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Protein

Follistatin-related protein 3

Gene

Fstl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10 (By similarity).By similarity

GO - Molecular functioni

  • activin binding Source: MGI
  • fibronectin binding Source: MGI

GO - Biological processi

Keywordsi

Biological processOsteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2473224 Antagonism of Activin by Follistatin
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI01.968

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 3
Alternative name(s):
Follistatin-like protein 3
Follistatin-related gene protein
Gene namesi
Name:Fstl3
Synonyms:Flrg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1890391 Fstl3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001011624 – 256Follistatin-related protein 3Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 59PROSITE-ProRule annotation
Disulfide bondi46 ↔ 90PROSITE-ProRule annotation
Disulfide bondi60 ↔ 93PROSITE-ProRule annotation
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation
Disulfide bondi119 ↔ 151PROSITE-ProRule annotation
Disulfide bondi123 ↔ 144PROSITE-ProRule annotation
Disulfide bondi133 ↔ 165PROSITE-ProRule annotation
Disulfide bondi193 ↔ 227PROSITE-ProRule annotation
Disulfide bondi198 ↔ 220PROSITE-ProRule annotation
Disulfide bondi209 ↔ 241PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQC7
PRIDEiQ9EQC7

PTM databases

PhosphoSitePlusiQ9EQC7

Expressioni

Tissue specificityi

Abundantly expressed in heart, lung, kidney and testis. Continuously expressed in embryonic heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000020325 Expressed in 147 organ(s), highest expression level in placenta
CleanExiMM_FSTL3
ExpressionAtlasiQ9EQC7 baseline and differential
GenevisibleiQ9EQC7 MM

Interactioni

Subunit structurei

Interacts with INHBA and INHBB. Interacts with FN1. Interacts with ADAM12. Interacts with MLLT10; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with MSTN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020575

Structurei

3D structure databases

ProteinModelPortaliQ9EQC7
SMRiQ9EQC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 105TBPROSITE-ProRule annotationAdd BLAST72
Domaini97 – 117Follistatin-like 1Add BLAST21
Domaini111 – 167Kazal-like 1PROSITE-ProRule annotationAdd BLAST57
Domaini168 – 191Follistatin-like 2Add BLAST24
Domaini187 – 243Kazal-like 2PROSITE-ProRule annotationAdd BLAST57

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiQ9EQC7
OMAiGAPGPLW
OrthoDBiEOG091G09I0
PhylomeDBiQ9EQC7
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00274 FOLN, 2 hits
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS51364 TB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EQC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSGALWPLL WGALVWTVGS VGAVMGSEDS VPGGVCWLQQ GREATCSLVL
60 70 80 90 100
KTRVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV
110 120 130 140 150
ECGPGKACRM LGGRPHCECV PNCEGLPAGF QVCGSDGATY RDECELRTAR
160 170 180 190 200
CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV
210 220 230 240 250
PSNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE

EEENFV
Length:256
Mass (Da):27,271
Last modified:March 1, 2001 - v1
Checksum:i5854A4B8C1C02EE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276238 mRNA Translation: AAG47666.1
AB024429 mRNA Translation: BAB32663.1
AF310616 mRNA Translation: AAG53666.1
BC061052 mRNA Translation: AAH61052.1
CCDSiCCDS23990.1
RefSeqiNP_113557.1, NM_031380.2
UniGeneiMm.251710

Genome annotation databases

EnsembliENSMUST00000020575; ENSMUSP00000020575; ENSMUSG00000020325
GeneIDi83554
KEGGimmu:83554
UCSCiuc007fzs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF276238 mRNA Translation: AAG47666.1
AB024429 mRNA Translation: BAB32663.1
AF310616 mRNA Translation: AAG53666.1
BC061052 mRNA Translation: AAH61052.1
CCDSiCCDS23990.1
RefSeqiNP_113557.1, NM_031380.2
UniGeneiMm.251710

3D structure databases

ProteinModelPortaliQ9EQC7
SMRiQ9EQC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020575

Protein family/group databases

MEROPSiI01.968

PTM databases

PhosphoSitePlusiQ9EQC7

Proteomic databases

PaxDbiQ9EQC7
PRIDEiQ9EQC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020575; ENSMUSP00000020575; ENSMUSG00000020325
GeneIDi83554
KEGGimmu:83554
UCSCiuc007fzs.2 mouse

Organism-specific databases

CTDi10272
MGIiMGI:1890391 Fstl3

Phylogenomic databases

eggNOGiKOG3649 Eukaryota
ENOG410YC3T LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiQ9EQC7
OMAiGAPGPLW
OrthoDBiEOG091G09I0
PhylomeDBiQ9EQC7
TreeFamiTF106409

Enzyme and pathway databases

ReactomeiR-MMU-2473224 Antagonism of Activin by Follistatin
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:Q9EQC7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020325 Expressed in 147 organ(s), highest expression level in placenta
CleanExiMM_FSTL3
ExpressionAtlasiQ9EQC7 baseline and differential
GenevisibleiQ9EQC7 MM

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 2 hits
SMARTiView protein in SMART
SM00274 FOLN, 2 hits
SM00280 KAZAL, 2 hits
SUPFAMiSSF100895 SSF100895, 2 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 2 hits
PS51364 TB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSTL3_MOUSE
AccessioniPrimary (citable) accession number: Q9EQC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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