Elovl4

Functionⁱ

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.UniRule annotation

Catalytic activityⁱ

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO₂.UniRule annotation

Pathwayⁱ: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functionⁱ

3-oxo-arachidoyl-CoA synthase activity Source: UniProtKB-EC
3-oxo-cerotoyl-CoA synthase activity Source: UniProtKB-EC
3-oxo-lignoceronyl-CoA synthase activity Source: UniProtKB-EC
fatty acid elongase activity
Source: Reactome
Inferred from experimentⁱ
- 18728184
very-long-chain 3-ketoacyl-CoA synthase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fatty acid elongation, monounsaturated fatty acid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fatty acid elongation, polyunsaturated fatty acid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fatty acid elongation, saturated fatty acid Source: UniProtKB
long-chain fatty-acyl-CoA biosynthetic process Source: UniProtKB-UniRule
sphingolipid biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
unsaturated fatty acid biosynthetic process Source: UniProtKB-UniRule
very long-chain fatty acid biosynthetic process Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayⁱ	UPA00094

UniPathwayⁱ

UPA00094

Chemistry databases

SwissLipidsⁱ	SLP:000000264

SwissLipidsⁱ

SLP:000000264

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongation of very long chain fatty acids protein 4UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity) Alternative name(s): 3-keto acyl-CoA synthase Elovl4UniRule annotation ELOVL fatty acid elongase 4UniRule annotation Short name: ELOVL FA elongase 4UniRule annotation Very long chain 3-ketoacyl-CoA synthase 4UniRule annotation Very long chain 3-oxoacyl-CoA synthase 4UniRule annotation
Gene namesⁱ	Name:Elovl4UniRule annotation
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:1933331 Elovl4

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	42 – 62	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	78 – 98	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	127 – 147	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	165 – 185	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	188 – 208	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	217 – 237	HelicalUniRule annotationAdd BLAST	21
Transmembraneⁱ	246 – 266	HelicalUniRule annotationAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000207545	1 – 312	Elongation of very long chain fatty acids protein 4Add BLAST		312

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	20	N-linked (GlcNAc...) asparagineUniRule annotation		1
Glycosylationⁱ	292	N-linked (GlcNAc...) asparagineUniRule annotation		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9EQC4
PRIDEⁱ	Q9EQC4

PTM databases

PhosphoSitePlusⁱ	Q9EQC4

PhosphoSitePlusⁱ

Q9EQC4

Expressionⁱ

Tissue specificityⁱ

Expressed in the retina, exclusively in photoreceptor cells and in the brain, skin, testis and lens.1 Publication

Developmental stageⁱ

Expressed in the ocular tissues of the retina at 10.5 dpc and becomes restricted predominantly to the photoreceptor layer in the mature retina (at protein level). Expressed in the embryo at 7 dpc.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000032262 Expressed in 210 organ(s), highest expression level in skin of external ear
ExpressionAtlasⁱ	Q9EQC4 baseline and differential
Genevisibleⁱ	Q9EQC4 MM

Interactionⁱ

Subunit structureⁱ

Oligomer.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034796

STRINGⁱ

10090.ENSMUSP00000034796

Structureⁱ

3D structure databases

SMRⁱ	Q9EQC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	308 – 312	Di-lysine motifUniRule annotation		5

Domainⁱ

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.UniRule annotation

Sequence similaritiesⁱ

Belongs to the ELO family. ELOVL4 subfamily.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3071 Eukaryota ENOG410XRWT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119122
HOGENOMⁱ	HOG000038120
HOVERGENⁱ	HBG051468
InParanoidⁱ	Q9EQC4
KEGG Orthology (KO) More...KOⁱ	K10249
OMAⁱ	AFIHVIM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N2V
TreeFamⁱ	TF323454

Family and domain databases

HAMAPⁱ	MF_03204 VLCF_elongase_4, 1 hit
InterProⁱ	View protein in InterPro IPR030457 ELO_CS IPR002076 ELO_fam IPR033678 ELOVL4
PANTHERⁱ	PTHR11157 PTHR11157, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01151 ELO, 1 hit
PROSITEⁱ	View protein in PROSITE PS01188 ELO, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9EQC4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLLDSEPGS VLNAMSTAFN DTVEFYRWTW TIADKRVADW PLMQSPWPTI 
        60         70         80         90        100
SISTLYLLFV WLGPKWMKDR EPFQMRLVLI IYNFGMVLLN LFIFRELFMG 
       110        120        130        140        150
SYNAGYSYIC QSVDYSNDVN EVRIAGALWW YFVSKGVEYL DTVFFILRKK 
       160        170        180        190        200
NNQVSFLHVY HHCTMFTLWW IGIKWVAGGQ AFFGAQMNSF IHVIMYSYYG 
       210        220        230        240        250
LTAFGPWIQK YLWWKRYLTM LQLVQFHVTI GHTALSLYTD CPFPKWMHWA 
       260        270        280        290        300
LIAYAISFIF LFLNFYTRTY NEPKQSKTGK TATNGISSNG VNKSEKALEN 
       310 
GKPQKNGKPK GE

Length:312

Mass (Da):36,506

Last modified:July 27, 2011 - v2

Checksum:ⁱB049772627D28294

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	V9GXI2	V9GXI2_MOUSE		Elongation of very long chain fatty... Elongation of very long chain fatty acids protein, EC 2.3.1.199 (Very-long-chain 3-oxoacyl-CoA synthase)	Elovl4	181	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	126	G → A in AAG47667 (PubMed:11138005).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF277093 mRNA Translation: AAG47667.1 AJ550628 AJ550633 Genomic DNA Translation: CAD80158.4 AK029065 mRNA Translation: BAC26274.1 CH466522 Genomic DNA Translation: EDL26470.1 BC037030 mRNA Translation: AAH37030.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS23376.1
NCBI Reference Sequences More...RefSeqⁱ	NP_683743.2, NM_148941.2
UniGeneⁱ	Mm.83949

Genome annotation databases

Ensemblⁱ	ENSMUST00000034796; ENSMUSP00000034796; ENSMUSG00000032262
GeneIDⁱ	83603
KEGGⁱ	mmu:83603
UCSC genome browser More...UCSCⁱ	uc012gxk.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9EQC4	Elongation of very long chain fatty acids protein 4		HUMAN		314	UniRef90_Q9GZR5
Elongation of very long chain fatty acids protein 4		TUPCH		389
Elongation of very long chain fatty acids protein 4		Enhydra lutris kenyoni		314
Elongation of very long chain fatty acids protein 4		SAIBB		314
Elongation of very long chain fatty acids protein 4		CANLF		314
+52

Protein	Similar proteins		Species	Score	Length	Source
Q9EQC4	Elongation of very long chain fatty acids protein 4		HUMAN		314	UniRef50_Q9GZR5
Elongation of very long chain fatty acids protein 4		MACFA		314
Elongation of very long chain fatty acids protein 4		MACMU		314
Elongation of very long chain fatty acids protein 4		TUPCH		389
Elongation of very long chain fatty acids protein 4		RHIBE		314
+188

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF277093 mRNA Translation: AAG47667.1 AJ550628 AJ550633 Genomic DNA Translation: CAD80158.4 AK029065 mRNA Translation: BAC26274.1 CH466522 Genomic DNA Translation: EDL26470.1 BC037030 mRNA Translation: AAH37030.1
CCDSⁱ	CCDS23376.1
RefSeqⁱ	NP_683743.2, NM_148941.2
UniGeneⁱ	Mm.83949

3D structure databases

SMRⁱ	Q9EQC4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000034796

STRINGⁱ

10090.ENSMUSP00000034796

Chemistry databases

SwissLipidsⁱ	SLP:000000264

SwissLipidsⁱ

SLP:000000264

PTM databases

PhosphoSitePlusⁱ	Q9EQC4

PhosphoSitePlusⁱ

Q9EQC4

Proteomic databases

PaxDbⁱ	Q9EQC4
PRIDEⁱ	Q9EQC4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034796; ENSMUSP00000034796; ENSMUSG00000032262
GeneIDⁱ	83603
KEGGⁱ	mmu:83603
UCSCⁱ	uc012gxk.1 mouse

Organism-specific databases

CTDⁱ	6785
MGIⁱ	MGI:1933331 Elovl4

Phylogenomic databases

eggNOGⁱ	KOG3071 Eukaryota ENOG410XRWT LUCA
GeneTreeⁱ	ENSGT00760000119122
HOGENOMⁱ	HOG000038120
HOVERGENⁱ	HBG051468
InParanoidⁱ	Q9EQC4
KOⁱ	K10249
OMAⁱ	AFIHVIM
OrthoDBⁱ	EOG091G0N2V
TreeFamⁱ	TF323454

Enzyme and pathway databases

UniPathwayⁱ	UPA00094

UniPathwayⁱ

UPA00094

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9EQC4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032262 Expressed in 210 organ(s), highest expression level in skin of external ear
ExpressionAtlasⁱ	Q9EQC4 baseline and differential
Genevisibleⁱ	Q9EQC4 MM

Family and domain databases

HAMAPⁱ	MF_03204 VLCF_elongase_4, 1 hit
InterProⁱ	View protein in InterPro IPR030457 ELO_CS IPR002076 ELO_fam IPR033678 ELOVL4
PANTHERⁱ	PTHR11157 PTHR11157, 1 hit
Pfamⁱ	View protein in Pfam PF01151 ELO, 1 hit
PROSITEⁱ	View protein in PROSITE PS01188 ELO, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELOV4_MOUSE
Accessionⁱ	Q9EQC4Primary (citable) accession number: Q9EQC4 Secondary accession number(s): Q8JZV3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q9EQC4 (ELOV4_MOUSE)

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Elongation of very long chain fatty acids protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: fatty acid biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ