FEESHVPATE
1160 1170 1180 1190 1200
DSLTRVQICE KAEELKDTVQ EKKSTLNGSQ PEMKYQSVHK TMSKKDPPRG
1210 1220 1230 1240 1250
SGHGEKSRLK GENGVTRRGR SASPKKSVNR HSEEHLEKIP RPLKSDPKEK
1260 1270 1280 1290 1300
SRDRSLSPRK GESKGRLTIK AGSGQDPYRK DRGRSSSPKK QQKIGGNSLS
1310 1320 1330 1340 1350
NTEGKLSEAG SRRAAGHPRD STEQLPDGRE KSGVSRKDLK QSQPGKTRTK
1360 1370 1380 1390 1400
SPEKKSSKVD ETSLPSKKTS STAGRVVSEK EKGKKPTAGE TSRETVEHTQ
1410 1420 1430 1440 1450
ISAKQLKQEA QEKTALGNAD DHKGRESEVT DRCRERAGCT PQSSSLVKKA
1460 1470
PITPGPWRVP RANKVTGTTG MADKQL
Length:1,476
Mass (Da):161,672
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA9F041B5EA4B6F3F
GO
Isoform 2 (identifier: Q9EQJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1112-1126: DWDTNSPSSSNVIYD → LAPSGLCSYVKPEQH
     1127-1476: Missing.

Show »
Length:1,126
Mass (Da):123,360
Checksum:iF015C302BC5D1BA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E8T6G5E8T6_MOUSE
Membrane-associated guanylate kinas...
Magi3
1,476Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32503 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti625I → N in BAC26773 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342881112 – 1126DWDTN…NVIYD → LAPSGLCSYVKPEQH in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0342891127 – 1476Missing in isoform 2. 2 PublicationsAdd BLAST350

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF213258 mRNA Translation: AAG43836.1
AC162922 Genomic DNA No translation available.
CU210868 Genomic DNA No translation available.
AK030083 mRNA Translation: BAC26773.1
AK173225 Transcribed RNA Translation: BAD32503.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17699.1 [Q9EQJ9-2]
CCDS51031.1 [Q9EQJ9-1]

NCBI Reference Sequences

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RefSeqi
NP_598614.1, NM_133853.3 [Q9EQJ9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000064371; ENSMUSP00000067932; ENSMUSG00000052539 [Q9EQJ9-2]
ENSMUST00000122303; ENSMUSP00000113713; ENSMUSG00000052539 [Q9EQJ9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
99470

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:99470

UCSC genome browser

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UCSCi
uc008qua.2, mouse [Q9EQJ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213258 mRNA Translation: AAG43836.1
AC162922 Genomic DNA No translation available.
CU210868 Genomic DNA No translation available.
AK030083 mRNA Translation: BAC26773.1
AK173225 Transcribed RNA Translation: BAD32503.1 Sequence problems.
CCDSiCCDS17699.1 [Q9EQJ9-2]
CCDS51031.1 [Q9EQJ9-1]
RefSeqiNP_598614.1, NM_133853.3 [Q9EQJ9-2]

3D structure databases

SMRiQ9EQJ9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9EQJ9, 7 interactors
MINTiQ9EQJ9
STRINGi10090.ENSMUSP00000112934

PTM databases

iPTMnetiQ9EQJ9
PhosphoSitePlusiQ9EQJ9

Proteomic databases

jPOSTiQ9EQJ9
PaxDbiQ9EQJ9
PeptideAtlasiQ9EQJ9
PRIDEiQ9EQJ9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1896, 66 antibodies

Genome annotation databases

EnsembliENSMUST00000064371; ENSMUSP00000067932; ENSMUSG00000052539 [Q9EQJ9-2]
ENSMUST00000122303; ENSMUSP00000113713; ENSMUSG00000052539 [Q9EQJ9-2]
GeneIDi99470
KEGGimmu:99470
UCSCiuc008qua.2, mouse [Q9EQJ9-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
260425
MGIiMGI:1923484, Magi3

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0707, Eukaryota
KOG3209, Eukaryota
GeneTreeiENSGT00940000156496
HOGENOMiCLU_004562_1_0_1
InParanoidiQ9EQJ9
KOiK06112
OMAiANRSRGQ
PhylomeDBiQ9EQJ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
99470, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Magi3, mouse

Protein Ontology

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PROi
PR:Q9EQJ9
RNActiQ9EQJ9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000052539, Expressed in dorsal root ganglion and 274 other tissues
GenevisibleiQ9EQJ9, MM

Family and domain databases

CDDicd00201, WW, 2 hits
Gene3Di2.30.42.10, 6 hits
InterProiView protein in InterPro
IPR008145, GK/Ca_channel_bsu
IPR008144, Guanylate_kin-like_dom
IPR020590, Guanylate_kinase_CS
IPR030035, MAGI3
IPR027417, P-loop_NTPase
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR10316:SF10, PTHR10316:SF10, 1 hit
PfamiView protein in Pfam
PF00625, Guanylate_kin, 1 hit
PF00595, PDZ, 4 hits
PF00397, WW, 2 hits
SMARTiView protein in SMART
SM00072, GuKc, 1 hit
SM00228, PDZ, 6 hits
SM00456, WW, 2 hits
SUPFAMiSSF50156, SSF50156, 6 hits
SSF51045, SSF51045, 2 hits
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856, GUANYLATE_KINASE_1, 1 hit
PS50052, GUANYLATE_KINASE_2, 1 hit
PS50106, PDZ, 6 hits
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGI3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQJ9
Secondary accession number(s): B0V3N7
, B0V3N8, Q69ZE1, Q8C0P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 7, 2020
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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