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UniProtKB - Q9DF67 (VSP2_PROJR)
Protein
Snake venom serine protease 2
Gene
N/A
Organism
Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii)
Status
Functioni
Snake venom serine protease that may act in the hemostasis system of the prey (By similarity).
Has weak fibrinogen clotting activity. Possesses amidolysis activity towards S-2251 (substrate for plasmin) but has no hydrolytic activity with S-2302 (plasma kalikrein substrate) or S-2238 (thrombin substrate).
By similarity1 PublicationMiscellaneous
Does not activate nor degrade plasminogen or prothrombin (F2). Does not activate factor XIII.
Activity regulationi
Inhibited by PMSF at 2 mM concentration but not by EDTA.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 65 | Charge relay systemBy similarity | 1 | |
Active sitei | 110 | Charge relay systemBy similarity | 1 | |
Active sitei | 204 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Fibrinolytic toxin, Hemostasis impairing toxin, Hydrolase, Protease, Serine protease, Toxin |
Protein family/group databases
MEROPSi | S01.186 |
Names & Taxonomyi
Protein namesi | Recommended name: Snake venom serine protease 2 (EC:3.4.21.-)Short name: SP2 Short name: SVSP Alternative name(s): Jerdonobin-II |
Organismi | Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii) |
Taxonomic identifieri | 242841 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Protobothrops |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
PropeptideiPRO_0000028403 | 19 – 24 | 1 Publication | 6 | |
ChainiPRO_0000028404 | 25 – 258 | Snake venom serine protease 2Add BLAST | 234 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 163 | PROSITE-ProRule annotation | ||
Glycosylationi | 44 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 50 ↔ 66 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 256 | PROSITE-ProRule annotation | ||
Glycosylationi | 122 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 210 | PROSITE-ProRule annotation | ||
Disulfide bondi | 174 ↔ 189 | PROSITE-ProRule annotation | ||
Glycosylationi | 185 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 200 ↔ 225 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 249 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 225 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9DF67-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLIRVLANL LILQLSYAQK SSELVFGGRP CNINEHRSLV VLFNSSGFLC
60 70 80 90 100
GGTLINQDWV VTAAHCDSEN FQLLFGVHSK KILNEDEQTR DPKEKFFCPN
110 120 130 140 150
RKNDDEVDKD IMLIKLDSSV SNSTHIAPLS LPSSPPSVGS VCRIMGWGKT
160 170 180 190 200
IPTKEIYPDV PHCANINILD HAVCRAAYSW RTVANTTLCA GILQGGKDTC
210 220 230 240 250
HADSGGPLIC NGQVQGIVSW GGHPCGQPRE PGVYTKVLDY NDWVQSIIAG
NTEATCPP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF292111 mRNA Translation: AAG10789.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF292111 mRNA Translation: AAG10789.1 |
3D structure databases
SMRi | Q9DF67 |
ModBasei | Search... |
Protein family/group databases
MEROPSi | S01.186 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VSP2_PROJR | |
Accessioni | Q9DF67Primary (citable) accession number: Q9DF67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 4, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 86 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families