UniProtKB - Q9EMA9 (V_MEASE)
Non-structural protein V
P/V
Functioni
Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host TYK2 and thereby inhibiting downstream STAT1 and STAT2 phosphorylation. Moderately affects the type II interferon signaling (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 232 | Zinc 1By similarity | 1 | |
Metal bindingi | 251 | Zinc 1By similarity | 1 | |
Metal bindingi | 255 | Zinc 2By similarity | 1 | |
Metal bindingi | 267 | Zinc 2By similarity | 1 | |
Metal bindingi | 269 | Zinc 2By similarity | 1 | |
Metal bindingi | 272 | Zinc 2By similarity | 1 | |
Metal bindingi | 276 | Zinc 1By similarity | 1 | |
Metal bindingi | 279 | Zinc 1By similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity Source: UniProtKB-KW
- suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity Source: UniProtKB-KW
- suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity Source: UniProtKB-KW
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity Source: UniProtKB-KW
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Non-structural protein V |
Gene namesi | Name:P/V |
Organismi | Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus) |
Taxonomic identifieri | 11235 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Orthoparamyxovirinae › Morbillivirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000142810 | 1 – 299 | Non-structural protein VAdd BLAST | 299 |
Interactioni
Subunit structurei
Interacts with host IFIH1/MDA5 and DHX58/LGP2.
Interacts with host TYK2; this interaction inhibits the type I interferon signaling pathway without affecting the type II pathway.
Interacts with host IRF7; this interaction inhibits IRF7 translocation to the nucleus.
Interacts with host CHUK and RELA.
Interacts (via C-terminus) with host STAT2 (By similarity).
By similarityBinary interactionsi
Q9EMA9
With | #Exp. | IntAct |
---|---|---|
DHX58 [Q96C10] from Homo sapiens. | 2 | EBI-6598728,EBI-744193 |
IFIH1 [Q9BYX4] from Homo sapiens. | 2 | EBI-6598728,EBI-6115771 |
Protein-protein interaction databases
IntActi | Q9EMA9, 2 interactors |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 99 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 134 – 168 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 134 – 149 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR024279, Paramyx_V_Zn-bd IPR028243, Paramyxo_P/V_N |
Pfami | View protein in Pfam PF13825, Paramyxo_P_V_N, 1 hit PF13008, zf-Paramyx-P, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MAEEQARHVK NGLECIRALK AEPIGSLAIE EAMAAWSEIS DNPGQERATC
60 70 80 90 100
REEKAGSSGL SKPCLSAIGS TEGGAPRIRG QGPGESDDDA ETLGIPPRNL
110 120 130 140 150
QASSTGLQCY YVYDHSGEAV KGIQDADSIM VQSGLDGDST LSGGDNESEN
160 170 180 190 200
SDVDIGEPDT EGYAITDRGS APISMGFRAS DVETAEGGEI HELLRLQSRG
210 220 230 240 250
NNFPKLGKTL NVPPPPDPGR ASTSETPIKK GHRREISLIW NGDRVFIDRW
260 270 280 290
CNPMCSKVTL GTIRARCTCG ECPRVCEQCR TDTGVDTRIW YHNLPEIPE
RNA editingi
Partially edited. RNA editing at this position consists of an insertion of one guanine nucleotide. The sequence displayed here is the V protein, derived from the edited RNA. The unedited RNA gives rise to the P protein (AC P03422).
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF266288 Genomic RNA Translation: AAF85677.2 |
PIRi | A31490 S20830 |
Keywords - Coding sequence diversityi
RNA editingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF266288 Genomic RNA Translation: AAF85677.2 |
PIRi | A31490 S20830 |
3D structure databases
SMRi | Q9EMA9 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9EMA9, 2 interactors |
Family and domain databases
InterProi | View protein in InterPro IPR024279, Paramyx_V_Zn-bd IPR028243, Paramyxo_P/V_N |
Pfami | View protein in Pfam PF13825, Paramyxo_P_V_N, 1 hit PF13008, zf-Paramyx-P, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | V_MEASE | |
Accessioni | Q9EMA9Primary (citable) accession number: Q9EMA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |