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UniProtKB - Q9EPB7 (GPR88_MOUSE)
Protein
Probable G-protein coupled receptor 88
Gene
Gpr88
Organism
Mus musculus (Mouse)
Status
Functioni
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.
By similarity1 PublicationGO - Molecular functioni
- cytoskeletal motor activity Source: UniProtKB
- G protein-coupled photoreceptor activity Source: GO_Central
- G protein-coupled receptor activity Source: MGI
- transmembrane signaling receptor activity Source: MGI
GO - Biological processi
- cellular response to light stimulus Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- locomotory behavior Source: MGI
- motor learning Source: UniProtKB
- neuromuscular process controlling balance Source: MGI
- neuronal action potential Source: MGI
- phototransduction Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 88Alternative name(s): Striatum-specific G-protein coupled receptor |
Gene namesi | Name:Gpr88 Synonyms:Strg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1927653, Gpr88 |
VEuPathDBi | HostDB:ENSMUSG00000068696 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood.By similarity
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 73 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 74 – 94 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 116 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 117 – 136 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 137 – 158 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 159 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 195 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 196 – 216 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 217 – 285 | CytoplasmicSequence analysisAdd BLAST | 69 | |
Transmembranei | 286 – 306 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 307 – 310 | ExtracellularSequence analysis | 4 | |
Transmembranei | 311 – 331 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 332 – 384 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
Mice have increased locomotion, increased motor stereotypical behavior, and impaired motor skill learning. Mutant mice also show facilitated hippocampal-mediated behaviors and decreased anxiety. Chronic blockade of delta opioid receptors and mu opioid, but not other Gi/o coupled receptors, using delta opioid receptor antagonist partially improved motor coordination and normalized spatial navigation and anxiety of mutant mice.1 Publication
Chemistry databases
ChEMBLi | CHEMBL3879835 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069598 | 1 – 384 | Probable G-protein coupled receptor 88Add BLAST | 384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9EPB7 |
PRIDEi | Q9EPB7 |
ProteomicsDBi | 271072 |
PTM databases
GlyGeni | Q9EPB7, 1 site |
PhosphoSitePlusi | Q9EPB7 |
Expressioni
Tissue specificityi
Expressed predominantly in the striatum.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000068696, Expressed in dorsal striatum and 230 other tissues |
Genevisiblei | Q9EPB7, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000087959 |
Chemistry databases
BindingDBi | Q9EPB7 |
Miscellaneous databases
RNActi | Q9EPB7, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000009609 |
HOGENOMi | CLU_053532_0_0_1 |
InParanoidi | Q9EPB7 |
OMAi | EPPGDWD |
OrthoDBi | 1258797at2759 |
PhylomeDBi | Q9EPB7 |
TreeFami | TF336499 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9EPB7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPSGSAE
110 120 130 140 150
PPGDWDGGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTVG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGPGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JGJ3 | A0A0G2JGJ3_MOUSE | Probable G-protein-coupled receptor... | Gpr88 | 32 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042408 mRNA Translation: BAB18245.1 AB042409 Genomic DNA Translation: BAB18246.1 BC051941 mRNA Translation: AAH51941.1 |
CCDSi | CCDS38610.1 |
RefSeqi | NP_071872.1, NM_022427.2 XP_006501919.1, XM_006501856.1 XP_006501920.1, XM_006501857.1 |
Genome annotation databases
Ensembli | ENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696 |
GeneIDi | 64378 |
KEGGi | mmu:64378 |
UCSCi | uc008rbz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB042408 mRNA Translation: BAB18245.1 AB042409 Genomic DNA Translation: BAB18246.1 BC051941 mRNA Translation: AAH51941.1 |
CCDSi | CCDS38610.1 |
RefSeqi | NP_071872.1, NM_022427.2 XP_006501919.1, XM_006501856.1 XP_006501920.1, XM_006501857.1 |
3D structure databases
SMRi | Q9EPB7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000087959 |
Chemistry databases
BindingDBi | Q9EPB7 |
ChEMBLi | CHEMBL3879835 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9EPB7, 1 site |
PhosphoSitePlusi | Q9EPB7 |
Proteomic databases
PaxDbi | Q9EPB7 |
PRIDEi | Q9EPB7 |
ProteomicsDBi | 271072 |
Protocols and materials databases
Antibodypediai | 19999, 205 antibodies from 26 providers |
DNASUi | 64378 |
Genome annotation databases
Ensembli | ENSMUST00000090473; ENSMUSP00000087959; ENSMUSG00000068696 |
GeneIDi | 64378 |
KEGGi | mmu:64378 |
UCSCi | uc008rbz.2, mouse |
Organism-specific databases
CTDi | 54112 |
MGIi | MGI:1927653, Gpr88 |
VEuPathDBi | HostDB:ENSMUSG00000068696 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000009609 |
HOGENOMi | CLU_053532_0_0_1 |
InParanoidi | Q9EPB7 |
OMAi | EPPGDWD |
OrthoDBi | 1258797at2759 |
PhylomeDBi | Q9EPB7 |
TreeFami | TF336499 |
Miscellaneous databases
BioGRID-ORCSi | 64378, 1 hit in 63 CRISPR screens |
PROi | PR:Q9EPB7 |
RNActi | Q9EPB7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068696, Expressed in dorsal striatum and 230 other tissues |
Genevisiblei | Q9EPB7, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR88_MOUSE | |
Accessioni | Q9EPB7Primary (citable) accession number: Q9EPB7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families