Pycard

Functionⁱ

Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Required for recruitment of caspase-1 to inflammasomes containing certain pattern recognition receptors, such as NLRP2, NLRP3, AIM2 and probably IFI16. In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1. In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation. May be involved in DDX58-triggered proinflammatory responses and inflammasome activation. In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8. In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form. Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways. For regulation of NF-kappa-B activating and inhibiting functions have been reported. Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK. Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing. Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA (PubMed:28314590).5 Publications

GO - Molecular functionⁱ

BMP receptor binding Source: MGI
cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
enzyme binding Source: MGI
identical protein binding Source: MGI
interleukin-6 receptor binding Source: MGI
ion channel binding Source: MGI
myosin I binding Source: MGI
peptidase activator activity involved in apoptotic process
Source: MGI
Inferred from sequence orthologyⁱ
- 11139337
protease binding Source: MGI
protein dimerization activity
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24407287
protein homodimerization activity Source: HGNC
Pyrin domain binding Source: HGNC
tropomyosin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity
Source: CACAO
Inferred from mutant phenotypeⁱ
- 23302887
activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 17008311
activation of innate immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19158675
apoptotic process
Source: MGI
Inferred from sequence orthologyⁱ
- 11139337
cellular response to interleukin-1 Source: MGI
cellular response to lipopolysaccharide Source: MGI
cellular response to tumor necrosis factor Source: MGI
defense response to Gram-negative bacterium Source: MGI
defense response to virus Source: MGI
inflammatory response
Source: MGI
Inferred from mutant phenotypeⁱ
- 15190255
innate immune response Source: UniProtKB-KW
interleukin-1 beta production
Source: MGI
Inferred from genetic interactionⁱ
- 19158679
intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
macropinocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
myeloid dendritic cell activation Source: MGI
myeloid dendritic cell activation involved in immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
negative regulation of interferon-beta production Source: MGI
negative regulation of NF-kappaB transcription factor activity Source: MGI
negative regulation of protein serine/threonine kinase activity Source: MGI
positive regulation of actin filament polymerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of activated T cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of adaptive immune response Source: MGI
positive regulation of antigen processing and presentation of peptide antigen via MHC class II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of apoptotic process Source: MGI
positive regulation of chemokine secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21487011
positive regulation of cysteine-type endopeptidase activity Source: MGI
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: HGNC
positive regulation of defense response to virus by host
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19158675
positive regulation of DNA-binding transcription factor activity Source: MGI
positive regulation of ERK1 and ERK2 cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21487011
positive regulation of extrinsic apoptotic signaling pathway Source: MGI
positive regulation of interferon-gamma production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of interleukin-10 secretion Source: MGI
positive regulation of interleukin-1 beta secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19158675
positive regulation of interleukin-6 production
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of interleukin-6 secretion Source: MGI
positive regulation of interleukin-8 secretion Source: MGI
positive regulation of JNK cascade Source: MGI
positive regulation of NF-kappaB transcription factor activity Source: MGI
positive regulation of phagocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of release of cytochrome c from mitochondria Source: MGI
positive regulation of T cell activation Source: MGI
positive regulation of T cell migration
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
positive regulation of tumor necrosis factor production Source: MGI
regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15190255
regulation of autophagy
Source: MGI
Inferred from mutant phenotypeⁱ
- 24581500
regulation of cysteine-type endopeptidase activity involved in apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 15190255
regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
regulation of inflammatory response
Source: MGI
Inferred from mutant phenotypeⁱ
- 22002608
- 22297845
regulation of intrinsic apoptotic signaling pathway Source: MGI
regulation of protein stability
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21892172
regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
response to bacterium
Source: MGI
Inferred from mutant phenotypeⁱ
- 24581500
tumor necrosis factor-mediated signaling pathway Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Immunity, Inflammatory response, Innate immunity

Biological process

Apoptosis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5660668 CLEC7A/inflammasome pathway R-MMU-6798695 Neutrophil degranulation R-MMU-844456 The NLRP3 inflammasome

Reactomeⁱ

R-MMU-5660668 CLEC7A/inflammasome pathway
R-MMU-6798695 Neutrophil degranulation
R-MMU-844456 The NLRP3 inflammasome

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Apoptosis-associated speck-like protein containing a CARD Short name: mASC Alternative name(s): PYD and CARD domain-containing protein
Gene namesⁱ	Name:Pycard Synonyms:Asc
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1931465 Pycard

Keywords - Cellular componentⁱ

Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Increased resistance to endotoxic shock and severe defects in caspase-1 activation and interleukin-1 beta and interleukin-18 production in macrophages in response to several pro-inflammatory molecules (PubMed:15190255, PubMed:15507117). Mutants are resitant to vaccinia virus (VACV) but not vesicular somatitis virus (VSV) infection. They show lower viral loads in the lungs compared to wild type mice, they produce higher levels of type I IFN, IL6 and RSAD2/Viperin after VCAV INFECTION (PubMed:28314590).3 Publications

Keywords - Diseaseⁱ

Tumor suppressor

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064693	1 – 193	Apoptosis-associated speck-like protein containing a CARDAdd BLAST		193

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	193	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9EPB4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9EPB4
PaxDbⁱ	Q9EPB4
PRIDEⁱ	Q9EPB4

PTM databases

iPTMnetⁱ	Q9EPB4
PhosphoSitePlusⁱ	Q9EPB4

Expressionⁱ

Tissue specificityⁱ

Expressed in small intestine, colon, thymus, spleen, brain, heart, skeletal muscle, kidney, lung and liver.

Developmental stageⁱ

Strongly expressed at E9.5 in the telencephalon, thalamic areas of the diencephalon, heart and liver.

Gene expression databases

Bgeeⁱ	ENSMUSG00000030793 Expressed in 228 organ(s), highest expression level in small intestine
CleanExⁱ	MM_PYCARD
ExpressionAtlasⁱ	Q9EPB4 baseline and differential
Genevisibleⁱ	Q9EPB4 MM

Interactionⁱ

Subunit structureⁱ

Self-associates; enforced oligomerization induces apoptosis, NF-kappa-B regulation and interleukin-1 beta secretion. Homooligomers can form disk-like particles of approximately 12 nm diameter and approximately 1 nm height. Component of several inflammasomes containing one pattern recognition receptor/sensor, such as NLRP1, NLRP2, NLRP3, AIM2, MEFV or NOD2, and probably NLRC4, NLRP12 or IFI16. Major component of the ASC pyroptosome, a 1-2 um supramolecular assembly (one per macrophage cell) which consists of oligomerized PYCARD dimers and CASP1. Interacts with CASP1 (precursor form); the interaction induces activation of CASP1 leading to the processing of interleukin-1 beta; PYCARD competes with RIPK2 for binding to CASP1. Interacts with NLRP3; the interaction requires the homooligomerization of NLRP3. Interacts with NLRP2, NLRC4, MEFV, CARD16, AIM2, IFI16, NOD2, DDX58, RIPK2, PYDC1, PYDC2, NLRP10, CASP8, CHUK, IKBKB and BAX.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Casp1	P29452	2	EBI-6253348,EBI-489700
Nlrp3	Q8R4B8	3	EBI-6253348,EBI-6910832

GO - Molecular functionⁱ

BMP receptor binding Source: MGI
enzyme binding Source: MGI
identical protein binding Source: MGI
interleukin-6 receptor binding Source: MGI
ion channel binding Source: MGI
myosin I binding Source: MGI
protease binding Source: MGI
protein dimerization activity
Source: AgBase
Inferred from mutant phenotypeⁱ
- 24407287
protein homodimerization activity Source: HGNC
Pyrin domain binding Source: HGNC
tropomyosin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	211743, 3 interactors
Database of interacting proteins More...DIPⁱ	DIP-27619N
IntActⁱ	Q9EPB4, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q9EPB4
STRINGⁱ	10090.ENSMUSP00000033056

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9EPB4
SMRⁱ	Q9EPB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 91	PyrinPROSITE-ProRule annotationAdd BLAST		91
Domainⁱ	105 – 193	CARDPROSITE-ProRule annotationAdd BLAST		89

Domainⁱ

The CARD domain mediates interaction with CASP1 and NLRC4.By similarity

The pyrin domain mediates homotypic interactions with pyrin domains of proteins such as of NLRP3, PYDC1, PYDC2 and AIM2.By similarity

Phylogenomic databases

eggNOGⁱ	ENOG410J02A Eukaryota ENOG4111XEQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00440000033973
HOGENOMⁱ	HOG000034090
HOVERGENⁱ	HBG018739
InParanoidⁱ	Q9EPB4
KEGG Orthology (KO) More...KOⁱ	K12799
OMAⁱ	AWNLTCK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OWO
PhylomeDBⁱ	Q9EPB4
TreeFamⁱ	TF337882

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08330 CARD_ASC_NALP1, 1 hit
InterProⁱ	View protein in InterPro IPR001315 CARD IPR033516 CARD8/ASC/NALP1_CARD IPR004020 DAPIN IPR011029 DEATH-like_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 2 hits
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit PS50824 DAPIN, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9EPB4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGRARDAILD ALENLSGDEL KKFKMKLLTV QLREGYGRIP RGALLQMDAI 
        60         70         80         90        100
DLTDKLVSYY LESYGLELTM TVLRDMGLQE LAEQLQTTKE ESGAVAAAAS 
       110        120        130        140        150
VPAQSTARTG HFVDQHRQAL IARVTEVDGV LDALHGSVLT EGQYQAVRAE 
       160        170        180        190 
TTSQDKMRKL FSFVPSWNLT CKDSLLQALK EIHPYLVMDL EQS

Length:193

Mass (Da):21,459

Last modified:March 1, 2001 - v1

Checksum:ⁱ2A4EA40194870B31

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0U1RQ20	A0A0U1RQ20_MOUSE		Apoptosis-associated speck-like pro... Apoptosis-associated speck-like protein-containing a CARD	Pycard	151	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	159	K → E in BAB31341 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032249 mRNA Translation: BAB16609.1 AF310104 mRNA Translation: AAG30287.1 AK009852 mRNA Translation: BAB26543.1 AK007742 mRNA Translation: BAB25229.1 AK018682 mRNA Translation: BAB31341.1 BC008252 mRNA Translation: AAH08252.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21888.1
NCBI Reference Sequences More...RefSeqⁱ	NP_075747.3, NM_023258.4
UniGeneⁱ	Mm.24163

Genome annotation databases

Ensemblⁱ	ENSMUST00000033056; ENSMUSP00000033056; ENSMUSG00000030793
GeneIDⁱ	66824
KEGGⁱ	mmu:66824
UCSC genome browser More...UCSCⁱ	uc009jxu.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9EPB4	Apoptosis-associated speck-like protein containing CARD		MOUSE		193	UniRef100_Q9EPB4
Apoptosis-associated speck-like protein-containing a CARD (Fragment)		MOUSE		151
UPI0006CE4950		MOUSE		89

Protein	Similar proteins		Species	Score	Length	Source
Q9EPB4	Apoptosis-associated speck-like protein containing CARD		MOUSE		193	UniRef90_Q9EPB4
UPI000A30417F		MUSPA		193
UPI000A31B2CA		MUSCR		193
Apoptosis-associated speck-like protein-containing a CARD (Fragment)		MOUSE		151
UPI0006CE4950		MOUSE		89

Protein	Similar proteins		Species	Score	Length	Source
Q9EPB4	Apoptosis-associated speck-like protein containing a CARD		BOVIN		195	UniRef50_Q9EPB4
Apoptosis-associated speck-like protein containing CARD		MOUSE		193
apoptosis-associated speck-like protein containing a CARD		MESAU		192
apoptosis-associated speck-like protein containing a CARD		Florida manatee		205
Uncharacterized protein		PROCO		176
+130

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB032249 mRNA Translation: BAB16609.1 AF310104 mRNA Translation: AAG30287.1 AK009852 mRNA Translation: BAB26543.1 AK007742 mRNA Translation: BAB25229.1 AK018682 mRNA Translation: BAB31341.1 BC008252 mRNA Translation: AAH08252.1
CCDSⁱ	CCDS21888.1
RefSeqⁱ	NP_075747.3, NM_023258.4
UniGeneⁱ	Mm.24163

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2N1F	Other	4.00	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O	2-90	[»]
ProteinModelPortalⁱ	Q9EPB4
SMRⁱ	Q9EPB4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	211743, 3 interactors
DIPⁱ	DIP-27619N
IntActⁱ	Q9EPB4, 10 interactors
MINTⁱ	Q9EPB4
STRINGⁱ	10090.ENSMUSP00000033056

PTM databases

iPTMnetⁱ	Q9EPB4
PhosphoSitePlusⁱ	Q9EPB4

Proteomic databases

EPDⁱ	Q9EPB4
MaxQBⁱ	Q9EPB4
PaxDbⁱ	Q9EPB4
PRIDEⁱ	Q9EPB4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	66824
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033056; ENSMUSP00000033056; ENSMUSG00000030793
GeneIDⁱ	66824
KEGGⁱ	mmu:66824
UCSCⁱ	uc009jxu.2 mouse

Organism-specific databases

CTDⁱ	29108
MGIⁱ	MGI:1931465 Pycard

Phylogenomic databases

eggNOGⁱ	ENOG410J02A Eukaryota ENOG4111XEQ LUCA
GeneTreeⁱ	ENSGT00440000033973
HOGENOMⁱ	HOG000034090
HOVERGENⁱ	HBG018739
InParanoidⁱ	Q9EPB4
KOⁱ	K12799
OMAⁱ	AWNLTCK
OrthoDBⁱ	EOG091G0OWO
PhylomeDBⁱ	Q9EPB4
TreeFamⁱ	TF337882

Enzyme and pathway databases

Reactomeⁱ	R-MMU-5660668 CLEC7A/inflammasome pathway R-MMU-6798695 Neutrophil degranulation R-MMU-844456 The NLRP3 inflammasome

Reactomeⁱ

R-MMU-5660668 CLEC7A/inflammasome pathway
R-MMU-6798695 Neutrophil degranulation
R-MMU-844456 The NLRP3 inflammasome

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9EPB4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030793 Expressed in 228 organ(s), highest expression level in small intestine
CleanExⁱ	MM_PYCARD
ExpressionAtlasⁱ	Q9EPB4 baseline and differential
Genevisibleⁱ	Q9EPB4 MM

Family and domain databases

CDDⁱ	cd08330 CARD_ASC_NALP1, 1 hit
InterProⁱ	View protein in InterPro IPR001315 CARD IPR033516 CARD8/ASC/NALP1_CARD IPR004020 DAPIN IPR011029 DEATH-like_dom_sf
Pfamⁱ	View protein in Pfam PF00619 CARD, 1 hit PF02758 PYRIN, 1 hit
SMARTⁱ	View protein in SMART SM01289 PYRIN, 1 hit
SUPFAMⁱ	SSF47986 SSF47986, 2 hits
PROSITEⁱ	View protein in PROSITE PS50209 CARD, 1 hit PS50824 DAPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ASC_MOUSE
Accessionⁱ	Q9EPB4Primary (citable) accession number: Q9EPB4 Secondary accession number(s): Q9D2W9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	March 1, 2001
	Last modified:	September 12, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9EPB4 (ASC_MOUSE)

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Apoptosis-associated speck-like protein containing a CARD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Nucleus

Endoplasmic reticulum

Other locations

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ