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Entry version 126 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Envelope glycoprotein E1

Gene
N/A
Organism
Hepatitis G virus isolate PEI
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-dependent RNA polymerase that performs primer-template recognition and RNA synthesis during viral replication.ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.ARBA annotation EC:3.4.21.98

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseARBA annotation, Hydrolase, Ion channel, Multifunctional enzymeARBA annotation, Nucleotidyltransferase, Protease, RNA-bindingARBA annotation, RNA-directed RNA polymeraseARBA annotation, Serine proteaseARBA annotation, Thiol proteaseARBA annotation, Transferase, Viral ion channelARBA annotation
Biological processActivation of host autophagy by virusARBA annotation, Fusion of virus membrane with host endosomal membraneARBA annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virusARBA annotation, Inhibition of host MAVS by virusARBA annotation, Inhibition of host RLR pathway by virus, Ion transport, Transcription, Transcription regulationARBA annotation, Transport, Viral attachment to host cellARBA annotation, Viral immunoevasion, Viral penetration into host cytoplasm, Viral RNA replicationARBA annotation, Virus entry into host cell
LigandATP-binding, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding, ZincARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Envelope glycoprotein E1ARBA annotation (EC:2.7.7.48ARBA annotation, EC:3.4.21.98ARBA annotation, EC:3.6.1.15ARBA annotation, EC:3.6.4.13ARBA annotation)
Alternative name(s):
Envelope glycoprotein E2ARBA annotation
Genome polyproteinARBA annotation
HepacivirinARBA annotation
NS1ARBA annotation
NS3 helicaseARBA annotation
NS3 proteaseARBA annotation
NS3PARBA annotation
NS5BARBA annotation
Non-structural protein 4AARBA annotation
Non-structural protein 4BARBA annotation
Non-structural protein 5AARBA annotation
Protease NS2ARBA annotation
RNA-directed RNA polymeraseARBA annotation
Serine protease/helicase NS3ARBA annotation
Viroporin p7ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHepatitis G virus isolate PEIImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri140024 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeKitrinoviricotaFlasuviricetesAmarilloviralesFlaviviridaePegivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000141049 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei93 – 117HelicalSequence analysisAdd BLAST25
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei191 – 210HelicalSequence analysisAdd BLAST20
Transmembranei548 – 574HelicalSequence analysisAdd BLAST27
Transmembranei599 – 622HelicalSequence analysisAdd BLAST24
Transmembranei634 – 653HelicalSequence analysisAdd BLAST20
Transmembranei677 – 701HelicalSequence analysisAdd BLAST25
Transmembranei750 – 772HelicalSequence analysisAdd BLAST23
Transmembranei1525 – 1548HelicalSequence analysisAdd BLAST24
Transmembranei1709 – 1736HelicalSequence analysisAdd BLAST28
Transmembranei1742 – 1764HelicalSequence analysisAdd BLAST23
Transmembranei1776 – 1800HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Capsid proteinARBA annotation, Host cytoplasmARBA annotation, Host endoplasmic reticulumARBA annotation, Host membraneARBA annotation, Host nucleusARBA annotation, Membrane, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

GlycoproteinARBA annotation, Lipoprotein, PalmitateARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini769 – 894Peptidase C18InterPro annotationAdd BLAST126
Domaini894 – 1074Peptidase S29InterPro annotationAdd BLAST181
Domaini1081 – 1237Helicase ATP-bindingInterPro annotationAdd BLAST157
Domaini1223 – 1404Helicase C-terminalInterPro annotationAdd BLAST182
Domaini2487 – 2601RdRp catalyticInterPro annotationAdd BLAST115

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1559 – 1590DisorderedSequence analysisAdd BLAST32
Regioni2122 – 2175DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2140 – 2173PolarSequence analysisAdd BLAST34

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.25.210, 1 hit
3.30.70.270, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR024347, GB_virus_envelope
IPR002518, HCV_NS2
IPR000745, HCV_NS4a
IPR001490, HCV_NS4b
IPR002868, HCV_NS5a
IPR013193, HCV_NS5a_1B_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR013192, NS5A_1a
IPR038170, NS5A_1a_sf
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR004109, Peptidase_S29_NS3
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12786, GBV-C_env, 1 hit
PF01538, HCV_NS2, 1 hit
PF01006, HCV_NS4a, 1 hit
PF01001, HCV_NS4b, 1 hit
PF01506, HCV_NS5a, 1 hit
PF08300, HCV_NS5a_1a, 1 hit
PF08301, HCV_NS5a_1b, 1 hit
PF02907, Peptidase_S29, 1 hit
PF00998, RdRP_3, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51693, HCV_NS2_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51822, HV_PV_NS3_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9DXH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLLLLLVV EAGAIXAPAT HACRANGQYF LTNCCAPEDV GFCLEGGCLV
60 70 80 90 100
ALGCTICTDR CWPLYQXGLA VRPGKSXAQL VGELGSLYGP LSVSAXVAGI
110 120 130 140 150
LGLGEVYSGV LAVGVALTRR VYPMPNLTCA VECELKWESE FWRWTEQLAS
160 170 180 190 200
NYWILEYLWK VPFDFWKGVM SLTPLLVCVA ALLLLEQRVV MVFLLVTMAG
210 220 230 240 250
MXQGAPAAVL GSRPFDYGLT WQSCSCRSNG SRLITGEKVW DRGNVTLLCD
260 270 280 290 300
CPNGPWVWLP ALCQAVGWGD PITHWSHGQN QWPLSCPQYV YGSVSXTCVW
310 320 330 340 350
GSAXWFASTG GRDSKIDVWS LVPVGSAXCT IAALGSSDXD TVVEXSEXGV
360 370 380 390 400
PCVTCILDRR PASCGTCVRD CWPETGSVRF PFHRCGTGPR LTXDLEAVPF
410 420 430 440 450
VNRTTPFAIX GPLGNQGRGN PVRSPLGFGS YTMTKIRDTL HLVKCPTPAI
460 470 480 490 500
EPPTXTFGFX PGVPPLNNCM LLGTEVSEVL GGAGXTGGFY EPLVRRCSEL
510 520 530 540 550
XGRRNPVCPG YAWLSSGRPD GFIHVQGHLQ EVDAGNFIPP PRWLLLDFVF
560 570 580 590 600
VLLYLMKLAE ARLVPLILLL LWWWXNQLAV XGLPAVDAAV XGEVFAGPAL
610 620 630 640 650
SWCLGLPTVS MILGLANLVL YFRWMGPQRL MFLVLWKLAR GAFPLALLMG
660 670 680 690 700
ISATRGRTSV LGAEFCFDVT FEVDTSVLGW VVASVVAWAI ALLSSMSAGG
710 720 730 740 750
WKHKAXIYRT WCKGYQAIRQ RVVRSPLGEG RPTKPLTFAW CLASYIWPDA
760 770 780 790 800
VMMVVVALVL LFGLFDALDW ALEELLVSRP SLRRLARVVE CCVMAGEKAT
810 820 830 840 850
TIRLVSKMCA RGAYLFDHMG SFSRAVKERL LEWDAALEPL SFTRTDCRII
860 870 880 890 900
RDAARTLSCG QCVMGLPVVA RRGDEVLIGV FQDVNHLPPG FVPTAPVVIR
910 920 930 940 950
RCGKGFLGVT KAALTGRDPD LHPGNVMVLG TATSRSMGTC LNGLLFTTFH
960 970 980 990 1000
GASSRTIATP VGALNPRWWS ASDDVTVYPL PDGATSLTPC TCQAESCWVI
1010 1020 1030 1040 1050
RSDGALCHGL CKGDKVELDV AMEVSDFRGS SGSPVLCDEG HAVGMLVSVL
1060 1070 1080 1090 1100
HSGGRVTAAR FTRPWTQVPT DAKTTTEPPP VPAKGVFKEA PLFMPTGAGK
1110 1120 1130 1140 1150
STRVPLEYGN MGHKVLILNP SVATVXAMGP YMERLAGKHP SIYCGHDTTA
1160 1170 1180 1190 1200
FTRITDSPLT YSTYGRFLAN PXQMLRGVSV VICDECHSHD STVLLGIGRV
1210 1220 1230 1240 1250
RELARGCGVQ LVLYATATPP GSPMTQHPSI IETKLDVGEI PFYGHGIPLE
1260 1270 1280 1290 1300
RMRTGRHLVF CHSKAECERL AGQFSARGVN AIAYYRGKDS SIIKDGDLVV
1310 1320 1330 1340 1350
CATDALSTGY TGNFDSVTDC GLVVEEVVEV TLDPTITISL RTVPASAELS
1360 1370 1380 1390 1400
MQRRGRTGRG RSGRYYYAGV GKAPAGVVRS XPVWSAVEAG VTWYGMEPDL
1410 1420 1430 1440 1450
TANXLRLYDD CPYTAAVAAD IGEAXVFFSG LAPLRMHPDV SWAKVRGVNW
1460 1470 1480 1490 1500
PLLVGVXRTM CRETLSPGPS DDPQWAGLKG PNPVPLLLRW GNDLPSKVAG
1510 1520 1530 1540 1550
HHIVDDLVRR LGVAEGYVRC DAGPILMVGL AIAGGMIYAS YTGSLVVVTD
1560 1570 1580 1590 1600
WDVKGGGSPL YRHGDQATPQ PVVQVPPVDH RPGGESAPSD AKTVTDAVXA
1610 1620 1630 1640 1650
IQVDCDWSVM TLSIGEVLSL AQAKTAEAYT ATAKWLAGCY TGTRAVPTVS
1660 1670 1680 1690 1700
IVDKLFAGGW AAVVGHCHSV IAAAVAAYGA SRSPPLAAAA SYLMGLGVGG
1710 1720 1730 1740 1750
NAQTRLASAL LLGAAGTALG TPVVGLTMAG AFMGGASVSP SLVTILLGAV
1760 1770 1780 1790 1800
GGWEGVVNAA SLVFDFMAGK LSSEDLWYAI PVLTSPGAGL XGIALXLVLY
1810 1820 1830 1840 1850
SANNSGTTTW LNRLLTTLPR SSCIPDSYFQ QADYCDKVSA VLRRLSLTRT
1860 1870 1880 1890 1900
VVXLVNREPK VDEVQVGYVW DLWEXIMRQV RMVMARLRAL CPVVSLPLWH
1910 1920 1930 1940 1950
CGEGWSGEWL LDGHVESRCL CGCVITGDVL NGQLKEPVYS TKLCRHYWMG
1960 1970 1980 1990 2000
TVPVNMLGYG ETSPLLASDT PKVVPFGTSG WAEVVVTPTH VVIRRTSXYK
2010 2020 2030 2040 2050
LLRQQILSAA VXEPYYVDGI PVSWDADARA PAMVYGPGQS VTIDGERYTL
2060 2070 2080 2090 2100
PHQLRLRNVA PSEVSSEVSI DIGTETEDSE LTEADLPPAA AALQAIENAA
2110 2120 2130 2140 2150
RILEPHIDVI MEDCSTPSLC GSSREMPVWG EDIPRTPSPA LISVTESSSD
2160 2170 2180 2190 2200
EKTPSVSPSQ EDTPSSDSFE VIQESETAEG EESVFNVALS VLXALFPQSD
2210 2220 2230 2240 2250
ATRKLTVKMS CCVEXSVTRF FSLGLTVADV ASLCEMEIQN HTAYCDKVRT
2260 2270 2280 2290 2300
PLELQVGCLV GNELTFECDK CEARQETLAS FSYIWSGVPL TRATPAKPPV
2310 2320 2330 2340 2350
VRPVGSLLVA DTTKVYVTNP DNVGRRVDKV TFWRAPRVHD KYLVDSIERA
2360 2370 2380 2390 2400
KRAAQACLSM GYTYEEAIRT VRPHAAMGWG SKVSVKDLPT PXGKMAVHDR
2410 2420 2430 2440 2450
LQEILEGXPV PFTLTVKKEV FFKDRKEEKA PRLIVFPPLD FRIAEKLILG
2460 2470 2480 2490 2500
DPGRVAKAVL GGAYAFQYTP NQRVREMLKL WESKKTPCAI CVDATCFDSS
2510 2520 2530 2540 2550
ITEEDVALET ELYALASDHP EWVRALGKYY ASGTMVTPEG VPVGERYCRS
2560 2570 2580 2590 2600
SGVLTTXASN CLTCYIKVKA ACERVGLKNV SLLIAGDDCL IICERPMCDP
2610 2620 2630 2640 2650
SDALGRALAS YGYACEPSYH ASLDTAPFCS TWLAECNADG KRHFFLTTDF
2660 2670 2680 2690 2700
RRPLARMSSE YSDPMASAIG YILLYPWHPI TRWVIIPHVL TCAFRGGGTP
2710 2720 2730 2740 2750
SDPVWCQVHG NYYKFPLDKL PNIIVALHGP AALRVTADTT KTKMEAGKVL
2760 2770 2780 2790 2800
SDLKLPGLAV HRKKAGAXRT RMLRSXGWAE LARGLLWHPX LRLPPPEIAG
2810 2820 2830 2840
IPGGFPLSPP YMGVVHQLDF TSQRSRWRWL GFLALLIVAL FG
Length:2,842
Mass (Da):307,415
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6F519CFD2E56C87
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF309966 Transcribed RNA Translation: AAG26007.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309966 Transcribed RNA Translation: AAG26007.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Family and domain databases

Gene3Di2.20.25.210, 1 hit
3.30.70.270, 2 hits
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR024347, GB_virus_envelope
IPR002518, HCV_NS2
IPR000745, HCV_NS4a
IPR001490, HCV_NS4b
IPR002868, HCV_NS5a
IPR013193, HCV_NS5a_1B_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR013192, NS5A_1a
IPR038170, NS5A_1a_sf
IPR027417, P-loop_NTPase
IPR009003, Peptidase_S1_PA
IPR004109, Peptidase_S29_NS3
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR007094, RNA-dir_pol_PSvirus
IPR002166, RNA_pol_HCV
PfamiView protein in Pfam
PF12786, GBV-C_env, 1 hit
PF01538, HCV_NS2, 1 hit
PF01006, HCV_NS4a, 1 hit
PF01001, HCV_NS4b, 1 hit
PF01506, HCV_NS5a, 1 hit
PF08300, HCV_NS5a_1a, 1 hit
PF08301, HCV_NS5a_1b, 1 hit
PF02907, Peptidase_S29, 1 hit
PF00998, RdRP_3, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF52540, SSF52540, 2 hits
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS51693, HCV_NS2_PRO, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS51822, HV_PV_NS3_PRO, 1 hit
PS50507, RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9DXH4_9FLAV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DXH4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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