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Protein

39S ribosomal protein L46, mitochondrial

Gene

Mrpl46

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840 Mitochondrial translation elongation
R-MMU-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L46, mitochondrial
Short name:
L46mt
Short name:
MRP-L46
Gene namesi
Name:Mrpl46
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914558 Mrpl46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030577? – 28339S ribosomal protein L46, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei217N6-succinyllysineCombined sources1
Modified residuei228N6-acetyllysineBy similarity1
Modified residuei246N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9EQI8
MaxQBiQ9EQI8
PaxDbiQ9EQI8
PeptideAtlasiQ9EQI8
PRIDEiQ9EQI8

PTM databases

iPTMnetiQ9EQI8
PhosphoSitePlusiQ9EQI8

Expressioni

Gene expression databases

BgeeiENSMUSG00000030612 Expressed in 282 organ(s), highest expression level in facial nucleus
CleanExiMM_MRPL46
GenevisibleiQ9EQI8 MM

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi212093, 1 interactor
STRINGi10090.ENSMUSP00000032841

Structurei

3D structure databases

ProteinModelPortaliQ9EQI8
SMRiQ9EQI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4548 Eukaryota
ENOG4111HSF LUCA
GeneTreeiENSGT00390000015400
HOGENOMiHOG000047532
HOVERGENiHBG057426
InParanoidiQ9EQI8
KOiK17427
OMAiEKWDLYA
OrthoDBiEOG091G0CQP
PhylomeDBiQ9EQI8
TreeFamiTF324756

Family and domain databases

CDDicd04661 MRP_L46, 1 hit
InterProiView protein in InterPro
IPR033650 MRP_L46_NUDIX
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR021757 Ribosomal_L46
PfamiView protein in Pfam
PF11788 MRP-L46, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPVGRTLL GLARGWRQLD RFWAGSSRGL SLEAASSSSR SPWRLSGALC
60 70 80 90 100
LQRPPLITKA LTPLQEEMAG LLQQIEVERS LYSDHELRAL DEAQRLAKKK
110 120 130 140 150
ADLYDEEQEQ GITLAQDLED MWEQAFLQFR PGARETEADK KNDRTSLHRK
160 170 180 190 200
LDRNLVLLVR EKLGDQDVWM LPQVEWQPGE TLRGTAERIL ATLSENNMEA
210 220 230 240 250
KFLGNAPCGH YKFKFPKAIQ TESDLGVKVF FFKALLLTGD FVQAGKKSRH
260 270 280
VWASKEELGD YLQPKYLAQV RRFLLDSDGL SCL
Length:283
Mass (Da):32,132
Last modified:March 1, 2001 - v1
Checksum:iBF715A364CCE53B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217090 mRNA Translation: AAG44099.1
BC061094 mRNA Translation: AAH61094.1
CCDSiCCDS21373.1
RefSeqiNP_075820.1, NM_023331.2
UniGeneiMm.193181

Genome annotation databases

EnsembliENSMUST00000032841; ENSMUSP00000032841; ENSMUSG00000030612
GeneIDi67308
KEGGimmu:67308
UCSCiuc009hxl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRM46_MOUSE
AccessioniPrimary (citable) accession number: Q9EQI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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