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Protein

Alpha-parvin

Gene

Parva

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development.2 Publications

GO - Molecular functioni

  • actin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processAngiogenesis, Cell adhesion, Cell shape, Chemotaxis, Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-parvin
Alternative name(s):
Actopaxin
Gene namesi
Name:Parva
Synonyms:Actp
ORF Names:MNCb-0301
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1931144 Parva

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethality, due to severe cardiovascular defects causing whole body edema and severe bleeding due to vessel rupture. Embryos show defects in the septation of the heart outflow tract. Their cardiomyocytes are round and fail to align in a parallel manner. Blood vessels are frequently enlarged and show numerous microaneurisms. Besides, blood vessels show abnormal constrictions and increased vascular sprouting. Vascular mural cells and pericytes display a rounded shape and impaired adhesion to the underlying vascular endothelium. Cells display highly dynamic formation of membrane ruffles with increased random motility, but impaired chemotaxis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001215812 – 372Alpha-parvinAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei28PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9EPC1
PaxDbiQ9EPC1
PeptideAtlasiQ9EPC1
PRIDEiQ9EPC1

PTM databases

iPTMnetiQ9EPC1
PhosphoSitePlusiQ9EPC1

Expressioni

Gene expression databases

BgeeiENSMUSG00000030770 Expressed in 298 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_PARVA
ExpressionAtlasiQ9EPC1 baseline and differential
GenevisibleiQ9EPC1 MM

Interactioni

Subunit structurei

Interacts with ARHGAP31. Interacts with TGFB1I1. Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with the actin cytoskeleton.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IlkO552226EBI-6690233,EBI-6690138

GO - Molecular functioni

Protein-protein interaction databases

BioGridi208263, 2 interactors
CORUMiQ9EPC1
DIPiDIP-57658N
IntActiQ9EPC1, 3 interactors
MINTiQ9EPC1
STRINGi10090.ENSMUSP00000033030

Structurei

3D structure databases

ProteinModelPortaliQ9EPC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 202Calponin-homology (CH) 1PROSITE-ProRule annotationAdd BLAST108
Domaini262 – 369Calponin-homology (CH) 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 25Interaction with ARHGAP311 Publication5

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9EPC1
KOiK06275
OrthoDBiEOG091G0ULB
PhylomeDBiQ9EPC1
TreeFamiTF314025

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9EPC1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSPQKSPL VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSEFQ
60 70 80 90 100
EEGMNAINLP LSPISFELDP EDTLLEENEV RTMVDPNSRN DPKLQELMKV
110 120 130 140 150
LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE
160 170 180 190 200
IAQKQKLQTV LEKINETLKL PPRSIKWNVD SVHAKNLVAI LHLLVALSQY
210 220 230 240 250
FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF
260 270 280 290 300
DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
310 320 330 340 350
GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV
360 370
NCDLKSTLRV LYNLFTKYRN VE
Length:372
Mass (Da):42,330
Last modified:March 1, 2001 - v1
Checksum:i1251F2586A1ACBC6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UF75Q3UF75_MOUSE
Alpha-parvin
Parva
336Annotation score:
D6RHM9D6RHM9_MOUSE
Alpha-parvin
Parva
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33L → H in BAA97981 (Ref. 3) Curated1
Sequence conflicti66F → S in BAA97981 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237774 mRNA Translation: AAG27175.1
AF264766 mRNA Translation: AAG09803.1
AB045321 mRNA Translation: BAA97981.1
BC059236 mRNA Translation: AAH59236.1
CCDSiCCDS40091.1
RefSeqiNP_065631.3, NM_020606.5
UniGeneiMm.143763

Genome annotation databases

EnsembliENSMUST00000033030; ENSMUSP00000033030; ENSMUSG00000030770
ENSMUST00000106643; ENSMUSP00000102254; ENSMUSG00000030770
GeneIDi57342
KEGGimmu:57342
UCSCiuc009jgt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237774 mRNA Translation: AAG27175.1
AF264766 mRNA Translation: AAG09803.1
AB045321 mRNA Translation: BAA97981.1
BC059236 mRNA Translation: AAH59236.1
CCDSiCCDS40091.1
RefSeqiNP_065631.3, NM_020606.5
UniGeneiMm.143763

3D structure databases

ProteinModelPortaliQ9EPC1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208263, 2 interactors
CORUMiQ9EPC1
DIPiDIP-57658N
IntActiQ9EPC1, 3 interactors
MINTiQ9EPC1
STRINGi10090.ENSMUSP00000033030

PTM databases

iPTMnetiQ9EPC1
PhosphoSitePlusiQ9EPC1

Proteomic databases

MaxQBiQ9EPC1
PaxDbiQ9EPC1
PeptideAtlasiQ9EPC1
PRIDEiQ9EPC1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033030; ENSMUSP00000033030; ENSMUSG00000030770
ENSMUST00000106643; ENSMUSP00000102254; ENSMUSG00000030770
GeneIDi57342
KEGGimmu:57342
UCSCiuc009jgt.1 mouse

Organism-specific databases

CTDi55742
MGIiMGI:1931144 Parva

Phylogenomic databases

eggNOGiKOG3631 Eukaryota
ENOG410XQWH LUCA
GeneTreeiENSGT00390000009673
HOGENOMiHOG000247027
HOVERGENiHBG053517
InParanoidiQ9EPC1
KOiK06275
OrthoDBiEOG091G0ULB
PhylomeDBiQ9EPC1
TreeFamiTF314025

Miscellaneous databases

ChiTaRSiParva mouse
PROiPR:Q9EPC1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030770 Expressed in 298 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_PARVA
ExpressionAtlasiQ9EPC1 baseline and differential
GenevisibleiQ9EPC1 MM

Family and domain databases

Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR028433 Parvin
PANTHERiPTHR12114 PTHR12114, 1 hit
PfamiView protein in Pfam
PF00307 CH, 2 hits
PIRSFiPIRSF039131 Parvin, 1 hit
SMARTiView protein in SMART
SM00033 CH, 2 hits
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPARVA_MOUSE
AccessioniPrimary (citable) accession number: Q9EPC1
Secondary accession number(s): Q9JJ65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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