UniProtKB - Q9EPH1 (A1BG_RAT)
Protein
Alpha-1B-glycoprotein
Gene
A1bg
Organism
Rattus norvegicus (Rat)
Status
Functioni
Enzyme and pathway databases
Reactomei | R-RNO-114608, Platelet degranulation R-RNO-6798695, Neutrophil degranulation |
Protein family/group databases
MEROPSi | I43.950 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1B-glycoproteinAlternative name(s): Alpha-1-B glycoprotein C44 Liver regeneration-related protein 1 |
Gene namesi | Name:A1bgImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 69417, A1bg |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000014503 | 21 – 513 | Alpha-1B-glycoproteinSequence analysisAdd BLAST | 493 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 49 ↔ 96 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 153 ↔ 195 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 245 ↔ 292 | PROSITE-ProRule annotationBy similarity | ||
Disulfide bondi | 343 ↔ 392 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 369 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 441 ↔ 488 | PROSITE-ProRule annotationBy similarity | ||
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9EPH1 |
PRIDEi | Q9EPH1 |
PTM databases
GlyGeni | Q9EPH1, 7 sites |
SwissPalmi | Q9EPH1 |
Expressioni
Tissue specificityi
Isoform 1 is expressed in normal liver. Isoform 2 is expressed in the regenerating liver after partial hepatectomy and at very low levels in the normal lung, brain and testis.2 Publications
Developmental stagei
Expressed in females at day 35 with higher levels detected at day 56. Not detected in males of any age.1 Publication
Inductioni
Up-regulated by continuous exposure to growth hormone.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000004692, Expressed in liver and 8 other tissues |
Genevisiblei | Q9EPH1, RN |
Interactioni
Subunit structurei
Interacts with CRISP3.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006273 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 126 | Ig-like V-type 1Sequence analysisAdd BLAST | 105 | |
Domaini | 127 – 219 | Ig-like V-type 2Sequence analysisAdd BLAST | 93 | |
Domaini | 220 – 312 | Ig-like V-type 3Sequence analysisAdd BLAST | 93 | |
Domaini | 313 – 415 | Ig-like V-type 4Sequence analysisAdd BLAST | 103 | |
Domaini | 416 – 513 | Ig-like V-type 5Sequence analysisAdd BLAST | 98 |
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
GeneTreei | ENSGT00980000198504 |
HOGENOMi | CLU_042929_1_0_1 |
InParanoidi | Q9EPH1 |
OMAi | IKHQFLL |
OrthoDBi | 1327293at2759 |
PhylomeDBi | Q9EPH1 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR016332, A1B_glyco/leuk_Ig-like_rcpt IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
PIRSFi | PIRSF001979, Alpha_1B_glycoprot_prd, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 11 Publication (identifier: Q9EPH1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLLTTVLLL WGFTLGPGNA LWLDSGSEPE LRAEPQSLLE PWANLTLVCA
60 70 80 90 100
VDLPTKVFEL IMNGWFLSQV RLETPVLSYR FSLGAITSNN SGVYRCRCGV
110 120 130 140 150
EPPVDIQLPA LSKWTMLSNA LEVTGKEPLP PPSAHADPVS WITPGGLPVY
160 170 180 190 200
IMCRVAMRGV TYLLRKEGVD GTQKPDVQHK GTAGFLIYKP GNYSCSYLTH
210 220 230 240 250
AGGKPSEPSA IVTIKMSATQ LPPSLCLMGS YLTIYPQKTH ETLACKAPRN
260 270 280 290 300
AAEFQLRQGE RVLNIQGFSP TRDATIYYVN LKELDNQSPF TCRYRMHKYM
310 320 330 340 350
HVWSEDSKPV ELMWSDEKLP APVLTAEPSS HNLEPGSTVQ LRCTAHKAGL
360 370 380 390 400
RFGLQRQGKP DLVVVQMLNS SGTEAVFELH NISTIDSGNY SCIYMEQAPP
410 420 430 440 450
FSGSASSEPL ELRINGPAPK PRLEALWKGK VPLGHEAIFQ CHGHVPRVSM
460 470 480 490 500
ELVREGFKTP FWMASTTSTS AFLKLSFVGP QHTGNYSCRY TALSPFTFES
510
GISDPVEVVV EGS
Sequence cautioni
The sequence AAF68963 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 | D → N in CAC19029 (PubMed:11356721).Curated | 1 | |
Sequence conflicti | 204 | K → E in CAC19029 (PubMed:11356721).Curated | 1 | |
Sequence conflicti | 239 | T → A in AAF68963 (PubMed:11097837).Curated | 1 | |
Sequence conflicti | 242 | T → M in AAF68963 (PubMed:11097837).Curated | 1 | |
Sequence conflicti | 283 | E → K in AAF68963 (PubMed:11097837).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051640 | 417 – 473 | PAPKP…TSAFL → ELRRTMTEEGTERYSLRNQG SCAVISQLYLNEVLGFENLE EISLRCETWKSGLFRIL in isoform 2. 1 PublicationAdd BLAST | 57 | |
Alternative sequenceiVSP_051641 | 474 – 513 | Missing in isoform 2. 1 PublicationAdd BLAST | 40 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302031 mRNA Translation: CAC19029.1 BC089771 mRNA Translation: AAH89771.1 AF236054 mRNA Translation: AAF68963.1 Different initiation. |
RefSeqi | NP_071594.2, NM_022258.2 |
Genome annotation databases
Ensembli | ENSRNOT00000006273; ENSRNOP00000006273; ENSRNOG00000004692 [Q9EPH1-1] |
GeneIDi | 140656 |
KEGGi | rno:140656 |
UCSCi | RGD:69417, rat [Q9EPH1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ302031 mRNA Translation: CAC19029.1 BC089771 mRNA Translation: AAH89771.1 AF236054 mRNA Translation: AAF68963.1 Different initiation. |
RefSeqi | NP_071594.2, NM_022258.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006273 |
Protein family/group databases
MEROPSi | I43.950 |
PTM databases
GlyGeni | Q9EPH1, 7 sites |
SwissPalmi | Q9EPH1 |
Proteomic databases
PaxDbi | Q9EPH1 |
PRIDEi | Q9EPH1 |
Genome annotation databases
Ensembli | ENSRNOT00000006273; ENSRNOP00000006273; ENSRNOG00000004692 [Q9EPH1-1] |
GeneIDi | 140656 |
KEGGi | rno:140656 |
UCSCi | RGD:69417, rat [Q9EPH1-1] |
Organism-specific databases
CTDi | 1 |
RGDi | 69417, A1bg |
Phylogenomic databases
eggNOGi | ENOG502RYEX, Eukaryota |
GeneTreei | ENSGT00980000198504 |
HOGENOMi | CLU_042929_1_0_1 |
InParanoidi | Q9EPH1 |
OMAi | IKHQFLL |
OrthoDBi | 1327293at2759 |
PhylomeDBi | Q9EPH1 |
TreeFami | TF336644 |
Enzyme and pathway databases
Reactomei | R-RNO-114608, Platelet degranulation R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:Q9EPH1 |
Gene expression databases
Bgeei | ENSRNOG00000004692, Expressed in liver and 8 other tissues |
Genevisiblei | Q9EPH1, RN |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR016332, A1B_glyco/leuk_Ig-like_rcpt IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
PIRSFi | PIRSF001979, Alpha_1B_glycoprot_prd, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 3 hits |
SUPFAMi | SSF48726, SSF48726, 5 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A1BG_RAT | |
Accessioni | Q9EPH1Primary (citable) accession number: Q9EPH1 Secondary accession number(s): Q5EBD6, Q9JKL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | August 12, 2020 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |