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UniProtKB - Q9EQH4 (TAF8_MOUSE)

Entry version 144 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Transcription initiation factor TFIID subunit 8

Gene

Taf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity).

May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.

By similarity2 Publications

Miscellaneous

'Taube nuss' means 'empty nut' in German.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-6807505, RNA polymerase II transcribes snRNA genes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 8
Alternative name(s):
Protein taube nuss
TBP-associated factor 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Taf8
Synonyms:Tbn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1926879, Taf8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000023980

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death during early embryonic development. The inner cell mass cells of mutant embryos died of apoptosis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003153982 – 308Transcription initiation factor TFIID subunit 8Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei128PhosphothreonineBy similarity1
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9EQH4

PeptideAtlas

More...PeptideAtlasi		Q9EQH4

PRoteomics IDEntifications database

More...PRIDEi		Q9EQH4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		263244 [Q9EQH4-1]
263245 [Q9EQH4-2]
263246 [Q9EQH4-3]
263247 [Q9EQH4-4]
263248 [Q9EQH4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9EQH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9EQH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Low level of expression throughout the brain with slightly higher expression in the hippocampus.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed ubiquitously at very low levels throughout embryonic development. Higher levels of expression seen in inner cell mass and heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000023980, Expressed in secondary oocyte and 287 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9EQH4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).

Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L.

Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region (By similarity).

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-920, SAGA complex
CPX-932, General transcription factor complex TFIID
CPX-959, General transcription factor complex TFIID, Taf4b variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9EQH4

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000063201

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9EQH4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 102Histone-foldAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 29DisorderedSequence analysisAdd BLAST29
Regioni235 – 308DisorderedSequence analysisAdd BLAST74

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi292 – 305Nuclear localization signalSequence analysisAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 27Polar residuesSequence analysisAdd BLAST15
Compositional biasi250 – 285Polar residuesSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF8 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4336, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017567

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070829_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9EQH4

Identification of Orthologs from Complete Genome Data

More...OMAi		PHYVPSY

Database of Orthologous Groups

More...OrthoDBi		1290064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9EQH4

TreeFam database of animal gene trees

More...TreeFami		TF316311

Family and domain databases

Conserved Domains Database

More...CDDi		cd08049, TAF8, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR037818, TAF8
IPR019473, TFIID_su8_C

The PANTHER Classification System

More...PANTHERi		PTHR46469, PTHR46469, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07524, Bromo_TP, 1 hit
PF10406, TAF8_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00576, BTP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47113, SSF47113, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9EQH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220        230        240        250
LFKDDVSTFP LIAARPFTIP YLTALLPSEL EIQQMEETDS SEQEEQTDTE 
       260        270        280        290        300
NNALHISTDD SGAEKESASV LQQSSSLSGS RNGEESVIDN PYLRPVKKPK 

IRRKKSLS
Length:308
Mass (Da):33,988
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD527CD7905CC8D9
GO
Isoform 2 (identifier: Q9EQH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     306-308: Missing.

Show »
Length:305
Mass (Da):33,701
Checksum:iC7905CC8D9ED1AD4
GO
Isoform 3 (identifier: Q9EQH4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-265: DDSGAEK → GHPEASA
     266-308: Missing.

Show »
Length:265
Mass (Da):29,196
Checksum:i9EC61183C9051CFB
GO
Isoform 4 (identifier: Q9EQH4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     259-308: DDSGAEKESA...PKIRRKKSLS → VGPPLLPASQ...LLGSHTFSRW

Show »
Length:322
Mass (Da):35,440
Checksum:iE05BE93D76FE5D7A
GO
Isoform 5 (identifier: Q9EQH4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-221: AARPFTIPY → SDQHLIKAP
     222-308: Missing.

Show »
Length:221
Mass (Da):24,361
Checksum:i924CADAB54196D11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127V → L in BAC36363 (PubMed:16141072).Curated1
Sequence conflicti153D → V in BAC34001 (PubMed:16141072).Curated1
Sequence conflicti236E → G in BAC34001 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030550213 – 221AARPFTIPY → SDQHLIKAP in isoform 5. 1 Publication9
Alternative sequenceiVSP_030551222 – 308Missing in isoform 5. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_030552259 – 308DDSGA…KKSLS → VGPPLLPASQQSQNSLSHIL PLPLGTEQGLPQVSGWLLQA CMMGCVSSLHHETHLLGSHT FSRW in isoform 4. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_030553259 – 265DDSGAEK → GHPEASA in isoform 3. 1 Publication7
Alternative sequenceiVSP_030554266 – 308Missing in isoform 3. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_030555306 – 308Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF222802 mRNA Translation: AAG01682.1
AK045108 mRNA Translation: BAC32225.1
AK049949 mRNA Translation: BAC34001.1
AK076486 mRNA Translation: BAC36363.1
AK086656 mRNA Translation: BAC39712.1
AK162110 mRNA Translation: BAE36731.1
BC057895 mRNA Translation: AAH57895.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37642.1 [Q9EQH4-1]
CCDS89109.1 [Q9EQH4-3]

NCBI Reference Sequences

More...RefSeqi		NP_071298.1, NM_022015.3 [Q9EQH4-1]
XP_006524827.1, XM_006524764.2
XP_006524828.1, XM_006524765.3
XP_006524830.1, XM_006524767.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000067103; ENSMUSP00000063201; ENSMUSG00000023980 [Q9EQH4-1]
ENSMUST00000233121; ENSMUSP00000156629; ENSMUSG00000023980 [Q9EQH4-2]
ENSMUST00000233174; ENSMUSP00000156668; ENSMUSG00000023980 [Q9EQH4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		63856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:63856

UCSC genome browser

More...UCSCi		uc008cvh.1, mouse [Q9EQH4-1]
uc008cvj.1, mouse [Q9EQH4-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222802 mRNA Translation: AAG01682.1
AK045108 mRNA Translation: BAC32225.1
AK049949 mRNA Translation: BAC34001.1
AK076486 mRNA Translation: BAC36363.1
AK086656 mRNA Translation: BAC39712.1
AK162110 mRNA Translation: BAE36731.1
BC057895 mRNA Translation: AAH57895.1
CCDSiCCDS37642.1 [Q9EQH4-1]
CCDS89109.1 [Q9EQH4-3]
RefSeqiNP_071298.1, NM_022015.3 [Q9EQH4-1]
XP_006524827.1, XM_006524764.2
XP_006524828.1, XM_006524765.3
XP_006524830.1, XM_006524767.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-920, SAGA complex
CPX-932, General transcription factor complex TFIID
CPX-959, General transcription factor complex TFIID, Taf4b variant
CORUMiQ9EQH4
STRINGi10090.ENSMUSP00000063201

PTM databases

iPTMnetiQ9EQH4
PhosphoSitePlusiQ9EQH4

Proteomic databases

PaxDbiQ9EQH4
PeptideAtlasiQ9EQH4
PRIDEiQ9EQH4
ProteomicsDBi263244 [Q9EQH4-1]
263245 [Q9EQH4-2]
263246 [Q9EQH4-3]
263247 [Q9EQH4-4]
263248 [Q9EQH4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30123, 144 antibodies

The DNASU plasmid repository

More...DNASUi		63856

Genome annotation databases

EnsembliENSMUST00000067103; ENSMUSP00000063201; ENSMUSG00000023980 [Q9EQH4-1]
ENSMUST00000233121; ENSMUSP00000156629; ENSMUSG00000023980 [Q9EQH4-2]
ENSMUST00000233174; ENSMUSP00000156668; ENSMUSG00000023980 [Q9EQH4-3]
GeneIDi63856
KEGGimmu:63856
UCSCiuc008cvh.1, mouse [Q9EQH4-1]
uc008cvj.1, mouse [Q9EQH4-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		129685
MGIiMGI:1926879, Taf8
VEuPathDBiHostDB:ENSMUSG00000023980

Phylogenomic databases

eggNOGiKOG4336, Eukaryota
GeneTreeiENSGT00390000017567
HOGENOMiCLU_070829_0_0_1
InParanoidiQ9EQH4
OMAiPHYVPSY
OrthoDBi1290064at2759
PhylomeDBiQ9EQH4
TreeFamiTF316311

Enzyme and pathway databases

ReactomeiR-MMU-6807505, RNA polymerase II transcribes snRNA genes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		63856, 17 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Taf8, mouse

Protein Ontology

More...PROi		PR:Q9EQH4
RNActiQ9EQH4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000023980, Expressed in secondary oocyte and 287 other tissues
GenevisibleiQ9EQH4, MM

Family and domain databases

CDDicd08049, TAF8, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR006565, BTP
IPR009072, Histone-fold
IPR037818, TAF8
IPR019473, TFIID_su8_C
PANTHERiPTHR46469, PTHR46469, 1 hit
PfamiView protein in Pfam
PF07524, Bromo_TP, 1 hit
PF10406, TAF8_C, 1 hit
SMARTiView protein in SMART
SM00576, BTP, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQH4
Secondary accession number(s): Q3TSE4
, Q6PES8, Q8C382, Q8C664, Q8C7L7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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