Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pescadillo homolog

Gene

Pes1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Pescadillo homologUniRule annotation
Gene namesi
Name:Pes1
Synonyms:Pes
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1890613 Pes1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos die during preimplantation stages of development, with blastomeres failing to progress past morula stages. Within blastocysts the nucleoli fail to form correctly and the number of ribosomes appears dramatically reduced.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861891 – 584Pescadillo homologAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98N6-acetyllysineBy similarity1
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Sumoylated.UniRule annotation

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9EQ61
MaxQBiQ9EQ61
PaxDbiQ9EQ61
PRIDEiQ9EQ61

PTM databases

iPTMnetiQ9EQ61
PhosphoSitePlusiQ9EQ61

Expressioni

Tissue specificityi

Ubiquitous. Highest levels appear to be found in tissues that contain a population of proliferating cells, such as ovary and testis. Also appears to be highly expressed in kidney and liver. In the brain expression is restricted to neural progenitor cells and postmitotic neurons. Highly expressed in malignant astrocytes.2 Publications

Developmental stagei

In 2-cell and 4-cell stage interphase blastomeres expression is restricted to a sub-nuclear band that encircles one or more large vacuoles within the nucleus. These vacuoles may give rise to the mature nucleolus. Later in embryogenesis high levels are detected in developing liver. Is also widely and highly expressed throughout the developing brain and spinal cord at embryonic day 13.2 Publications

Inductioni

Induced in malignant astrocytes following the loss of p53. Induced in hepatocytes following partial hepatectomy.2 Publications

Gene expression databases

BgeeiENSMUSG00000020430 Expressed in 288 organ(s), highest expression level in ear
ExpressionAtlasiQ9EQ61 baseline and differential
GenevisibleiQ9EQ61 MM

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:15225545). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The PeBoW complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex also associates with DDX27, PES1 interacts directly with DDX27 (By similarity). Interacts with IRS1 and UBTF (PubMed:15169904). May interact with MAP1B (PubMed:17308336).UniRule annotation3 Publications

Protein-protein interaction databases

BioGridi211118, 3 interactors
CORUMiQ9EQ61
IntActiQ9EQ61, 1 interactor
MINTiQ9EQ61
STRINGi10090.ENSMUSP00000020705

Structurei

3D structure databases

ProteinModelPortaliQ9EQ61
SMRiQ9EQ61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini321 – 414BRCTUniRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 257Sufficient for nucleolar localizationBy similarityAdd BLAST257
Regioni1 – 54Required for 28S ribosomal RNA processingBy similarityAdd BLAST54
Regioni312 – 414Sufficient for interaction with MAP1B1 PublicationAdd BLAST103
Regioni535 – 584Required for 28S ribosomal RNA processingBy similarityAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi454 – 527Glu-richAdd BLAST74

Sequence similaritiesi

Belongs to the pescadillo family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2481 Eukaryota
COG5163 LUCA
GeneTreeiENSGT00390000002626
HOGENOMiHOG000006022
HOVERGENiHBG023409
InParanoidiQ9EQ61
KOiK14843
OMAiVDFKVMS

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.10190, 1 hit
HAMAPiMF_03028 Pescadillo, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR010613 PES
PANTHERiPTHR12221 PTHR12221, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF06732 Pescadillo_N, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9EQ61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGLEKKKYE RGSATNYITR NKARKKLQLS LPDFRRLCIL KGIYPHEPKH
60 70 80 90 100
KKKVNKGSTA ARTFYLIKDI KFLLHEPIVN KFREYKVFVR KLRKAYGKSE
110 120 130 140 150
WNAVERLKDN KPCYKLDHIV KERYPTFIDA LRDLDDALSM CFLFSTFPRT
160 170 180 190 200
GKCHVQTIQL CRRLTVEFLH YVITARALRK VFLSIKGIYY QAEVLGQPIV
210 220 230 240 250
WIAPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFRLYQ SLNLHYPPKL
260 270 280 290 300
EGQAQAETKI SEDTYALDSE SSMEKLAALS ASLARVVVPA IEEAEADEFP
310 320 330 340 350
TDGEVTAQEE DRKKELEAQE KHKKLFEGLK FFLNREVPRE ALAFIIRSFG
360 370 380 390 400
GDVSWDKSLC IGATYDVTDS CITHQIVDRP GQQTPIIGRY YVQPQWVFDC
410 420 430 440 450
VNARLLLPVA EYFPGMQLPP HLSPFVSEKE GDYIPPEKLK LLALQRGEDP
460 470 480 490 500
GHLEEEEEED EDDDNEGDVA AENEEEDVEV ESEEEEEEEV HLSALEQHRL
510 520 530 540 550
EEKKPQVMAG TVKLEDKQRL AQEEESEAKR LAIMMMKKRE KYLYQKIMFG
560 570 580
KRRKIREANK LAEKRKAHDD AVRSEKKAKR TRPV
Length:584
Mass (Da):67,796
Last modified:March 1, 2001 - v1
Checksum:i63D3C352DF5E9893
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SQ20Q5SQ20_MOUSE
Pescadillo homolog
Pes1 PES1
588Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289539 mRNA Translation: AAG40734.1
AK029075 mRNA Translation: BAC26278.1
AK088831 mRNA Translation: BAC40599.1
BC004844 mRNA Translation: AAH04844.1
BC011142 mRNA Translation: AAH11142.1
CCDSiCCDS24372.1
RefSeqiNP_075027.1, NM_022889.3
UniGeneiMm.28659

Genome annotation databases

EnsembliENSMUST00000020705; ENSMUSP00000020705; ENSMUSG00000020430
GeneIDi64934
KEGGimmu:64934
UCSCiuc007hua.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF289539 mRNA Translation: AAG40734.1
AK029075 mRNA Translation: BAC26278.1
AK088831 mRNA Translation: BAC40599.1
BC004844 mRNA Translation: AAH04844.1
BC011142 mRNA Translation: AAH11142.1
CCDSiCCDS24372.1
RefSeqiNP_075027.1, NM_022889.3
UniGeneiMm.28659

3D structure databases

ProteinModelPortaliQ9EQ61
SMRiQ9EQ61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211118, 3 interactors
CORUMiQ9EQ61
IntActiQ9EQ61, 1 interactor
MINTiQ9EQ61
STRINGi10090.ENSMUSP00000020705

PTM databases

iPTMnetiQ9EQ61
PhosphoSitePlusiQ9EQ61

Proteomic databases

EPDiQ9EQ61
MaxQBiQ9EQ61
PaxDbiQ9EQ61
PRIDEiQ9EQ61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020705; ENSMUSP00000020705; ENSMUSG00000020430
GeneIDi64934
KEGGimmu:64934
UCSCiuc007hua.1 mouse

Organism-specific databases

CTDi23481
MGIiMGI:1890613 Pes1

Phylogenomic databases

eggNOGiKOG2481 Eukaryota
COG5163 LUCA
GeneTreeiENSGT00390000002626
HOGENOMiHOG000006022
HOVERGENiHBG023409
InParanoidiQ9EQ61
KOiK14843
OMAiVDFKVMS

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

PROiPR:Q9EQ61
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020430 Expressed in 288 organ(s), highest expression level in ear
ExpressionAtlasiQ9EQ61 baseline and differential
GenevisibleiQ9EQ61 MM

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.10190, 1 hit
HAMAPiMF_03028 Pescadillo, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR010613 PES
PANTHERiPTHR12221 PTHR12221, 1 hit
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF06732 Pescadillo_N, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 1 hit
SUPFAMiSSF52113 SSF52113, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPESC_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ61
Secondary accession number(s): Q542F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again