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Protein

Kell blood group glycoprotein homolog

Gene

Kel

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3 (By similarity).By similarity1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi562Zinc; catalyticPROSITE-ProRule annotation1
Active sitei563PROSITE-ProRule annotation1
Metal bindingi566Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi615Zinc; catalyticPROSITE-ProRule annotation1
Active sitei619Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • metalloendopeptidase activity Source: HGNC
  • metallopeptidase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors

Protein family/group databases

MEROPSiM13.090

Names & Taxonomyi

Protein namesi
Recommended name:
Kell blood group glycoprotein homolog (EC:3.4.24.-)
Alternative name(s):
CD_antigen: CD238
Gene namesi
Name:Kel
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1346053 Kel

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini49 – 713ExtracellularSequence analysisAdd BLAST665

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003198861 – 713Kell blood group glycoprotein homologAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53Interchain (with C-347 in XK)By similarity
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi326N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9EQF2
PaxDbiQ9EQF2
PRIDEiQ9EQF2

PTM databases

PhosphoSitePlusiQ9EQF2

Expressioni

Tissue specificityi

Highly expressed in spleen. Weaker expression in testis and heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000029866 Expressed in 71 organ(s), highest expression level in blood
CleanExiMM_KEL
ExpressionAtlasiQ9EQF2 baseline and differential
GenevisibleiQ9EQF2 MM

Interactioni

Subunit structurei

Heterodimer with XK; disulfide-linked.1 Publication

Protein-protein interaction databases

IntActiQ9EQF2, 1 interactor
STRINGi10090.ENSMUSP00000031899

Structurei

3D structure databases

ProteinModelPortaliQ9EQF2
SMRiQ9EQF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M13 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
HOGENOMiHOG000245574
HOVERGENiHBG002194
InParanoidiQ9EQF2
KOiK06577
OMAiSYAQVMC
OrthoDBiEOG091G033Z
PhylomeDBiQ9EQF2
TreeFamiTF315192

Family and domain databases

CDDicd08662 M13, 1 hit
Gene3Di3.40.390.10, 3 hits
InterProiView protein in InterPro
IPR029737 KEL
IPR024079 MetalloPept_cat_dom_sf
IPR000718 Peptidase_M13
IPR018497 Peptidase_M13_C
IPR008753 Peptidase_M13_N
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF128 PTHR11733:SF128, 1 hit
PfamiView protein in Pfam
PF01431 Peptidase_M13, 1 hit
PF05649 Peptidase_M13_N, 1 hit
PRINTSiPR00786 NEPRILYSIN
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9EQF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPPWSQESS PEERLPTEWS RQLTRARWVL LAVLLCGLLL GSSMLWFYIF
60 70 80 90 100
RNCGPCPCET PVCMELLDHY LASGNRSVAP CTDFFSFACE KANGTSDSFQ
110 120 130 140 150
ALTEENKSRL WRLLEAPGSW HLGSGEEKAF QFYNSCMDTD AIEASGSGPL
160 170 180 190 200
IQIIEELGGW NITGNWTSLD FNQNLRLLMS QYGHFPFFRA YLRPHPAPPH
210 220 230 240 250
TPIIQIDQPE FDILLQQEQE QKVYAQILRE YVTYLNRLGT LLGSNPQEAQ
260 270 280 290 300
QHASWSIVFT SRLFQFLRPQ QQQQAQDKLF HVVTIDELQE MAPAIDWLSC
310 320 330 340 350
LQAIFTPMSL NSSQTLVVHD LDYLRNMSQL VEEGLLNHRE SIQSYMILGL
360 370 380 390 400
VDTLSPALDT KFQEARRELI QELRKLKERP PLPAYPRWMK CVEQTGAFFE
410 420 430 440 450
PTLAALFVRE AFGPSIQSAA MELFAEIKDA VIIRLKKLSW ISEETQKEAL
460 470 480 490 500
NKLAQLQVEM GAPKRAVKPD IATQEYNDIQ LGPSFLQSFL SCVRSLRARN
510 520 530 540 550
VQSFLQPFPY HRWQKSPWEV NAYYSISDHM VVFPAGLLQP PFFHPGYPRA
560 570 580 590 600
VNFGAAGSIM AHELLHIFYQ LLLPGGCPAC DTHVLQEALL CLERHYAAFP
610 620 630 640 650
LPSISSFNGS HTLLENAADI GGVAIAFQAY SKRIVEHTGE LTLPNLDLSP
660 670 680 690 700
YQLFFRSYAQ VMCRGLSSQD PQDPHSPPSL RVHGPLSNTP DFAKHFHCPR
710
GTLLNPSARC KLW
Length:713
Mass (Da):80,866
Last modified:March 1, 2001 - v1
Checksum:i5A1F32009F55DFE1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YVT2A0A0A6YVT2_MOUSE
Kell blood group glycoprotein homol...
Kel
286Annotation score:
A0A0A6YXM8A0A0A6YXM8_MOUSE
Kell blood group glycoprotein homol...
Kel
69Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti268R → G in AAH99961 (PubMed:15489334).Curated1
Sequence conflicti377K → Q in AAH99961 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252870 mRNA Translation: AAG48572.1
AF336378 Genomic DNA Translation: AAM53407.1
AK028430 mRNA Translation: BAC25947.1
BC099961 mRNA Translation: AAH99961.1
CCDSiCCDS20055.1
RefSeqiNP_115929.3, NM_032540.3
XP_006506120.1, XM_006506057.3
UniGeneiMm.19958

Genome annotation databases

EnsembliENSMUST00000031899; ENSMUSP00000031899; ENSMUSG00000029866
GeneIDi23925
KEGGimmu:23925
UCSCiuc009bqf.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252870 mRNA Translation: AAG48572.1
AF336378 Genomic DNA Translation: AAM53407.1
AK028430 mRNA Translation: BAC25947.1
BC099961 mRNA Translation: AAH99961.1
CCDSiCCDS20055.1
RefSeqiNP_115929.3, NM_032540.3
XP_006506120.1, XM_006506057.3
UniGeneiMm.19958

3D structure databases

ProteinModelPortaliQ9EQF2
SMRiQ9EQF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EQF2, 1 interactor
STRINGi10090.ENSMUSP00000031899

Protein family/group databases

MEROPSiM13.090

PTM databases

PhosphoSitePlusiQ9EQF2

Proteomic databases

MaxQBiQ9EQF2
PaxDbiQ9EQF2
PRIDEiQ9EQF2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031899; ENSMUSP00000031899; ENSMUSG00000029866
GeneIDi23925
KEGGimmu:23925
UCSCiuc009bqf.2 mouse

Organism-specific databases

CTDi3792
MGIiMGI:1346053 Kel

Phylogenomic databases

eggNOGiKOG3624 Eukaryota
COG3590 LUCA
GeneTreeiENSGT00760000119162
HOGENOMiHOG000245574
HOVERGENiHBG002194
InParanoidiQ9EQF2
KOiK06577
OMAiSYAQVMC
OrthoDBiEOG091G033Z
PhylomeDBiQ9EQF2
TreeFamiTF315192

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors

Miscellaneous databases

PROiPR:Q9EQF2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029866 Expressed in 71 organ(s), highest expression level in blood
CleanExiMM_KEL
ExpressionAtlasiQ9EQF2 baseline and differential
GenevisibleiQ9EQF2 MM

Family and domain databases

CDDicd08662 M13, 1 hit
Gene3Di3.40.390.10, 3 hits
InterProiView protein in InterPro
IPR029737 KEL
IPR024079 MetalloPept_cat_dom_sf
IPR000718 Peptidase_M13
IPR018497 Peptidase_M13_C
IPR008753 Peptidase_M13_N
PANTHERiPTHR11733 PTHR11733, 1 hit
PTHR11733:SF128 PTHR11733:SF128, 1 hit
PfamiView protein in Pfam
PF01431 Peptidase_M13, 1 hit
PF05649 Peptidase_M13_N, 1 hit
PRINTSiPR00786 NEPRILYSIN
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKELL_MOUSE
AccessioniPrimary (citable) accession number: Q9EQF2
Secondary accession number(s): Q499D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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