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Protein

Lysophosphatidic acid receptor 3

Gene

Lpar3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • bleb assembly Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • positive regulation of calcium ion transport Source: MGI
  • positive regulation of collateral sprouting Source: MGI
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: MGI
  • positive regulation of MAPK cascade Source: MGI

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
Gene namesi
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1929469 Lpar3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 67CytoplasmicSequence analysisAdd BLAST15
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 101ExtracellularSequence analysisAdd BLAST13
Transmembranei102 – 124Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini125 – 146CytoplasmicSequence analysisAdd BLAST22
Transmembranei147 – 167Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini168 – 186ExtracellularSequence analysisAdd BLAST19
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 240CytoplasmicSequence analysisAdd BLAST33
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 276ExtracellularSequence analysisAdd BLAST15
Transmembranei277 – 295Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini296 – 354CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694341 – 354Lysophosphatidic acid receptor 3Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9EQ31
PRIDEiQ9EQ31

PTM databases

iPTMnetiQ9EQ31
PhosphoSitePlusiQ9EQ31

Expressioni

Tissue specificityi

Most abundantly expressed in testes, kidney, and lung, with moderate levels in small intestine, and low levels in heart, stomach, spleen, and adult and perinatal brain. Little or no expression in embryonic brain, liver, or thymus.

Gene expression databases

BgeeiENSMUSG00000036832
ExpressionAtlasiQ9EQ31 baseline and differential
GenevisibleiQ9EQ31 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037712

Structurei

3D structure databases

ProteinModelPortaliQ9EQ31
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ9EQ31
KOiK04294
OMAiHSNLTKR
OrthoDBiEOG091G0DD4
PhylomeDBiQ9EQ31
TreeFamiTF330052

Family and domain databases

CDDicd15343 7tmA_LPAR3_Edg7, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR005385 LPA_rcpt_EDG7
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01560 EDG7RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQ31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWFLRQGLLD TSLTASLANL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF
210 220 230 240 250
IMVAVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM
310 320 330 340 350
YNTMRKMICC ALQDSNTERR PSRNPSTIHS RSETGSQYLE DSISQGPVCN

KNGS
Length:354
Mass (Da):40,316
Last modified:March 1, 2001 - v1
Checksum:i8B6F9A3CA9C1F062
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF293845 mRNA Translation: AAG13674.1
AF272365, AF272364 Genomic DNA Translation: AAK02017.1
CCDSiCCDS17901.1
RefSeqiNP_075359.1, NM_022983.4
UniGeneiMm.155520

Genome annotation databases

EnsembliENSMUST00000039164; ENSMUSP00000037712; ENSMUSG00000036832
GeneIDi65086
KEGGimmu:65086
UCSCiuc008rra.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLPAR3_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ31
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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