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Protein

Voltage-dependent T-type calcium channel subunit alpha-1H

Gene

Cacna1h

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:11073957). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (By similarity).By similarityCurated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi140ZincBy similarity1
Metal bindingi189ZincBy similarity1
Metal bindingi191ZincBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei378Calcium ion selectivity and permeabilityBy similarity1
Sitei971Calcium ion selectivity and permeabilityBy similarity1
Sitei1515Calcium ion selectivity and permeabilityBy similarity1
Sitei1813Calcium ion selectivity and permeabilityBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • low voltage-gated calcium channel activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1H
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1h
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
68943 Cacna1h

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei101 – 119Helical; Name=S1 of repeat ISequence analysisAdd BLAST19
Topological domaini120 – 141ExtracellularSequence analysisAdd BLAST22
Transmembranei142 – 160Helical; Name=S2 of repeat ISequence analysisAdd BLAST19
Topological domaini161 – 169CytoplasmicSequence analysis9
Transmembranei170 – 184Helical; Name=S3 of repeat ISequence analysisAdd BLAST15
Topological domaini185 – 193ExtracellularSequence analysis9
Transmembranei194 – 212Helical; Name=S4 of repeat ISequence analysisAdd BLAST19
Topological domaini213 – 232CytoplasmicSequence analysisAdd BLAST20
Transmembranei233 – 253Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini254 – 394ExtracellularSequence analysisAdd BLAST141
Transmembranei395 – 419Helical; Name=S6 of repeat ISequence analysisAdd BLAST25
Topological domaini420 – 790CytoplasmicSequence analysisAdd BLAST371
Transmembranei791 – 811Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini812 – 824ExtracellularSequence analysisAdd BLAST13
Transmembranei825 – 846Helical; Name=S2 of repeat IISequence analysisAdd BLAST22
Topological domaini847 – 852CytoplasmicSequence analysis6
Transmembranei853 – 871Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini872 – 879ExtracellularSequence analysis8
Transmembranei880 – 903Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini904 – 914CytoplasmicSequence analysisAdd BLAST11
Transmembranei915 – 935Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini936 – 987ExtracellularSequence analysisAdd BLAST52
Transmembranei988 – 1012Helical; Name=S6 of repeat IISequence analysisAdd BLAST25
Topological domaini1013 – 1301CytoplasmicSequence analysisAdd BLAST289
Transmembranei1302 – 1324Helical; Name=S1 of repeat IIISequence analysisAdd BLAST23
Topological domaini1325 – 1342ExtracellularSequence analysisAdd BLAST18
Transmembranei1343 – 1363Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1364 – 1373CytoplasmicSequence analysis10
Transmembranei1374 – 1393Helical; Name=S3 of repeat IIISequence analysisAdd BLAST20
Topological domaini1394 – 1407ExtracellularSequence analysisAdd BLAST14
Transmembranei1408 – 1429Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1430 – 1439CytoplasmicSequence analysis10
Transmembranei1440 – 1463Helical; Name=S5 of repeat IIISequence analysisAdd BLAST24
Topological domaini1464 – 1540ExtracellularSequence analysisAdd BLAST77
Transmembranei1541 – 1566Helical; Name=S6 of repeat IIISequence analysisAdd BLAST26
Topological domaini1567 – 1621CytoplasmicSequence analysisAdd BLAST55
Transmembranei1622 – 1642Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1643 – 1656ExtracellularSequence analysisAdd BLAST14
Transmembranei1657 – 1678Helical; Name=S2 of repeat IVSequence analysisAdd BLAST22
Topological domaini1679 – 1685CytoplasmicSequence analysis7
Transmembranei1686 – 1704Helical; Name=S3 of repeat IVSequence analysisAdd BLAST19
Topological domaini1705 – 1718ExtracellularSequence analysisAdd BLAST14
Transmembranei1719 – 1742Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1743 – 1756CytoplasmicSequence analysisAdd BLAST14
Transmembranei1757 – 1777Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1778 – 1840ExtracellularSequence analysisAdd BLAST63
Transmembranei1841 – 1868Helical; Name=S6 of repeat IVSequence analysisAdd BLAST28
Topological domaini1869 – 2359CytoplasmicSequence analysisAdd BLAST491

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5134

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539561 – 2359Voltage-dependent T-type calcium channel subunit alpha-1HAdd BLAST2359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi271N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1477N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EQ60

PRoteomics IDEntifications database

More...
PRIDEi
Q9EQ60

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q9EQ60

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EQ60

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminal cytoplasmic domain) with STAC.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000042239

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9EQ60

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9EQ60

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 422IAdd BLAST336
Repeati776 – 1015IIAdd BLAST240
Repeati1292 – 1569IIIAdd BLAST278
Repeati1607 – 1868IVAdd BLAST262

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi521 – 531Poly-HisAdd BLAST11
Compositional biasi1594 – 1597Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2302 Eukaryota
ENOG410XNP6 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007742

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050764

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EQ60

KEGG Orthology (KO)

More...
KOi
K04855

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9EQ60

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9EQ60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEGTLAADE VRVPLGASPP APAAPVRASP ASPGAPGREE QGGSGSGVLA
60 70 80 90 100
PESPGTECGA DLGADEEQPV PYPALAATVF FCLGQTTRPR SWCLRLVCNP
110 120 130 140 150
WFEHISMLVI MLNCVTLGMF RPCEDVECRS ERCSILEAFD DFIFAFFAVE
160 170 180 190 200
MVIKMVALGL FGQKCYLGDT WNRLDFFIVM AGMMEYSLDG HNVSLSAIRT
210 220 230 240 250
VRVLRPLRAI NRVPSMRILV TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ
260 270 280 290 300
LWAGLLRNRC FLDSAFVRNN NLTFLRPYYQ TEEGEENPFI CSSRRDNGMQ
310 320 330 340 350
KCSHIPSRRE LRVQCTLGWE AYGQPQAEDG GAGRNACINW NQYYNVCRSG
360 370 380 390 400
EFNPHNGAIN FDNIGYAWIA IFQVITLEGW VDIMYYVMDA HSFYNFIYFI
410 420 430 440 450
LLIIMGSFFM INLCLVVIAT QFSETKQREN QLMREQRARY LSNDSTLASF
460 470 480 490 500
SEPGSCYEEL LKYVGHIFRK VKRRSLRLYA RWQSRWRKKV DPSSTVHGQG
510 520 530 540 550
PGRRPRRAGR RTASVHHLVY HHHHHHHHHY HFSHGGPRRP SPEPGAGDNR
560 570 580 590 600
LVRACAPPSP PSPGHGPPDS ESVHSIYHAD CHVEGPQERA RVAHSIATAA
610 620 630 640 650
SLKLASGLGT MNYPTILPSG TVNSKGGTSS RPKGLRGAGA PGAAVHSPLS
660 670 680 690 700
LGSPRPYEKI QDVVGEQGLG RASSHLSGLS VPCPLPSPQA GTLTCELKSC
710 720 730 740 750
PYCASALEDP EFEFSGSESG DSDAHGVYEF TQDVRHGDCR DPVQQPHEVG
760 770 780 790 800
TPGHSNERRR TPLRKASQPG GIGHLWASFS GKLRRIVDSK YFNRGIMAAI
810 820 830 840 850
LVNTLSMGVE YHEQPEELTN ALEISNIVFT SMFALEMLLK LLACGPLGYI
860 870 880 890 900
RNPYNIFDGI VVVISVWEIV GQANGGLSVL RTFRLLRVLK LVRFLPALRR
910 920 930 940 950
QLVVLMRTMD NVATFCMLLM LFIFIFSILG MHLFGCKFSL KTDSGDTVPD
960 970 980 990 1000
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSSWAAL YFVALMTFGN
1010 1020 1030 1040 1050
YVLFNLLVAI LVEGFQAEGD ATRSDTDEDK TSTQLEGDFD KLRDLRATEM
1060 1070 1080 1090 1100
KMYSLAVTPN GHLEGRGSLP PPLITHTAAT PMPTPKSSPN LDVAHALLDS
1110 1120 1130 1140 1150
RRSSSGSVDP QLGDQKSLAS LRSSPCTPWG PNSAGSSRRS SWNSLGRAPS
1160 1170 1180 1190 1200
LKRRNQCGER ESLLSGEGKG STDDEAEDSR PSTGTHPGAS PGPRATPLRR
1210 1220 1230 1240 1250
AESLDHRSTL DLCPPRPAAL LPTKFHDCNG QMVALPSEFF LRIDSHKEDA
1260 1270 1280 1290 1300
AEFDDDIEDS CCFRLHKVLE PYAPQWCRSR ESWALYLFPP QNRLRVSCQK
1310 1320 1330 1340 1350
VIAHKMFDHV VLVFIFLNCI TIALERPDID PGSTERAFLS VSNYIFTAIF
1360 1370 1380 1390 1400
VVEMMVKVVA LGLLWGEHAY LQSSWNVLDG LLVLVSLVDI IVAMASAGGA
1410 1420 1430 1440 1450
KILGVLRVLR LLRTLRPLRV ISRAPGLKLV VETLISSLRP IGNIVLICCA
1460 1470 1480 1490 1500
FFIIFGILGV QLFKGKFYYC EGTDTRNITT KAECHAAHYR WVRRKYNFDN
1510 1520 1530 1540 1550
LGQALMSLFV LSSKDGWVNI MYDGLDAVGI DQQPVQNHNP WMLLYFISFL
1560 1570 1580 1590 1600
LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLERRRRKAQ
1610 1620 1630 1640 1650
RRPYYADYSH TRRSIHSLCT SHYLDLFITF IICLNVITMS MEHYNQPKSL
1660 1670 1680 1690 1700
DEALKYCNYV FTIVFVFEAA LKLVAFGFRR FFKDRWNQLD LAIVLLSIMG
1710 1720 1730 1740 1750
IALEEIEMNA ALPINPTIIR IMRVLRIARV LKLLKMATGM RALLDTVVQA
1760 1770 1780 1790 1800
LPQVGNLGLL FMLLFFIYAA LGVELFGRLE CSEDNPCEGL SRHATFTNFG
1810 1820 1830 1840 1850
MAFLTLFRVS TGDNWNGIMK DTLRECTRED KHCLSYLPAL SPVYFVTFML
1860 1870 1880 1890 1900
VAQFVLVNVV VAVLMKHLEE SNKEAREDAE MDAEIELEMA QGSTAQPPPT
1910 1920 1930 1940 1950
AQESQGTQPD TPNLLVVRKV SVSRMLSLPN DSYMFRPVAP AAAPHSHPLQ
1960 1970 1980 1990 2000
EVEMETYTGP VTSAHSPPLE PRASFQVPSA ASSPARVSDP LCALSPRGTP
2010 2020 2030 2040 2050
RSLSLSRILC RQEAMHSESL EGKVDDVGGD SIPDYTEPAE NMSTSQASTG
2060 2070 2080 2090 2100
APRSPPCSPR PASVRTRKHT FGQRCISSRP PTLGGDEAEA ADPADEEVSH
2110 2120 2130 2140 2150
ITSSAHPWPA TEPHSPEASP TASPVKGTMG SGRDPRRFCS VDAQSFLDKP
2160 2170 2180 2190 2200
GRPDAQRWSS VELDNGESHL ESGEVRGRAS ELEPALGSRR KKKMSPPCIS
2210 2220 2230 2240 2250
IEPPTKDEGS SRPPAAEGGN TTLRRRTPSC EAALHRDCPE PTEGPGTGGD
2260 2270 2280 2290 2300
PVAKGERWGQ ASCRAEHLTV PNFAFEPLDM GGPGGDCFLD SDQSVTPEPR
2310 2320 2330 2340 2350
VSSLGAIVPL ILETELSMPS GDCPEKEQGL YLTVPQTPLK KPGSTPATPA

PDDSGDEPV
Length:2,359
Mass (Da):261,113
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E708FA1D8E3765E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V9C6G3V9C6_RAT
Calcium channel, voltage-dependent,...
Cacna1h rCG_33015
2,359Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF290213 mRNA Translation: AAG35187.2

NCBI Reference Sequences

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RefSeqi
NP_722521.1, NM_153814.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Rn.49178

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
114862

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
rno:114862

UCSC genome browser

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UCSCi
RGD:68943 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290213 mRNA Translation: AAG35187.2
RefSeqiNP_722521.1, NM_153814.2
UniGeneiRn.49178

3D structure databases

ProteinModelPortaliQ9EQ60
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042239

Chemistry databases

BindingDBiQ9EQ60
ChEMBLiCHEMBL5134
GuidetoPHARMACOLOGYi536

PTM databases

CarbonylDBiQ9EQ60
PhosphoSitePlusiQ9EQ60

Proteomic databases

PaxDbiQ9EQ60
PRIDEiQ9EQ60

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114862
KEGGirno:114862
UCSCiRGD:68943 rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8912
RGDi68943 Cacna1h

Phylogenomic databases

eggNOGiKOG2302 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000007742
HOVERGENiHBG050764
InParanoidiQ9EQ60
KOiK04855
PhylomeDBiQ9EQ60

Miscellaneous databases

Protein Ontology

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PROi
PR:Q9EQ60

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAC1H_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EQ60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 20, 2005
Last modified: December 5, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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