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Entry version 148 (29 Sep 2021)
Sequence version 3 (16 Oct 2013)
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Protein

Transcription factor 20

Gene

Tcf20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1565 – 1579A.T hookAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1856 – 1892C2HC pre-PHD-type; degeneratePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri1912 – 1960PHD-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 20
Short name:
TCF-20
Alternative name(s):
Nuclear factor SPBP
Stromelysin-1 PDGF-responsive element-binding protein
Short name:
SPRE-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tcf20
Synonyms:Spbp
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108399, Tcf20

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000041852

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1629A → T: Loss of interaction with RNF4; when associated with S-1702; R-1736 and V-1737. 1 Publication1
Mutagenesisi1702P → S: Loss of interaction with RNF4; when associated with T-1629; R-1736 and V-1737. 1 Publication1
Mutagenesisi1736 – 1737CG → RV: Loss of interaction with RNF4; when associated with T-1629 and S-1702. 1 Publication2
Mutagenesisi1926C → A: Reduces the inhibitory effect of the atypical PHD domain. 1 Publication1
Mutagenesisi1931C → A: Reduces the inhibitory effect of the atypical PHD domain. 1 Publication1
Mutagenesisi1936H → L: Reduces the inhibitory effect of the atypical PHD domain. 1 Publication1
Mutagenesisi1939C → A: Reduces the inhibitory effect of the atypical PHD domain. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724491 – 1987Transcription factor 20Add BLAST1987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59Omega-N-methylarginineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki316Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei447PhosphoserineBy similarity1
Modified residuei458PhosphoserineBy similarity1
Modified residuei567PhosphoserineBy similarity1
Modified residuei588PhosphoserineBy similarity1
Modified residuei603PhosphoserineBy similarity1
Modified residuei612PhosphoserineCombined sources1
Modified residuei631N6-acetyllysineCombined sources1
Modified residuei669PhosphoserineBy similarity1
Cross-linki739Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki762Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki777Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki852Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki861Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki873Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei900PhosphoserineBy similarity1
Cross-linki949Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki951Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki958Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki958Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki985Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei994PhosphoserineBy similarity1
Modified residuei1033PhosphoserineBy similarity1
Cross-linki1043Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1052Omega-N-methylarginineBy similarity1
Modified residuei1081PhosphoserineBy similarity1
Cross-linki1114Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1165Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1201Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1206Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1238Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1302Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1333PhosphoserineBy similarity1
Cross-linki1337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1363PhosphoserineBy similarity1
Cross-linki1366Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1389PhosphoserineBy similarity1
Cross-linki1417Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1437Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1474Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1538Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1550PhosphoserineBy similarity1
Cross-linki1552Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki1641Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei1697PhosphoserineBy similarity1
Modified residuei1699PhosphothreonineBy similarity1
Modified residuei1790PhosphothreonineCombined sources1
Modified residuei1792PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9EPQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EPQ8

PeptideAtlas

More...
PeptideAtlasi
Q9EPQ8

PRoteomics IDEntifications database

More...
PRIDEi
Q9EPQ8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
263146 [Q9EPQ8-1]
263147 [Q9EPQ8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EPQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EPQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, lung, liver, kidney and testes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform 2 is exclusively expressed at 7-11 days of development. Isoform 1 is found only at low levels in 15-17 days embryos.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000041852, Expressed in secondary oocyte and 304 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9EPQ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EPQ8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable).

Interacts with RNF4 and JUN. Binds to the regulatory region of MMP3.

Curated2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
204004, 6 interactors

Protein interaction database and analysis system

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IntActi
Q9EPQ8, 2 interactors

Molecular INTeraction database

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MINTi
Q9EPQ8

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000105136

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9EPQ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 79DisorderedSequence analysisAdd BLAST79
Regioni96 – 432DisorderedSequence analysisAdd BLAST337
Regioni446 – 481DisorderedSequence analysisAdd BLAST36
Regioni502 – 816DisorderedSequence analysisAdd BLAST315
Regioni844 – 891DisorderedSequence analysisAdd BLAST48
Regioni949 – 1065DisorderedSequence analysisAdd BLAST117
Regioni1136 – 1372DisorderedSequence analysisAdd BLAST237
Regioni1198 – 1219Leucine-zipperAdd BLAST22
Regioni1415 – 1434DisorderedSequence analysisAdd BLAST20
Regioni1446 – 1636DisorderedSequence analysisAdd BLAST191
Regioni1685 – 1710DisorderedSequence analysisAdd BLAST26
Regioni1760 – 1865DisorderedSequence analysisAdd BLAST106
Regioni1966 – 1987DisorderedSequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1282 – 1295Nuclear localization signalAdd BLAST14
Motifi1604 – 1628Nuclear localization signalAdd BLAST25
Motifi1812 – 1819Nuclear localization signal8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 60Polar residuesSequence analysisAdd BLAST60
Compositional biasi114 – 432Polar residuesSequence analysisAdd BLAST319
Compositional biasi502 – 541Polar residuesSequence analysisAdd BLAST40
Compositional biasi548 – 608Polar residuesSequence analysisAdd BLAST61
Compositional biasi615 – 632Polar residuesSequence analysisAdd BLAST18
Compositional biasi662 – 678Polar residuesSequence analysisAdd BLAST17
Compositional biasi693 – 737Polar residuesSequence analysisAdd BLAST45
Compositional biasi764 – 778Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi953 – 967Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1032 – 1046Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1145 – 1166Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1209 – 1235Polar residuesSequence analysisAdd BLAST27
Compositional biasi1254 – 1276Polar residuesSequence analysisAdd BLAST23
Compositional biasi1301 – 1318Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1335 – 1349Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1465 – 1481Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1482 – 1504Polar residuesSequence analysisAdd BLAST23
Compositional biasi1582 – 1598Pro residuesSequence analysisAdd BLAST17
Compositional biasi1608 – 1623Basic residuesSequence analysisAdd BLAST16
Compositional biasi1692 – 1710Polar residuesSequence analysisAdd BLAST19
Compositional biasi1773 – 1803Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1842 – 1858Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The atypical PHD domain functions as a negative modulator of cofactor binding.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1856 – 1892C2HC pre-PHD-type; degeneratePROSITE-ProRule annotationAdd BLAST37
Zinc fingeri1912 – 1960PHD-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1084, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157896

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_234705_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9EPQ8

Identification of Orthologs from Complete Genome Data

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OMAi
GHMLNRQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9EPQ8

TreeFam database of animal gene trees

More...
TreeFami
TF331317

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15699, ePHD_TCF20, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR034732, EPHD
IPR041972, TCF-20_ePHD
IPR001965, Znf_PHD
IPR013083, Znf_RING/FYVE/PHD

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00249, PHD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51805, EPHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EPQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQSFREQSSY HGNQQSYPQE VHSSSRIEEF SPRQAQMFQN FGGAGGGSSG
60 70 80 90 100
TGSSSSGRRG TAAAAAAMAS ETSGHQGYQG FRKEAGDFYY MAGNKDTVAA
110 120 130 140 150
GTPQPPQRRP SGPVQSYGPP QGSSFGNQYA SEGHVSQFQA QHSALGGVSH
160 170 180 190 200
YQQDYTGPFS PGSAQYQQQA SSQQQQQQQQ QQQQQQQQQQ QQVQQLRQQL
210 220 230 240 250
YQSHQPLPQT TGQPASGSSH LQPMQRPSTL PSSAGYQLRV GQFGQHYQSS
260 270 280 290 300
ASSSSSSSFP SPQRFSQSGQ SYDGSYSVNA GSQYEGHNVG SNAQAYGTQS
310 320 330 340 350
NYSYQPQSMK NFEQAKIPPG NQQGQQQQQQ QPQPQQQQPQ QQQQQQQQQQ
360 370 380 390 400
HPPQHVMQYT NAATKMPLQS QVGQYNQPEV PVRSPMQFHQ NFSPISNPSP
410 420 430 440 450
AASVVQSPSC SSTPSPLMQS GENLQCGQGN VPMSSRNRIL QLMPQLSPTP
460 470 480 490 500
SMMPSPNSHA AGFKGFGLEG VPEKRLTDPG LSSLSALSSQ VANLPNTVQH
510 520 530 540 550
MLLSDALTPQ KKTSKRPSSS SKKADSCTNS EGSSQPEEQL KSPMAESLDG
560 570 580 590 600
GCSSSSEDQG ERVRQLSGQS TSSDTTYKCG ASEKAGSSPT QGAQNEAPRL
610 620 630 640 650
STSPATRDEA ASPGAKDTSL SSEGNTKVNE KTVGVIVSRE AMTGRVEKSG
660 670 680 690 700
GQDKGSQEDD PAASQRPPSN SGVKEISHTS LPQPDPPGGG SKGNKNGDNN
710 720 730 740 750
SSNHNGEGNG PSSHSAVGPS FTGRTEPSKS PGSLRYSYKE SFGSAVPRNV
760 770 780 790 800
SGYPQYPSGQ EKGDFGSHGE RKGRNEKFPS LLQEVLQGYH HHPDRRYPRS
810 820 830 840 850
AQEHQGMASG LEGTARPNIL VSQTNELASR GLLNKSIGSL LENPHWGPWE
860 870 880 890 900
RKSSSTAPEM KQINLSDYPI PRKFEIEPPS SAHEPGGSLS ERRSVICDIS
910 920 930 940 950
PLRQIVRDPG AHSLGHMGTD ARIGRNERLN PSLSQSVILP GGLVSMETKL
960 970 980 990 1000
KSQSGQIKEE DFEQSKSQAS FNKKSGDHCH PTSIKHETYR GNASPGAAAH
1010 1020 1030 1040 1050
DSISDYGPQD SRSTPMRRVP GRVGSRETMR GRSSSQYHDF AEKLKMSPGR
1060 1070 1080 1090 1100
SRGPGGDPHH MNPHMTFSER ANRSSLHAPF SPNSESLASA YHTNTRAHAY
1110 1120 1130 1140 1150
GDPNTGLNSQ LHYKRQMYQQ QQEEYKDWAS SSAQGVIAAA QHRQEGPRKS
1160 1170 1180 1190 1200
PRQQQFLDRV RSPLKNDKDG MMYGPPVGTY HDPSTQEAGR CLMSSDGLPA
1210 1220 1230 1240 1250
KSMELKHSSQ KLQESCWDLS RQTSPAKSSG PPGMSNQKRY GPPHEPDGHG
1260 1270 1280 1290 1300
LAESAQSSKP SNVMLRLPGQ EDHSSQNPLI MRRRVRSFIS PIPSKRQSQD
1310 1320 1330 1340 1350
VKNSNADDKG RLLHPSKEGA DKAYNSYSHL SHSQDIKSIP KRDSSKDLPN
1360 1370 1380 1390 1400
PDNRNCPAVT LTSPAKTKIL PPRKGRGLKL EAIVQKITSP NIRRSASANS
1410 1420 1430 1440 1450
AEAGGDTVTL DDILSLKSGP PEGGTVATQE AEMEKRKCEV VSDLVSVTNQ
1460 1470 1480 1490 1500
ESNVEKPLPG PSEEWRGSGD DKVKTEAHVE TASTGKEPSG TMTSTASQKP
1510 1520 1530 1540 1550
GGNQGRPDGS LGGAAPLIFP DSKNVAPVGI LAPEANPKAE EKENDTVMIS
1560 1570 1580 1590 1600
PKQESFPPKG YFPSGKKKGR PIGSVNKQKK QQQQPPPPPQ PPQMPEGSAD
1610 1620 1630 1640 1650
GEPKPKKQRQ RRERRKPGAQ PRKRKTKQAV PIVEPQEPEI KLKYATQPLD
1660 1670 1680 1690 1700
KTDAKNKSFF PYIHVVNKCE LGAVCTIINA EEEEQTKLVR SRKGQRSLTP
1710 1720 1730 1740 1750
PPSSTESKVL PASSFMLQGP VVTESSVMGH LVCCLCGKWA SYRNMGDLFG
1760 1770 1780 1790 1800
PFYPQDYAAT LPKNPPPKRS SEMQSKVKVR HKSASNGSKT DTEEEEEQQQ
1810 1820 1830 1840 1850
QKEQRSLAAH PRFKRRHRSE DCGGGPRSLS RGLPCKKAAT EGSSEKTVSD
1860 1870 1880 1890 1900
TKPSVPTTSE GGPELELQIP ELPLDSNEFW VHEGCILWAN GIYLVCGRLY
1910 1920 1930 1940 1950
GLQEALEIAR EMKCSHCQEA GATLGCYNKG CSFRYHYPCA IDADCLLHEE
1960 1970 1980
NFSVRCPKHK PPLPCPLPPL QNKTAKGSLS TEQSERG
Length:1,987
Mass (Da):215,683
Last modified:October 16, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDB6EE205C311DB59
GO
Isoform 2 (identifier: Q9EPQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1961-1987: PPLPCPLPPLQNKTAKGSLSTEQSERG → VRLWR

Show »
Length:1,965
Mass (Da):213,566
Checksum:i1B21452F2D195BE2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VHC6A0A2R8VHC6_MOUSE
Transcription factor 20
Tcf20
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8W6K2A0A2R8W6K2_MOUSE
Transcription factor 20
Tcf20
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VKG9A0A2R8VKG9_MOUSE
Transcription factor 20
Tcf20
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA86495 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti355H → R in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti366M → I in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti443M → L in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti954S → G in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti1022R → I in AAA86495 (PubMed:7760812).Curated1
Sequence conflicti1082P → R in AAA86495 (PubMed:7760812).Curated1
Sequence conflicti1161R → G in AAA86495 (PubMed:7760812).Curated1
Sequence conflicti1201K → Q in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti1216C → R in AAG28929 (PubMed:10995766).Curated1
Sequence conflicti1297Q → R in AAA86495 (PubMed:7760812).Curated1
Sequence conflicti1418S → G in AAA86495 (PubMed:7760812).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0039861961 – 1987PPLPC…QSERG → VRLWR in isoform 2. 2 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY007594 mRNA Translation: AAG28929.1
AC087902 Genomic DNA No translation available.
AC129563 Genomic DNA No translation available.
BC138038 mRNA Translation: AAI38039.1
U20284 mRNA Translation: AAA86495.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27693.1 [Q9EPQ8-2]
CCDS49681.1 [Q9EPQ8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001107612.1, NM_001114140.1 [Q9EPQ8-1]
XP_006520795.1, XM_006520732.2 [Q9EPQ8-1]
XP_006520796.1, XM_006520733.1 [Q9EPQ8-1]
XP_011243853.1, XM_011245551.2 [Q9EPQ8-1]
XP_011243855.1, XM_011245553.2 [Q9EPQ8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048966; ENSMUSP00000048486; ENSMUSG00000041852 [Q9EPQ8-2]
ENSMUST00000109510; ENSMUSP00000105136; ENSMUSG00000041852 [Q9EPQ8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
21411

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:21411

UCSC genome browser

More...
UCSCi
uc007wzo.3, mouse [Q9EPQ8-1]
uc007wzp.3, mouse [Q9EPQ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007594 mRNA Translation: AAG28929.1
AC087902 Genomic DNA No translation available.
AC129563 Genomic DNA No translation available.
BC138038 mRNA Translation: AAI38039.1
U20284 mRNA Translation: AAA86495.1 Frameshift.
CCDSiCCDS27693.1 [Q9EPQ8-2]
CCDS49681.1 [Q9EPQ8-1]
RefSeqiNP_001107612.1, NM_001114140.1 [Q9EPQ8-1]
XP_006520795.1, XM_006520732.2 [Q9EPQ8-1]
XP_006520796.1, XM_006520733.1 [Q9EPQ8-1]
XP_011243853.1, XM_011245551.2 [Q9EPQ8-1]
XP_011243855.1, XM_011245553.2 [Q9EPQ8-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi204004, 6 interactors
IntActiQ9EPQ8, 2 interactors
MINTiQ9EPQ8
STRINGi10090.ENSMUSP00000105136

PTM databases

iPTMnetiQ9EPQ8
PhosphoSitePlusiQ9EPQ8

Proteomic databases

jPOSTiQ9EPQ8
PaxDbiQ9EPQ8
PeptideAtlasiQ9EPQ8
PRIDEiQ9EPQ8
ProteomicsDBi263146 [Q9EPQ8-1]
263147 [Q9EPQ8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
21411

Genome annotation databases

EnsembliENSMUST00000048966; ENSMUSP00000048486; ENSMUSG00000041852 [Q9EPQ8-2]
ENSMUST00000109510; ENSMUSP00000105136; ENSMUSG00000041852 [Q9EPQ8-1]
GeneIDi21411
KEGGimmu:21411
UCSCiuc007wzo.3, mouse [Q9EPQ8-1]
uc007wzp.3, mouse [Q9EPQ8-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6942
MGIiMGI:108399, Tcf20
VEuPathDBiHostDB:ENSMUSG00000041852

Phylogenomic databases

eggNOGiKOG1084, Eukaryota
GeneTreeiENSGT00940000157896
HOGENOMiCLU_234705_0_0_1
InParanoidiQ9EPQ8
OMAiGHMLNRQ
PhylomeDBiQ9EPQ8
TreeFamiTF331317

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
21411, 2 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Tcf20, mouse

Protein Ontology

More...
PROi
PR:Q9EPQ8
RNActiQ9EPQ8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000041852, Expressed in secondary oocyte and 304 other tissues
ExpressionAtlasiQ9EPQ8, baseline and differential
GenevisibleiQ9EPQ8, MM

Family and domain databases

CDDicd15699, ePHD_TCF20, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR034732, EPHD
IPR041972, TCF-20_ePHD
IPR001965, Znf_PHD
IPR013083, Znf_RING/FYVE/PHD
SMARTiView protein in SMART
SM00249, PHD, 1 hit
PROSITEiView protein in PROSITE
PS51805, EPHD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCF20_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EPQ8
Secondary accession number(s): B9EHJ7, Q60792
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 16, 2013
Last modified: September 29, 2021
This is version 148 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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