Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9EPE9 (AT131_MOUSE)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Manganese-transporting ATPase 13A1

Gene

Atp13a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei5304-aspartylphosphate intermediateBy similarity1
Metal bindingi861MagnesiumBy similarity1
Metal bindingi865MagnesiumBy similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese-transporting ATPase 13A1 (EC:3.6.3.-)
Short name:
CATP
Gene namesi
Name:Atp13a1
Synonyms:Atp13a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2180801 Atp13a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 92ExtracellularSequence analysis8
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 240CytoplasmicSequence analysisAdd BLAST127
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 440ExtracellularSequence analysisAdd BLAST179
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 985CytoplasmicSequence analysisAdd BLAST524
Transmembranei986 – 1006HelicalSequence analysisAdd BLAST21
Topological domaini1007ExtracellularSequence analysis1
Transmembranei1008 – 1028HelicalSequence analysisAdd BLAST21
Topological domaini1029 – 1047CytoplasmicSequence analysisAdd BLAST19
Transmembranei1048 – 1068HelicalSequence analysisAdd BLAST21
Topological domaini1069 – 1092ExtracellularSequence analysisAdd BLAST24
Transmembranei1093 – 1113HelicalSequence analysisAdd BLAST21
Topological domaini1114 – 1128CytoplasmicSequence analysisAdd BLAST15
Transmembranei1129 – 1149HelicalSequence analysisAdd BLAST21
Topological domaini1150 – 1162ExtracellularSequence analysisAdd BLAST13
Transmembranei1163 – 1183HelicalSequence analysisAdd BLAST21
Topological domaini1184 – 1200CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464221 – 1200Manganese-transporting ATPase 13A1Add BLAST1200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi284N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei896PhosphoserineCombined sources1
Modified residuei902PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9EPE9
MaxQBiQ9EPE9
PaxDbiQ9EPE9
PeptideAtlasiQ9EPE9
PRIDEiQ9EPE9

PTM databases

iPTMnetiQ9EPE9
PhosphoSitePlusiQ9EPE9
SwissPalmiQ9EPE9

Expressioni

Gene expression databases

BgeeiENSMUSG00000031862
CleanExiMM_ATP13A1
GenevisibleiQ9EPE9 MM

Interactioni

Protein-protein interaction databases

IntActiQ9EPE9, 3 interactors
MINTiQ9EPE9
STRINGi10090.ENSMUSP00000034326

Structurei

3D structure databases

ProteinModelPortaliQ9EPE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0209 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00550000075064
HOGENOMiHOG000199432
HOVERGENiHBG050602
InParanoidiQ9EPE9
KOiK14950
OMAiQVSTFAI
OrthoDBiEOG091G00UD
TreeFamiTF300725

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EPE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVVGNAVPC GARPGGARDN GSPQPGSRLR PGLAAGPALI ANGDELVAAV 
        60         70         80         90        100
WPYRRLALLR RLTVLPFAGL LYPAWLGAAA SGCWGWGSSW TQIPEAALLA 
       110        120        130        140        150
LATICLAHAL TVLSGHWSVH AHCALTCTPE YDPNKVTFVK VVPTPNNGST 
       160        170        180        190        200
ELVALHRDKG EDGLEVLSFE FQKIKYSYDA LEKKQFLPVA FPVGNAFSYY 
       210        220        230        240        250
QSNRGFQEDS EIRAAEKKFG SNKAEMVVPD FSELFKERAT APFFVFQVFC 
       260        270        280        290        300
VGLWCLDEYW YYSVFTLSML VAFEASLVQQ QMRNMSEIRK MGNKPHMIQV 
       310        320        330        340        350
YRSRKWRPVA SDDIVPGDIV SIGRSPQENL VPCDVLLLRG RCIVDEAMLT 
       360        370        380        390        400
GESVPQMKEP IEDLSPDRVL DLQADARLHV IFGGTKVVQH IPPQKATSGL 
       410        420        430        440        450
KPVDNGCVAF VLRTGFNTSQ GRLLRTILFG VKRVTANNLE TFIFILFLLV 
       460        470        480        490        500
FAIAAAAYVW VEGTKDPSRN RYKLFLECTL ILTSVVPPEL PIELSLAVNT 
       510        520        530        540        550
SLIALAKLYM YCTEPFRIPF AGKVEVCCFD KTGTLTSDSL VVRGVAGLRD 
       560        570        580        590        600
GKEVTPVSSI PIETHRALAS CHSLMQLDDG TLVGDPLEKA MLTAVDWTLT 
       610        620        630        640        650
KDEKVFPRSI KTQGLKIHQR FHFASALKRM SVLASYEKLG STDLCYIAAV 
       660        670        680        690        700
KGAPETLHSM FSQCPPDYHH IHTEISREGA RVLALGYKEL GHLTHQQARE 
       710        720        730        740        750
IKREALECSL KFVGFIVVSC PLKADSKAVI REIQNASHRV VMITGDNPLT 
       760        770        780        790        800
ACHVAQELHF IDKAHTLILH PPSEKGQPCE WRSIDSSIVL PLTLGSPKAL 
       810        820        830        840        850
ALEHALCLTG DGLAHLQAVD PQQLLCLIPH VQVFARVAPK QKEFVITSLK 
       860        870        880        890        900
ELGYVTLMCG DGTNDVGALK HADVGVALLA NAPERVVERR RRPRDSPVLS 
       910        920        930        940        950
NSGPRVSRST KQKSALLSPE EPPASHRDRL SQVLRDLEEE STPIVKLGDA 
       960        970        980        990       1000
SIAAPFTSKL SSIQCICHVI KQGRCTLVTT LQMFKILALN ALILAYSQSV 
      1010       1020       1030       1040       1050
LYLEGVKFSD FQATLQGLLL AGCFLFISRS KPLKTLSRER PLPNIFNLYT 
      1060       1070       1080       1090       1100
ILTVMLQFSV HFLSLVYLYR EAQARSPEKQ EQFVDLYKEF EPSLVNSTVY 
      1110       1120       1130       1140       1150
IMAMAMQMAT FAINYKGPPF MESLPENKPL VWSLAVSLLA IIGLLLGSSP 
      1160       1170       1180       1190       1200
DFNSQFGLVD IPVEFKLVIG QVLALDFCLA LLADRVLQFF LGTPKLRVPS
Length:1,200
Mass (Da):132,388
Last modified:July 27, 2011 - v2
Checksum:i059C366D63030B82
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188P → S in BAB20095 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035381 mRNA Translation: BAB20095.1
CH466569 Genomic DNA Translation: EDL28752.1
BC138721 mRNA Translation: AAI38722.1
BC138722 mRNA Translation: AAI38723.1
CCDSiCCDS22349.1
RefSeqiNP_573487.2, NM_133224.2
UniGeneiMm.186066

Genome annotation databases

EnsembliENSMUST00000034326; ENSMUSP00000034326; ENSMUSG00000031862
GeneIDi170759
KEGGimmu:170759
UCSCiuc009lxr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAT131_MOUSE
AccessioniPrimary (citable) accession number: Q9EPE9
Secondary accession number(s): B2RS54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health