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Protein

C-X-C chemokine receptor type 6

Gene

Cxcr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the C-X-C chemokine CXCL16.1 Publication

GO - Molecular functioni

  • coreceptor activity Source: InterPro
  • C-X-C chemokine binding Source: UniProtKB
  • C-X-C chemokine receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 6
Short name:
CXC-R6
Short name:
CXCR-6
Alternative name(s):
CD_antigen: CD186
Gene namesi
Name:Cxcr6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1934582 Cxcr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 68Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini69 – 77CytoplasmicSequence analysis9
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 112ExtracellularSequence analysisAdd BLAST14
Transmembranei113 – 134Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini135 – 152CytoplasmicSequence analysisAdd BLAST18
Transmembranei153 – 173Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini174 – 196ExtracellularSequence analysisAdd BLAST23
Transmembranei197 – 224Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini225 – 240CytoplasmicSequence analysisAdd BLAST16
Transmembranei241 – 268Helical; Name=6Sequence analysisAdd BLAST28
Topological domaini269 – 284ExtracellularSequence analysisAdd BLAST16
Transmembranei285 – 302Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini303 – 351CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003032301 – 351C-X-C chemokine receptor type 6Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EQ16
PRIDEiQ9EQ16

PTM databases

PhosphoSitePlusiQ9EQ16

Expressioni

Gene expression databases

BgeeiENSMUSG00000048521
CleanExiMM_CXCR6
ExpressionAtlasiQ9EQ16 baseline and differential
GenevisibleiQ9EQ16 MM

Interactioni

GO - Molecular functioni

  • C-X-C chemokine binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060776

Structurei

3D structure databases

ProteinModelPortaliQ9EQ16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiQ9EQ16
KOiK04191
OMAiTPFNLVK
OrthoDBiEOG091G0D3V
PhylomeDBiQ9EQ16
TreeFamiTF330966

Family and domain databases

CDDicd15173 7tmA_CXCR6, 1 hit
InterProiView protein in InterPro
IPR002235 Chemokine_CXCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF705 PTHR10489:SF705, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01105 CXCCHMKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EQ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDGHQESAL YDGHYEGDFW LFNNSSDNSQ ENKRFLKFKE VFLPCVYLVV
60 70 80 90 100
FVFGLLGNSL VLIIYIFYQK LRTLTDVFLL NLPLADLVFV CTLPFWAYAG
110 120 130 140 150
TYEWVFGTVM CKTLRGMYTM NFYVSMLTLT CITVDRFIVV VQATKAFNRQ
160 170 180 190 200
AKWKIWGQVI CLLIWVVSLL VSLPQIIYGH VQDIDKLICQ YHSEEISTMV
210 220 230 240 250
LVIQMTLGFF LPLLTMILCY SGIIKTLLHA RNFQKHKSLK IIFLVVAVFL
260 270 280 290 300
LTQTPFNLAM LIQSTSWEYY TITSFKYAIV VTEAIAYFRA CLNPVLYAFV
310 320 330 340 350
GLKFRKNVWK LMKDIGCLSH LGVSSQWKSS EDSSKTCSAS HNVETTSMFQ

L
Length:351
Mass (Da):40,468
Last modified:March 1, 2001 - v1
Checksum:i5658788372B4C65A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119T → A in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti207L → R in AAG31284 (Ref. 2) Curated1
Sequence conflicti305R → W in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti321L → Q in AAH96491 (PubMed:15489334).Curated1
Sequence conflicti324S → P in AAH96491 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF301018 mRNA Translation: AAG34367.1
AF305709 mRNA Translation: AAG31284.1
AK052901 mRNA Translation: BAC35196.1
AK137703 mRNA Translation: BAE23469.1
AK153914 mRNA Translation: BAE32252.1
BC096491 mRNA Translation: AAH96491.1
CCDSiCCDS23664.1
RefSeqiNP_109637.3, NM_030712.4
UniGeneiMm.124289

Genome annotation databases

EnsembliENSMUST00000049810; ENSMUSP00000060776; ENSMUSG00000048521
GeneIDi80901
KEGGimmu:80901
UCSCiuc009sgt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCXCR6_MOUSE
AccessioniPrimary (citable) accession number: Q9EQ16
Secondary accession number(s): Q4VA95, Q9ERH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 1, 2001
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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