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Protein

Importin-7

Gene

Ipo7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: MGI
  • protein transporter activity Source: GO_Central
  • Ran GTPase binding Source: InterPro
  • SMAD binding Source: MGI

GO - Biological processi

  • innate immune response Source: MGI
  • protein import into nucleus Source: MGI
  • signal transduction Source: GO_Central

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-7
Short name:
Imp7
Alternative name(s):
Ran-binding protein 7
Short name:
RanBP7
Gene namesi
Name:Ipo7
Synonyms:Ranbp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2152414 Ipo7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176785

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001207511 – 1038Importin-7Add BLAST1038

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei886PhosphoserineBy similarity1
Modified residuei898PhosphothreonineBy similarity1
Modified residuei903PhosphoserineBy similarity1
Modified residuei1020PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9EPL8
MaxQBiQ9EPL8
PaxDbiQ9EPL8
PeptideAtlasiQ9EPL8
PRIDEiQ9EPL8

PTM databases

iPTMnetiQ9EPL8
PhosphoSitePlusiQ9EPL8
SwissPalmiQ9EPL8

Expressioni

Gene expression databases

BgeeiENSMUSG00000066232 Expressed in 296 organ(s), highest expression level in parotid gland
CleanExiMM_IPO7
ExpressionAtlasiQ9EPL8 baseline and differential
GenevisibleiQ9EPL8 MM

Interactioni

Subunit structurei

Forms a heterodimer with KPNB1. Interacts with KPNB1, RNUT1, XPO1, RPL23A, RPS7 and RPL5. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Interacts with SMAD4 and NUP93; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231437, 5 interactors
IntActiQ9EPL8, 6 interactors
MINTiQ9EPL8
STRINGi10090.ENSMUSP00000081782

Structurei

3D structure databases

ProteinModelPortaliQ9EPL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101Importin N-terminalPROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi886 – 958Asp-richAdd BLAST73

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGiKOG1991 Eukaryota
COG5656 LUCA
GeneTreeiENSGT00550000074736
HOGENOMiHOG000006586
HOVERGENiHBG006824
InParanoidiQ9EPL8
KOiK20223
OMAiSCTFAAK
OrthoDBiEOG091G01IF
PhylomeDBiQ9EPL8
TreeFamiTF300634

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013713 Cse1
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF08506 Cse1, 1 hit
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9EPL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL
60 70 80 90 100
PVRQAGVIYL KNMITQYWPD REATPGDIAP YTIPEEDRHC IRENIVEAII
110 120 130 140 150
HSPELIRVQL TTCIHHIIKH DYPSRWTAIV DKIGFYLQSD NSACWLGILL
160 170 180 190 200
CLYQLVKNYE YKKPEERSPL VAAMQHFLPV LKDRFIQLLS DQSDQSVLIQ
210 220 230 240 250
KQIFKIFYAL VQYTLPLELI NQQNLTEWVE ILKTVVNRDV PNETLQVEED
260 270 280 290 300
DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV
310 320 330 340 350
QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII
360 370 380 390 400
QDVIFPLMCY TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA
410 420 430 440 450
CSKRKEVLQK TMGFCYQILT EPNADPRKKD GALHMIGSLA EILLKKKIYK
460 470 480 490 500
DQMEYMLQNH VFPLFSSELG YMRARACWVL HYFCEVKFKS DQNLQTALEL
510 520 530 540 550
TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR PVMQALLHII
560 570 580 590 600
RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG
610 620 630 640 650
SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE
660 670 680 690 700
FYEEIFSLAH SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY
710 720 730 740 750
VTVDTDTLLS DTKYLEMIYS MCKKVLTGVA GEDAECHAAK LLEVIILQCK
760 770 780 790 800
GRGIDQCIPL FVEAALERLT REVKTSELRT MCLQVAIAAL YYNPHLLLNT
810 820 830 840 850
LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG LCALIDMEQI
860 870 880 890 900
PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDE DAEDDDETEE
910 920 930 940 950
LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID
960 970 980 990 1000
DEDNPVDEYQ IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD
1010 1020 1030
QRRAAHESKM IEKHGGYKFS APVVPSSFNF GGPAPGMN
Length:1,038
Mass (Da):119,486
Last modified:March 15, 2004 - v2
Checksum:i0AB7104A93FA72EC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LHD0A0A140LHD0_MOUSE
Importin 7, isoform CRA_b
Ipo7 mCG_6712
70Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160E → G in BAC35405 (PubMed:16141072).Curated1
Sequence conflicti407V → VV in CAC17143 (PubMed:11528126).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278435 Genomic DNA Translation: CAC17143.1
AY316153 mRNA Translation: AAP79888.1
AK039534 mRNA Translation: BAC30376.1
AK053498 mRNA Translation: BAC35405.1
BC053524 mRNA Translation: AAH53524.1
BC064825 mRNA Translation: AAH64825.1
CCDSiCCDS40085.1
RefSeqiNP_852658.2, NM_181517.3
UniGeneiMm.222328

Genome annotation databases

EnsembliENSMUST00000084731; ENSMUSP00000081782; ENSMUSG00000066232
GeneIDi233726
KEGGimmu:233726
UCSCiuc009jeu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIPO7_MOUSE
AccessioniPrimary (citable) accession number: Q9EPL8
Secondary accession number(s): Q7TN09
, Q7TQ63, Q8BKD8, Q8BYI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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