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Protein

Solute carrier organic anion transporter family member 2A1

Gene

Slco2a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

GO - Molecular functioni

GO - Biological processi

  • prostaglandin transport Source: MGI
  • sodium-independent organic anion transport Source: GO_Central

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-879518 Transport of organic anions

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 2A1
Alternative name(s):
Prostaglandin transporter
Short name:
PGT
Solute carrier family 21 member 2
Gene namesi
Name:Slco2a1
Synonyms:Oatp2a1, Slc21a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1346021 Slco2a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 52Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini53 – 71ExtracellularSequence analysisAdd BLAST19
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 98CytoplasmicSequence analysis6
Transmembranei99 – 123Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini124 – 167ExtracellularSequence analysisAdd BLAST44
Transmembranei168 – 196Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini197 – 215CytoplasmicSequence analysisAdd BLAST19
Transmembranei216 – 236Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini237 – 254ExtracellularSequence analysisAdd BLAST18
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 320CytoplasmicSequence analysisAdd BLAST41
Transmembranei321 – 342Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini343 – 362ExtracellularSequence analysisAdd BLAST20
Transmembranei363 – 386Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini387 – 390CytoplasmicSequence analysis4
Transmembranei391 – 414Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini415 – 517ExtracellularSequence analysisAdd BLAST103
Transmembranei518 – 540Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini541 – 549CytoplasmicSequence analysis9
Transmembranei550 – 575Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini576 – 609ExtracellularSequence analysisAdd BLAST34
Transmembranei610 – 628Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini629 – 643CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi610V → M: No effect. 1 Publication1
Mutagenesisi611I → G: No effect. 1 Publication1

Chemistry databases

ChEMBLiCHEMBL2073699

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910591 – 643Solute carrier organic anion transporter family member 2A1Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi443 ↔ 469PROSITE-ProRule annotation
Disulfide bondi447 ↔ 458PROSITE-ProRule annotation
Disulfide bondi449 ↔ 473PROSITE-ProRule annotation
Glycosylationi477N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi490N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9EPT5
PeptideAtlasiQ9EPT5
PRIDEiQ9EPT5

PTM databases

iPTMnetiQ9EPT5
PhosphoSitePlusiQ9EPT5
SwissPalmiQ9EPT5

Expressioni

Tissue specificityi

Highly expressed in lung and liver. Detected at lower levels in kidney and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000032548
ExpressionAtlasiQ9EPT5 baseline and differential
GenevisibleiQ9EPT5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035148

Chemistry databases

BindingDBiQ9EPT5

Structurei

3D structure databases

ProteinModelPortaliQ9EPT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini437 – 495Kazal-likePROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626 Eukaryota
ENOG410XRSF LUCA
GeneTreeiENSGT00760000119014
HOGENOMiHOG000231269
HOVERGENiHBG108345
InParanoidiQ9EPT5
KOiK14345
OMAiIYLNCSC
OrthoDBiEOG091G08QD
PhylomeDBiQ9EPT5
TreeFamiTF317540

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR004156 OATP
PANTHERiPTHR11388 PTHR11388, 1 hit
PfamiView protein in Pfam
PF07648 Kazal_2, 1 hit
PF03137 OATP, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF103473 SSF103473, 3 hits
TIGRFAMsiTIGR00805 oat, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 1 hit
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9EPT5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA
60 70 80 90 100
YFKSSLTTIE KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM
110 120 130 140 150
IGIGGLLLAA GAFVLTLPHF LSEPYQYAST TAGNSSHFQT DLCQKHLPGL
160 170 180 190 200
LPSKCHSTVP DTQKETSSMW SLMVVAQLLA GVGTVPIQPF GISYVDDFAE
210 220 230 240 250
PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD TATVNLSPGD
260 270 280 290 300
PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE
310 320 330 340 350
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK
360 370 380 390 400
FLEKQYDASA AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA
410 420 430 440 450
ATIMTISIIL CAPLFFMGCS TPAVAEVYPP STPSSIHPQP PACRRDCLCP
460 470 480 490 500
DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS AASKQPIYLN CSCVTGGSAS
510 520 530 540 550
AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL RVVNQDEKSF
560 570 580 590 600
AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA
610 620 630 640
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI
Length:643
Mass (Da):70,147
Last modified:January 10, 2003 - v2
Checksum:iAC487386F847D9D8
GO
Isoform 2 (identifier: Q9EPT5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     368-414: GAVNLPAAAL...TISIILCAPL → AHQVLYIRSL...PAMLAAAAST
     415-643: Missing.

Note: No experimental confirmation available.
Show »
Length:414
Mass (Da):44,901
Checksum:iE9E97C62A1F43799
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3L → F in AAG40332 (PubMed:10484490).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006128368 – 414GAVNL…LCAPL → AHQVLYIRSLPPAAGTACAQ IPSSTLSAETMESSTSPPAM LAAAAST in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_006129415 – 643Missing in isoform 2. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323958 mRNA Translation: AAG40332.1
BC035200 mRNA Translation: AAH35200.1
CCDSiCCDS23448.1 [Q9EPT5-1]
RefSeqiNP_201571.2, NM_033314.3 [Q9EPT5-1]
UniGeneiMm.207106
Mm.412758

Genome annotation databases

EnsembliENSMUST00000035148; ENSMUSP00000035148; ENSMUSG00000032548 [Q9EPT5-1]
ENSMUST00000188664; ENSMUSP00000140533; ENSMUSG00000032548 [Q9EPT5-2]
GeneIDi24059
KEGGimmu:24059
UCSCiuc009rgd.1 mouse [Q9EPT5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSO2A1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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