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Protein

Nucleotide exchange factor SIL1

Gene

Sil1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity).By similarity

GO - Molecular functioni

  • adenyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleotide exchange factor SIL1
Gene namesi
Name:Sil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1932040 Sil1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Mice develop adult-onset ataxia with cerebellar Purkinje cell loss. Affected cells have intracellular protein accumulations in the endoplasmic reticulum and the nucleus.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000022335532 – 465Nucleotide exchange factor SIL1Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9EPK6
MaxQBiQ9EPK6
PaxDbiQ9EPK6
PeptideAtlasiQ9EPK6
PRIDEiQ9EPK6

PTM databases

iPTMnetiQ9EPK6
PhosphoSitePlusiQ9EPK6
SwissPalmiQ9EPK6

Expressioni

Tissue specificityi

Expressed in several areas of the brain including the cerebellum, cerebral cortex, cortical neurons, glial cells of white matter, hippocampus, olfactory bulb, Purkinje cells, inferior olive and the choroids plexus. Also expressed in the eye and skeletal muscle.3 Publications

Developmental stagei

Expressed in the developing retina and epithelial cells of the lens at E12.5. Expressed in the developing cerebral cortex at E15.5.1 Publication

Gene expression databases

BgeeiENSMUSG00000024357 Expressed in 263 organ(s), highest expression level in lacrimal gland
GenevisibleiQ9EPK6 MM

Interactioni

Subunit structurei

Interacts with HSPA5.1 Publication

Protein-protein interaction databases

BioGridi219881, 2 interactors
IntActiQ9EPK6, 1 interactor
MINTiQ9EPK6
STRINGi10090.ENSMUSP00000025215

Structurei

3D structure databases

ProteinModelPortaliQ9EPK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 260Interaction with HSPA5 and localization to the endoplasmic reticulum1 PublicationAdd BLAST260

Sequence similaritiesi

Belongs to the SIL1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2160 Eukaryota
ENOG410Y90B LUCA
GeneTreeiENSGT00510000048102
HOGENOMiHOG000154326
HOVERGENiHBG093955
InParanoidiQ9EPK6
KOiK14001
OMAiLREQGWC
OrthoDBiEOG091G0196
PhylomeDBiQ9EPK6
TreeFamiTF324307

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9EPK6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPQHLPSTR MASPGMLLGL LLTSCLTLCL SCQNSNNFAL TNPEKSIHQE
60 70 80 90 100
SDTKETREEE ELDTEILEVF HPTQEWQTLQ PGQAVPAGSH VRMNLQTGVN
110 120 130 140 150
EVKLQQEDKF QNNLKGFKRG RRLDINANTY TSQDLKSALA KFKEGTEMEN
160 170 180 190 200
SKDELARQAT VKQLFRPIEE LKKEFDELNV VLETDMQIMV RLINKFNSSS
210 220 230 240 250
SSLEEKVAAL FDLEYYVHQM DNAQDLLSFG GLQVVINGLN STEPLVKEYA
260 270 280 290 300
AFVLGAAFSS NPKVQVEAIE GGALQKLLVI LATNQPLPAK KKVLFALCSL
310 320 330 340 350
LRHFPYAQQQ FLKLGGLQVL RSLVQEKSAK VLAVRVVTLL YDLVTEKMFA
360 370 380 390 400
EEEAELTQDS SPEKLQQYRQ VQLLPGLQEQ GWCEITAQLL ALPEHDAREK
410 420 430 440 450
VLQTLGALLT TCRDRYRQDL QLSRTLGRLQ AEYQALASLE LQEGEDDGYF
460
RELLASINSL MKELR
Length:465
Mass (Da):52,430
Last modified:February 21, 2006 - v2
Checksum:iC3E2DB44394F1161
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143K → T in CAC17789 (PubMed:11101517).Curated1
Sequence conflicti152K → Q in CAC17789 (PubMed:11101517).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297884 mRNA Translation: CAC17789.1
AK170415 mRNA Translation: BAE41781.1
BC016119 mRNA Translation: AAH16119.1
BC016466 mRNA Translation: AAH16466.1
CCDSiCCDS29140.1
RefSeqiNP_109674.2, NM_030749.2
XP_006526428.1, XM_006526365.3
XP_006526429.1, XM_006526366.3
XP_011245345.1, XM_011247043.2
UniGeneiMm.291482

Genome annotation databases

EnsembliENSMUST00000025215; ENSMUSP00000025215; ENSMUSG00000024357
GeneIDi81500
KEGGimmu:81500
UCSCiuc008emc.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297884 mRNA Translation: CAC17789.1
AK170415 mRNA Translation: BAE41781.1
BC016119 mRNA Translation: AAH16119.1
BC016466 mRNA Translation: AAH16466.1
CCDSiCCDS29140.1
RefSeqiNP_109674.2, NM_030749.2
XP_006526428.1, XM_006526365.3
XP_006526429.1, XM_006526366.3
XP_011245345.1, XM_011247043.2
UniGeneiMm.291482

3D structure databases

ProteinModelPortaliQ9EPK6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219881, 2 interactors
IntActiQ9EPK6, 1 interactor
MINTiQ9EPK6
STRINGi10090.ENSMUSP00000025215

PTM databases

iPTMnetiQ9EPK6
PhosphoSitePlusiQ9EPK6
SwissPalmiQ9EPK6

Proteomic databases

EPDiQ9EPK6
MaxQBiQ9EPK6
PaxDbiQ9EPK6
PeptideAtlasiQ9EPK6
PRIDEiQ9EPK6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025215; ENSMUSP00000025215; ENSMUSG00000024357
GeneIDi81500
KEGGimmu:81500
UCSCiuc008emc.2 mouse

Organism-specific databases

CTDi64374
MGIiMGI:1932040 Sil1

Phylogenomic databases

eggNOGiKOG2160 Eukaryota
ENOG410Y90B LUCA
GeneTreeiENSGT00510000048102
HOGENOMiHOG000154326
HOVERGENiHBG093955
InParanoidiQ9EPK6
KOiK14001
OMAiLREQGWC
OrthoDBiEOG091G0196
PhylomeDBiQ9EPK6
TreeFamiTF324307

Miscellaneous databases

ChiTaRSiSil1 mouse
PROiPR:Q9EPK6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024357 Expressed in 263 organ(s), highest expression level in lacrimal gland
GenevisibleiQ9EPK6 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIL1_MOUSE
AccessioniPrimary (citable) accession number: Q9EPK6
Secondary accession number(s): Q91V34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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