Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9EPR4 (S23A2_MOUSE)

Entry version 149 (08 May 2019)
Sequence version 2 (22 Sep 2009)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Solute carrier family 23 member 2

Gene

Slc23a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-196836 Vitamin C (ascorbate) metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 23 member 2
Alternative name(s):
Na(+)/L-ascorbic acid transporter 2
Sodium-dependent vitamin C transporter 2
Short name:
SVCT-2
Short name:
mSVCT2
Yolk sac permease-like molecule 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc23a2
Synonyms:Kiaa0238, Svct2, Yspl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1859682 Slc23a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini9 – 110CytoplasmicSequence analysisAdd BLAST102
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 139ExtracellularSequence analysis8
Transmembranei140 – 160HelicalSequence analysisAdd BLAST21
Topological domaini161CytoplasmicSequence analysis1
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 216ExtracellularSequence analysisAdd BLAST34
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 264CytoplasmicSequence analysisAdd BLAST27
Transmembranei265 – 282HelicalSequence analysisAdd BLAST18
Topological domaini283 – 286ExtracellularSequence analysis4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei287 – 300HelicalSequence analysisAdd BLAST14
Topological domaini301 – 307ExtracellularSequence analysis7
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 369CytoplasmicSequence analysisAdd BLAST41
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 415ExtracellularSequence analysisAdd BLAST25
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 459CytoplasmicSequence analysisAdd BLAST23
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 483ExtracellularSequence analysis3
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 514CytoplasmicSequence analysis10
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21
Topological domaini536 – 545ExtracellularSequence analysis10
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 648CytoplasmicSequence analysisAdd BLAST82

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Elevated expression levels in the adrenals of diabetic mice.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001659791 – 648Solute carrier family 23 member 2Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei70PhosphoserineCombined sources1
Modified residuei75PhosphothreonineBy similarity1
Modified residuei78PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei81PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei647PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9EPR4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9EPR4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9EPR4

PeptideAtlas

More...PeptideAtlasi		Q9EPR4

PRoteomics IDEntifications database

More...PRIDEi		Q9EPR4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9EPR4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9EPR4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9EPR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000027340 Expressed in 269 organ(s), highest expression level in choroid plexus of fourth ventricle

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9EPR4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9EPR4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000028815

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1292 Eukaryota
COG2233 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182953

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000038201

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9EPR4

KEGG Orthology (KO)

More...KOi		K14611

Identification of Orthologs from Complete Genome Data

More...OMAi		WKCNNTD

Database of Orthologous Groups

More...OrthoDBi		387031at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9EPR4

TreeFam database of animal gene trees

More...TreeFami		TF313272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC

The PANTHER Classification System

More...PANTHERi		PTHR11119:SF33 PTHR11119:SF33, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00860 Xan_ur_permease, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD 
        60         70         80         90        100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY 
       110        120        130        140        150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI 
       160        170        180        190        200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE 
       210        220        230        240        250
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA 
       260        270        280        290        300
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG 
       310        320        330        340        350
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR 
       360        370        380        390        400
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA 
       410        420        430        440        450
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK 
       460        470        480        490        500
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG 
       510        520        530        540        550
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV 
       560        570        580        590        600
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN 
       610        620        630        640 
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV
Length:648
Mass (Da):70,049
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2590BB11B2A257CB
GO
Isoform 2 (identifier: Q9EPR4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-272: LPLFQASAFA...RAGKHWGIAM → DYSCQWNGRA...SLVEYLKQSH
     273-648: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):30,188
Checksum:i1C8D45706B56F5BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2ANL1A2ANL1_MOUSE
Solute carrier family 23 member 2
Slc23a2
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG02252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA90751 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65509 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007367162 – 272LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_007368273 – 648Missing in isoform 2. 1 PublicationAdd BLAST376

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY004874 mRNA Translation: AAG02252.1 Different initiation.
AK087175 mRNA Translation: BAC39819.1
AL831706 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28341.1
BC050823 mRNA Translation: AAH50823.1
AB038145 mRNA Translation: BAA90751.1 Different initiation.
AK122227 Transcribed RNA Translation: BAC65509.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS16769.1 [Q9EPR4-1]

NCBI Reference Sequences

More...RefSeqi		NP_061294.2, NM_018824.2 [Q9EPR4-1]
XP_006499969.1, XM_006499906.3 [Q9EPR4-1]
XP_006499970.1, XM_006499907.3 [Q9EPR4-1]
XP_011238000.1, XM_011239698.2 [Q9EPR4-1]
XP_017174620.1, XM_017319131.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340 [Q9EPR4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54338

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:54338

UCSC genome browser

More...UCSCi		uc008mmi.1 mouse [Q9EPR4-1]
uc008mmj.1 mouse [Q9EPR4-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY004874 mRNA Translation: AAG02252.1 Different initiation.
AK087175 mRNA Translation: BAC39819.1
AL831706 Genomic DNA No translation available.
CH466519 Genomic DNA Translation: EDL28341.1
BC050823 mRNA Translation: AAH50823.1
AB038145 mRNA Translation: BAA90751.1 Different initiation.
AK122227 Transcribed RNA Translation: BAC65509.1 Sequence problems.
CCDSiCCDS16769.1 [Q9EPR4-1]
RefSeqiNP_061294.2, NM_018824.2 [Q9EPR4-1]
XP_006499969.1, XM_006499906.3 [Q9EPR4-1]
XP_006499970.1, XM_006499907.3 [Q9EPR4-1]
XP_011238000.1, XM_011239698.2 [Q9EPR4-1]
XP_017174620.1, XM_017319131.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028815

PTM databases

iPTMnetiQ9EPR4
PhosphoSitePlusiQ9EPR4
SwissPalmiQ9EPR4

Proteomic databases

EPDiQ9EPR4
jPOSTiQ9EPR4
PaxDbiQ9EPR4
PeptideAtlasiQ9EPR4
PRIDEiQ9EPR4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340 [Q9EPR4-1]
GeneIDi54338
KEGGimmu:54338
UCSCiuc008mmi.1 mouse [Q9EPR4-1]
uc008mmj.1 mouse [Q9EPR4-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9962
MGIiMGI:1859682 Slc23a2

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG1292 Eukaryota
COG2233 LUCA
GeneTreeiENSGT00950000182953
HOGENOMiHOG000038201
InParanoidiQ9EPR4
KOiK14611
OMAiWKCNNTD
OrthoDBi387031at2759
PhylomeDBiQ9EPR4
TreeFamiTF313272

Enzyme and pathway databases

ReactomeiR-MMU-196836 Vitamin C (ascorbate) metabolism

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q9EPR4

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000027340 Expressed in 269 organ(s), highest expression level in choroid plexus of fourth ventricle
ExpressionAtlasiQ9EPR4 baseline and differential
GenevisibleiQ9EPR4 MM

Family and domain databases

InterProiView protein in InterPro
IPR029956 SlC23A2
IPR006042 Xan_ur_permease
IPR006043 Xant/urac/vitC
PANTHERiPTHR11119:SF33 PTHR11119:SF33, 1 hit
PfamiView protein in Pfam
PF00860 Xan_ur_permease, 1 hit
PROSITEiView protein in PROSITE
PS01116 XANTH_URACIL_PERMASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS23A2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EPR4
Secondary accession number(s): Q80Y23, Q8C327, Q9JM78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: September 22, 2009
Last modified: May 8, 2019
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again