Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

P2Y purinoceptor 12

Gene

P2ry12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99ADPBy similarity1
Binding sitei103ADP; via carbonyl oxygenBy similarity1
Binding sitei111ADPBy similarity1
Binding sitei193ADPBy similarity1
Binding sitei197ADPBy similarity1
Binding sitei269ADPBy similarity1
Binding sitei286ADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 165ADPBy similarity4
Nucleotide bindingi181 – 185ADPBy similarity5
Nucleotide bindingi262 – 265ADPBy similarity4

GO - Molecular functioni

  • ADP receptor activity Source: RGD
  • G-protein coupled adenosine receptor activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-RNO-392170 ADP signalling through P2Y purinoceptor 12
R-RNO-417957 P2Y receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 12
Short name:
P2Y12
Alternative name(s):
P2Y12 platelet ADP receptor
Gene namesi
Name:P2ry12
Synonyms:P2y12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621681 P2ry12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 56Helical; Name=1By similarityAdd BLAST23
Topological domaini57 – 67CytoplasmicBy similarityAdd BLAST11
Transmembranei68 – 88Helical; Name=2By similarityAdd BLAST21
Topological domaini89 – 103ExtracellularBy similarityAdd BLAST15
Transmembranei104 – 124Helical; Name=3By similarityAdd BLAST21
Topological domaini125 – 148CytoplasmicBy similarityAdd BLAST24
Transmembranei149 – 168Helical; Name=4By similarityAdd BLAST20
Topological domaini169 – 191ExtracellularBy similarityAdd BLAST23
Transmembranei192 – 213Helical; Name=5By similarityAdd BLAST22
Topological domaini214 – 239CytoplasmicBy similarityAdd BLAST26
Transmembranei240 – 265Helical; Name=6By similarityAdd BLAST26
Topological domaini266 – 284ExtracellularBy similarityAdd BLAST19
Transmembranei285 – 304Helical; Name=7By similarityAdd BLAST20
Topological domaini305 – 343CytoplasmicBy similarityAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2188

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700391 – 343P2Y purinoceptor 12Add BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi23 ↔ 276PROSITE-ProRule annotation
Modified residuei61PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9EPX4
PRIDEiQ9EPX4

PTM databases

iPTMnetiQ9EPX4
PhosphoSitePlusiQ9EPX4

Expressioni

Gene expression databases

BgeeiENSRNOG00000013902 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ9EPX4 RN

Interactioni

Protein-protein interaction databases

BioGridi249199, 1 interactor
STRINGi10116.ENSRNOP00000018600

Chemistry databases

BindingDBiQ9EPX4

Structurei

3D structure databases

ProteinModelPortaliQ9EPX4
SMRiQ9EPX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The transmembrane domain is composed of seven transmembrane helices; most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices (By similarity).By similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFYD Eukaryota
ENOG410ZJD1 LUCA
GeneTreeiENSGT00640000091213
HOGENOMiHOG000273884
HOVERGENiHBG108228
InParanoidiQ9EPX4
KOiK04298
OMAiIKVFIII
OrthoDBiEOG091G0B3H
PhylomeDBiQ9EPX4
TreeFamiTF330969

Family and domain databases

CDDicd15150 7tmA_P2Y12, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005394 P2Y12_rcpt
PANTHERiPTHR24233:SF0 PTHR24233:SF0, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01569 P2Y12PRNCPTR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPX4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVPGANATS ANTTSIPGTS TLCSRDYKIT QVLFPLLYTV LFFAGLITNS
60 70 80 90 100
LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGHLRT
110 120 130 140 150
LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
160 170 180 190 200
SVAIWAFMFL LSLPNMILTN RRPKDKDITK CSFLKSEFGL VWHEIVNYIC
210 220 230 240 250
QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKAPKKRV NIKVFIIIAV
260 270 280 290 300
FFICFVPFHF ARIPYTLSQT RAVFDCNAEN TLFYVKESTL WLTSLNACLD
310 320 330 340
PFIYFFLCKS FRNSLMSMLR CSTSGANKKK GQEGGDPSEE TPM
Length:343
Mass (Da):39,047
Last modified:March 1, 2001 - v1
Checksum:i7AE0AFCE66674136
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF313450 mRNA Translation: AAG48945.1
RefSeqiNP_073637.1, NM_022800.1
XP_006232468.1, XM_006232406.3
XP_006232469.1, XM_006232407.3
XP_006232470.1, XM_006232408.3
UniGeneiRn.64592

Genome annotation databases

EnsembliENSRNOT00000018600; ENSRNOP00000018600; ENSRNOG00000013902
GeneIDi64803
KEGGirno:64803
UCSCiRGD:621681 rat

Similar proteinsi

Entry informationi

Entry nameiP2Y12_RAT
AccessioniPrimary (citable) accession number: Q9EPX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again