Nuclear receptor coactivator 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• acetyl-CoA

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  • See the description of this molecule in ChEBI.

  + L-lysyl-[protein]

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  = CoA

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  + H⁺

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  • See the description of this molecule in ChEBI.

  + N⁶-acetyl-L-lysyl-[protein]

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  EC:2.3.1.48
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  • See the description of this EC number in ENZYME.
  • Search reactions for this EC number in Rhea.
  Source: Rhea

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  • See the description of this reaction in Rhea.

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  acetyl-CoA

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  • See the description of this molecule in ChEBI.

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  +

  L-lysyl-[protein]

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  L-lysine residue

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  =

  CoA

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  • See the description of this molecule in ChEBI.

  

  +

  H⁺

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

  

  +

  N⁶-acetyl-L-lysyl-[protein]

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  • Search chemical reactions in Rhea for this molecule.

  

  N⁶-acetyl-L-lysine residue

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  • Search chemical reactions in Rhea for this molecule.
  • See the description of this molecule in ChEBI.

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<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• androgen receptor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• chromatin binding Source: RGD
• disordered domain specific binding Source: RGD
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • "The activating enzyme of NEDD8 inhibits steroid receptor function."
    Fan M., Long X., Bailey J.A., Reed C.A., Osborne E., Gize E.A., Kirk E.A., Bigsby R.M., Nephew K.P.
    Mol. Endocrinol. 16:315-330(2002) [PubMed] [Europe PMC] [Abstract]
• histone acetyltransferase activity Source: RGD
• nuclear receptor binding Source: RGD
• nuclear receptor coactivator activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Evidence for estrogenic contamination of the MAPK inhibitor PD98059."
    Long X., Gize E.A., Nephew K., Bigsby R.M.
    Endocrinology 142:5390-5393(2001) [PubMed] [Europe PMC] [Abstract]
• peroxisome proliferator activated receptor binding Source: RGDInferred from physical interactionⁱ
  • "Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis."
    Asano J., Kudo T., Shimizu T., Fan Y., Nanashima N., Yamana D., Miura T., Yamada T., Tsuchida S.
    Cancer Sci 101:869-875(2010) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex binding Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis."
    Asano J., Kudo T., Shimizu T., Fan Y., Nanashima N., Yamana D., Miura T., Yamada T., Tsuchida S.
    Cancer Sci 101:869-875(2010) [PubMed] [Europe PMC] [Abstract]
• protein N-terminus binding Source: RGD
• RNA polymerase II complex binding Source: UniProtKB
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: RGDInferred from direct assayⁱ
  • "The synergistic effect of dexamethasone and all-trans-retinoic acid on hepatic phosphoenolpyruvate carboxykinase gene expression involves the coactivator p300."
    Wang X.L., Herzog B., Waltner-Law M., Hall R.K., Shiota M., Granner D.K.
    J Biol Chem 279:34191-34200(2004) [PubMed] [Europe PMC] [Abstract]
• transcription coactivator activity Source: RGD

GO - Biological processⁱ

• cell dedifferentiation Source: UniProtKB
• cellular response to estradiol stimulus Source: RGD
• cellular response to hormone stimulus Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• developmental growth Source: RGD
• labyrinthine layer morphogenesis Source: RGD
• male gonad development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential expression of p160 steroid receptor coactivators in the rat testis and epididymis."
    Igarashi-Migitaka J., Takeshita A., Koibuchi N., Yamada S., Ohtani-Kaneko R., Hirata K.
    Eur J Endocrinol 153:595-604(2005) [PubMed] [Europe PMC] [Abstract]
• mammary gland branching involved in thelarche Source: RGD
• multicellular organism growth Source: RGD
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein."
    Sun Y., Perera J., Rubin B.P., Huang J.
    J Biol Chem 286:18623-18632(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of stem cell differentiation Source: RGD
• positive regulation of cell growth Source: RGDInferred from mutant phenotypeⁱ
  • "SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein."
    Sun Y., Perera J., Rubin B.P., Huang J.
    J Biol Chem 286:18623-18632(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of DNA-binding transcription factor activity Source: RGDInferred from direct assayⁱ
  • "Evidence for estrogenic contamination of the MAPK inhibitor PD98059."
    Long X., Gize E.A., Nephew K., Bigsby R.M.
    Endocrinology 142:5390-5393(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: RGD
• positive regulation of intracellular estrogen receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Evidence for estrogenic contamination of the MAPK inhibitor PD98059."
    Long X., Gize E.A., Nephew K., Bigsby R.M.
    Endocrinology 142:5390-5393(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intracellular steroid hormone receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes."
    Grenier J., Trousson A., Chauchereau A., Cartaud J., Schumacher M., Massaad C.
    Mol Endocrinol 20:254-267(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of keratinocyte differentiation Source: RGD
• positive regulation of stem cell population maintenance Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from mutant phenotypeⁱ
  • "Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions."
    Trousson A., Grenier J., Fonte C., Massaad-Massade L., Schumacher M., Massaad C.
    J Steroid Biochem Mol Biol 104:305-311(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of stem cell division Source: UniProtKB
• regulation of stem cell population maintenance Source: RGD
• regulation of stem cell proliferation Source: RGD
• vagina development Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• androgen receptor binding Source: RGDInferred from physical interactionⁱ
  • "The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay."
    Ozers M.S., Marks B.D., Gowda K., Kupcho K.R., Ervin K.M., De Rosier T., Qadir N., Eliason H.C., Riddle S.M., Shekhani M.S.
    Biochemistry 46:683-695(2007) [PubMed] [Europe PMC] [Abstract]
• disordered domain specific binding Source: RGD
• estrogen receptor binding Source: RGDInferred from physical interactionⁱ
  • "The activating enzyme of NEDD8 inhibits steroid receptor function."
    Fan M., Long X., Bailey J.A., Reed C.A., Osborne E., Gize E.A., Kirk E.A., Bigsby R.M., Nephew K.P.
    Mol. Endocrinol. 16:315-330(2002) [PubMed] [Europe PMC] [Abstract]
• nuclear receptor binding Source: RGD
• peroxisome proliferator activated receptor binding Source: RGDInferred from physical interactionⁱ
  • "Histone acetylation and steroid receptor coactivator expression during clofibrate-induced rat hepatocarcinogenesis."
    Asano J., Kudo T., Shimizu T., Fan Y., Nanashima N., Yamana D., Miura T., Yamada T., Tsuchida S.
    Cancer Sci 101:869-875(2010) [PubMed] [Europe PMC] [Abstract]
• protein N-terminus binding Source: RGD
• RNA polymerase II complex binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
IIRRCIQRFF SLNDGQSWSQ KRHYQEAYIH GHAETPVYRF SLADGTIVSA 
        60         70         80         90        100
QTKSKLFRNP VTNDRHGFVS THFLQREQNG CRPNPILQDK GIRPPAAGCG 
       110        120        130        140        150
MSLSPSQSVQ MLGSRTYGVA DPSNTGQMAG ARYGASSSVA SLTPGQSLQS 
       160        170        180        190        200
PSSYQSNSYG LNMSSPPHGS PGLGPNQQNI MISPRNRGSP KMASHQFSPA 
       210        220        230        240        250
AGVHSPMGSS GNTGSHSFSS SSLSALQAIS EGVGTSLLST LSSPGPKLDN 
       260        270        280        290        300
SPNMNINQPS KASSQDSKSP LGLYCEQNPV ESSVCPSNSR DPPVTKENKE 
       310        320        330        340        350
NSGEASETPR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSNCKDSS 
       360        370        380        390        400
ISVTSPSGVS SSTSGAVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK 
       410        420        430        440        450
ITAEATGKDT SSTASGGEGS VXQEQLSPXK KENNALLRYL LDRDDPSDVL 
       460        470        480        490        500
AKELQPQADG GDSKLSQCSC XTNPSSGQEK DPKIKTEEVS GDLDNLDAIL 
       510        520        530        540        550
GDLTSSDFYN SPTNGSHPGA KQQMFAGPSS LGLRSPQPVQ SVRPPYNRAL 
       560        570        580        590        600
SLDSPVSVGS VPPVKNVSAF PVLPKQPILA GNPRMMDSQE NYGANMGGPN 
       610        620        630        640        650
RNVPVNPTSS SGDWGLANSR ASRMEPLASS PLGRAGGDYS AALPRPALGS 
       660        670        680        690        700
SGPTLPLRSN RLPGARPTLM LQMRAGEVPM GMGVSPYSPA VPSNQPGSWP 
       710        720        730        740        750
EGMLSMEQGP HGAQNRPLLR NSLDELLGPP SNPEGQSDER ALLDQLHTLL 
       760        770        780        790        800
SNTDATGLEE IDRALGIPEL VSQGQALESK QDVFQGQEAA VMMDQKAALY 
       810        820        830        840        850
GQTYPAQGPP LQGGFHLQGQ SPSLNSMMSQ ISQQGSFPLQ GLHPRASMVR 
       860        870        880        890        900
PRTNTPKQLR MQLQQRLQGQ QFLNQSRQAL EMKMESPTGA AVMRPMLQSQ 
       910        920        930        940        950
QAFFNAQMAA QQKRELMNHH LQQQRMAMMM SQPQPQAFSP PPNVTASPSM 
       960        970        980        990       1000
DGVLAGSAMP QAPPQQFPYA TNYGMGQPPE PAFGRGSSPP SAMMSSRMGP 
      1010       1020       1030       1040       1050
SQNAMVQHPQ TAPMYQSSEM KGWPSGNLAR NGSFPQQQFA PQANPAAYNM 
      1060       1070       1080 
VHMNSSGSHL GQMTMTPMPM SGMPMGPDQK YC                    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families