UniProtKB - Q9EPR4 (S23A2_MOUSE)
Protein
Solute carrier family 23 member 2
Gene
Slc23a2
Organism
Mus musculus (Mouse)
Status
Functioni
Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na+ for each ascorbate (By similarity).By similarity
GO - Molecular functioni
- L-ascorbate:sodium symporter activity Source: MGI
- L-ascorbic acid transmembrane transporter activity Source: UniProtKB
- sodium-dependent L-ascorbate transmembrane transporter activity Source: MGI
GO - Biological processi
- L-ascorbic acid metabolic process Source: MGI
- L-ascorbic acid transmembrane transport Source: UniProtKB
- negative regulation of neuron death Source: MGI
- positive regulation of dendrite extension Source: MGI
- response to oxidative stress Source: Ensembl
- transepithelial L-ascorbic acid transport Source: MGI
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-MMU-196836, Vitamin C (ascorbate) metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 23 member 2Alternative name(s): Na(+)/L-ascorbic acid transporter 2 Sodium-dependent vitamin C transporter 2 Short name: SVCT-2 Short name: mSVCT2 Yolk sac permease-like molecule 2 |
Gene namesi | Name:Slc23a2 Synonyms:Kiaa0238, Svct2, Yspl2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1859682, Slc23a2 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein
Plasma Membrane
- apical plasma membrane Source: MGI
- basal plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: MGI
- integral component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 9 – 110 | CytoplasmicSequence analysisAdd BLAST | 102 | |
Transmembranei | 111 – 131 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 132 – 139 | ExtracellularSequence analysis | 8 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 162 – 182 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 183 – 216 | ExtracellularSequence analysisAdd BLAST | 34 | |
Transmembranei | 217 – 237 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 264 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 265 – 282 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 283 – 286 | ExtracellularSequence analysis | 4 | |
Intramembranei | 287 – 300 | HelicalSequence analysisAdd BLAST | 14 | |
Topological domaini | 301 – 307 | ExtracellularSequence analysis | 7 | |
Transmembranei | 308 – 328 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 329 – 369 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 370 – 390 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 391 – 415 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 416 – 436 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 437 – 459 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 460 – 480 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 481 – 483 | ExtracellularSequence analysis | 3 | |
Transmembranei | 484 – 504 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 505 – 514 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 515 – 535 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 536 – 545 | ExtracellularSequence analysis | 10 | |
Transmembranei | 546 – 566 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 567 – 648 | CytoplasmicSequence analysisAdd BLAST | 82 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Elevated expression levels in the adrenals of diabetic mice.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000165979 | 1 – 648 | Solute carrier family 23 member 2Add BLAST | 648 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 75 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 79 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 647 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9EPR4 |
jPOSTi | Q9EPR4 |
PaxDbi | Q9EPR4 |
PeptideAtlasi | Q9EPR4 |
PRIDEi | Q9EPR4 |
PTM databases
GlyGeni | Q9EPR4, 2 sites |
iPTMneti | Q9EPR4 |
PhosphoSitePlusi | Q9EPR4 |
SwissPalmi | Q9EPR4 |
Expressioni
Tissue specificityi
Expressed in metabolically active and specialized tissues, including high expression in brain and adrenals. Detected in a wide range of tissues. Expression in kidney is almost undetectable.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000027340, Expressed in secondary oocyte and 286 other tissues |
ExpressionAtlasi | Q9EPR4, baseline and differential |
Genevisiblei | Q9EPR4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000028815 |
Miscellaneous databases
RNActi | Q9EPR4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1292, Eukaryota |
GeneTreei | ENSGT00950000182953 |
HOGENOMi | CLU_017959_5_4_1 |
InParanoidi | Q9EPR4 |
OMAi | PGMLLKY |
OrthoDBi | 387031at2759 |
PhylomeDBi | Q9EPR4 |
TreeFami | TF313272 |
Family and domain databases
InterProi | View protein in InterPro IPR029956, SlC23A2 IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
PANTHERi | PTHR11119:SF33, PTHR11119:SF33, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9EPR4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMGIGKNTAS KSVEAGGSTE GKYEEEAKHS NFFTLPVVIN GGATSSGEQD
60 70 80 90 100
NEDTELMAIY TTENGIAEKS SLAETLDSTG SLDPQRSDMI YTIEDVPPWY
110 120 130 140 150
LCIFLGLQHY LTCFSGTIAV PFLLADAMCV GDDQWATSQL IGTIFFCVGI
160 170 180 190 200
TTLLQTTFGC RLPLFQASAF AFLAPARAIL SLDKWKCNTT EITVANGTAE
210 220 230 240 250
LLEHIWHPRI QEIQGAIIMS SLIEVVIGLL GLPGALLRYI GPLTITPTVA
260 270 280 290 300
LIGLSGFQAA GERAGKHWGI AMLTIFLVLL FSQYARNVKF PLPIYKSKKG
310 320 330 340 350
WTAYKFQLFK MFPIILAILV SWLLCFIFTV TDVFPSNSTD YGYYARTDAR
360 370 380 390 400
KGVLLVAPWF KVPYPFQWGM PTVSAAGVIG MLSAVVASII ESIGDYYACA
410 420 430 440 450
RLSCAPPPPI HAINRGIFVE GLSCVLDGIF GTGNGSTSSS PNIGVLGITK
460 470 480 490 500
VGSRRVIQYG AALMLGLGMV GKFSALFASL PDPVLGALFC TLFGMITAVG
510 520 530 540 550
LSNLQFIDLN SSRNLFVLGF SIFFGLVLPS YLRQNPLVTG ITGIDQILNV
560 570 580 590 600
LLTTAMFVGG CVAFILDNTI PGTPEERGIK KWKKGVSKGS KSLDGMESYN
610 620 630 640
LPFGMNIIKK YRCFSYLPIS PTFAGYTWKG FGKSENSRSS DKDSQATV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA2ANL1 | A2ANL1_MOUSE | Solute carrier family 23 member 2 | Slc23a2 | 41 | Annotation score: |
Sequence cautioni
The sequence AAG02252 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA90751 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC65509 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007367 | 162 – 272 | LPLFQ…WGIAM → DYSCQWNGRAVGTHLASPNP RDPGGYHHVLTDRSGHWPPW PAWGSAEVYWTLDHHTHRGP HWPLWFPGSRRESRKALGHC HAVSVLRELQGWGTIFTTMW DSLVEYLKQSH in isoform 2. 1 PublicationAdd BLAST | 111 | |
Alternative sequenceiVSP_007368 | 273 – 648 | Missing in isoform 2. 1 PublicationAdd BLAST | 376 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY004874 mRNA Translation: AAG02252.1 Different initiation. AK087175 mRNA Translation: BAC39819.1 AL831706 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28341.1 BC050823 mRNA Translation: AAH50823.1 AB038145 mRNA Translation: BAA90751.1 Different initiation. AK122227 Transcribed RNA Translation: BAC65509.1 Sequence problems. |
CCDSi | CCDS16769.1 [Q9EPR4-1] |
RefSeqi | NP_061294.2, NM_018824.2 [Q9EPR4-1] XP_006499969.1, XM_006499906.3 [Q9EPR4-1] XP_006499970.1, XM_006499907.3 [Q9EPR4-1] XP_011238000.1, XM_011239698.2 [Q9EPR4-1] XP_017174620.1, XM_017319131.1 |
Genome annotation databases
Ensembli | ENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340 [Q9EPR4-1] |
GeneIDi | 54338 |
KEGGi | mmu:54338 |
UCSCi | uc008mmi.1, mouse [Q9EPR4-1] uc008mmj.1, mouse [Q9EPR4-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY004874 mRNA Translation: AAG02252.1 Different initiation. AK087175 mRNA Translation: BAC39819.1 AL831706 Genomic DNA No translation available. CH466519 Genomic DNA Translation: EDL28341.1 BC050823 mRNA Translation: AAH50823.1 AB038145 mRNA Translation: BAA90751.1 Different initiation. AK122227 Transcribed RNA Translation: BAC65509.1 Sequence problems. |
CCDSi | CCDS16769.1 [Q9EPR4-1] |
RefSeqi | NP_061294.2, NM_018824.2 [Q9EPR4-1] XP_006499969.1, XM_006499906.3 [Q9EPR4-1] XP_006499970.1, XM_006499907.3 [Q9EPR4-1] XP_011238000.1, XM_011239698.2 [Q9EPR4-1] XP_017174620.1, XM_017319131.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000028815 |
PTM databases
GlyGeni | Q9EPR4, 2 sites |
iPTMneti | Q9EPR4 |
PhosphoSitePlusi | Q9EPR4 |
SwissPalmi | Q9EPR4 |
Proteomic databases
EPDi | Q9EPR4 |
jPOSTi | Q9EPR4 |
PaxDbi | Q9EPR4 |
PeptideAtlasi | Q9EPR4 |
PRIDEi | Q9EPR4 |
Protocols and materials databases
Antibodypediai | 42663, 112 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028815; ENSMUSP00000028815; ENSMUSG00000027340 [Q9EPR4-1] |
GeneIDi | 54338 |
KEGGi | mmu:54338 |
UCSCi | uc008mmi.1, mouse [Q9EPR4-1] uc008mmj.1, mouse [Q9EPR4-2] |
Organism-specific databases
CTDi | 9962 |
MGIi | MGI:1859682, Slc23a2 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1292, Eukaryota |
GeneTreei | ENSGT00950000182953 |
HOGENOMi | CLU_017959_5_4_1 |
InParanoidi | Q9EPR4 |
OMAi | PGMLLKY |
OrthoDBi | 387031at2759 |
PhylomeDBi | Q9EPR4 |
TreeFami | TF313272 |
Enzyme and pathway databases
Reactomei | R-MMU-196836, Vitamin C (ascorbate) metabolism |
Miscellaneous databases
BioGRID-ORCSi | 54338, 2 hits in 18 CRISPR screens |
ChiTaRSi | Slc23a2, mouse |
PROi | PR:Q9EPR4 |
RNActi | Q9EPR4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027340, Expressed in secondary oocyte and 286 other tissues |
ExpressionAtlasi | Q9EPR4, baseline and differential |
Genevisiblei | Q9EPR4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029956, SlC23A2 IPR006042, Xan_ur_permease IPR006043, Xant/urac/vitC |
PANTHERi | PTHR11119:SF33, PTHR11119:SF33, 1 hit |
Pfami | View protein in Pfam PF00860, Xan_ur_permease, 1 hit |
PROSITEi | View protein in PROSITE PS01116, XANTH_URACIL_PERMASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S23A2_MOUSE | |
Accessioni | Q9EPR4Primary (citable) accession number: Q9EPR4 Secondary accession number(s): Q80Y23, Q8C327, Q9JM78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | September 22, 2009 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families