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Protein

Syncoilin

Gene

Sync

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins.2 Publications

GO - Molecular functioni

GO - Biological processi

  • intermediate filament-based process Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Syncoilin
Alternative name(s):
Syncoilin intermediate filament 1
Syncoilin-1
Gene namesi
Name:Sync
Synonyms:Sync1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1916078 Sync

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament

Pathology & Biotechi

Disruption phenotypei

Displays no obvious abnormalities, have a reduced capacity to generate force during isometric contractions in skeletal muscle.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003061811 – 470SyncoilinAdd BLAST470

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei314PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9EPM5
PRIDEiQ9EPM5

PTM databases

iPTMnetiQ9EPM5
PhosphoSitePlusiQ9EPM5

Expressioni

Tissue specificityi

Detected strongly in skeletal muscle and heart and weakly in lung (at protein level). Highly expressed in skeletal muscle and lung and weakly in lung and testis.1 Publication

Inductioni

Up-regulated in dystrophic muscle (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000001333 Expressed in 146 organ(s), highest expression level in ascending aorta
CleanExiMM_SYNC
ExpressionAtlasiQ9EPM5 baseline and differential
GenevisibleiQ9EPM5 MM

Interactioni

Subunit structurei

May link the dystrophin-associated glycoprotein complex (DAPC) to intracellular desmin (DES) filaments. Interacts with DES and DTNA.2 Publications

Protein-protein interaction databases

BioGridi213071, 2 interactors
MINTiQ9EPM5
STRINGi10090.ENSMUSP00000099659

Structurei

3D structure databases

ProteinModelPortaliQ9EPM5
SMRiQ9EPM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 452IF rodPROSITE-ProRule annotationAdd BLAST296

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 148HeadAdd BLAST148
Regioni158 – 192Coil 1AAdd BLAST35
Regioni193 – 219Linker 1Add BLAST27
Regioni220 – 297Coil 1bAdd BLAST78
Regioni298 – 337Linker 2Add BLAST40
Regioni338 – 445Coil 2Add BLAST108
Regioni446 – 470TailAdd BLAST25

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKIK Eukaryota
ENOG410Y2YI LUCA
GeneTreeiENSGT00390000018108
HOGENOMiHOG000010275
HOVERGENiHBG108528
InParanoidiQ9EPM5
KOiK10377
OMAiQLECRRQ
OrthoDBiEOG091G0V3M
PhylomeDBiQ9EPM5

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR027702 Syncoilin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF216 PTHR23239:SF216, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q9EPM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPEPLRGG DGARASREPH TEASFPLQES ESPKEAKTFN PEATLSLEGT
60 70 80 90 100
VNLEDILYLG ASGDFEESFY EEEYEKPALT LFIDESRQPD EALGLEEPVR
110 120 130 140 150
PEEMLSVEES VTPDEVQISE QPVEPAKSPT ACEGEMVATE GSLPAQPIPN
160 170 180 190 200
TEEDPLSVED LERLEARFQQ CVQAVSQLEE ERDQLIHELV LLREPALQEV
210 220 230 240 250
QQVHQDILAA YKLHAQAELE RDGLREEIRT VKQKLFKVTK ECVAYQYQLE
260 270 280 290 300
CRQQDVAQFA DCREALTTRA AQLSEELTQL RDACQKQKEQ LQQQLEAPPT
310 320 330 340 350
QSDGHFLQES RRLSTQFENL MAESRQGLEE EYEPQLLRLL ERKEAGTKAL
360 370 380 390 400
QDTQAEIQEM REALRPLEAE ARQLQLQNRN LEDQITLVRQ KRDEEVQQYR
410 420 430 440 450
EQLEEMEERQ RQLRSGVQVQ QQKNKEMERL RMSLAEELST YKAMLPKSLE
460 470
QADAPTSQAG GVEAQSPGTV
Length:470
Mass (Da):53,630
Last modified:March 1, 2001 - v1
Checksum:i3D3B6026B099B229
GO
Isoform 21 Publication (identifier: Q9EPM5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-453: AMLPKSLEQAD → SVFSASQVSQI
     454-470: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:453
Mass (Da):52,041
Checksum:i9F7360528BE73B54
GO
Isoform 31 Publication (identifier: Q9EPM5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:367
Mass (Da):42,230
Checksum:i4C0EE9F8994C9F1C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → E in AAI06856 (PubMed:15489334).Curated1
Sequence conflicti79L → Q in AAI06856 (PubMed:15489334).Curated1
Sequence conflicti377Q → K in BAC38387 (PubMed:16141072).Curated1
Sequence conflicti432M → T in AAI06856 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0525501 – 103Missing in isoform 3. 1 PublicationAdd BLAST103
Alternative sequenceiVSP_052551443 – 453AMLPKSLEQAD → SVFSASQVSQI in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_052552454 – 470Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251641 mRNA Translation: CAC17787.1
AK004279 mRNA Translation: BAB23246.1
AK081983 mRNA Translation: BAC38387.1
AK160756 mRNA Translation: BAE35992.1
AK166916 mRNA Translation: BAE39114.1
AL607123 Genomic DNA No translation available.
BC106855 mRNA Translation: AAI06856.1
CCDSiCCDS18687.1 [Q9EPM5-1]
RefSeqiNP_075974.3, NM_023485.3 [Q9EPM5-1]
UniGeneiMm.132243

Genome annotation databases

EnsembliENSMUST00000102599; ENSMUSP00000099659; ENSMUSG00000001333 [Q9EPM5-1]
GeneIDi68828
KEGGimmu:68828
UCSCiuc008uwq.1 mouse [Q9EPM5-2]
uc008uwr.1 mouse [Q9EPM5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251641 mRNA Translation: CAC17787.1
AK004279 mRNA Translation: BAB23246.1
AK081983 mRNA Translation: BAC38387.1
AK160756 mRNA Translation: BAE35992.1
AK166916 mRNA Translation: BAE39114.1
AL607123 Genomic DNA No translation available.
BC106855 mRNA Translation: AAI06856.1
CCDSiCCDS18687.1 [Q9EPM5-1]
RefSeqiNP_075974.3, NM_023485.3 [Q9EPM5-1]
UniGeneiMm.132243

3D structure databases

ProteinModelPortaliQ9EPM5
SMRiQ9EPM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213071, 2 interactors
MINTiQ9EPM5
STRINGi10090.ENSMUSP00000099659

PTM databases

iPTMnetiQ9EPM5
PhosphoSitePlusiQ9EPM5

Proteomic databases

PaxDbiQ9EPM5
PRIDEiQ9EPM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102599; ENSMUSP00000099659; ENSMUSG00000001333 [Q9EPM5-1]
GeneIDi68828
KEGGimmu:68828
UCSCiuc008uwq.1 mouse [Q9EPM5-2]
uc008uwr.1 mouse [Q9EPM5-1]

Organism-specific databases

CTDi81493
MGIiMGI:1916078 Sync

Phylogenomic databases

eggNOGiENOG410IKIK Eukaryota
ENOG410Y2YI LUCA
GeneTreeiENSGT00390000018108
HOGENOMiHOG000010275
HOVERGENiHBG108528
InParanoidiQ9EPM5
KOiK10377
OMAiQLECRRQ
OrthoDBiEOG091G0V3M
PhylomeDBiQ9EPM5

Miscellaneous databases

PROiPR:Q9EPM5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001333 Expressed in 146 organ(s), highest expression level in ascending aorta
CleanExiMM_SYNC
ExpressionAtlasiQ9EPM5 baseline and differential
GenevisibleiQ9EPM5 MM

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR039008 IF_rod_dom
IPR027702 Syncoilin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF216 PTHR23239:SF216, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYNCI_MOUSE
AccessioniPrimary (citable) accession number: Q9EPM5
Secondary accession number(s): Q3KP79
, Q3TKN1, Q3TUH9, Q8C4J4, Q9CT88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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