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Entry version 137 (22 Apr 2020)
Sequence version 1 (01 Mar 2001)
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Protein

X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

Gene

Rpgrip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSensory transduction, Vision

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Short name:
RPGR-interacting protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rpgrip1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1932134 Rpgrip1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutant mice are born at the expected Mendelian rate, appear healthy and are fertile. They have initially a complete set of photoreceptor cells in the retina, but the photoreceptor cells present defects in the outer segments indicative of cell death, and loss of photoreceptor cells is almost complete after three months.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000974331 – 1331X-linked retinitis pigmentosa GTPase regulator-interacting protein 1Add BLAST1331

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9EPQ2

PRoteomics IDEntifications database

More...
PRIDEi
Q9EPQ2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9EPQ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9EPQ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the retina (at protein level).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057132 Expressed in brain and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9EPQ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9EPQ2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NPHP4.

Interacts with NEK4 (By similarity). Forms homodimers and elongated homopolymers (PubMed:12651948).

Interacts with RPGR (PubMed:11104772).

Interacts with SPATA7 (PubMed:25398945, PubMed:29899041).

Interacts with CEP290/NPHP6; mediating the association between RPGR and CEP290/NPHP6 (By similarity).

By similarity4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
219040, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9EPQ2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107230

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9EPQ2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9EPQ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini745 – 870C2PROSITE-ProRule annotationAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1136 – 1326Interaction with RPGRBy similarityAdd BLAST191

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili236 – 352Sequence analysisAdd BLAST117
Coiled coili498 – 546Sequence analysisAdd BLAST49
Coiled coili908 – 999Sequence analysisAdd BLAST92

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2 domain does not bind calcium ions, and does not bind phosphoinositides.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RPGRIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGZN Eukaryota
ENOG410YNUX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002108_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9EPQ2

KEGG Orthology (KO)

More...
KOi
K16512

Database of Orthologous Groups

More...
OrthoDBi
152378at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9EPQ2

TreeFam database of animal gene trees

More...
TreeFami
TF328883

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021656 C2-C2_1
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR031134 RPGRIP1
IPR041091 RPGRIP1_C
IPR031139 RPGRIP1_fam

The PANTHER Classification System

More...
PANTHERi
PTHR14240 PTHR14240, 2 hits
PTHR14240:SF3 PTHR14240:SF3, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF11618 C2-C2_1, 1 hit
PF18111 RPGR1_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9EPQ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQHLLEYMPE DLPVRDTDSS PLLKGTSGKN VRAQPHLGRM NQKELNCRRL
60 70 80 90 100
HLHEEPTLVK EPSPKQRDKN RRRRTNVQRS TTTQPDLRTL AVLQEPERRR
110 120 130 140 150
RPWVSASPSP SAPPRAPVPG RKAHVQRLCP STAVGSAQPR VHAGRRLPHI
160 170 180 190 200
AGPNDRRSHT APPAFKDYVA DKNTRIEITR EPSQLTHTMT TDSTHVEEIP
210 220 230 240 250
RSPEKTSKVE KPEQRSSEEC TQKAAELRAS IKENVELIRL KKLLQERNTS
260 270 280 290 300
LAATEAQLTR VQEAYEDLLQ KNQGILDTAH NAFLSQVNEL KAELSEESKK
310 320 330 340 350
AVSLRTQLGD VSILQITLKE FQVRVEDLEK ERKLLSDSYD RLLENMLDSS
360 370 380 390 400
HQPLDSSHQP HWSTELTGKQ LPPQVCPLLD QMGTALEETK VFRQATNKAA
410 420 430 440 450
QDGKLKFQDT DILYQHEQEE ESLQSTATVA SSPEELCELA AQPTLLPQTD
460 470 480 490 500
QRESSEPKAQ DENDLSQVLS ELQVSHAETT LELEKTRDML LLQRKINMCY
510 520 530 540 550
QEELEATLTK ADRENRDHEE KLERLNHLLD FKNSRIKQLE GILRSHGLPT
560 570 580 590 600
SEQLKDVAYG TLPPSLCLEP LAAHRGDDEV DMSLLHPSEN LFELHVHQAF
610 620 630 640 650
LTPAALTQAG DTQPTTFCTY SFYDFETHCT PLSTGPQPLY DFTSQYVVQA
660 670 680 690 700
DYLLLHYLQG TSVRLDLHQA MASEYHVLAT GWISLDKVLG TVERVHGLAT
710 720 730 740 750
LAGAGGEDLG VLEYWMRLCL PLKPSLQACN KRKKAQAYLS VSVLGARKVQ
760 770 780 790 800
SNESRSETWA PQNELRVEIT RCCGLRSRRL GRQPSPYVMY RFFTFPDHDT
810 820 830 840 850
IIIPASSNPY FKDQALFPVL VTSDLDQYLR REALSVYVFD DEDPEPGSYL
860 870 880 890 900
GRAQVPLLPL AQNKSIKGDF NLTDSGEKSN GSIKVQLDWK SHYLAPEGFQ
910 920 930 940 950
MSEAEKPEGE EKEEEGGEEE VKEEEVEEEE EEEEEEEEVK EEKEEEEEEE
960 970 980 990 1000
REEEEEKEEE KEEEEEEDEK EEEEEEEEEE EEEEEDENKD VLEASFTEEW
1010 1020 1030 1040 1050
VPFFSQDQIA STEIPIEAGQ YPEKRKPPVI AEKKEREHQV ASYSRRKHSK
1060 1070 1080 1090 1100
KPGVQDKNRM EYLSCNILNG NTQQMHYTEW KFSGLKKAED GGLKAQDKRE
1110 1120 1130 1140 1150
EPPSPRSALR QEHPSHPRNA FSLADQESCE QASEVSETQT TDSDDIIVTP
1160 1170 1180 1190 1200
QAQTVPKADS EKMCIEIVSL AFCPEADVMS DETIQQVYVE YKFCDLPLSE
1210 1220 1230 1240 1250
TETPMSLRKP RAGEEIHFHF SKVIDLDPVE HQSRRQFLFA MLHAQDSDEG
1260 1270 1280 1290 1300
RFKFTVVSDP LDEEKKECQD IGYAYLELWQ IFQSGKDILE QELEIVSPRN
1310 1320 1330
QAIQIGRLKV SLQAAAALHG IYKEMTEDLF S
Length:1,331
Mass (Da):151,996
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEDA7F33750D593E
GO
Isoform 2 (identifier: Q9EPQ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-399: Missing.
     552-554: EQL → GKS
     555-1331: Missing.

Show »
Length:553
Mass (Da):62,963
Checksum:i3BC001461F109746
GO
Isoform 3 (identifier: Q9EPQ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-345: EFQVRVEDLEKERKLLSDSYDRLLEN → MLKLCNKDAGSYSFEDPSDTEPGVFS
     399-399: Missing.
     552-867: Missing.

Show »
Length:695
Mass (Da):80,026
Checksum:iA29EA1E45C263F6B
GO
Isoform 4 (identifier: Q9EPQ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-319: Missing.
     320-345: EFQVRVEDLEKERKLLSDSYDRLLEN → MLKLCNKDAGSYSFEDPSDTEPGVFS
     541-867: Missing.

Show »
Length:685
Mass (Da):78,977
Checksum:iB54B3C39E11BB587
GO
Isoform 5 (identifier: Q9EPQ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1074: Missing.

Show »
Length:257
Mass (Da):29,286
Checksum:i1B9D4EE6787784AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QQ97E9QQ97_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7CHD7E7CHD7_MOUSE
RPGRIP1 variant-11aa
Rpgrip1
1,320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QW56M0QW56_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QWC0M0QWC0_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QWM1M0QWM1_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QW58M0QW58_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
201Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QWL3M0QWL3_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QWT5M0QWT5_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QWI1M0QWI1_MOUSE
X-linked retinitis pigmentosa GTPas...
Rpgrip1
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti921V → A in BAB29938 (PubMed:16141072).Curated1
Sequence conflicti1096Q → H in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1156P → L in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1197P → S in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1204P → S in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1210 – 1211PR → LM in BAB29685 (PubMed:16141072).Curated2
Sequence conflicti1219H → Y in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1222K → N in BAB29685 (PubMed:16141072).Curated1
Sequence conflicti1252F → V in BAB29685 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0095291 – 1074Missing in isoform 5. 1 PublicationAdd BLAST1074
Alternative sequenceiVSP_0095281 – 319Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST319
Alternative sequenceiVSP_009530320 – 345EFQVR…RLLEN → MLKLCNKDAGSYSFEDPSDT EPGVFS in isoform 3 and isoform 4. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_009531399Missing in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_009533541 – 867Missing in isoform 4. 1 PublicationAdd BLAST327
Alternative sequenceiVSP_009534552 – 867Missing in isoform 3. 1 PublicationAdd BLAST316
Alternative sequenceiVSP_009532552 – 554EQL → GKS in isoform 2. 1 Publication3
Alternative sequenceiVSP_009535555 – 1331Missing in isoform 2. 1 PublicationAdd BLAST777

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY008297 mRNA Translation: AAG22857.1
AK015037 mRNA Translation: BAB29685.1
AK015701 mRNA Translation: BAB29938.1
AK029955 mRNA Translation: BAC26697.1
AK039097 mRNA Translation: BAC30237.1
BC016092 mRNA Translation: AAH16092.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36918.1 [Q9EPQ2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001161987.1, NM_001168515.1
NP_076368.1, NM_023879.3 [Q9EPQ2-1]
XP_006519759.1, XM_006519696.3 [Q9EPQ2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000111603; ENSMUSP00000107230; ENSMUSG00000057132 [Q9EPQ2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
77945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:77945

UCSC genome browser

More...
UCSCi
uc007tok.2 mouse [Q9EPQ2-1]
uc007ton.1 mouse [Q9EPQ2-4]
uc007too.1 mouse [Q9EPQ2-3]
uc011zkl.1 mouse [Q9EPQ2-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY008297 mRNA Translation: AAG22857.1
AK015037 mRNA Translation: BAB29685.1
AK015701 mRNA Translation: BAB29938.1
AK029955 mRNA Translation: BAC26697.1
AK039097 mRNA Translation: BAC30237.1
BC016092 mRNA Translation: AAH16092.1
CCDSiCCDS36918.1 [Q9EPQ2-1]
RefSeqiNP_001161987.1, NM_001168515.1
NP_076368.1, NM_023879.3 [Q9EPQ2-1]
XP_006519759.1, XM_006519696.3 [Q9EPQ2-3]

3D structure databases

SMRiQ9EPQ2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi219040, 2 interactors
IntActiQ9EPQ2, 2 interactors
STRINGi10090.ENSMUSP00000107230

PTM databases

iPTMnetiQ9EPQ2
PhosphoSitePlusiQ9EPQ2

Proteomic databases

PaxDbiQ9EPQ2
PRIDEiQ9EPQ2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
47230 89 antibodies

Genome annotation databases

EnsembliENSMUST00000111603; ENSMUSP00000107230; ENSMUSG00000057132 [Q9EPQ2-1]
GeneIDi77945
KEGGimmu:77945
UCSCiuc007tok.2 mouse [Q9EPQ2-1]
uc007ton.1 mouse [Q9EPQ2-4]
uc007too.1 mouse [Q9EPQ2-3]
uc011zkl.1 mouse [Q9EPQ2-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57096
MGIiMGI:1932134 Rpgrip1

Phylogenomic databases

eggNOGiENOG410IGZN Eukaryota
ENOG410YNUX LUCA
GeneTreeiENSGT00520000055620
HOGENOMiCLU_002108_1_0_1
InParanoidiQ9EPQ2
KOiK16512
OrthoDBi152378at2759
PhylomeDBiQ9EPQ2
TreeFamiTF328883

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rpgrip1 mouse

Protein Ontology

More...
PROi
PR:Q9EPQ2
RNActiQ9EPQ2 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057132 Expressed in brain and 245 other tissues
ExpressionAtlasiQ9EPQ2 baseline and differential
GenevisibleiQ9EPQ2 MM

Family and domain databases

Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR021656 C2-C2_1
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR031134 RPGRIP1
IPR041091 RPGRIP1_C
IPR031139 RPGRIP1_fam
PANTHERiPTHR14240 PTHR14240, 2 hits
PTHR14240:SF3 PTHR14240:SF3, 2 hits
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF11618 C2-C2_1, 1 hit
PF18111 RPGR1_C, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPGR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9EPQ2
Secondary accession number(s): Q8CAC2
, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2001
Last modified: April 22, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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