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Entry version 119 (02 Jun 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Teneurin-2

Gene

TENM2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a ligand of the ADGRL1 receptor (By similarity).

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer.

By similarity3 Publications

Induces gene transcription inhibition.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processCell adhesion, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-2
Short name:
Ten-2
Alternative name(s):
Neurestin
Protein Odd Oz/ten-m homolog 2
Tenascin-M2
Short name:
Ten-m2
Teneurin transmembrane protein 2
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENM2
Synonyms:ODZ2, TNM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 407CytoplasmicSequence analysisAdd BLAST407
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei408 – 428HelicalSequence analysisAdd BLAST21
Topological domaini429 – 2802ExtracellularSequence analysisAdd BLAST2374

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus, Postsynaptic cell membrane, Synapse, Synaptosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595041 – 2802Teneurin-2Add BLAST2802
ChainiPRO_00004210171 – ?Ten-2 intracellular domain
ChainiPRO_0000421018557 – 2802Ten-2, soluble formAdd BLAST2246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi510N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi604 ↔ 614PROSITE-ProRule annotation
Disulfide bondi608 ↔ 619PROSITE-ProRule annotation
Disulfide bondi621 ↔ 630PROSITE-ProRule annotation
Disulfide bondi639 ↔ 650PROSITE-ProRule annotation
Disulfide bondi652 ↔ 661PROSITE-ProRule annotation
Disulfide bondi668 ↔ 679PROSITE-ProRule annotation
Disulfide bondi673 ↔ 684PROSITE-ProRule annotation
Disulfide bondi686 ↔ 695PROSITE-ProRule annotation
Disulfide bondi700 ↔ 711PROSITE-ProRule annotation
Disulfide bondi705 ↔ 716PROSITE-ProRule annotation
Disulfide bondi718 ↔ 727PROSITE-ProRule annotation
Disulfide bondi738 ↔ 751PROSITE-ProRule annotation
Disulfide bondi753 ↔ 762PROSITE-ProRule annotation
Disulfide bondi767 ↔ 777PROSITE-ProRule annotation
Disulfide bondi771 ↔ 782PROSITE-ProRule annotation
Disulfide bondi784 ↔ 793PROSITE-ProRule annotation
Disulfide bondi798 ↔ 808PROSITE-ProRule annotation
Disulfide bondi802 ↔ 813PROSITE-ProRule annotation
Disulfide bondi815 ↔ 824PROSITE-ProRule annotation
Disulfide bondi838 ↔ 848PROSITE-ProRule annotation
Disulfide bondi842 ↔ 857PROSITE-ProRule annotation
Disulfide bondi859 ↔ 868PROSITE-ProRule annotation
Glycosylationi953N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi976N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1777N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1835N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1920N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2021N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2225N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2676N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Derives from the membrane form by proteolytic processing.
Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei556 – 557CleavageCurated2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9DER5

PRoteomics IDEntifications database

More...
PRIDEi
Q9DER5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in external plexiform layer and laminae 1 and 3 within the inner plexiform layer (at protein level). Expression started to be detectable in 4-day-old embryos, both in the body as well as the head (brain) of the embryos. Expressed in neurons of the inner plexiform layer (IPL), the optic fiber layer (OFL) and the optic nerve at embryonic day (E) 11. Expressed in the neurons of the entire retinal ganglion cell layer at E12. Expressed by the neurons of the thalamofugal visual pathway at E18. Expressed in the developing limb buds, somites, and craniofacial mesenchyme at E19. In the limbs, expressed transiently in the apical ectodermal ridge (AER) and later at sites of tendon morphogenesis. Also found in the notochord, dorsal neural tube, and dorsomedial lip of the somite as well as the flank mesoderm.3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (Probable). Heterodimer with other teneurins (By similarity).

By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
674934, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000002709

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12802
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9DER5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 403Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST403
Domaini603 – 631EGF-like 1PROSITE-ProRule annotationAdd BLAST29
Domaini633 – 662EGF-like 2PROSITE-ProRule annotationAdd BLAST30
Domaini664 – 696EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini697 – 729EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini730 – 763EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini766 – 794EGF-like 6PROSITE-ProRule annotationAdd BLAST29
Domaini797 – 825EGF-like 7PROSITE-ProRule annotationAdd BLAST29
Domaini836 – 869EGF-like 8PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1300 – 1344NHL 1Add BLAST45
Repeati1370 – 1414NHL 2Add BLAST45
Repeati1429 – 1480NHL 3Add BLAST52
Repeati1502 – 1529NHL 4Add BLAST28
Repeati1558 – 1601NHL 5Add BLAST44
Repeati1611 – 1630YD 1Add BLAST20
Repeati1647 – 1667YD 2Add BLAST21
Repeati1710 – 1729YD 3Add BLAST20
Repeati1730 – 1752YD 4Add BLAST23
Repeati1923 – 1942YD 5Add BLAST20
Repeati1964 – 1982YD 6Add BLAST19
Repeati1983 – 2003YD 7Add BLAST21
Repeati2010 – 2027YD 8Add BLAST18
Repeati2028 – 2049YD 9Add BLAST22
Repeati2050 – 2067YD 10Add BLAST18
Repeati2070 – 2090YD 11Add BLAST21
Repeati2093 – 2113YD 12Add BLAST21
Repeati2121 – 2141YD 13Add BLAST21
Repeati2147 – 2164YD 14Add BLAST18
Repeati2165 – 2191YD 15Add BLAST27
Repeati2193 – 2206YD 16Add BLAST14
Repeati2207 – 2230YD 17Add BLAST24
Repeati2233 – 2253YD 18Add BLAST21
Repeati2254 – 2274YD 19Add BLAST21
Repeati2276 – 2296YD 20Add BLAST21
Repeati2308 – 2328YD 21Add BLAST21
Repeati2330 – 2350YD 22Add BLAST21
Repeati2376 – 2417YD 23Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni138 – 170DisorderedSequence analysisAdd BLAST33
Regioni190 – 299DisorderedSequence analysisAdd BLAST110
Regioni446 – 482DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi138 – 157Polar residuesSequence analysisAdd BLAST20
Compositional biasi190 – 219Polar residuesSequence analysisAdd BLAST30
Compositional biasi225 – 275Polar residuesSequence analysisAdd BLAST51

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1225, Eukaryota
KOG4659, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9DER5

Database of Orthologous Groups

More...
OrthoDBi
7516at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9DER5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR011047, Quinoprotein_ADH-like_supfam
IPR022385, Rhs_assc_core
IPR027689, Ten-2
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD

The PANTHER Classification System

More...
PANTHERi
PTHR11219:SF8, PTHR11219:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974, EGF_2, 1 hit
PF06484, Ten_N, 1 hit
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits
SM00179, EGF_CA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit
SSF50998, SSF50998, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS51361, TENEURIN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9DER5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIKDRRHRS LTRGRCGKEC RYTSSSLDSE DCRVPAQKSY SSSETLKAYG
60 70 80 90 100
HDTRMHYGNR VSDLVHRESD EFPRQGTNFT LAELGICEPS PHRSGYCSDI
110 120 130 140 150
GILHQGYSLS TGSDADSDTE GGMSPEHAIR LWGRGIKSSR SSGLSSRENS
160 170 180 190 200
ALTLTDSDNE NKSDEENDFH THLSEKLKDR QTSWQQLAET KNSLIRRPIP
210 220 230 240 250
PTSSSSLLPS AQLPSSHNPP PVSCQMPLLD SNTSHQIMDT NPDEEFSPNS
260 270 280 290 300
YLLRACSGPQ QASSSGPSNH HSQSTLRPPL PPPHNHSLSH HHSSANSLNR
310 320 330 340 350
NSLTNRRNQI HAPAPAPNDL ATTPESVQLQ DSWVLNSNVP LETRHFLFKT
360 370 380 390 400
SSGTTPLFSS SSPGYPLTSG TVYTPPPRLL PRNTFSRNAF KLKKPSKYCS
410 420 430 440 450
WKCAALSAIA AAVLLAILLA YFIAMHLLGL NWQLQPADGH TFSNGLRPGA
460 470 480 490 500
AGAEDGAAAP PAGRGPWVTR NSSIDSGETE VGRKVTQEVP PGVFWRSQIH
510 520 530 540 550
ISQPQFLKFN ISLGKDALFG VYIRRGLPPS HAQYDFMERL DGKEKWSVVE
560 570 580 590 600
SPRERRSIQT LVQNEAVFVQ YLDVGLWHLA FYNDGKDKEV VSFSTVILDS
610 620 630 640 650
VQDCPRNCHG NGECVSGVCH CFPGFHGADC AKAACPVLCS GNGQYSKGTC
660 670 680 690 700
LCYSGWKGPE CDVPISQCID PSCGGHGSCI EGNCVCSIGY KGENCEEVDC
710 720 730 740 750
LDPTCSNHGV CVNGECLCSP GWGGINCELP RAQCPDQCSG HGTYLSDTGL
760 770 780 790 800
CSCDPNWMGP DCSVEVCSVD CGTHGVCIGG ACRCEEGWTG VACDQRVCHP
810 820 830 840 850
RCTEHGTCKD GKCECREGWN GEHCTIGRQT TGTETDGCPD LCNGNGRCTL
860 870 880 890 900
GQNSWQCVCQ TGWRGPGCNV AMETSCADNK DNEGDGLVDC LVPDCCLQST
910 920 930 940 950
CQNSLLCRGS RDPLDIIQQS HSGSPAVKSF YDRIKLLVGK DSTHIIPGEN
960 970 980 990 1000
PFNSSLVSLI RGQVVTTDGT PLVGVNVSFV KYPKYGYTIT RQDGMFDLVA
1010 1020 1030 1040 1050
NGGSSLTLHF ERAPFMSQER TVWLPWNSFY AMDTLVMKTE ENSIPSCDLS
1060 1070 1080 1090 1100
GFVRPDPVII SSPLSTFFSD APGRNPIVPE TQVLHEEIEV PGSSIKLIYL
1110 1120 1130 1140 1150
SSRTAGYKSL LKIIMTQSLV PLNLIKVHLM VAVEGHLFQK SFLASPNLAY
1160 1170 1180 1190 1200
TFIWDKTDAY GQKVYGLSDA VVSVGFEYET CPSLILWEKR TALLQGFELD
1210 1220 1230 1240 1250
PSNLGGWSLD KHHVLNVKSG ILHKGNGENQ FLTQQPAVIT SIMGNGRRRS
1260 1270 1280 1290 1300
ISCPSCNGLA EGNKLLAPVA LAVGIDGSLF VGDFNYIRRI FPSRNVTSIL
1310 1320 1330 1340 1350
ELRNKEFKHS NNPAHKYYLA VDPVSGSLYV SDTNSRRIYK VKSLTGTKDL
1360 1370 1380 1390 1400
AGNSEVVAGT GEQCLPFDEA RCGDGGKAVD ATLMSPRGIA VDKYGLMYFV
1410 1420 1430 1440 1450
DATMIRKVDQ NGIISTLLGS NDLTAVRPLS CDSSMDVSQV RLEWPTDLAV
1460 1470 1480 1490 1500
DPMDNSLYVL ENNVILRITE NHQVSIIAGR PMHCQVPGID YSLSKLAIHS
1510 1520 1530 1540 1550
ALESASAIAI SHTGVLYISE TDEKKINRLR QVTTNGEICL LAGAASDCDC
1560 1570 1580 1590 1600
KNDVNCNCYS GDDGYATDAI LNSPSSLAVA PDGTIYIADL GNIRIRAVSK
1610 1620 1630 1640 1650
NRPILNSFNQ YEAASPGEQE LYVFNADGIH QYTLSLVTGE YLYNFTYSSD
1660 1670 1680 1690 1700
NDVTEVMDSN GNSLKVRRDA SGMPRHLLMP DNQIVTLAVG TNGGLKLVST
1710 1720 1730 1740 1750
QTLELGLMTY NGNSGLLATK SDETGWTTFY DYDHEGRLTN VTRPTGVVTS
1760 1770 1780 1790 1800
LHREMEKSIT IDIENSNRDD DVTVITNLSS VEASYTVVQD QVRNSYQLCN
1810 1820 1830 1840 1850
NGTLRVMYAN GMSISFHSEP HVLAGTVTPT IGRCNISLPM ENGLNSIEWR
1860 1870 1880 1890 1900
LRKEQIKGKV TVFGRKLRVH GRNLLSIDYD RNIRTEKIYD DHRKFTLRII
1910 1920 1930 1940 1950
YDQLGRPFLW LPSSGLAAVN VSYFFNGRLA GLQRGAMSER TDIDKQGRII
1960 1970 1980 1990 2000
SRMFADGKVW SYTYLEKSMV LLLQSQRQYI FEYDSSDRLH AVTMPSVARH
2010 2020 2030 2040 2050
SMSTHTSVGY IRNIYNPPES NASVIFDYSD DGRILKTSFL GTGRQVFYKY
2060 2070 2080 2090 2100
GKLSKLSEIV YDSTAVTFGY DETTGVLKMV NLQSGGFSCT IRYRKIGPLV
2110 2120 2130 2140 2150
DKQIYRFSEE GMVNARFDYT YHDNSFRIAS IKPIISETPL PVDLYRYDEI
2160 2170 2180 2190 2200
SGKVEHFGKF GVIYYDINQI ITTAVMTLSK HFDTHGRIKE VQYEMFRSLM
2210 2220 2230 2240 2250
YWMTVQYDSM GRVTKRELKL GPYANTTKYT YDYDGDGQLQ SVAVNDRPTW
2260 2270 2280 2290 2300
RYSYDLNGNL HLLNPGNSVR LMPLRYDLRD RITRLGDIPY KIDDDGFLCQ
2310 2320 2330 2340 2350
RGSDVFEYNS KGLLTRAYNK ANGWNVQYRY DGLGRRASCK TNLGHHLQYF
2360 2370 2380 2390 2400
YADLHNPTRV THVYNHSNSE ITSLYYDLQG HLFAMESSSG EEYYVASDNT
2410 2420 2430 2440 2450
GTPLAVFSIN GLMIKQLQYT AYGEIYYDSN PDFQLVIGFH GGLYDPLTKL
2460 2470 2480 2490 2500
VHFTQRDYDV LAGRWTSPDY TMWKNIGREP APFNLYMFKS NNPLSNELDL
2510 2520 2530 2540 2550
KNYVTDVKSW LVMFGFQLSN IIPGFPRAKM YFVSPPYELT ESQACENGQL
2560 2570 2580 2590 2600
ITGVQQTTER HNQAFMALEG QVISKRLHAS IREKAGHWFA TSTPIIGKGI
2610 2620 2630 2640 2650
MFAVKKGRVT TGISSIATDD SRKIASVLNS AHYLEKMHYS IEGKDTHYFV
2660 2670 2680 2690 2700
KIGSADSDLV TLAMTSGRKV LDSGVNVTVS QPTLLINGRT RRFTNIEFQY
2710 2720 2730 2740 2750
STLLINIRYG LTADTLDEEK ARVLDQARQR ALGSAWAKEQ QKARDGREGS
2760 2770 2780 2790 2800
RVWTDGEKQQ LLNTGRVQGY EGYYVLPVEQ YPELADSSSN IQFLRQNEMG

KR
Length:2,802
Mass (Da):310,749
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1FBC2C84EDFA4B3
GO
Isoform 2 (identifier: Q9DER5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-196: DFHTHLSEKLKDRQTSWQQLAETKNSLIR → G

Show »
Length:2,774
Mass (Da):307,313
Checksum:i2F5E12D1498E85D6
GO
Isoform 3 (identifier: Q9DER5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-836: Missing.

Show »
Length:2,794
Mass (Da):309,915
Checksum:i41E18DEB7D7075B0
GO
Isoform 4 (identifier: Q9DER5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     836-859: DGCPDLCNGNGRCTLGQNSWQCVC → SYCFLFINRRDIVTVVYCDRLFL
     860-2802: Missing.

Show »
Length:858
Mass (Da):93,581
Checksum:iDCFAACF590DA9752
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36A → T in CAB57257 (PubMed:10588872).Curated1
Sequence conflicti50G → D in CAB57257 (PubMed:10588872).Curated1
Sequence conflicti139S → R in CAB57257 (PubMed:10588872).Curated1
Sequence conflicti836 – 859DGCPD…WQCVC → GSYCFLFINRRDIVTVVYCD RLFL in CAB57257 (PubMed:10588872).CuratedAdd BLAST24

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_021398168 – 196DFHTH…NSLIR → G in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_021399829 – 836Missing in isoform 3. 1 Publication8
Alternative sequenceiVSP_021400836 – 859DGCPD…WQCVC → SYCFLFINRRDIVTVVYCDR LFL in isoform 4. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_021401860 – 2802Missing in isoform 4. 1 PublicationAdd BLAST1943

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ279031 mRNA Translation: CAC09416.1
AJ245711 mRNA Translation: CAB57257.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003718.1, NM_001003718.1
NP_989428.2, NM_204097.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
373854

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:373854

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ279031 mRNA Translation: CAC09416.1
AJ245711 mRNA Translation: CAB57257.1
RefSeqiNP_001003718.1, NM_001003718.1
NP_989428.2, NM_204097.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6FB3X-ray2.38A/B/C/D955-2802[»]
6SKAX-ray3.86A956-2798[»]
6SKEX-ray3.62A/C1047-2802[»]
SMRiQ9DER5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi674934, 4 interactors
STRINGi9031.ENSGALP00000002709

Proteomic databases

PaxDbiQ9DER5
PRIDEiQ9DER5

Genome annotation databases

GeneIDi373854
KEGGigga:373854

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57451

Phylogenomic databases

eggNOGiKOG1225, Eukaryota
KOG4659, Eukaryota
InParanoidiQ9DER5
OrthoDBi7516at2759
PhylomeDBiQ9DER5

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9DER5

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR011047, Quinoprotein_ADH-like_supfam
IPR022385, Rhs_assc_core
IPR027689, Ten-2
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD
PANTHERiPTHR11219:SF8, PTHR11219:SF8, 1 hit
PfamiView protein in Pfam
PF07974, EGF_2, 1 hit
PF06484, Ten_N, 1 hit
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00179, EGF_CA, 2 hits
SUPFAMiSSF49464, SSF49464, 1 hit
SSF50998, SSF50998, 1 hit
TIGRFAMsiTIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 5 hits
PS51361, TENEURIN_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN2_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DER5
Secondary accession number(s): Q9PU49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2001
Last modified: June 2, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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