Hamartin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATPase inhibitor activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.10

    "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients."
    Woodford M.R., Sager R.A., Marris E., Dunn D.M., Blanden A.R., Murphy R.L., Rensing N., Shapiro O., Panaretou B., Prodromou C., Loh S.N., Gutmann D.H., Bourboulia D., Bratslavsky G., Wong M., Mollapour M.
    EMBO J. 36:3650-3665(2017) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HSP90AA1, DISRUPTION PHENOTYPE.
• chaperone binding Source: MGI
• GTPase activating protein binding Source: MGI
• Hsp70 protein binding Source: MGI
• Hsp90 protein binding Source: MGI
• protein N-terminus binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho."
    Lamb R.F., Roy C., Diefenbach T.J., Vinters H.V., Johnson M.W., Jay D.G., Hall A.
    Nat. Cell Biol. 2:281-287(2000) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of GTPase activity Source: MGI
• adaptive immune response Source: MGIInferred from mutant phenotypeⁱ
  • "Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs."
    Shrestha S., Yang K., Wei J., Karmaus P.W., Neale G., Chi H.
    Proc. Natl. Acad. Sci. U.S.A. 111:14858-14863(2014) [PubMed] [Europe PMC] [Abstract]
• adult locomotory behavior Source: ParkinsonsUK-UCL
• cardiac muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.2

    "A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice."
    Kobayashi T., Minowa O., Sugitani Y., Takai S., Mitani H., Kobayashi E., Noda T., Hino O.
    Proc. Natl. Acad. Sci. U.S.A. 98:8762-8767(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• cell-matrix adhesion Source: MGI
• cell projection organization Source: MGIInferred from mutant phenotypeⁱ
  • "Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2."
    Tavazoie S.F., Alvarez V.A., Ridenour D.A., Kwiatkowski D.J., Sabatini B.L.
    Nat. Neurosci. 8:1727-1734(2005) [PubMed] [Europe PMC] [Abstract]
• cellular response to oxygen-glucose deprivation Source: ParkinsonsUK-UCL
• cerebral cortex development Source: MGIInferred from mutant phenotypeⁱ
  • "A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival."
    Meikle L., Talos D.M., Onda H., Pollizzi K., Rotenberg A., Sahin M., Jensen F.E., Kwiatkowski D.J.
    J. Neurosci. 27:5546-5558(2007) [PubMed] [Europe PMC] [Abstract]
• glucose import Source: MGIInferred from mutant phenotypeⁱ
  • "The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake."
    Jiang X., Kenerson H., Aicher L., Miyaoka R., Eary J., Bissler J., Yeung R.S.
    Am. J. Pathol. 172:1748-1756(2008) [PubMed] [Europe PMC] [Abstract]
• hippocampus development Source: MGIInferred from mutant phenotypeⁱ
  • "A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival."
    Meikle L., Talos D.M., Onda H., Pollizzi K., Rotenberg A., Sahin M., Jensen F.E., Kwiatkowski D.J.
    J. Neurosci. 27:5546-5558(2007) [PubMed] [Europe PMC] [Abstract]
• kidney development Source: MGIInferred from mutant phenotypeⁱ
  • "A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma."
    Wilson C., Idziaszczyk S., Parry L., Guy C., Griffiths D.F., Lazda E., Bayne R.A., Smith A.J., Sampson J.R., Cheadle J.P.
    Hum. Mol. Genet. 14:1839-1850(2005) [PubMed] [Europe PMC] [Abstract]
• memory T cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs."
    Shrestha S., Yang K., Wei J., Karmaus P.W., Neale G., Chi H.
    Proc. Natl. Acad. Sci. U.S.A. 111:14858-14863(2014) [PubMed] [Europe PMC] [Abstract]
• myelination Source: MGIInferred from mutant phenotypeⁱ
  • "A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival."
    Meikle L., Talos D.M., Onda H., Pollizzi K., Rotenberg A., Sahin M., Jensen F.E., Kwiatkowski D.J.
    J. Neurosci. 27:5546-5558(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ATPase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients."
    Woodford M.R., Sager R.A., Marris E., Dunn D.M., Blanden A.R., Murphy R.L., Rensing N., Shapiro O., Panaretou B., Prodromou C., Loh S.N., Gutmann D.H., Bourboulia D., Bratslavsky G., Wong M., Mollapour M.
    EMBO J. 36:3650-3665(2017) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HSP90AA1, DISRUPTION PHENOTYPE.
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • Ref.2

    "A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice."
    Kobayashi T., Minowa O., Sugitani Y., Takai S., Mitani H., Kobayashi E., Noda T., Hino O.
    Proc. Natl. Acad. Sci. U.S.A. 98:8762-8767(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• negative regulation of cell size Source: MGIInferred from mutant phenotypeⁱ
  • "Glutathione metabolism in long-living Ames dwarf mice."
    Brown-Borg H.M., Rakoczy S.G.
    Exp. Gerontol. 40:115-120(2005) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2."
    Tavazoie S.F., Alvarez V.A., Ridenour D.A., Kwiatkowski D.J., Sabatini B.L.
    Nat. Neurosci. 8:1727-1734(2005) [PubMed] [Europe PMC] [Abstract]
  • "A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival."
    Meikle L., Talos D.M., Onda H., Pollizzi K., Rotenberg A., Sahin M., Jensen F.E., Kwiatkowski D.J.
    J. Neurosci. 27:5546-5558(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of GTPase activity Source: MGI
• negative regulation of insulin receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of macroautophagy Source: ParkinsonsUK-UCL
• negative regulation of neuron projection development Source: MGI
• negative regulation of oxidative stress-induced neuron death Source: MGI
• negative regulation of TOR signaling Source: ParkinsonsUK-UCL
• negative regulation of translation Source: MGI
• nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "A mouse model of tuberous sclerosis: neuronal loss of Tsc1 causes dysplastic and ectopic neurons, reduced myelination, seizure activity, and limited survival."
    Meikle L., Talos D.M., Onda H., Pollizzi K., Rotenberg A., Sahin M., Jensen F.E., Kwiatkowski D.J.
    J. Neurosci. 27:5546-5558(2007) [PubMed] [Europe PMC] [Abstract]
• neural tube closure Source: MGIInferred from mutant phenotypeⁱ
  • Ref.2

    "A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice."
    Kobayashi T., Minowa O., Sugitani Y., Takai S., Mitani H., Kobayashi E., Noda T., Hino O.
    Proc. Natl. Acad. Sci. U.S.A. 98:8762-8767(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
• positive regulation of focal adhesion assembly Source: MGI
• positive regulation of macroautophagy Source: MGI
• positive regulation of stress fiber assembly Source: MGI
• potassium ion transport Source: MGIInferred from mutant phenotypeⁱ
  • "Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes."
    Jansen L.A., Uhlmann E.J., Crino P.B., Gutmann D.H., Wong M.
    Epilepsia 46:1871-1880(2005) [PubMed] [Europe PMC] [Abstract]
• protein heterooligomerization Source: MGI
• protein stabilization Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients."
    Woodford M.R., Sager R.A., Marris E., Dunn D.M., Blanden A.R., Murphy R.L., Rensing N., Shapiro O., Panaretou B., Prodromou C., Loh S.N., Gutmann D.H., Bourboulia D., Bratslavsky G., Wong M., Mollapour M.
    EMBO J. 36:3650-3665(2017) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HSP90AA1, DISRUPTION PHENOTYPE.
• regulation of cell cycle Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-matrix adhesion Source: MGI
• regulation of focal adhesion assembly Source: MGI
• regulation of neuron death Source: ParkinsonsUK-UCL
• regulation of phosphoprotein phosphatase activity Source: MGI
• regulation of protein kinase activity Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation."
    Uhlmann E.J., Li W., Scheidenhelm D.K., Gau C.L., Tamanoi F., Gutmann D.H.
    Glia 47:180-188(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of stress fiber assembly Source: MGI
• regulation of translation Source: MGI
• response to insulin Source: MGI
• rRNA export from nucleus Source: MGI
• synapse organization Source: MGIInferred from mutant phenotypeⁱ
  • "Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2."
    Tavazoie S.F., Alvarez V.A., Ridenour D.A., Kwiatkowski D.J., Sabatini B.L.
    Nat. Neurosci. 8:1727-1734(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• chaperone binding Source: MGI
• GTPase activating protein binding Source: MGI
• Hsp70 protein binding Source: MGI
• Hsp90 protein binding Source: MGI
• protein N-terminus binding Source: UniProtKBInferred from physical interactionⁱ
  • "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho."
    Lamb R.F., Roy C., Diefenbach T.J., Vinters H.V., Johnson M.W., Jay D.G., Hall A.
    Nat. Cell Biol. 2:281-287(2000) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAQLANIGEL LSMLDSSTLG VRDDVTAIFK ESLNSERGPM LVNTLVDYYL 
        60         70         80         90        100
ETNSQPVLHI LTTLQEPHDK HLLDKINEYV GKAATRLSIL SLLGHVVRLQ 
       110        120        130        140        150
PSWKHKLSQA PLLPSLLKCL KMDTDVVVLT TGVLVLITML PMIPQSGKQH 
       160        170        180        190        200
LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL HASVYALFHR LYGMYPCNFV 
       210        220        230        240        250
SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH ELDPRRWKTL 
       260        270        280        290        300
ETHDVVIECA KISLDPTEAS YEDGYSVSHQ LSACFPYRSA DVTTSPYVDT 
       310        320        330        340        350
QNSYGGSTST PSSSSRLMLF SPPGQLPQSL SSPSTRLLPE PLQASLWSPS 
       360        370        380        390        400
AVCGMTTPPT SPGNVPADLS HPYSKAFGTT AGGKGTPSGT PATSPPPAPP 
       410        420        430        440        450
CPQDDCVHGS AAQASATAPR KEERADSSRP YLHRQSNDRG LEDPPGSKGS 
       460        470        480        490        500
VTLRNLPDFL GDLASEEDSI EKDKEEAAIS KELSEITTAE ADPVVPRGGF 
       510        520        530        540        550
DSPFYRDSLS GSQRKTHSAA SGTQGSSVNP EPLHSSLDKH GPDTPKQAFT 
       560        570        580        590        600
PIDPPSGSAD VSPAGDRDRQ TSLETSILTP SPCKIPPQRG VSFGSGQLPP 
       610        620        630        640        650
YDHLFEVALP KTACHFVSKK TEELLKKVKG NPEEDCVPST SPMEVLDRLI 
       660        670        680        690        700
EQGAGAHSKE LSRLSLPSKS VDWTHFGGSP PSDELRTLRD QLLLLHNQLL 
       710        720        730        740        750
YERFKRQQHA LRNRRLLRKV IRAAALEEHN AAMKDQLKLQ EKDIQMWKVS 
       760        770        780        790        800
LQKEQARYSQ LQEQRDTMVT QLHSQIRQLQ HDREEFYNQS QELQTKLEDC 
       810        820        830        840        850
RNMIAELRVE LKKANNKVCH TELLLSQVSQ KLSNSESVQQ QMEFLNRQLL 
       860        870        880        890        900
VLGEVNELYL EQLQSKHPDT TKEVEMMKTA YRKELEKNRS HLLQQNQRLD 
       910        920        930        940        950
ASQRRVLELE SLLAKKDHLL LEQKKYLEDV KSQASGQLLA AESRYEAQRK 
       960        970        980        990       1000
ITRVLELEIL DLYGRLEKDG RLRKLEEDRA EAAEAAEERL DCCSDGCTDS 
      1010       1020       1030       1040       1050
LVGHNEEASG HNGETRTSRP GGTRASCGGR VTGGSSSSSS ELSTPEKPPS 
      1060       1070       1080       1090       1100
QRFSSRWEPA LGEPSSSIPT TVGSLPSSKS FLGMKARELF RNKSESQCDE 
      1110       1120       1130       1140       1150
DSVTMSSSSL SETLKTELGK DSGTENKTSL SLDAPHPSSP NSDNVGQLHI 
      1160 
MDYNETHPEH S                                           

        10         20         30         40         50
MAQLANIGEL LSMLDSSTLG VRDDVTAIFK ESLNSERGPM LVNTLVDYYL 
        60         70         80         90        100
ETNSQPVLHI LTTLQEPHDK HLLDKINEYV GKAATRLSIL SLLGHVVRLQ 
       110        120        130        140        150
PSWKHKLSQA PLLPSLLKCL KMDTDVVVLT TGVLVLITML PMIPQSGKQH 
       160        170        180        190        200
LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL HASVYALFHR LYGMYPCNFV 
       210        220        230        240        250
SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH ELDPRRWKTL 
       260        270        280        290        300
ETHDVVIECA KISLDPTEAS YEDGYSVSHQ LSACFPYRSA DVTTSPYVDT 
       310        320        330        340        350
QNSYGGSTST PSSSSRLMLF SPPGQLPQSL SSPSTRLLPE PLQASLWSPS 
       360        370        380        390        400
AVCGMTTPPT SPGNVPADLS HPYSKAFGTT GGKGTPSGTP ATSPPPAPPC 
       410        420        430        440        450
PQDDCVHGSA AQASATAPRK EERADSSRPY LHRQSNDRGL EDPPGSKGSV 
       460        470        480        490        500
TLRNLPDFLG DLASEEDSIE KDKEEAAISK ELSEITTAEA DPVVPRGGFD 
       510        520        530        540        550
SPFYRDSLSG SQRKTHSAAS GTQGSSVNPE PLHSSLDKHG PDTPKQAFTP 
       560        570        580        590        600
IDPPSGSADV SPAGDRDRQT SLETSILTPS PCKIPPQRGV SFGSGQLPPY 
       610        620        630        640        650
DHLFEVALPK TACHFVSKKT EELLKKVKGN PEEDCVPSTS PMEVLDRLIE 
       660        670        680        690        700
QGAGAHSKEL SRLSLPSKSV DWTHFGGSPP SDELRTLRDQ LLLLHNQLLY 
       710        720        730        740        750
ERFKRQQHAL RNRRLLRKVI RAAALEEHNA AMKDQLKLQE KDIQMWKVSL 
       760        770        780        790        800
QKEQARYSQL QEQRDTMVTQ LHSQIRQLQH DREEFYNQSQ ELQTKLEDCR 
       810        820        830        840        850
NMIAELRVEL KKANNKVCHT ELLLSQVSQK LSNSESVQQQ MEFLNRQLLV 
       860        870        880        890        900
LGEVNELYLE QLQSKHPDTT KEVEMMKTAY RKELEKNRSH LLQQNQRLDA 
       910        920        930        940        950
SQRRVLELES LLAKKDHLLL EQKKYLEDVK SQASGQLLAA ESRYEAQRKI 
       960        970        980        990       1000
TRVLELEILD LYGRLEKDGR LRKLEEDRAE AAEAAEERLD CCSDGCTDSL 
      1010       1020       1030       1040       1050
VGHNEEASGH NGETRTSRPG GTRASCGGRV TGGSSSSSSE LSTPEKPPSQ 
      1060       1070       1080       1090       1100
RFSSRWEPAL GEPSSSIPTT VGSLPSSKSF LGMKARELFR NKSESQCDED 
      1110       1120       1130       1140       1150
SVTMSSSSLS ETLKTELGKD SGTENKTSLS LDAPHPSSPN SDNVGQLHIM 
      1160
DYNETHPEHS                                             

        10         20         30         40         50
MAQLANIGEL LSMLDSSTLG VRDDVTAIFK ESLNSERGPM LVNTLVDYYL 
        60         70         80         90        100
ETNSQPVLHI LTTLQEPHDK HLLDKINEYV GKAATRLSIL SLLGHVVRLQ 
       110        120        130        140        150
PSWKHKLSQA PLLPSLLKCL KMDTDVVVLT TGVLVLITML PMIPQSGKQH 
       160        170        180        190        200
LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL HASVYALFHR LYGMYPCNFV 
       210        220        230        240        250
SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH ELDPRRWKTL 
       260        270        280        290        300
ETHDVVIECA KISLDPTEAS YEDGYSVSHQ LSACFPYRSA DVTTSPYVDT 
       310        320        330        340        350
QNSYGGSTST PSSSSRLMLF SPPGQLPQSL SSPSTRLLPE PLQASLWSPS 
       360        370        380        390        400
AVCGMTTPPT SPGNVPADLS HPYSKAFGTT GGKGTPSGTP ATSPPPAPPC 
       410        420        430        440        450
PQDDCVHGSA AQASATAPRK EERADSSRPY LHRQSNDRGL EDPPGSKGSV 
       460        470        480        490        500
TLRNLPDFLG DLASEEDSIE KDKEEAAISK ELSEITTAEA DPVVPRGGFD 
       510        520        530        540        550
SPFYRDSLSG SQRKTHSAAS GTQGSSVNPE PLHSSLDKHG PDTPKQAFTP 
       560        570        580        590        600
IDPPSGSADV SPAGDRDRQT SLETSILTPS PCKIPPQRGV SFGSGQLPPY 
       610        620        630        640        650
DHLFEVALPK TACHFVSKKT EELLKKVKGN PEEDCVPSTS PMEVLDRLIE 
       660        670        680        690        700
QGAGAHSKEL SRLSLPSKSV DWTHFGDELR TLRDQLLLLH NQLLYERFKR 
       710        720        730        740        750
QQHALRNRRL LRKVIRAAAL EEHNAAMKDQ LKLQEKDIQM WKVSLQKEQA 
       760        770        780        790        800
RYSQLQEQRD TMVTQLHSQI RQLQHDREEF YNQSQELQTK LEDCRNMIAE 
       810        820        830        840        850
LRVELKKANN KVCHTELLLS QVSQKLSNSE SVQQQMEFLN RQLLVLGEVN 
       860        870        880        890        900
ELYLEQLQSK HPDTTKEVEM MKTAYRKELE KNRSHLLQQN QRLDASQRRV 
       910        920        930        940        950
LELESLLAKK DHLLLEQKKY LEDVKSQASG QLLAAESRYE AQRKITRVLE 
       960        970        980        990       1000
LEILDLYGRL EKDGRLRKLE EDRAEAAEAA EERLDCCSDG CTDSLVGHNE 
      1010       1020       1030       1040       1050
EASGHNGETR TSRPGGTRAS CGGRVTGGSS SSSSELSTPE KPPSQRFSSR 
      1060       1070       1080       1090       1100
WEPALGEPSS SIPTTVGSLP SSKSFLGMKA RELFRNKSES QCDEDSVTMS 
      1110       1120       1130       1140       1150
SSSLSETLKT ELGKDSGTEN KTSLSLDAPH PSSPNSDNVG QLHIMDYNET 

HPEHS                                                  

        10         20         30         40         50
MAQLANIGEL LSMLDSSTLG VRDDVTAIFK ESLNSERGPM LVNTLVDYYL 
        60         70         80         90        100
ETNSQPVLHI LTTLQEPHDK HLLDKINEYV GKAATRLSIL SLLGHVVRLQ 
       110        120        130        140        150
PSWKHKLSQA PLLPSLLKCL KMDTDVVVLT TGVLVLITML PMIPQSGKQH 
       160        170        180        190        200
LLDFFDIFGR LSSWCLKKPG HVTEVYLVHL HASVYALFHR LYGMYPCNFV 
       210        220        230        240        250
SFLRSHYSMK ENVETFEEVV KPMMEHVRIH PELVTGSKDH ELDPRRWKTL 
       260        270        280        290        300
ETHDVVIECA KISLDPTEAS YEDGYSVSHQ LSACFPYRSA DVTTSPYVDT 
       310        320        330        340        350
QNSYGGSTST PSSSSRLMLF SPPGQLPQSL SSPSTRLLPE PLQASLWSPS 
       360        370        380        390        400
AVCGMTTPPT SPGNVPADLS HPYSKAFGTT GGKGTPSGTP ATSPPPAPPC 
       410        420        430        440        450
PQDDCVHGSA AQASATAPRK EERADSSRPY LHRQSNDRGL EDPPGSKGSV 
       460        470        480        490        500
TLRNLPDFLG DLASEEDSIE KDKEEAAISK ELSEITTAEA DPVVPRGGFD 
       510        520        530        540        550
SPFYRDSLSG SQRKTHSAAS GTQGSSVNPE PLHSSLDKHG PDTPKQAFTP 
       560        570        580        590        600
IDPPSGSADV SPAGDRDRQT SLETSILTPS PCKIPPQRGV SFGSGQLPPY 
       610        620        630        640        650
DHLFEVALPK TACHFVSKKT EELLKKVKGN PEEDCVPSTS PMEVLDRLIE 
       660        670        680        690        700
QGAGAHSKEL SRLSLPSKSV DWTHFGGSPP SDELRTLRDQ LLLLHNQLLY 
       710        720        730        740        750
ERFKRQQHAL RNRRLLRKVI RAAALEEHNA AMKDQLKLQE KDIQMWKVSL 
       760        770        780        790        800
QKEQARYSQL QEQRDTMVTQ LHSQIRQLQH DREEFYNQSQ ELQTKLEDCR 
       810        820        830        840        850
NMIAELRVEL KKANNKVCHT ELLLSQVSQK LSNSESVQQQ MEFLNRQLLV 
       860        870        880        890        900
LGEVNELYLE QLQSKHPDTT KEVEMMKTAY RKELEKNRSH LLQQNQRLDA 
       910        920        930        940        950
SQRRVLELES LLAKKDHLLL EQKKYLEDVK SQASGQLLAA ESRYEAQRKI 
       960        970        980        990       1000
TRVLELEILD LYGRLEKDGR LRKLEEDRAE AAEAAEERLD CCSDGCTDSL 
      1010       1020       1030       1040       1050
VGHNEEASGH NGETRTSRPG GTRASCGGRV TGGSSSSSSE LSTPEKPPSQ 
      1060       1070       1080       1090       1100
RFSSIPTTVG SLPSSKSFLG MKARELFRNK SESQCDEDSV TMSSSSLSET 
      1110       1120       1130       1140 
LKTELGKDSG TENKTSLSLD APHPSSPNSD NVGQLHIMDY NETHPEHS   

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot