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Protein

Envelope glycoprotein H

Gene

gH

Organism
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.UniRule annotation1 Publication

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell
LigandSialic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein HUniRule annotation
Short name:
gHUniRule annotation
Gene namesi
Name:gHUniRule annotation
ORF Names:UL22
OrganismiHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10304 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion membrane UniRule annotation1 Publication; Single-pass type I membrane protein UniRule annotation1 Publication
  • Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation1 Publication
  • Host endosome membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation1 Publication
  • Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 803Virion surfaceUniRule annotationAdd BLAST785
Transmembranei804 – 824HelicalUniRule annotationAdd BLAST21
Topological domaini825 – 838IntravirionUniRule annotationAdd BLAST14

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18UniRule annotationAdd BLAST18
ChainiPRO_000038547119 – 838Envelope glycoprotein HUniRule annotationAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi120N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi216N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi332N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi437N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi670N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi784N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

Post-translational modificationi

N-glycosylated, O-glycosylated, and sialylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9DHD5
SMRiQ9DHD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 323Interaction with gLUniRule annotationAdd BLAST65

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein H family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.60.40.3190, 1 hit
HAMAPiMF_04033 HSV_GH, 1 hit
InterProiView protein in InterPro
IPR003493 Herpes_gH
IPR035305 Herpes_glycoH_C
IPR038172 Herpes_glycoH_C_sf
PfamiView protein in Pfam
PF17488 Herpes_glycoH_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9DHD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNGLWFVGV IILGAAWGQV HDWTEQTDPW FLDGLGMDRM YWRDTNTGRL
60 70 80 90 100
WLPNTPDPQK PPRGFLAPPD ELNLTTASLP LLRWYEERFC FVLVTTAEFP
110 120 130 140 150
RDPGQLLYIP KTYLLGRPPN ASLPAPTTVE PTAQPPPAVA PLKGLLHNPT
160 170 180 190 200
ASVLLRSRAW VTFSAVPDPE ALTFPRGDNV ATASHPSGPR DTPPPRPPVG
210 220 230 240 250
ARRHPTTELD ITHLHNASTT WLATRGLLRS PGRYVYFSPS ASTWPVGIWT
260 270 280 290 300
TGELVLGCDA ALVRARYGRE FMGLVISMHD SPPAEVMVVP AGQTLDRVGD
310 320 330 340 350
PADENPPGAL PGPPGGPRYR VFVLGSLTRA DNGSALDALR RVGGYPEEGT
360 370 380 390 400
NYAQFLSRAY AEFFSGDAGA EQGPRPPLFW RLTGLLATSG FAFVNAAHAN
410 420 430 440 450
GAVCLSDLLG FLAHSRALAG LAARGAAGCA ADSVFFNVSV LDPTARLQLE
460 470 480 490 500
ARLQHLVAEI LEREQSLALH ALGYQLAFVL DSPSAYDAVA PSAAHLIDAL
510 520 530 540 550
YAEFLGGRVV TTPVVHRALF YASAVLRQPF LAGVPSAVQR ERARRSLLIA
560 570 580 590 600
SALCTSDVAA ATNADLRTAL ARADHQKTLF WLPDHFSPCA ASLRFDLDES
610 620 630 640 650
VFILDALAQA TRSETPVEVL AQQTHGLAST LTRWAHYNAL IRAFVPEASH
660 670 680 690 700
RCGGQSANVE PRILVPITHN ASYVVTHSPL PRGIGYKLTG VDVRRPLFLT
710 720 730 740 750
YLTATCEGST RDIESKRLVR TQNQRDLGLV GAVFMRYTPA GEVMSVLLVD
760 770 780 790 800
TDNTQQQIAA GPTEGAPSVF SSDVPSTALL LFPNGTVIHL LAFDTQPVAA
810 820 830
IAPGFLAASA LGVVMITAAL AGILKVLRTS VPFFWRRE
Length:838
Mass (Da):90,310
Last modified:March 1, 2001 - v1
Checksum:iEE73EF3DC9884922
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF296257 Genomic DNA Translation: AAG17895.1

Similar proteinsi

Entry informationi

Entry nameiGH_HHV1F
AccessioniPrimary (citable) accession number: Q9DHD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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