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Protein

NIF3-like protein 1

Gene

Nif3l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of nucleic acid-templated transcription Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 11 Publication
Gene namesi
Name:Nif3l1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929485 Nif3l1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001473541 – 376NIF3-like protein 1Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei108N6-acetyllysineBy similarity1
Modified residuei254PhosphothreonineCombined sources1
Modified residuei258PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EQ80
MaxQBiQ9EQ80
PaxDbiQ9EQ80
PeptideAtlasiQ9EQ80
PRIDEiQ9EQ80

PTM databases

iPTMnetiQ9EQ80
PhosphoSitePlusiQ9EQ80

Expressioni

Tissue specificityi

Ubiquitous. Detected in all tissues tested with higher expression in cerebellum, heart and kidney and to a lower level in cerebrum, lung, liver, spleen and muscle.2 Publications

Developmental stagei

Expressed in the developping brain from E10.5 until E14.5. The expression decreases after E16.5, but an up-regulation is observed at P5 and the expression remains constant thereafter.1 Publication

Gene expression databases

BgeeiENSMUSG00000026036 Expressed in 268 organ(s), highest expression level in ear
CleanExiMM_NIF3L1
ExpressionAtlasiQ9EQ80 baseline and differential
GenevisibleiQ9EQ80 MM

Interactioni

Subunit structurei

Homodimer (By similarity). Interacts with COPS2 (PubMed:12522100). Interacts with THOC7 (PubMed:12951069).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9EQ80, 1 interactor
MINTiQ9EQ80
STRINGi10090.ENSMUSP00000084799

Structurei

3D structure databases

ProteinModelPortaliQ9EQ80
SMRiQ9EQ80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni243 – 376Mediates interaction with COPS21 PublicationAdd BLAST134

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4131 Eukaryota
COG0327 LUCA
GeneTreeiENSGT00390000003590
HOGENOMiHOG000014260
HOVERGENiHBG029337
InParanoidiQ9EQ80
OMAiYHPPIFK
OrthoDBiEOG091G0AAM
TreeFamiTF324125

Family and domain databases

InterProiView protein in InterPro
IPR002678 GTP_cyclohydrolase_I/Nif3
IPR036069 GTP_cyclohydrolase_I/Nif3_sf
IPR017222 NIF3L1_animal
PANTHERiPTHR13799 PTHR13799, 1 hit
PfamiView protein in Pfam
PF01784 NIF3, 1 hit
PIRSFiPIRSF037490 UCP037490_NIF3_euk, 1 hit
SUPFAMiSSF102705 SSF102705, 1 hit
TIGRFAMsiTIGR00486 YbgI_SA1388, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9EQ80-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSSAHLVPT SVQRAQSWIC RSSRSFMDLK ALLSSLNDFA SLSFAESWDN
60 70 80 90 100
VGLLVEPSPP HTVNTLFLTN DLTEEVMDEA LQKKADFILS YHPPIFRPMK
110 120 130 140 150
HITWKTWKEC LVIRALENRV AVYSPHTAYD AAPQGVNSWL AKGLGTCTTR
160 170 180 190 200
PIHPSRAPDY PTEGAHRLEF SVNRSQDLDK VMSTLRGVGG VSVTSFPARC
210 220 230 240 250
DGEEQTRISL NCTQKTLMQV LAFLSQDRQL YQKTEILSLE KPLLLHTGMG
260 270 280 290 300
RLCTLDESVS LAIMIERIKT HLKLSHLRLA LGVGRTLESQ VKVVALCAGS
310 320 330 340 350
GGSVLQGVEA DLYLTGEMSH HDVLDAASKG INVILCEHSN TERGFLSELQ
360 370
EMLGVHFENK INIILSETDR DPLRVV
Length:376
Mass (Da):41,746
Last modified:July 27, 2011 - v4
Checksum:i5B8693C5C621DC3D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0G0D3Z0G0_MOUSE
NIF3-like protein 1
Nif3l1 mCG_117462
329Annotation score:
D3YYF0D3YYF0_MOUSE
NIF3-like protein 1
Nif3l1
131Annotation score:
E9PWJ6E9PWJ6_MOUSE
NIF3-like protein 1
Nif3l1
155Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7L → I in AAG45961 (PubMed:11124544).Curated1
Sequence conflicti190G → S in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti204E → K in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti217L → F in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti221L → Q in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti224L → F in BAB27769 (PubMed:16141072).Curated1
Sequence conflicti234T → I in BAB27769 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284439 mRNA Translation: AAG45961.1
AK011670 mRNA Translation: BAB27769.1
AK154815 mRNA Translation: BAE32848.1
AK158616 mRNA Translation: BAE34583.1
CH466548 Genomic DNA Translation: EDL00082.1
BC065163 mRNA Translation: AAH65163.1
CCDSiCCDS14973.1
RefSeqiNP_075364.2, NM_022988.3
XP_006496249.1, XM_006496186.1
UniGeneiMm.340248

Genome annotation databases

EnsembliENSMUST00000087521; ENSMUSP00000084799; ENSMUSG00000026036
ENSMUST00000171597; ENSMUSP00000127501; ENSMUSG00000026036
GeneIDi65102
KEGGimmu:65102
UCSCiuc007bbz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF284439 mRNA Translation: AAG45961.1
AK011670 mRNA Translation: BAB27769.1
AK154815 mRNA Translation: BAE32848.1
AK158616 mRNA Translation: BAE34583.1
CH466548 Genomic DNA Translation: EDL00082.1
BC065163 mRNA Translation: AAH65163.1
CCDSiCCDS14973.1
RefSeqiNP_075364.2, NM_022988.3
XP_006496249.1, XM_006496186.1
UniGeneiMm.340248

3D structure databases

ProteinModelPortaliQ9EQ80
SMRiQ9EQ80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9EQ80, 1 interactor
MINTiQ9EQ80
STRINGi10090.ENSMUSP00000084799

PTM databases

iPTMnetiQ9EQ80
PhosphoSitePlusiQ9EQ80

Proteomic databases

EPDiQ9EQ80
MaxQBiQ9EQ80
PaxDbiQ9EQ80
PeptideAtlasiQ9EQ80
PRIDEiQ9EQ80

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087521; ENSMUSP00000084799; ENSMUSG00000026036
ENSMUST00000171597; ENSMUSP00000127501; ENSMUSG00000026036
GeneIDi65102
KEGGimmu:65102
UCSCiuc007bbz.1 mouse

Organism-specific databases

CTDi60491
MGIiMGI:1929485 Nif3l1

Phylogenomic databases

eggNOGiKOG4131 Eukaryota
COG0327 LUCA
GeneTreeiENSGT00390000003590
HOGENOMiHOG000014260
HOVERGENiHBG029337
InParanoidiQ9EQ80
OMAiYHPPIFK
OrthoDBiEOG091G0AAM
TreeFamiTF324125

Miscellaneous databases

PROiPR:Q9EQ80
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026036 Expressed in 268 organ(s), highest expression level in ear
CleanExiMM_NIF3L1
ExpressionAtlasiQ9EQ80 baseline and differential
GenevisibleiQ9EQ80 MM

Family and domain databases

InterProiView protein in InterPro
IPR002678 GTP_cyclohydrolase_I/Nif3
IPR036069 GTP_cyclohydrolase_I/Nif3_sf
IPR017222 NIF3L1_animal
PANTHERiPTHR13799 PTHR13799, 1 hit
PfamiView protein in Pfam
PF01784 NIF3, 1 hit
PIRSFiPIRSF037490 UCP037490_NIF3_euk, 1 hit
SUPFAMiSSF102705 SSF102705, 1 hit
TIGRFAMsiTIGR00486 YbgI_SA1388, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIF3L_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ80
Secondary accession number(s): Q6P1B7, Q9D098
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 123 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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