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Entry version 133 (07 Oct 2020)
Sequence version 2 (27 Jul 2011)
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Protein

VPS10 domain-containing receptor SorCS2

Gene

Sorcs2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).By similarity6 Publications

Miscellaneous

SORCS2 expression is decreased after the onset of symptoms in mouse models for Huntington disease (HD). SORCS2 does not interact with wild-type HTT, but does interact with mutant HTT containing a long polyglutamine stretch.1 Publication

Caution

Gene disruption gives rise to contradictory results (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:28346477, PubMed:30840898). The majority of studies report normal body weight, normal startle responses to noise and relatively minor behavorial defects (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:30840898). Another publication finds that gene disruption gives rise to mice with strongly reduced body weight and profound deafness. Gene disruption was due to random insertion of a Cre construct under the control of the TEK promoter. Analysis of the genomic DNA showed that in 21 cases the Cre construct had inserted in an Ig kappa locus, and in 13 cases the construct had inserted into the first intron of the SORCS2 gene, leading to strongly reduced SORCS2 expression (PubMed:28346477). The reasons for these discrepancies are not clear, but may be due to the way the experiments were done. The fact that an identical phenotype was found when the Cre construct under the control of the TEK promoter had inserted in an Ig kappa locus suggests that there are additional, unidentified causes that play a role in the observed defects.1 Publication5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
VPS10 domain-containing receptor SorCS2
Cleaved into the following 3 chains:
SorCS2 122 kDa chain1 Publication
SorCS2 104 kDa chain1 Publication
SorCS2 18 kDa chain1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sorcs2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932289, Sorcs2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini50 – 1078ExtracellularCuratedAdd BLAST1029
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1079 – 1099HelicalSequence analysisAdd BLAST21
Topological domaini1100 – 1159CytoplasmicCuratedAdd BLAST60

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and fertile and display no obvious phenotype, but their neurons do not display growth cone collapse in response to proBDNF (PubMed:24908487, PubMed:29909994). Cultured neurons from mutant mice display longer neurites than wild-type neurons, and the frontal cortex of 12 week old mice is hyperinnervated with fibers from tyrosine hydroxylase-positive neurons (PubMed:24908487, PubMed:29909994). Mutant mice display mildly increased spontaneous locomotor activity; contrary to wild-type, treatment with amphetamine decreases their locomotor activity. After sciatic nerve injury, 2 day old and adult mice show discreased Schwann cell apoptosis distal to the lesion (PubMed:24908487). Mutant mice show increased mortality after seizures caused by repeated treatments with the convulsant pentylenetetrazol (PTZ). Hippocampus neurons from mutant mice display increased levels of oxidative stress and increased apoptosis (PubMed:30840898). Mutant mice display subtle behavorial defects, with hyperactivity, altered acquisition of spatial memory, but a normal startle response to noise (PubMed:27457814). Heterozygous mice have normal body weight and motor skills, but combination with a mouse model for Huntington disease (HD) gives rise to increased severity of impaired motor skills (PubMed:28469074). After a cross of mice carrying a Cre construct under the control of the Tek promoter with mice carrying a floxed Nppc gene a subset of the offspring displayed behavorial defects, including hyperactivity and hanging from cage tops. A subset (11 out of 33 mice) displayed strongly reduced body weight and profound deafness, with defects in the organization of the outer and inner hair cell bundles in the organ of Corti. Analysis of the genomic DNA from deaf mice showed that in 13 cases, these mice had the Cre construct inserted into the first intron of the Sorcs2 gene, but in 21 cases, the insertion had occured in an Ig kappa locus (PubMed:28346477).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi630F → N: Introduces an N-glycosylation site and disrupts interaction with NGF and BDNF. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 49Sequence analysisAdd BLAST49
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003317350 – 1159VPS10 domain-containing receptor SorCS2Add BLAST1110
ChainiPRO_0000447472118 – 1030SorCS2 104 kDa chain1 PublicationAdd BLAST913
ChainiPRO_00004474731031 – 1159SorCS2 18 kDa chain1 PublicationAdd BLAST129
ChainiPRO_0000447474? – 1159SorCS2 122 kDa chain1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi158N-linked (GlcNAc...) asparagineCombined sources1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi324 ↔ 329Combined sources1 Publication
Glycosylationi328N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi362N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi494 ↔ 499Combined sources1 Publication
Glycosylationi600N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi649 ↔ 684Combined sources1 Publication
Disulfide bondi667 ↔ 699Combined sources1 Publication
Disulfide bondi701 ↔ 760Combined sources1 Publication
Disulfide bondi708 ↔ 725Combined sources1 Publication
Disulfide bondi740 ↔ 775Combined sources1 Publication
Glycosylationi830N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi891N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Glycosylationi902N-linked (GlcNAc...) asparagineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
Proteolytic cleavage removes a propeptide, giving rise to a 122 kDa chain that includes a cytoplasmic tail. Further cleavage gives rise to a 104 kDa chain that lacks the cytoplasmic tail, and a membrane-bound 18 kDa chain (PubMed:24908487). The 104 kDa chain remains bound to the 18 kDa chain (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei117 – 118CleavageBy similarity2
Sitei1030 – 1031CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9EPR5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EPR5

PRoteomics IDEntifications database

More...
PRIDEi
Q9EPR5

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2824, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9EPR5, 8 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EPR5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EPR5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in Purkinje cells and pyramidal neurons in brain cortex, cerebellum, dentate gyrus, striatum and hippocampus, and in glia cells in dorsal root ganglia (DRG) (PubMed:24908487, PubMed:27457814, PubMed:28469074, PubMed:30840898). Not detected in neurons from the dorsal root ganglia (PubMed:24908487). Detected in hair cells and supporting cells in the organ of Corti, utricuar maculae and cristae (at protein level) (PubMed:28346477). Detected in brain, lung and testis (PubMed:11165493). Detected in the inner ear in neonates (PubMed:28346477).6 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is highest in developing brain. Transiently expressed in all 3 germ layers (PubMed:11165493). Detected in midbrain, spinal cord, heart and lung at 15.5 dpc (PubMed:24908487). Coexpressed with NGFR in neurons in the ventral part of the hippocampus CA1 region at 23 and 30 days after birth. The number of neurons that coexpress SORCS2 and NGFR is increased 30 days after birth. SORCS2 and NGFR are no longer coexpressed in hippocampus neurons in 60 day old adults (PubMed:29909994).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029093, Expressed in cardiac ventricle and 272 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EPR5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (in vitro) (PubMed:30061605). Heterodimer with NGFR (PubMed:22155786, PubMed:24908487, PubMed:27457814). The extracellular domains of the heterodimer bind the precursor form of NGF (proNGF) (PubMed:22155786). Can also bind mature NGF and BDNF. Each chain in the receptor dimer interacts (via extracellular domain) with an NGF dimer (in vitro) (PubMed:30061605).

Interacts with the precursor forms of BDNF (proBDNF) and NTF3 (proNT3) (By similarity). The cytoplasmic region of the heterodimer formed by NGFR and SORCS2 binds TRIO. ProNGF binding mediates dissociation of TRIO from the receptor complex (By similarity).

Interacts with SLC1A1 (PubMed:30840898).

Interacts with VPS35.

Interacts (via extracellular domain) with NTRK2 (via extracellular domain) (PubMed:27457814).

Interacts with VPS35.

Interacts (via extracellular domain) with GRIN2A (PubMed:28469074).

By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
219891, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q9EPR5, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9EPR5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EPR5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati182 – 193BNR 1Add BLAST12
Repeati232 – 243BNR 2Add BLAST12
Repeati273 – 284BNR 3Add BLAST12
Repeati468 – 479BNR 4Add BLAST12
Repeati545 – 556BNR 5Add BLAST12
Repeati587 – 598BNR 6Add BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini786 – 876PKDPROSITE-ProRule annotationAdd BLAST91

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi715 – 720Poly-Ser6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3511, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203671

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010702_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EPR5

Identification of Orthologs from Complete Genome Data

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OMAi
ANKCFAN

Database of Orthologous Groups

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OrthoDBi
1046610at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324918

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00801, PKD, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00602, VPS10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50093, PKD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9EPR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHRGPPSAP KRPGPTAPDR SFQALLPPCW PRSWPLLLLL LVLVAACGAM
60 70 80 90 100
GRSPQPGRQG PGVQITRLLP AGRTESGDRK DPQARESEPS VPGLGPGSAS
110 120 130 140 150
GPSTDGAPAP GKGRRARAVP VAGAASASRA QVSLISTSFV LKGDATHNQA
160 170 180 190 200
MVHWTGENSS VILILTKYYH ADMGKVLESS LWRSSDFGTT YTKLTLQPGV
210 220 230 240 250
TTVIDNFYIC PANKRKIILV SSSLGDREQS LFLSTDEGAT FQKYPVPFLV
260 270 280 290 300
EMLLFHPKEE DKVLAYTKDS KLYVSSDLGK KWTLLQERVT KDHVFWAVSG
310 320 330 340 350
VDDDPNLVHV EAQDLSGGYR YYTCLIYNCS AQPHIAPFSG PIDRGSLTVQ
360 370 380 390 400
DEYIFLKATS TNRTKYYVSY RRSDFVLMKL PKYALPKDLQ IISTDEQQVF
410 420 430 440 450
VAVQEWNQVD TYNLYQSDLR GVRYSLVLEN VRSSRQAEEN VVIDILEVRG
460 470 480 490 500
VKGVFLANQK VDGKVTTVIT YNKGRDWDYL RPPSTDMNGK PTNCQPPDCY
510 520 530 540 550
LHLHLRWADN PYVSGTVHTK DTAPGLIMGA GNLGSQLVEY KEEMYITSDC
560 570 580 590 600
GHTWRQVFEE EHHVLYLDHG GVIAAIKDTS IPLKILKFSV DEGHTWSTHN
610 620 630 640 650
FTSTSVFVDG LLSEPGDETL VMTVFGHISF RSDWELVKVD FRPSFPRQCG
660 670 680 690 700
EDDYSSWDLT DLQGDHCIMG QQRSYRKRKS TSWCVKGRSF TSALTSRVCK
710 720 730 740 750
CRDSDFLCDY GFERSSSSES TANKCSANFW FNPLSPPEDC VLGQTYTSSL
760 770 780 790 800
GYRKVVSNVC EGGVDLQQSP VQLQCPLQAP RGLQVSIRGE AVAVRPREDV
810 820 830 840 850
LFVVRQEQGD VLTTKYQVDL GDGFKAMYVN LTLTGEPIRH HYESPGIYRV
860 870 880 890 900
SVRAENMAGH DEAVLFVQVN SPLQALYLEV VPVIGVNQEV NLTAVLLPLN
910 920 930 940 950
PNLTVFYWWI GHSLQPLLSL DNSVTTKFTD AGDVRVTVQA ACGNSVLQDS
960 970 980 990 1000
RLVRVLDQFQ VVPLRFSREL DTFNPNTPEW REDVGLVVTR LLSKETSIPE
1010 1020 1030 1040 1050
ELLVTVVKPG LPTIADLYVL LPLPRPTRKR SLTSDKRLAA VQQALNSHRI
1060 1070 1080 1090 1100
SFILRGGLRI LVELRDTDTG PQRPGGSGGY WAVVVLFVIG LFAVGAFILY
1110 1120 1130 1140 1150
KFKRKRPGRT VYAQMHNEKE QEMTSPVSHS EDAQSTMQGN HSGVVLSINS

REMHSYLVG
Length:1,159
Mass (Da):128,902
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i551F42E2BFEFD457
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BI74Q8BI74_MOUSE
VPS10 domain-containing receptor So...
Sorcs2
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YYF4D3YYF4_MOUSE
VPS10 domain-containing receptor So...
Sorcs2
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti252M → T in AAF88135 (PubMed:11165493).Curated1
Sequence conflicti252M → T in AAI38876 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY004316 mRNA Translation: AAF88135.1
CH466524 Genomic DNA Translation: EDL37502.1
BC138873 mRNA Translation: AAI38874.1
BC138875 mRNA Translation: AAI38876.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19237.1

NCBI Reference Sequences

More...
RefSeqi
NP_112151.2, NM_030889.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037370; ENSMUSP00000041828; ENSMUSG00000029093

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:81840

UCSC genome browser

More...
UCSCi
uc008xek.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004316 mRNA Translation: AAF88135.1
CH466524 Genomic DNA Translation: EDL37502.1
BC138873 mRNA Translation: AAI38874.1
BC138875 mRNA Translation: AAI38876.1
CCDSiCCDS19237.1
RefSeqiNP_112151.2, NM_030889.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FFYX-ray3.90A116-1077[»]
6FG9X-ray4.20A/B116-1077[»]
SMRiQ9EPR5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi219891, 4 interactors
IntActiQ9EPR5, 3 interactors
STRINGi10090.ENSMUSP00000041828

PTM databases

GlyConnecti2824, 1 N-Linked glycan (1 site)
GlyGeniQ9EPR5, 8 sites
iPTMnetiQ9EPR5
PhosphoSitePlusiQ9EPR5

Proteomic databases

MaxQBiQ9EPR5
PaxDbiQ9EPR5
PRIDEiQ9EPR5

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22709, 76 antibodies

Genome annotation databases

EnsembliENSMUST00000037370; ENSMUSP00000041828; ENSMUSG00000029093
GeneIDi81840
KEGGimmu:81840
UCSCiuc008xek.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57537
MGIiMGI:1932289, Sorcs2

Phylogenomic databases

eggNOGiKOG3511, Eukaryota
GeneTreeiENSGT00990000203671
HOGENOMiCLU_010702_0_0_1
InParanoidiQ9EPR5
OMAiANKCFAN
OrthoDBi1046610at2759
TreeFamiTF324918

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
81840, 1 hit in 19 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sorcs2, mouse

Protein Ontology

More...
PROi
PR:Q9EPR5
RNActiQ9EPR5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029093, Expressed in cardiac ventricle and 272 other tissues
GenevisibleiQ9EPR5, MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00801, PKD, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit
SMARTiView protein in SMART
SM00602, VPS10, 1 hit
SUPFAMiSSF49299, SSF49299, 1 hit
PROSITEiView protein in PROSITE
PS50093, PKD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSORC2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EPR5
Secondary accession number(s): B2RSI2, B2RSI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: July 27, 2011
Last modified: October 7, 2020
This is version 133 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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