UniProtKB - Q9DES8 (Q9DES8_DANRE)
Protein
Submitted name:
Glycine receptor betaZ subunit
Gene
glrba
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
GO - Molecular functioni
- extracellularly glycine-gated chloride channel activity Source: InterPro
- neurotransmitter receptor activity Source: GO_Central
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: GO_Central
- chloride transmembrane transport Source: GO_Central
- ion transmembrane transport Source: GO_Central
- nervous system process Source: GO_Central
- neuropeptide signaling pathway Source: GO_Central
- regulation of membrane potential Source: GO_Central
- response to amino acid Source: GO_Central
- signal transduction Source: GO_Central
- synaptic transmission, glycinergic Source: GO_Central
Keywordsi
Molecular function | Ion channelUniRule annotation, ReceptorImportedARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Glycine receptor betaZ subunitImportedSubmitted name: Glycine receptor, beta aImported |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-010410-2, glrba |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- postsynaptic membrane Source: InterPro
Other locations
- neuron projection Source: GO_Central
- synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 265 – 286 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 328 – 349 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 476 – 496 | HelicalUniRule annotationAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | UniRule annotationAdd BLAST | 22 | |
ChainiPRO_5015099692 | 23 – 498 | UniRule annotationAdd BLAST | 476 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000052782, Expressed in brain and 9 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 264 | Neur_chan_LBDInterPro annotationAdd BLAST | 207 | |
Domaini | 272 – 494 | Neur_chan_membInterPro annotationAdd BLAST | 223 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 369 – 390 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 447 – 466 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG3644, Eukaryota |
GeneTreei | ENSGT00940000156344 |
HOGENOMi | CLU_010920_1_4_1 |
OMAi | FRSMILL |
OrthoDBi | 614790at2759 |
TreeFami | TF315453 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR008060, Glycine_rcpt_B IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF29, PTHR18945:SF29, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01677, GLYRBETA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9DES8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRCAAMLLKG LILLMLLVQF SAEEGGKPKK GKKGKQVICP SQLSAEDLDR
60 70 80 90 100
VPANSTSNIL NRLLMTYDSR IRPNFKGIPV EDKVNIFINS FGSIQETTMD
110 120 130 140 150
YRVNIFLRQR WNDPRLRLPT DFKSDALTVD PKMFQCLWKP DLFFANEKNA
160 170 180 190 200
NFHDVTQENI LLFIFRNGDV LISMRLSVTL SCPLALQLFP MDTQYCKMQL
210 220 230 240 250
ESFGYTTKDL VFMWQSGDPV QMDEIALPQF DVKQEDIKYA NCTKFYPGTG
260 270 280 290 300
YYTCVEVIFT LRRQVGFYMM GVYAPTLLIV VLSWLSFWIN PDASAARVPL
310 320 330 340 350
GILSVLSLSS ECTSLASELP KVSYVKAIDI WMIACLLYGF ASLVEYAVVQ
360 370 380 390 400
VMLNSPKRIE AEKIKMAEKE KAREKENKTP AKTNSANGTG GTPIHVSTLQ
410 420 430 440 450
VVENRCKKVC TSKSDLRSND FSIVGSLPRD FELSNFDCYG KPIEVTDASG
460 470 480 490
KPQNKNNKKP APPKPVIPSA AKRVDLYARA LFPFTFLFFN VIYWSVYL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8QRM1 | A0A2R8QRM1_DANRE | Glycine receptor, beta a | glrba | 499 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284619 Genomic DNA No translation available. CU075714 Genomic DNA No translation available. AJ404971 mRNA Translation: CAC16688.1 |
RefSeqi | NP_571856.1, NM_131781.1 |
Genome annotation databases
Ensembli | ENSDART00000102790; ENSDARP00000093565; ENSDARG00000052782 |
GeneIDi | 83412 |
KEGGi | dre:83412 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284619 Genomic DNA No translation available. CU075714 Genomic DNA No translation available. AJ404971 mRNA Translation: CAC16688.1 |
RefSeqi | NP_571856.1, NM_131781.1 |
3D structure databases
SMRi | Q9DES8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000093565 |
Genome annotation databases
Ensembli | ENSDART00000102790; ENSDARP00000093565; ENSDARG00000052782 |
GeneIDi | 83412 |
KEGGi | dre:83412 |
Organism-specific databases
CTDi | 83412 |
ZFINi | ZDB-GENE-010410-2, glrba |
Phylogenomic databases
eggNOGi | KOG3644, Eukaryota |
GeneTreei | ENSGT00940000156344 |
HOGENOMi | CLU_010920_1_4_1 |
OMAi | FRSMILL |
OrthoDBi | 614790at2759 |
TreeFami | TF315453 |
Gene expression databases
Bgeei | ENSDARG00000052782, Expressed in brain and 9 other tissues |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR008060, Glycine_rcpt_B IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF29, PTHR18945:SF29, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR01677, GLYRBETA PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9DES8_DANRE | |
Accessioni | Q9DES8Primary (citable) accession number: Q9DES8 Secondary accession number(s): E9QB20 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |