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UniProtKB - Q9EQG6 (KDIS_RAT)

Entry version 125 (29 Sep 2021)
Sequence version 2 (01 Oct 2001)
Previous versions | rss
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Protein

Kinase D-interacting substrate of 220 kDa

Gene

Kidins220

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-170984, ARMS-mediated activation
R-RNO-9696270, RND2 GTPase cycle
R-RNO-9696273, RND1 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinase D-interacting substrate of 220 kDa
Alternative name(s):
Ankyrin repeat-rich membrane-spanning protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kidins220
Synonyms:Arms
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		619949, Kidins220

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 508CytoplasmicCuratedAdd BLAST508
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei509 – 529HelicalSequence analysisAdd BLAST21
Topological domaini530 – 533ExtracellularCurated4
Transmembranei534 – 554HelicalSequence analysisAdd BLAST21
Topological domaini555 – 668CytoplasmicCuratedAdd BLAST114
Transmembranei669 – 689HelicalSequence analysisAdd BLAST21
Topological domaini690 – 696ExtracellularCurated7
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 1680CytoplasmicCuratedAdd BLAST963

Keywords - Cellular componenti

Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi918S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi1760S → D: Loss of binding to PDZ domain of SNTA1 and SNTB2. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003221201 – 1762Kinase D-interacting substrate of 220 kDaAdd BLAST1762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei882PhosphoserineBy similarity1
Modified residuei885PhosphoserineBy similarity1
Modified residuei914PhosphothreonineBy similarity1
Modified residuei918Phosphoserine; by PKDCombined sources1 Publication1
Modified residuei1163PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1344PhosphoserineBy similarity1
Modified residuei1351PhosphoserineBy similarity1
Modified residuei1353PhosphoserineBy similarity1
Modified residuei1354PhosphoserineBy similarity1
Modified residuei1357PhosphoserineBy similarity1
Modified residuei1513PhosphoserineCombined sources1
Modified residuei1518PhosphoserineCombined sources1
Modified residuei1547PhosphoserineBy similarity1
Modified residuei1566PhosphoserineBy similarity1
Modified residuei1615PhosphoserineBy similarity1
Modified residuei1625PhosphoserineBy similarity1
Modified residuei1671PhosphothreonineBy similarity1
Modified residuei1673PhosphoserineBy similarity1
Modified residuei1676PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4. Phosphorylation at Ser-918 is induced by phorbol ester treatment. Phosphorylation by NTRK2 is induced by brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 is induced by nerve growth factor (NGF).4 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9EQG6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9EQG6

PRoteomics IDEntifications database

More...PRIDEi		Q9EQG6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9EQG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9EQG6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9EQG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in developing nervous system and in highly plastic areas of the adult brain. Also expressed in neuroendocrine cells, where it concentrates at the tip of neurites. Expressed in developing muscle and is concentrated at the neuromuscular junction (NMS). SNTA1 can regulate its localization in the NMS.3 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in postmitotic neurons during the stage of development in which extensive axon pathfinding is occurring. At embryonic day 14 (E14), expressed in both spinal cord and dorsal root ganglia. Present on the sarcolemma in postnstal day 1 (P1) gastrocnemius muscle. By P8, becomes more concentrated at the junctional sites and by P21, colocalizes with acetylcholine receptor clusters.2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1 and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (PubMed:17724123).

Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (PubMed:17724123). Isoform 2 interacts (via C-terminal domain) with MAGI2 isoform 1 (via PDZ domain) (PubMed:17724123).

Interacts with NTRK1, NTRK2, NTRK3, ERKL and NGFR (PubMed:11150334, PubMed:15167895, PubMed:15378608). Can form a ternary complex with NGFR and NTRK1 and this complex is affected by the expression levels of KIDINS220/ARMS (PubMed:15378608). An increase in KIDINS220/ARMS expression leads to a decreased association of NGFR and NTRK1 (PubMed:15378608).

Interacts (via PDZ-binding motif) with SNTA1 and SNTB2 (via PDZ domains) (PubMed:15939763).

Interacts with EPHA4 and PRKD1 (PubMed:10998417, PubMed:15939763).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9EQG6

Protein interaction database and analysis system

More...IntActi		Q9EQG6, 5 interactors

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000063889

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11762
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9EQG6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 74ANK 1Sequence analysisAdd BLAST30
Repeati78 – 107ANK 2Sequence analysisAdd BLAST30
Repeati111 – 140ANK 3Sequence analysisAdd BLAST30
Repeati145 – 174ANK 4Sequence analysisAdd BLAST30
Repeati178 – 207ANK 5Sequence analysisAdd BLAST30
Repeati211 – 240ANK 6Sequence analysisAdd BLAST30
Repeati244 – 273ANK 7Sequence analysisAdd BLAST30
Repeati277 – 306ANK 8Sequence analysisAdd BLAST30
Repeati310 – 339ANK 9Sequence analysisAdd BLAST30
Repeati343 – 372ANK 10Sequence analysisAdd BLAST30
Repeati376 – 405ANK 11Sequence analysisAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini440 – 953KAP NTPaseAdd BLAST514

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1089 – 1092Mediates interaction with CRKL1 Publication4
Regioni1279 – 1305DisorderedSequence analysisAdd BLAST27
Regioni1336 – 1358DisorderedSequence analysisAdd BLAST23
Regioni1390 – 1440DisorderedSequence analysisAdd BLAST51
Regioni1452 – 1556DisorderedSequence analysisAdd BLAST105
Regioni1571 – 1628DisorderedSequence analysisAdd BLAST58
Regioni1704 – 1762DisorderedSequence analysisAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1757 – 1762PDZ-binding1 Publication6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1337 – 1358Polar residuesSequence analysisAdd BLAST22
Compositional biasi1390 – 1422Polar residuesSequence analysisAdd BLAST33
Compositional biasi1423 – 1440Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1523 – 1556Basic and acidic residuesSequence analysisAdd BLAST34
Compositional biasi1580 – 1594Polar residuesSequence analysisAdd BLAST15
Compositional biasi1595 – 1618Basic and acidic residuesSequence analysisAdd BLAST24
Compositional biasi1705 – 1755Polar residuesSequence analysisAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane domain mediates interaction with NTRK1.1 Publication

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0502, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9EQG6

Database of Orthologous Groups

More...OrthoDBi		58543at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9EQG6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.50, 1 hit
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011646, KAP_P-loop
IPR013761, SAM/pointed_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 4 hits
PF07693, KAP_NTPase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EQG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVLISQSVI NYVEEENIPA LKALLEKCKD VDERNECGQT PLMLAAEQGN 
        60         70         80         90        100
VEIVKELLKN GANCNLEDLD NWTALISASK EGHIHIVEEL LKSGASLEHR 
       110        120        130        140        150
DMGGWTALMW ACYKGRTDVV ELLLSHGANP SVTGLYSVYP IIWAAGRGHA 
       160        170        180        190        200
DIVHLLLQNG AKVNCSDKYG TTPLVWAARK GHLECVKHLL AMGADVDQEG 
       210        220        230        240        250
ANSMTALIVA VKGGYTQSVK EILKRNPNVN LTDKDGNTAL MIASKEGHIE 
       260        270        280        290        300
IVQDLLDAGT YVNIPDRSGD TVLIGAVRGG HVEIVRALLQ KYADIDIRGQ 
       310        320        330        340        350
DNKTALYWAV EKGNATMVRD ILQCNPDTEI CTKDGETPLI KATKMRNIEV 
       360        370        380        390        400
VELLLDKGAK VSAVDKKGDT PLHVAIRGRS RRLAELLLRN PKDGRLLYRP 
       410        420        430        440        450
NKAGETPYNI DCSHQKSILT QIFGARHLSP TETDGDMLGY DLYSSALADI 
       460        470        480        490        500
LSEPTMQPPI CVGLYAQWGS GKSFLLKKLE DEMKTFAGQQ TEPLFQFSWL 
       510        520        530        540        550
IVFLTLLLCG GLGLVFAFTV DTNLAIAISL SFLALIYIFF IVIYFGGRRE 
       560        570        580        590        600
GESWNWAWAL STRLARHIGY LELLFKLMFV NPPELPEQTT KALPVRFLFT 
       610        620        630        640        650
DYNRLSSVGG ETSLAEMIAT LSDACEREFG FLATRLFRVF RTEESQGKKK 
       660        670        680        690        700
WKKTCCLPSF VIFLFIVGCI IAGITLLAIF RVDPKHLTVN AILISIASVV 
       710        720        730        740        750
GLAFVLNCRT WWQVLDSLLN SQRKRLHSAA SKLHKLKSEG FMKVLKCEVE 
       760        770        780        790        800
LMARMAKTID SFTQNQTRLV VIIDGLDACE QDKVLQMLDT VRVLFSKGPF 
       810        820        830        840        850
IAIFASDPHI IIKAINQNLN SVLRDSNING HDYMRNIVHL PVFLNSRGLS 
       860        870        880        890        900
NARKFLVTSA TNGDITCSDT TGTQEDTDRR VSQNSLGEMT KLGSKTALNR 
       910        920        930        940        950
RDTYRRRQMQ RTITRQMSFD LTKLLVTEDW FSDISPQTMR RLLNIVSVTG 
       960        970        980        990       1000
RLLRANQITF NWDRLASWIN LTEQWPYRTS WLILYLEETE GLPDQMTLKT 
      1010       1020       1030       1040       1050
IYERISKNIP TTKDVEPLLE IDGDIRNFEV FLSSRTPVLV ARDVKTFLPC 
      1060       1070       1080       1090       1100
TVNLDPKLRE IIADVRAARE QINIGGLAYP PLPLHEGPPR PPSGYSQPAS 
      1110       1120       1130       1140       1150
VCSSASFNGP FPGGVVSPQP HSSYYSGLSG PQHPFYNRPF FAPYLYTPRY 
      1160       1170       1180       1190       1200
YPGGSQHLIS RSSVKTSLPR DQNNGLPCDS GFNKQRQAAV PATGSSLLLS 
      1210       1220       1230       1240       1250
SMTVDVVCEK LRQIEGLDQS MMPQYCTTIK KANINGRVLS QCNIDELKKE 
      1260       1270       1280       1290       1300
MAMNFGDWHL FRSMVLEMRS VESQVVPEDP RFLNENSSAP VPHGESARRS 
      1310       1320       1330       1340       1350
SHTELPLTEL SSQTPYTLNF SFEELNTLGL DEGAPRHSNL SWQSQTRRTP 
      1360       1370       1380       1390       1400
SLSSLNSQDS SIEISKLTDK VQAEYRDAYR EYIAQMSQLE GGTGSSTISG 
      1410       1420       1430       1440       1450
RSSPHSTYYI GQSSSGGSIH STLEQERGKE GELKQEDGRK SFLMKRGDVI 
      1460       1470       1480       1490       1500
DYSSSGVSTN EASPLDPITE EDEKSDQSGS KLLPGKKSSE RPSLFQTDLK 
      1510       1520       1530       1540       1550
LKGGGLRYQK LPSDEDESGT EESDNTPLLK DDKDKKAEGK AERVCKSPEH 
      1560       1570       1580       1590       1600
SAEPIRTFIK AKEYLSDALL DKKDSSDSGV RSNESSPNHS LHNEAADDSQ 
      1610       1620       1630       1640       1650
LEKANLIELE DEGHSGKRGM PHSLSGLQDP IIARMSICSE DKKSPSECSL 
      1660       1670       1680       1690       1700
IASSPEESWP ACQKAYNLNR TPSTVTLNNN TAPTNRANQN FDEIEGIRET 
      1710       1720       1730       1740       1750
SQVILRPGPS PNPTAVQNEN LKSMAHKRSQ RSSYTRLSKD ASELHAASSE 
      1760 
STGFGEERES IL
Length:1,762
Mass (Da):195,716
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0CB2689A571F8AE4
GO
Isoform 2 (identifier: Q9EQG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: L → LQ
     1139-1187: Missing.

Show »
Length:1,714
Mass (Da):190,272
Checksum:i95EEEB55C2AF0E99
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3ZWB2D3ZWB2_RAT
Kinase D-interacting substrate of 2...
Kidins220
1,762Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D4ABK9D4ABK9_RAT
Kinase D-interacting substrate of 2...
Kidins220
1,712Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG34167 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti519T → P in AAG34167 (PubMed:11150334).Curated1
Sequence conflicti1001I → M in AAG34167 (PubMed:11150334).Curated1
Sequence conflicti1220S → N in AAG34167 (PubMed:11150334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031868135L → LQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_0318691139 – 1187Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF239045 mRNA Translation: AAG35185.2
AF313464 mRNA Translation: AAG34167.1 Frameshift.

NCBI Reference Sequences

More...RefSeqi		NP_446247.1, NM_053795.1 [Q9EQG6-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116478

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:116478

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239045 mRNA Translation: AAG35185.2
AF313464 mRNA Translation: AAG34167.1 Frameshift.
RefSeqiNP_446247.1, NM_053795.1 [Q9EQG6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7D6FX-ray2.70B1748-1762[»]
SMRiQ9EQG6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

CORUMiQ9EQG6
IntActiQ9EQG6, 5 interactors
STRINGi10116.ENSRNOP00000063889

PTM databases

iPTMnetiQ9EQG6
PhosphoSitePlusiQ9EQG6
SwissPalmiQ9EQG6

Proteomic databases

jPOSTiQ9EQG6
PaxDbiQ9EQG6
PRIDEiQ9EQG6

Genome annotation databases

GeneIDi116478
KEGGirno:116478

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57498
RGDi619949, Kidins220

Phylogenomic databases

eggNOGiKOG0502, Eukaryota
InParanoidiQ9EQG6
OrthoDBi58543at2759
PhylomeDBiQ9EQG6

Enzyme and pathway databases

ReactomeiR-RNO-170984, ARMS-mediated activation
R-RNO-9696270, RND2 GTPase cycle
R-RNO-9696273, RND1 GTPase cycle

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9EQG6

Family and domain databases

Gene3Di1.10.150.50, 1 hit
1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR011646, KAP_P-loop
IPR013761, SAM/pointed_sf
PfamiView protein in Pfam
PF12796, Ank_2, 4 hits
PF07693, KAP_NTPase, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 11 hits
SUPFAMiSSF47769, SSF47769, 1 hit
SSF48403, SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 10 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKDIS_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQG6
Secondary accession number(s): Q9ERD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2001
Last modified: September 29, 2021
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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