Atp13a1

Functionⁱ

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity).By similarity

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	530	4-aspartylphosphate intermediateBy similarity	1
Metal bindingⁱ	861	MagnesiumBy similarity	1
Metal bindingⁱ	865	MagnesiumBy similarity	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
calcium-transporting ATPase activity Source: GO_Central
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular calcium ion homeostasis Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Transport
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-936837 Ion transport by P-type ATPases

Reactomeⁱ

R-MMU-936837 Ion transport by P-type ATPases

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Manganese-transporting ATPase 13A1 (EC:3.6.3.-) Short name: CATP
Gene namesⁱ	Name:Atp13a1 Synonyms:Atp13a
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2180801 Atp13a1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 63	CytoplasmicSequence analysisAdd BLAST	63
Transmembraneⁱ	64 – 84	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	85 – 92	ExtracellularSequence analysis	8
Transmembraneⁱ	93 – 113	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	114 – 240	CytoplasmicSequence analysisAdd BLAST	127
Transmembraneⁱ	241 – 261	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	262 – 440	ExtracellularSequence analysisAdd BLAST	179
Transmembraneⁱ	441 – 461	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	462 – 985	CytoplasmicSequence analysisAdd BLAST	524
Transmembraneⁱ	986 – 1006	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1007	ExtracellularSequence analysis	1
Transmembraneⁱ	1008 – 1028	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1029 – 1047	CytoplasmicSequence analysisAdd BLAST	19
Transmembraneⁱ	1048 – 1068	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1069 – 1092	ExtracellularSequence analysisAdd BLAST	24
Transmembraneⁱ	1093 – 1113	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1114 – 1128	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	1129 – 1149	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1150 – 1162	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	1163 – 1183	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1184 – 1200	CytoplasmicSequence analysisAdd BLAST	17

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000046422	1 – 1200	Manganese-transporting ATPase 13A1Add BLAST		1200

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	284	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	417	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	896	PhosphoserineCombined sources	1
Modified residueⁱ	902	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9EPE9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9EPE9
PaxDbⁱ	Q9EPE9
PeptideAtlas More...PeptideAtlasⁱ	Q9EPE9
PRIDEⁱ	Q9EPE9

PTM databases

iPTMnetⁱ	Q9EPE9
PhosphoSitePlusⁱ	Q9EPE9
SwissPalmⁱ	Q9EPE9

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000031862 Expressed in 285 organ(s), highest expression level in pancreas
CleanExⁱ	MM_ATP13A1
Genevisibleⁱ	Q9EPE9 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q9EPE9, 3 interactors
Molecular INTeraction database More...MINTⁱ	Q9EPE9
STRINGⁱ	10090.ENSMUSP00000034326

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9EPE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0209 Eukaryota COG0474 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075064
HOGENOMⁱ	HOG000199432
HOVERGENⁱ	HBG050602
InParanoidⁱ	Q9EPE9
KEGG Orthology (KO) More...KOⁱ	K14950
OMAⁱ	QVSTFAI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00UD
TreeFamⁱ	TF300725

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006544 P-type_TPase_V IPR001757 P_typ_ATPase
SUPFAMⁱ	SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01494 ATPase_P-type, 2 hits TIGR01657 P-ATPase-V, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9EPE9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVVGNAVPC GARPGGARDN GSPQPGSRLR PGLAAGPALI ANGDELVAAV 
        60         70         80         90        100
WPYRRLALLR RLTVLPFAGL LYPAWLGAAA SGCWGWGSSW TQIPEAALLA 
       110        120        130        140        150
LATICLAHAL TVLSGHWSVH AHCALTCTPE YDPNKVTFVK VVPTPNNGST 
       160        170        180        190        200
ELVALHRDKG EDGLEVLSFE FQKIKYSYDA LEKKQFLPVA FPVGNAFSYY 
       210        220        230        240        250
QSNRGFQEDS EIRAAEKKFG SNKAEMVVPD FSELFKERAT APFFVFQVFC 
       260        270        280        290        300
VGLWCLDEYW YYSVFTLSML VAFEASLVQQ QMRNMSEIRK MGNKPHMIQV 
       310        320        330        340        350
YRSRKWRPVA SDDIVPGDIV SIGRSPQENL VPCDVLLLRG RCIVDEAMLT 
       360        370        380        390        400
GESVPQMKEP IEDLSPDRVL DLQADARLHV IFGGTKVVQH IPPQKATSGL 
       410        420        430        440        450
KPVDNGCVAF VLRTGFNTSQ GRLLRTILFG VKRVTANNLE TFIFILFLLV 
       460        470        480        490        500
FAIAAAAYVW VEGTKDPSRN RYKLFLECTL ILTSVVPPEL PIELSLAVNT 
       510        520        530        540        550
SLIALAKLYM YCTEPFRIPF AGKVEVCCFD KTGTLTSDSL VVRGVAGLRD 
       560        570        580        590        600
GKEVTPVSSI PIETHRALAS CHSLMQLDDG TLVGDPLEKA MLTAVDWTLT 
       610        620        630        640        650
KDEKVFPRSI KTQGLKIHQR FHFASALKRM SVLASYEKLG STDLCYIAAV 
       660        670        680        690        700
KGAPETLHSM FSQCPPDYHH IHTEISREGA RVLALGYKEL GHLTHQQARE 
       710        720        730        740        750
IKREALECSL KFVGFIVVSC PLKADSKAVI REIQNASHRV VMITGDNPLT 
       760        770        780        790        800
ACHVAQELHF IDKAHTLILH PPSEKGQPCE WRSIDSSIVL PLTLGSPKAL 
       810        820        830        840        850
ALEHALCLTG DGLAHLQAVD PQQLLCLIPH VQVFARVAPK QKEFVITSLK 
       860        870        880        890        900
ELGYVTLMCG DGTNDVGALK HADVGVALLA NAPERVVERR RRPRDSPVLS 
       910        920        930        940        950
NSGPRVSRST KQKSALLSPE EPPASHRDRL SQVLRDLEEE STPIVKLGDA 
       960        970        980        990       1000
SIAAPFTSKL SSIQCICHVI KQGRCTLVTT LQMFKILALN ALILAYSQSV 
      1010       1020       1030       1040       1050
LYLEGVKFSD FQATLQGLLL AGCFLFISRS KPLKTLSRER PLPNIFNLYT 
      1060       1070       1080       1090       1100
ILTVMLQFSV HFLSLVYLYR EAQARSPEKQ EQFVDLYKEF EPSLVNSTVY 
      1110       1120       1130       1140       1150
IMAMAMQMAT FAINYKGPPF MESLPENKPL VWSLAVSLLA IIGLLLGSSP 
      1160       1170       1180       1190       1200
DFNSQFGLVD IPVEFKLVIG QVLALDFCLA LLADRVLQFF LGTPKLRVPS

Length:1,200

Mass (Da):132,388

Last modified:July 27, 2011 - v2

Checksum:ⁱ059C366D63030B82

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	188	P → S in BAB20095 (Ref. 1) Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035381 mRNA Translation: BAB20095.1 CH466569 Genomic DNA Translation: EDL28752.1 BC138721 mRNA Translation: AAI38722.1 BC138722 mRNA Translation: AAI38723.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22349.1
NCBI Reference Sequences More...RefSeqⁱ	NP_573487.2, NM_133224.2
UniGeneⁱ	Mm.186066

Genome annotation databases

Ensemblⁱ	ENSMUST00000034326; ENSMUSP00000034326; ENSMUSG00000031862
GeneIDⁱ	170759
KEGGⁱ	mmu:170759
UCSC genome browser More...UCSCⁱ	uc009lxr.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9EPE9	Manganese-transporting ATPase 13A1		HUMAN		1204	UniRef90_Q9HD20
Cation-transporting ATPase		MACMU		1246
Cation-transporting ATPase		RHIBE		1243
Cation-transporting ATPase		NEOLE		1211
Cation-transporting ATPase		MACNE		1209
+141

Protein	Similar proteins		Species	Score	Length	Source
Q9EPE9	Manganese-transporting ATPase 13A1		HUMAN		1204	UniRef50_Q9HD20
Cation-transporting ATPase		MACMU		1246
Cation-transporting ATPase		RHIBE		1243
Cation-transporting ATPase		NEOLE		1211
Cation-transporting ATPase		MACFA		1209
+303

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB035381 mRNA Translation: BAB20095.1 CH466569 Genomic DNA Translation: EDL28752.1 BC138721 mRNA Translation: AAI38722.1 BC138722 mRNA Translation: AAI38723.1
CCDSⁱ	CCDS22349.1
RefSeqⁱ	NP_573487.2, NM_133224.2
UniGeneⁱ	Mm.186066

3D structure databases

ProteinModelPortalⁱ	Q9EPE9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q9EPE9, 3 interactors
MINTⁱ	Q9EPE9
STRINGⁱ	10090.ENSMUSP00000034326

PTM databases

iPTMnetⁱ	Q9EPE9
PhosphoSitePlusⁱ	Q9EPE9
SwissPalmⁱ	Q9EPE9

Proteomic databases

EPDⁱ	Q9EPE9
MaxQBⁱ	Q9EPE9
PaxDbⁱ	Q9EPE9
PeptideAtlasⁱ	Q9EPE9
PRIDEⁱ	Q9EPE9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000034326; ENSMUSP00000034326; ENSMUSG00000031862
GeneIDⁱ	170759
KEGGⁱ	mmu:170759
UCSCⁱ	uc009lxr.2 mouse

Organism-specific databases

CTDⁱ	57130
MGIⁱ	MGI:2180801 Atp13a1

Phylogenomic databases

eggNOGⁱ	KOG0209 Eukaryota COG0474 LUCA
GeneTreeⁱ	ENSGT00550000075064
HOGENOMⁱ	HOG000199432
HOVERGENⁱ	HBG050602
InParanoidⁱ	Q9EPE9
KOⁱ	K14950
OMAⁱ	QVSTFAI
OrthoDBⁱ	EOG091G00UD
TreeFamⁱ	TF300725

Enzyme and pathway databases

Reactomeⁱ	R-MMU-936837 Ion transport by P-type ATPases

Reactomeⁱ

R-MMU-936837 Ion transport by P-type ATPases

Miscellaneous databases

ChiTaRSⁱ	Atp13a1 mouse
Protein Ontology More...PROⁱ	PR:Q9EPE9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031862 Expressed in 285 organ(s), highest expression level in pancreas
CleanExⁱ	MM_ATP13A1
Genevisibleⁱ	Q9EPE9 MM

Family and domain databases

Gene3Dⁱ	3.40.1110.10, 1 hit 3.40.50.1000, 1 hit
InterProⁱ	View protein in InterPro IPR023299 ATPase_P-typ_cyto_dom_N IPR018303 ATPase_P-typ_P_site IPR023298 ATPase_P-typ_TM_dom_sf IPR008250 ATPase_P-typ_transduc_dom_A_sf IPR036412 HAD-like_sf IPR023214 HAD_sf IPR006544 P-type_TPase_V IPR001757 P_typ_ATPase
SUPFAMⁱ	SSF56784 SSF56784, 3 hits SSF81653 SSF81653, 1 hit SSF81660 SSF81660, 1 hit SSF81665 SSF81665, 3 hits
TIGRFAMsⁱ	TIGR01494 ATPase_P-type, 2 hits TIGR01657 P-ATPase-V, 1 hit
PROSITEⁱ	View protein in PROSITE PS00154 ATPASE_E1_E2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AT131_MOUSE
Accessionⁱ	Q9EPE9Primary (citable) accession number: Q9EPE9 Secondary accession number(s): B2RS54
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	July 27, 2011
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9EPE9 (AT131_MOUSE)

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Manganese-transporting ATPase 13A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ