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Protein

Elongation of very long chain fatty acids protein 4

Gene

Elovl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayi
UPA00094

Chemistry databases

SwissLipidsiSLP:000000264

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 4UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity)
Alternative name(s):
3-keto acyl-CoA synthase Elovl4UniRule annotation
ELOVL fatty acid elongase 4UniRule annotation
Short name:
ELOVL FA elongase 4UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 4UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 4UniRule annotation
Gene namesi
Name:Elovl4UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1933331 Elovl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalUniRule annotationAdd BLAST21
Transmembranei78 – 98HelicalUniRule annotationAdd BLAST21
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21
Transmembranei188 – 208HelicalUniRule annotationAdd BLAST21
Transmembranei217 – 237HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075451 – 312Elongation of very long chain fatty acids protein 4Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi20N-linked (GlcNAc...) asparagineUniRule annotation1
Glycosylationi292N-linked (GlcNAc...) asparagineUniRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9EQC4
PRIDEiQ9EQC4

PTM databases

PhosphoSitePlusiQ9EQC4

Expressioni

Tissue specificityi

Expressed in the retina, exclusively in photoreceptor cells and in the brain, skin, testis and lens.1 Publication

Developmental stagei

Expressed in the ocular tissues of the retina at 10.5 dpc and becomes restricted predominantly to the photoreceptor layer in the mature retina (at protein level). Expressed in the embryo at 7 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000032262 Expressed in 210 organ(s), highest expression level in skin of external ear
ExpressionAtlasiQ9EQC4 baseline and differential
GenevisibleiQ9EQC4 MM

Interactioni

Subunit structurei

Oligomer.UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034796

Structurei

3D structure databases

SMRiQ9EQC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi308 – 312Di-lysine motifUniRule annotation5

Domaini

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.UniRule annotation

Sequence similaritiesi

Belongs to the ELO family. ELOVL4 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038120
HOVERGENiHBG051468
InParanoidiQ9EQC4
KOiK10249
OMAiAFIHVIM
OrthoDBiEOG091G0N2V
TreeFamiTF323454

Family and domain databases

HAMAPiMF_03204 VLCF_elongase_4, 1 hit
InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
IPR033678 ELOVL4
PANTHERiPTHR11157 PTHR11157, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9EQC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLDSEPGS VLNAMSTAFN DTVEFYRWTW TIADKRVADW PLMQSPWPTI
60 70 80 90 100
SISTLYLLFV WLGPKWMKDR EPFQMRLVLI IYNFGMVLLN LFIFRELFMG
110 120 130 140 150
SYNAGYSYIC QSVDYSNDVN EVRIAGALWW YFVSKGVEYL DTVFFILRKK
160 170 180 190 200
NNQVSFLHVY HHCTMFTLWW IGIKWVAGGQ AFFGAQMNSF IHVIMYSYYG
210 220 230 240 250
LTAFGPWIQK YLWWKRYLTM LQLVQFHVTI GHTALSLYTD CPFPKWMHWA
260 270 280 290 300
LIAYAISFIF LFLNFYTRTY NEPKQSKTGK TATNGISSNG VNKSEKALEN
310
GKPQKNGKPK GE
Length:312
Mass (Da):36,506
Last modified:July 27, 2011 - v2
Checksum:iB049772627D28294
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXI2V9GXI2_MOUSE
Elongation of very long chain fatty...
Elovl4
181Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126G → A in AAG47667 (PubMed:11138005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277093 mRNA Translation: AAG47667.1
AJ550628
, AJ550629, AJ550630, AJ550631, AJ550632, AJ550633 Genomic DNA Translation: CAD80158.4
AK029065 mRNA Translation: BAC26274.1
CH466522 Genomic DNA Translation: EDL26470.1
BC037030 mRNA Translation: AAH37030.1
CCDSiCCDS23376.1
RefSeqiNP_683743.2, NM_148941.2
UniGeneiMm.83949

Genome annotation databases

EnsembliENSMUST00000034796; ENSMUSP00000034796; ENSMUSG00000032262
GeneIDi83603
KEGGimmu:83603
UCSCiuc012gxk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF277093 mRNA Translation: AAG47667.1
AJ550628
, AJ550629, AJ550630, AJ550631, AJ550632, AJ550633 Genomic DNA Translation: CAD80158.4
AK029065 mRNA Translation: BAC26274.1
CH466522 Genomic DNA Translation: EDL26470.1
BC037030 mRNA Translation: AAH37030.1
CCDSiCCDS23376.1
RefSeqiNP_683743.2, NM_148941.2
UniGeneiMm.83949

3D structure databases

SMRiQ9EQC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034796

Chemistry databases

SwissLipidsiSLP:000000264

PTM databases

PhosphoSitePlusiQ9EQC4

Proteomic databases

PaxDbiQ9EQC4
PRIDEiQ9EQC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034796; ENSMUSP00000034796; ENSMUSG00000032262
GeneIDi83603
KEGGimmu:83603
UCSCiuc012gxk.1 mouse

Organism-specific databases

CTDi6785
MGIiMGI:1933331 Elovl4

Phylogenomic databases

eggNOGiKOG3071 Eukaryota
ENOG410XRWT LUCA
GeneTreeiENSGT00760000119122
HOGENOMiHOG000038120
HOVERGENiHBG051468
InParanoidiQ9EQC4
KOiK10249
OMAiAFIHVIM
OrthoDBiEOG091G0N2V
TreeFamiTF323454

Enzyme and pathway databases

UniPathwayi
UPA00094

Miscellaneous databases

PROiPR:Q9EQC4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032262 Expressed in 210 organ(s), highest expression level in skin of external ear
ExpressionAtlasiQ9EQC4 baseline and differential
GenevisibleiQ9EQC4 MM

Family and domain databases

HAMAPiMF_03204 VLCF_elongase_4, 1 hit
InterProiView protein in InterPro
IPR030457 ELO_CS
IPR002076 ELO_fam
IPR033678 ELOVL4
PANTHERiPTHR11157 PTHR11157, 1 hit
PfamiView protein in Pfam
PF01151 ELO, 1 hit
PROSITEiView protein in PROSITE
PS01188 ELO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiELOV4_MOUSE
AccessioniPrimary (citable) accession number: Q9EQC4
Secondary accession number(s): Q8JZV3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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