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Entry version 73 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Large tegument protein deneddylase

Gene

MDV049

Organism
Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).UniRule annotation EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei85Important for catalytic activityUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei98UniRule annotation1
Active sitei232UniRule annotation1
Active sitei234UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processHost-virus interaction, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Large tegument protein deneddylaseUniRule annotation (EC:3.4.19.12UniRule annotation, EC:3.4.22.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDV049
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's disease herpesvirus type 1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10389 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiGallus gallus (Chicken) [TaxID: 9031]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008072 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004064981 – 3342Large tegument protein deneddylaseAdd BLAST3342

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9E6N3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host CUL1 and CUL4A; these interactions inhibit the E3 ligase activity of cullins.

Interacts with inner tegument protein.

Interacts with capsid vertex specific component CVC2.

Interacts with the major capsid protein/MCP.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9E6N3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 298Peptidase C76UniRule annotationAdd BLAST221

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 302Deubiquitination activityUniRule annotationAdd BLAST302
Regioni472 – 554DisorderedSequence analysisAdd BLAST83
Regioni630 – 656Interaction with inner tegument proteinUniRule annotationAdd BLAST27
Regioni2584 – 2603DisorderedSequence analysisAdd BLAST20
Regioni2654 – 2987DisorderedSequence analysisAdd BLAST334
Regioni3196 – 3279DisorderedSequence analysisAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi477 – 493Polar residuesSequence analysisAdd BLAST17
Compositional biasi509 – 530Polar residuesSequence analysisAdd BLAST22
Compositional biasi538 – 554Polar residuesSequence analysisAdd BLAST17
Compositional biasi2586 – 2600Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi2699 – 2903Pro residuesSequence analysisAdd BLAST205
Compositional biasi2905 – 2942Polar residuesSequence analysisAdd BLAST38
Compositional biasi3222 – 3252Polar residuesSequence analysisAdd BLAST31
Compositional biasi3265 – 3279Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae large tegument protein family.UniRule annotation

Keywords - Domaini

Repeat

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04044, HSV_LTP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005210, Herpes_LT_deneddylase
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04843, Herpes_teg_N, 1 hit
PF03586, Herpes_UL36, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51521, HTUSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9E6N3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDSTDSRQA TTNCRKYSRT TSNAPMLAAN VLRDKSTSGL CSLDRKHDPY
60 70 80 90 100
FGQIMDNPEV ILDEWAKMVI DTTDVTVVAV GIRNQFAPDL SPASSVSCLR
110 120 130 140 150
SSLAFLRIVF AYGLDTVISS DAIDRLLLQG KAWTIATSED GTYTTCVPHD
160 170 180 190 200
LPNRIISKDA GGNLCVAFSS SYGEFEFYLE ENTPTILDTQ ISARTFIEQI
210 220 230 240 250
WKKKRGDVYC LIVVGVLGIG VYRSGDGIYI FDPHGHGHIG QACIVRVSEG
260 270 280 290 300
YFYQYLTSYA DPSATPDWSA TFVYFVSTVS ICPPRDEIIS TVSRIYGTSD
310 320 330 340 350
IVLDLGRARE EDNRKVVSAD FDPPSRPQPR LTKLVIGSTD TTIQGSDYPC
360 370 380 390 400
IQAEDLNGED SRPLDHNLSY NDAPTNTESV APPSTKDCRD CINIQNPGET
410 420 430 440 450
LDDTHSTIVD PSTKDSISVT AWQGVFSDVI EDPPPKTNFQ FSFGTFAKVA
460 470 480 490 500
ENKIGTTSVE GCIRNYARHK RRRPLWTPQS SSENISLDGS SSSLSRKHSR
510 520 530 540 550
KSKRTLESRI VEAVTSTESS DVTENVDTYP PVISNIPDEP TLGSSPTTSN
560 570 580 590 600
RGEDTTVEHL LKNRPLFNFK SLTEDEDGLV QDRLWSDEYL SHYPLADIRD
610 620 630 640 650
KIEDVACSID SGLRIIVHVG SPYDSDGGLL YVCMMDIFAR LFNYIIENGA
660 670 680 690 700
RTTSDRESVV GYEMAALLKA FTIPVYFTTF IASTGMVLSE ASESIDLIER
710 720 730 740 750
VLAENSKIGN LALSKMILVA LEVEEVTDEL HKSLDAIEKE VGTADPYGIY
760 770 780 790 800
ERMAAILVDT LYHNSGKLYS EKTSSNSNQT LTDRVISLCT LIRDIEAVAI
810 820 830 840 850
RKAELILAEM EALEAGVRWM NTTLDAFIMG GSGSSPMIDA ADIVAKTSSA
860 870 880 890 900
VVTQRLGDIG KTVIDVVGHS LREYYLKVAL YSVKALTASS SDVSRFKIVV
910 920 930 940 950
TDQYEKINRF ASSLSVIDDV MVLIASRSNA RVPSPVSQAF ESELLGNLLE
960 970 980 990 1000
IGSDLDVPEK LTTWKNLMTS MQVGGWISRR ELDMLMKEID IVNEKATRHE
1010 1020 1030 1040 1050
TVLTELERLN ELETRFGSYT DLDTTVELQK LDEAIKIGED IVKLAIVLED
1060 1070 1080 1090 1100
KKNATSLSSD VREKLRDTRR KNETFITHLR ERYQEVKSTI EDLYSSIRKI
1110 1120 1130 1140 1150
LRPLPKFVGL RALDSKVKVI TESIPRGMGS FENFLASAPS DIIGSLQSDL
1160 1170 1180 1190 1200
WVLFIQYKTI LSRPTTEVAA ELSGLGVPFA LAIRLVFGPQ GSYPAASVFF
1210 1220 1230 1240 1250
GKHADVLSAT IAAAAVEPMS VEKTMAVVST LKAAISDIDR ANAIAPPQGI
1260 1270 1280 1290 1300
MSISSTERSD AFLFLKALLS TAEIAADVAN RGQHLESLIQ SVRTILDNLI
1310 1320 1330 1340 1350
TSNHKIRSLN PREVISENDT SVVASAKVEF SNAIQTVGNV TATLSTFEGL
1360 1370 1380 1390 1400
TYTSNPHIQR KIAELSKLIR SANQRAGELD IAIQTYEHNR ISAERSRSED
1410 1420 1430 1440 1450
LWISSINSLL LNAEVKSEFD AMEINRLEDA ARTGGYDTIR YKSRAEKIVI
1460 1470 1480 1490 1500
AHARVLESSI ESVLKFNPYS TQNMVHGLSP PIAALKSITW GDSFMTAAPY
1510 1520 1530 1540 1550
YTKLFGVNCD TVMDLLHISI AILRHANANS GNVDYYLLMG ELESALKSYP
1560 1570 1580 1590 1600
NLVKYVNFYR SGYVKFMSFL AHLEQRRVEA HHASGRVALE ISAALEDLAR
1610 1620 1630 1640 1650
THSPEGARRA LEYGVSIIIP SVNTIMSIAE ELKKDHVEEL EGTAYSEYGA
1660 1670 1680 1690 1700
HLLRRDTDAM TSLIHRVTTA IEDAKTRGEA ILKNLAEASY AADRESAELL
1710 1720 1730 1740 1750
ANLKNLLRLV SMPSHIAKAI DRSETVNDIV TQAALLLTKV EETKELDSQT
1760 1770 1780 1790 1800
VEWLRHAESV IDSHDLTVRI DESGPMSIYA DRIDALVNLS KRLEELKSEL
1810 1820 1830 1840 1850
ALAEVAWDDT WATFVHDKDR IDKSSEGFSS ARESAARTKV SVNMINALRS
1860 1870 1880 1890 1900
NAEYPRLPAK IIGLIDTKYR DRVVVLDAFL TTVKEIEATQ KQMEGLCEKI
1910 1920 1930 1940 1950
PSTFAINDLK KIYTQFEDIA KRLPKWYTKR VARYSRLLTL RLALYAGYSN
1960 1970 1980 1990 2000
TFEGNVGDPM LLPFDAGDAN NGANHTSNVG VVNRYLKHRV ASWIRPKVVA
2010 2020 2030 2040 2050
TLQEAFSEID SPGCLTYLDS TDKPLRYSLC FRTVGEKLAA CLCEPAAIGI
2060 2070 2080 2090 2100
KPQIPIQPIT TEETEAAAGM LSDIMTFRLG FVHDMANHLY SFTKYVRTKR
2110 2120 2130 2140 2150
HNWMQSDYIK ALGTIYCALI AITLTRKNRS NLSDIYFIPG RRTPIVDKKE
2160 2170 2180 2190 2200
LKKNAANGRG KQVVRLDPAD VMVTIMANIP GHMLTFSKLD LIDQYDFMDK
2210 2220 2230 2240 2250
TIYEVMTDSI STVAFVNCLS VQLSKDNIPD PNCRPLSLTG SVWDPAGGSL
2260 2270 2280 2290 2300
FSVRYSDWRQ GKLSDTDPLK LWEDLDGDAA DGLAKIRAAI PSSLLTTTTV
2310 2320 2330 2340 2350
LARMCIPPTA LAVIWSSLLP DGLEQNCKSY DDVVTARGDL ASSLDVTTSL
2360 2370 2380 2390 2400
LSCSENKNIS SITDSPNLYD LTGNVTTFTV VSTPPSRVLR VNAMDIATTA
2410 2420 2430 2440 2450
TLFGARIVIA AECPEAYSSE SGLSLCIRLF DSRHGSRGCF LEPTAVSSDM
2460 2470 2480 2490 2500
TSWGTKLLIT DNNPIENACL GQQLEHLSRI VASKPLASAP PCLLIVDSGM
2510 2520 2530 2540 2550
APIKVLWSKE ILDPIPIIRL ISEDDALISE LPYVDAGIRK EPELANEHMV
2560 2570 2580 2590 2600
IADVQEASKF FSDESRIYPC PIYNKCVSPD LSRDGDADIS SNRIDSEDDT
2610 2620 2630 2640 2650
YADSMGSGYL SIDPESMWDR VVENDMEGAQ VQLLLPGDII HHNDRHVSEN
2660 2670 2680 2690 2700
MNYPQIGHLD ISPNYRDPID ETSSNPPPFP KHSNLFPSDH DPTSESSSKP
2710 2720 2730 2740 2750
TPAPKPTPAP KPTPAPKPTP APKPTPAPKP TPAPKPTPAP KPKPPPDPDF
2760 2770 2780 2790 2800
KPSPAPKPSP ASKPTPAPKP SPAPKPKPPP DPDFKPTPAP KPSPASKPKP
2810 2820 2830 2840 2850
PPDPDFKPTP APKPKPPPDP DFKPSPAPKP SPAPKPKPPP DPDFKPTPAP
2860 2870 2880 2890 2900
KPSPASKPSP ASKPKPPPAP DSKPSPAPKP KPPPTPDSKP SPAPKPKSPS
2910 2920 2930 2940 2950
ASKPLPVLFP NSDSKTSPVP NPNTFSASKI PPTSSIAEET KPCQSNLPAI
2960 2970 2980 2990 3000
PLITKPDSVK NGYTTLKTDD KRKGSQSRYR NEKSRKHMHN THTAVYNTTF
3010 3020 3030 3040 3050
NWTGTAAASS RHDMELNQYS PGIVTFDNLI DKEGYRHESE TIPRESYSEH
3060 3070 3080 3090 3100
RKDLDWMSTP TVIANASSSL ITNNDYGGIG GIDLKKYRFK NGTGLLRQGS
3110 3120 3130 3140 3150
PTTRLHCRKN NSSRSITDIL VGTASPTNEP SPLLQRLKAH TISGDKKANM
3160 3170 3180 3190 3200
DAGTIRGRLY DYSSFWPPCI QGACSTSPKT IDLKYLSSEQ ATVAYPKHDD
3210 3220 3230 3240 3250
THHQTPTGLA PNDKHSDMHI SSIITETDTK ENSIPGYNNI PMRHSSESES
3260 3270 3280 3290 3300
LTSLDSDSDD SHLHVSGSTD TTTDGSSTSR VIPADALLTR RDFRNASRGA
3310 3320 3330 3340
LYALTKACKK VARQIVYVRE QLRTKVATLA IELFKIKMIL TG
Length:3,342
Mass (Da):367,314
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49B6E04418E54890
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF243438 Genomic DNA Translation: AAG14229.1

NCBI Reference Sequences

More...
RefSeqi
YP_001033965.1, NC_002229.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4811510

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:4811510

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF243438 Genomic DNA Translation: AAG14229.1
RefSeqiYP_001033965.1, NC_002229.3

3D structure databases

SMRiQ9E6N3
ModBaseiSearch...

Proteomic databases

PRIDEiQ9E6N3

Genome annotation databases

GeneIDi4811510
KEGGivg:4811510

Family and domain databases

HAMAPiMF_04044, HSV_LTP, 1 hit
InterProiView protein in InterPro
IPR005210, Herpes_LT_deneddylase
IPR006928, Herpes_teg_USP
IPR034702, HSV_LTP
IPR038765, Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF04843, Herpes_teg_N, 1 hit
PF03586, Herpes_UL36, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51521, HTUSP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLTP_GAHVM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9E6N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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