Ipo7

Functionⁱ

Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with KPNB1 mediates the nuclear import of H1 histone and the Ran-binding site of IPO7 is not required but synergizes with that of KPNB1 in importin/substrate complex dissociation (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.By similarity1 Publication

GO - Molecular functionⁱ

histone binding
Source: MGI
Inferred from direct assayⁱ
- 11493596
protein transporter activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Ran GTPase binding Source: InterPro
SMAD binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

innate immune response
Source: MGI
Inferred from mutant phenotypeⁱ
- 19805818
protein import into nucleus
Source: MGI
Inferred from direct assayⁱ
- 11493596

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Importin-7 Short name: Imp7 Alternative name(s): Ran-binding protein 7 Short name: RanBP7
Gene namesⁱ	Name:Ipo7 Synonyms:Ranbp7
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:2152414 Ipo7

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2176785

ChEMBLⁱ

CHEMBL2176785

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000120751	1 – 1038	Importin-7Add BLAST		1038

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	886	PhosphoserineBy similarity	1
Modified residueⁱ	898	PhosphothreonineBy similarity	1
Modified residueⁱ	903	PhosphoserineBy similarity	1
Modified residueⁱ	1020	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9EPL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9EPL8
PaxDbⁱ	Q9EPL8
PeptideAtlas More...PeptideAtlasⁱ	Q9EPL8
PRIDEⁱ	Q9EPL8

PTM databases

iPTMnetⁱ	Q9EPL8
PhosphoSitePlusⁱ	Q9EPL8
SwissPalmⁱ	Q9EPL8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000066232 Expressed in 296 organ(s), highest expression level in parotid gland
CleanExⁱ	MM_IPO7
ExpressionAtlasⁱ	Q9EPL8 baseline and differential
Genevisibleⁱ	Q9EPL8 MM

Interactionⁱ

Subunit structureⁱ

Forms a heterodimer with KPNB1. Interacts with KPNB1, RNUT1, XPO1, RPL23A, RPS7 and RPL5. Binds directly to nuclear pore complexes (By similarity). Interacts with H2A, H2B, H3 and H4 histones. Interacts with SMAD4 and NUP93; translocates SMAD4 to the nucleus through the NPC upon BMP7 stimulation resulting in activation of SMAD4 signaling (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

histone binding
Source: MGI
Inferred from direct assayⁱ
- 11493596
Ran GTPase binding Source: InterPro
SMAD binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	231437, 5 interactors
IntActⁱ	Q9EPL8, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q9EPL8
STRINGⁱ	10090.ENSMUSP00000081782

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9EPL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 101	Importin N-terminalPROSITE-ProRule annotationAdd BLAST		80

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	886 – 958	Asp-richAdd BLAST		73

Sequence similaritiesⁱ

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1991 Eukaryota COG5656 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074736
HOGENOMⁱ	HOG000006586
HOVERGENⁱ	HBG006824
InParanoidⁱ	Q9EPL8
KEGG Orthology (KO) More...KOⁱ	K20223
OMAⁱ	QCKGQID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01IF
PhylomeDBⁱ	Q9EPL8
TreeFamⁱ	TF300634

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR001494 Importin-beta_N IPR013713 XPO2_central
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08506 Cse1, 1 hit PF03810 IBN_N, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50166 IMPORTIN_B_NT, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9EPL8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPNTIIEAL RGTMDPALRE AAERQLNEAH KSLNFVSTLL QITMSEQLDL 
        60         70         80         90        100
PVRQAGVIYL KNMITQYWPD REATPGDIAP YTIPEEDRHC IRENIVEAII 
       110        120        130        140        150
HSPELIRVQL TTCIHHIIKH DYPSRWTAIV DKIGFYLQSD NSACWLGILL 
       160        170        180        190        200
CLYQLVKNYE YKKPEERSPL VAAMQHFLPV LKDRFIQLLS DQSDQSVLIQ 
       210        220        230        240        250
KQIFKIFYAL VQYTLPLELI NQQNLTEWVE ILKTVVNRDV PNETLQVEED 
       260        270        280        290        300
DRPELPWWKC KKWALHILAR LFERYGSPGN VSKEYNEFAE VFLKAFAVGV 
       310        320        330        340        350
QQVLLKVLYQ YKEKQYMAPR VLQQTLNYIN QGVSHALTWK NLKPHIQGII 
       360        370        380        390        400
QDVIFPLMCY TDADEELWQE DPYEYIRMKF DVFEDFISPT TAAQTLLFTA 
       410        420        430        440        450
CSKRKEVLQK TMGFCYQILT EPNADPRKKD GALHMIGSLA EILLKKKIYK 
       460        470        480        490        500
DQMEYMLQNH VFPLFSSELG YMRARACWVL HYFCEVKFKS DQNLQTALEL 
       510        520        530        540        550
TRRCLIDDRE MPVKVEAAIA LQVLISNQEK AKEYITPFIR PVMQALLHII 
       560        570        580        590        600
RETENDDLTN VIQKMICEYS EEVTPIAVEM TQHLAMTFNQ VIQTGPDEEG 
       610        620        630        640        650
SDDKAVTAMG ILNTIDTLLS VVEDHKEITQ QLEGICLQVI GTVLQQHVLE 
       660        670        680        690        700
FYEEIFSLAH SLTCQQVSPQ MWQLLPLVFE VFQQDGFDYF TDMMPLLHNY 
       710        720        730        740        750
VTVDTDTLLS DTKYLEMIYS MCKKVLTGVA GEDAECHAAK LLEVIILQCK 
       760        770        780        790        800
GRGIDQCIPL FVEAALERLT REVKTSELRT MCLQVAIAAL YYNPHLLLNT 
       810        820        830        840        850
LENLRFPNNV EPVTNHFITQ WLNDVDCFLG LHDRKMCVLG LCALIDMEQI 
       860        870        880        890        900
PQVLNQVSGQ ILPAFILLFN GLKRAYACHA EHENDSDDDE DAEDDDETEE 
       910        920        930        940        950
LGSDEDDIDE DGQEYLEILA KQAGEDGDDE DWEEDDAEET ALEGYSTIID 
       960        970        980        990       1000
DEDNPVDEYQ IFKAIFQTIQ NRNPVWYQAL THGLNEEQRK QLQDIATLAD 
      1010       1020       1030 
QRRAAHESKM IEKHGGYKFS APVVPSSFNF GGPAPGMN

Length:1,038

Mass (Da):119,486

Last modified:March 15, 2004 - v2

Checksum:ⁱ0AB7104A93FA72EC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A140LHD0	A0A140LHD0_MOUSE		Importin 7, isoform CRA_b Importin 7, isoform CRA_b (Importin-7)	Ipo7 mCG_6712	70	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	160	E → G in BAC35405 (PubMed:16141072).Curated		1
Sequence conflictⁱ	407	V → VV in CAC17143 (PubMed:11528126).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278435 Genomic DNA Translation: CAC17143.1 AY316153 mRNA Translation: AAP79888.1 AK039534 mRNA Translation: BAC30376.1 AK053498 mRNA Translation: BAC35405.1 BC053524 mRNA Translation: AAH53524.1 BC064825 mRNA Translation: AAH64825.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS40085.1
NCBI Reference Sequences More...RefSeqⁱ	NP_852658.2, NM_181517.3
UniGeneⁱ	Mm.222328

Genome annotation databases

Ensemblⁱ	ENSMUST00000084731; ENSMUSP00000081782; ENSMUSG00000066232
GeneIDⁱ	233726
KEGGⁱ	mmu:233726
UCSC genome browser More...UCSCⁱ	uc009jeu.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9EPL8	Importin-7-like protein (Fragment)		Daphnia magna		160	UniRef100_Q9EPL8
Importin-7-like protein (Fragment)		Daphnia magna		160

Protein	Similar proteins		Species	Score	Length	Source
Q9EPL8	Importin-7		HUMAN		1038	UniRef90_O95373
Importin-7		CALJA		1038
Importin-7		MACMU		1038
Uncharacterized protein		MUSPF		1038
importin-7 isoform X1		ODORO		1038
+195

Protein	Similar proteins		Species	Score	Length	Source
Q9EPL8	Importin-7		HUMAN		1038	UniRef50_O95373
Importin-7		CALJA		1038
Importin-7		MACMU		1038
Uncharacterized protein		MUSPF		1038
importin-7 isoform X1		ODORO		1038
+196

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ278435 Genomic DNA Translation: CAC17143.1 AY316153 mRNA Translation: AAP79888.1 AK039534 mRNA Translation: BAC30376.1 AK053498 mRNA Translation: BAC35405.1 BC053524 mRNA Translation: AAH53524.1 BC064825 mRNA Translation: AAH64825.1
CCDSⁱ	CCDS40085.1
RefSeqⁱ	NP_852658.2, NM_181517.3
UniGeneⁱ	Mm.222328

3D structure databases

ProteinModelPortalⁱ	Q9EPL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231437, 5 interactors
IntActⁱ	Q9EPL8, 6 interactors
MINTⁱ	Q9EPL8
STRINGⁱ	10090.ENSMUSP00000081782

Chemistry databases

ChEMBLⁱ	CHEMBL2176785

ChEMBLⁱ

CHEMBL2176785

PTM databases

iPTMnetⁱ	Q9EPL8
PhosphoSitePlusⁱ	Q9EPL8
SwissPalmⁱ	Q9EPL8

Proteomic databases

EPDⁱ	Q9EPL8
MaxQBⁱ	Q9EPL8
PaxDbⁱ	Q9EPL8
PeptideAtlasⁱ	Q9EPL8
PRIDEⁱ	Q9EPL8

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	233726
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000084731; ENSMUSP00000081782; ENSMUSG00000066232
GeneIDⁱ	233726
KEGGⁱ	mmu:233726
UCSCⁱ	uc009jeu.1 mouse

Organism-specific databases

CTDⁱ	10527
MGIⁱ	MGI:2152414 Ipo7

Phylogenomic databases

eggNOGⁱ	KOG1991 Eukaryota COG5656 LUCA
GeneTreeⁱ	ENSGT00550000074736
HOGENOMⁱ	HOG000006586
HOVERGENⁱ	HBG006824
InParanoidⁱ	Q9EPL8
KOⁱ	K20223
OMAⁱ	QCKGQID
OrthoDBⁱ	EOG091G01IF
PhylomeDBⁱ	Q9EPL8
TreeFamⁱ	TF300634

Miscellaneous databases

ChiTaRSⁱ	Ipo7 mouse
Protein Ontology More...PROⁱ	PR:Q9EPL8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000066232 Expressed in 296 organ(s), highest expression level in parotid gland
CleanExⁱ	MM_IPO7
ExpressionAtlasⁱ	Q9EPL8 baseline and differential
Genevisibleⁱ	Q9EPL8 MM

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR001494 Importin-beta_N IPR013713 XPO2_central
Pfamⁱ	View protein in Pfam PF08506 Cse1, 1 hit PF03810 IBN_N, 1 hit
SMARTⁱ	View protein in SMART SM00913 IBN_N, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50166 IMPORTIN_B_NT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IPO7_MOUSE
Accessionⁱ	Q9EPL8Primary (citable) accession number: Q9EPL8 Secondary accession number(s): Q7TN09 , Q7TQ63, Q8BKD8, Q8BYI0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
	Last sequence update:	March 15, 2004
	Last modified:	November 7, 2018
	This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9EPL8 (IPO7_MOUSE)

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Importin-7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ