Taf8

Functionⁱ

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.By similarity2 Publications

Miscellaneous

'Taube nuss' means 'empty nut' in German.

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB-KW
inner cell mass cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 11076765
maintenance of protein location in nucleus Source: MGI
positive regulation of transcription, DNA-templated
Source: MGI
Inferred from sequence orthologyⁱ
- 14580349
regulation of fat cell differentiation
Source: MGI
Inferred from sequence orthologyⁱ
- 14580349

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein
Biological process	Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6807505 RNA polymerase II transcribes snRNA genes

Reactomeⁱ

R-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription initiation factor TFIID subunit 8 Alternative name(s): Protein taube nuss TBP-associated factor 8
Gene namesⁱ	Name:Taf8 Synonyms:Tbn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:1926879 Taf8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Death during early embryonic development. The inner cell mass cells of mutant embryos died of apoptosis.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000315398	2 – 308	Transcription initiation factor TFIID subunit 8Add BLAST		307

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineBy similarity	1
Modified residueⁱ	128	PhosphothreonineBy similarity	1
Modified residueⁱ	269	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9EQH4
PeptideAtlas More...PeptideAtlasⁱ	Q9EQH4
PRIDEⁱ	Q9EQH4

PTM databases

iPTMnetⁱ	Q9EQH4
PhosphoSitePlusⁱ	Q9EQH4

Expressionⁱ

Tissue specificityⁱ

Low level of expression throughout the brain with slightly higher expression in the hippocampus.

Developmental stageⁱ

Expressed ubiquitously at very low levels throughout embryonic development. Higher levels of expression seen in inner cell mass and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000023980 Expressed in 261 organ(s), highest expression level in embryo
Genevisibleⁱ	Q9EQH4 MM

Interactionⁱ

Subunit structureⁱ

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region (By similarity).By similarity

GO - Molecular functionⁱ

protein heterodimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-920 SAGA complex CPX-932 General transcription factor complex TFIID CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMⁱ	Q9EQH4
STRINGⁱ	10090.ENSMUSP00000063201

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9EQH4
SMRⁱ	Q9EQH4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 102	Histone-foldAdd BLAST		68

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	292 – 305	Nuclear localization signalSequence analysisAdd BLAST		14

Sequence similaritiesⁱ

Belongs to the TAF8 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4336 Eukaryota ENOG410ZRN5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017567
HOGENOMⁱ	HOG000007034
HOVERGENⁱ	HBG105411
InParanoidⁱ	Q9EQH4
KEGG Orthology (KO) More...KOⁱ	K14649
OMAⁱ	LFPTEDN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O7T
PhylomeDBⁱ	Q9EQH4
TreeFamⁱ	TF316311

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08049 TAF8, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR006565 BTP IPR009072 Histone-fold IPR037818 TAF8 IPR019473 TFIID_su8_C
PANTHERⁱ	PTHR12321:SF102 PTHR12321:SF102, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07524 Bromo_TP, 1 hit PF10406 TAF8_C, 1 hit
SMARTⁱ	View protein in SMART SM00576 BTP, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9EQH4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220        230        240        250
LFKDDVSTFP LIAARPFTIP YLTALLPSEL EIQQMEETDS SEQEEQTDTE 
       260        270        280        290        300
NNALHISTDD SGAEKESASV LQQSSSLSGS RNGEESVIDN PYLRPVKKPK 

IRRKKSLS

Length:308

Mass (Da):33,988

Last modified:March 1, 2001 - v1

Checksum:ⁱFD527CD7905CC8D9

GO

Isoform 2 (identifier: Q9EQH4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
306-308: Missing.

« Hide

        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220        230        240        250
LFKDDVSTFP LIAARPFTIP YLTALLPSEL EIQQMEETDS SEQEEQTDTE 
       260        270        280        290        300
NNALHISTDD SGAEKESASV LQQSSSLSGS RNGEESVIDN PYLRPVKKPK 

IRRKK

Show »

Length:305

Mass (Da):33,701

Checksum:ⁱC7905CC8D9ED1AD4

GO

Isoform 3 (identifier: Q9EQH4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-265: DDSGAEK → GHPEASA
266-308: Missing.

« Hide

        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220        230        240        250
LFKDDVSTFP LIAARPFTIP YLTALLPSEL EIQQMEETDS SEQEEQTDTE 
       260 
NNALHISTGH PEASA

Show »

Length:265

Mass (Da):29,196

Checksum:ⁱ9EC61183C9051CFB

GO

Isoform 4 (identifier: Q9EQH4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
259-308: DDSGAEKESA...PKIRRKKSLS → VGPPLLPASQ...LLGSHTFSRW

« Hide

        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220        230        240        250
LFKDDVSTFP LIAARPFTIP YLTALLPSEL EIQQMEETDS SEQEEQTDTE 
       260        270        280        290        300
NNALHISTVG PPLLPASQQS QNSLSHILPL PLGTEQGLPQ VSGWLLQACM 
       310        320 
MGCVSSLHHE THLLGSHTFS RW

Show »

Length:322

Mass (Da):35,440

Checksum:ⁱE05BE93D76FE5D7A

GO

Isoform 5 (identifier: Q9EQH4-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
213-221: AARPFTIPY → SDQHLIKAP
222-308: Missing.

« Hide

        10         20         30         40         50
MADTAAGPGG SGTRPGSKQS TNPADNYHLA RRRTLQVVVS SLLTEAGFES 
        60         70         80         90        100
AEKASVETLT EMLQSYISEI GRSAKSYCEH TARTQPTLSD IVVTLVEMGF 
       110        120        130        140        150
NVDTLPAYAK RSQRMVITAP PVTNQPVTPK ALTAGQNRPH PPHIPSHFPE 
       160        170        180        190        200
FPDPHTYIKT PTYREPVSDY QILREKAASQ RRDVERALTR FMAKTGETQS 
       210        220 
LFKDDVSTFP LISDQHLIKA P

Note: No experimental confirmation available.

Show »

Length:221

Mass (Da):24,361

Checksum:ⁱ924CADAB54196D11

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	127	V → L in BAC36363 (PubMed:16141072).Curated	1
Sequence conflictⁱ	153	D → V in BAC34001 (PubMed:16141072).Curated	1
Sequence conflictⁱ	236	E → G in BAC34001 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_030550	213 – 221	AARPFTIPY → SDQHLIKAP in isoform 5. 1 Publication	9
Alternative sequenceⁱVSP_030551	222 – 308	Missing in isoform 5. 1 PublicationAdd BLAST	87
Alternative sequenceⁱVSP_030552	259 – 308	DDSGA…KKSLS → VGPPLLPASQQSQNSLSHIL PLPLGTEQGLPQVSGWLLQA CMMGCVSSLHHETHLLGSHT FSRW in isoform 4. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_030553	259 – 265	DDSGAEK → GHPEASA in isoform 3. 1 Publication	7
Alternative sequenceⁱVSP_030554	266 – 308	Missing in isoform 3. 1 PublicationAdd BLAST	43
Alternative sequenceⁱVSP_030555	306 – 308	Missing in isoform 2. 1 Publication	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF222802 mRNA Translation: AAG01682.1 AK045108 mRNA Translation: BAC32225.1 AK049949 mRNA Translation: BAC34001.1 AK076486 mRNA Translation: BAC36363.1 AK086656 mRNA Translation: BAC39712.1 AK162110 mRNA Translation: BAE36731.1 BC057895 mRNA Translation: AAH57895.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS37642.1 [Q9EQH4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_071298.1, NM_022015.3 [Q9EQH4-1] XP_006524827.1, XM_006524764.2 [Q9EQH4-4] XP_006524828.1, XM_006524765.3 [Q9EQH4-2] XP_006524830.1, XM_006524767.3
UniGeneⁱ	Mm.275901

Genome annotation databases

Ensemblⁱ	ENSMUST00000067103; ENSMUSP00000063201; ENSMUSG00000023980 [Q9EQH4-1]
GeneIDⁱ	63856
KEGGⁱ	mmu:63856
UCSC genome browser More...UCSCⁱ	uc008cvh.1 mouse [Q9EQH4-1] uc008cvj.1 mouse [Q9EQH4-4]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9EQH4	Transcription initiation factor TFIID subunit 8	)	HUMAN		310	UniRef90_Q7Z7C8
Transcription initiation factor TFIID subunit 8		BOVIN		310
Transcription initiation factor TFIID subunit 8		CHICK		244
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa		PANTR		310
TATA-box binding protein associated factor 8		MACMU		310
+179
Q9EQH4-3	transcription initiation factor TFIID subunit 8 isoform X1		MESAU		330	UniRef90_Q9EQH4-3
Transcription initiation factor TFIID subunit 8 (Fragment)		TINGU		269
Uncharacterized protein		PIG		267
Uncharacterized protein		MUSPF		267
transcription initiation factor TFIID subunit 8 isoform X4		Enhydra lutris kenyoni		267
+22

Protein	Similar proteins		Species	Score	Length	Source
Q9EQH4	Transcription initiation factor TFIID subunit 8	)	HUMAN		310	UniRef50_Q7Z7C8
Transcription initiation factor TFIID subunit 8		BOVIN		310
Transcription initiation factor TFIID subunit 8		CHICK		244
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa		PANTR		310
TATA-box binding protein associated factor 8		MACMU		310
+325
Q9EQH4-3	Isoform 3 of Transcription initiation factor TFIID subunit 8		HUMAN		338	UniRef50_Q7Z7C8-4
Transcription initiation factor TFIID subunit 8		XENLA		293
Transcription initiation factor TFIID subunit 8		DANRE		308
Transcription initiation factor TFIID subunit 8		XENTR		293
TAF8 isoform 3		PANTR		338
+251
Q9EQH4-4	Isoform 3 of Transcription initiation factor TFIID subunit 8		HUMAN		338	UniRef50_Q7Z7C8-4
Transcription initiation factor TFIID subunit 8		XENLA		293
Transcription initiation factor TFIID subunit 8		DANRE		308
Transcription initiation factor TFIID subunit 8		XENTR		293
TAF8 isoform 3		PANTR		338
+251
Q9EQH4-5	Isoform 2 of Transcription initiation factor TFIID subunit 8		DANRE		268	UniRef50_Q9EQH4-5
Transcription initiation factor TFIID subunit 8 (Fragment)		ANAPL		246
Uncharacterized protein		TAKRU		225
Uncharacterized protein		MACNE		260
UPI0007872522		ROUAE		250
+6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF222802 mRNA Translation: AAG01682.1 AK045108 mRNA Translation: BAC32225.1 AK049949 mRNA Translation: BAC34001.1 AK076486 mRNA Translation: BAC36363.1 AK086656 mRNA Translation: BAC39712.1 AK162110 mRNA Translation: BAE36731.1 BC057895 mRNA Translation: AAH57895.1
CCDSⁱ	CCDS37642.1 [Q9EQH4-1]
RefSeqⁱ	NP_071298.1, NM_022015.3 [Q9EQH4-1] XP_006524827.1, XM_006524764.2 [Q9EQH4-4] XP_006524828.1, XM_006524765.3 [Q9EQH4-2] XP_006524830.1, XM_006524767.3
UniGeneⁱ	Mm.275901

3D structure databases

ProteinModelPortalⁱ	Q9EQH4
SMRⁱ	Q9EQH4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-920 SAGA complex CPX-932 General transcription factor complex TFIID CPX-959 General transcription factor complex TFIID, Taf4b variant
CORUMⁱ	Q9EQH4
STRINGⁱ	10090.ENSMUSP00000063201

PTM databases

iPTMnetⁱ	Q9EQH4
PhosphoSitePlusⁱ	Q9EQH4

Proteomic databases

PaxDbⁱ	Q9EQH4
PeptideAtlasⁱ	Q9EQH4
PRIDEⁱ	Q9EQH4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	63856
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000067103; ENSMUSP00000063201; ENSMUSG00000023980 [Q9EQH4-1]
GeneIDⁱ	63856
KEGGⁱ	mmu:63856
UCSCⁱ	uc008cvh.1 mouse [Q9EQH4-1] uc008cvj.1 mouse [Q9EQH4-4]

Organism-specific databases

CTDⁱ	129685
MGIⁱ	MGI:1926879 Taf8

Phylogenomic databases

eggNOGⁱ	KOG4336 Eukaryota ENOG410ZRN5 LUCA
GeneTreeⁱ	ENSGT00390000017567
HOGENOMⁱ	HOG000007034
HOVERGENⁱ	HBG105411
InParanoidⁱ	Q9EQH4
KOⁱ	K14649
OMAⁱ	LFPTEDN
OrthoDBⁱ	EOG091G0O7T
PhylomeDBⁱ	Q9EQH4
TreeFamⁱ	TF316311

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6807505 RNA polymerase II transcribes snRNA genes

Reactomeⁱ

R-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9EQH4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023980 Expressed in 261 organ(s), highest expression level in embryo
Genevisibleⁱ	Q9EQH4 MM

Family and domain databases

CDDⁱ	cd08049 TAF8, 1 hit
Gene3Dⁱ	1.10.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR006565 BTP IPR009072 Histone-fold IPR037818 TAF8 IPR019473 TFIID_su8_C
PANTHERⁱ	PTHR12321:SF102 PTHR12321:SF102, 1 hit
Pfamⁱ	View protein in Pfam PF07524 Bromo_TP, 1 hit PF10406 TAF8_C, 1 hit
SMARTⁱ	View protein in SMART SM00576 BTP, 1 hit
SUPFAMⁱ	SSF47113 SSF47113, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TAF8_MOUSE
Accessionⁱ	Q9EQH4Primary (citable) accession number: Q9EQH4 Secondary accession number(s): Q3TSE4 , Q6PES8, Q8C382, Q8C664, Q8C7L7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9EQH4 (TAF8_MOUSE)

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Transcription initiation factor TFIID subunit 8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ