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Protein

Nuclear export protein

Gene

NS

Organism
Influenza C virus (strain C/Yamagata/1964)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.UniRule annotation

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear export proteinUniRule annotation
Short name:
NEPUniRule annotation
Alternative name(s):
Non-structural protein 2UniRule annotation
Short name:
NS2UniRule annotation
Gene namesi
Name:NSUniRule annotation
OrganismiInfluenza C virus (strain C/Yamagata/1964)
Taxonomic identifieri217166 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeGammainfluenzavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236811 – 182Nuclear export proteinAdd BLAST182

Interactioni

Subunit structurei

Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.UniRule annotation

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi96 – 105Nuclear export signalUniRule annotation10
Motifi122 – 132Nuclear export signalUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the influenza viruses NEP family.UniRule annotation

Family and domain databases

HAMAPiMF_04067 INFV_NEP, 1 hit
InterProiView protein in InterPro
IPR005188 Flu_C_NS2
IPR000968 Flu_NS2
PfamiView protein in Pfam
PF03555 Flu_C_NS2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform NEP (identifier: Q9ENZ3-1) [UniParc]FASTAAdd to basket
Also known as: NS2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDKTVKSTN LMAFVATKML ERQEDLDTCT EMQVEKMKTS TKARLRTESS
60 70 80 90 100
FAPRTWEDAI KDEILRRSVD TSSLNKWPEL KQELENVSDA LKADSLWLPM
110 120 130 140 150
KSLSLYSKVS NQEPSSIPIG EMKHQILTRL KLICSRLEKL DLNLSKAVLG
160 170 180
IQNSEDLILI IYNRDVCKNT ILMIKSLCNS LI
Length:182
Mass (Da):20,795
Last modified:March 1, 2001 - v1
Checksum:iF618F869F171637F
GO
Isoform NS1 (identifier: Q784P6-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q784P6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:246
Mass (Da):27,695
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB034155 Genomic RNA Translation: BAB12048.1

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEP_INCY6
AccessioniPrimary (citable) accession number: Q9ENZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: March 1, 2001
Last modified: April 25, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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