Kheper

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: UniProtKB-KW

GO - Biological processⁱ

• gastrulation Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Missense mutations in TCF8 cause late-onset Fuchs corneal dystrophy and interact with FCD4 on chromosome 9p."
    Riazuddin S.A., Zaghloul N.A., Al-Saif A., Davey L., Diplas B.H., Meadows D.N., Eghrari A.O., Minear M.A., Li Y.J., Klintworth G.K., Afshari N., Gregory S.G., Gottsch J.D., Katsanis N.
    Am. J. Hum. Genet. 86:45-53(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of cell-cell adhesion involved in gastrulation Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development."
    Vannier C., Mock K., Brabletz T., Driever W.
    J Biol Chem 288:18643-18659(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of cell motility Source: ZFINInferred from genetic interactionⁱ
  • "Identification and regulation of a molecular module for bleb-based cell motility."
    Goudarzi M., Banisch T.U., Mobin M.B., Maghelli N., Tarbashevich K., Strate I., van den Berg J., Blaser H., Bandemer S., Paluch E., Bakkers J., Tolic-Norrelykke I.M., Raz E.
    Dev Cell 23:210-218(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of gastrulation Source: ZFINInferred from genetic interactionⁱ
  • "Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development."
    Vannier C., Mock K., Brabletz T., Driever W.
    J Biol Chem 288:18643-18659(2013) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MADGPRCKRR KQANPRRTNV SNYSHVLEGQ SDSDDEDKLH IVEEEGSLLD 
        60         70         80         90        100
GADCDSVAPD DDPNGTADPD GRWDDVKEEC VSDEDERSRD ALVEEMLQQG 
       110        120        130        140        150
DTAVIFPEAP DDEPRQGTPE TSGHDENGTP DSFSQLLTCP YCSRGYKRYT 
       160        170        180        190        200
SLKEHIKYRH EKSEDNFSCS LCSYTFAYRT QLDRHMTAHK AGREQRHVTQ 
       210        220        230        240        250
SGGGGNRKFK CTECGKAFKY KHHLKEHLRI HSGEKPYECS NCKKRFSHSG 
       260        270        280        290        300
SYSSHISSKK CIGLISVNGR PRPSPATGAA KTPQCSSPYL PTSSPTARVQ 
       310        320        330        340        350
VRDKLDNSKP LQEQLPLTQI KSEPLDYEYK PVVVAPSARG VNGMFQGGAA 
       360        370        380        390        400
APLQGAVQAV VLPTVGLVSP ISINLGDLQN VLKVAVDGNV IRQVLESTQA 
       410        420        430        440        450
KGQQAGTGIV GAGGIAQATQ QVIQAISLPI LDQDGNAKIF INYSLDPSQA 
       460        470        480        490        500
QAVLQSPKKE PLGSNTEVCK GQKLPEDLTV KTNRDKTTLT VDEKSMLHND 
       510        520        530        540        550
ILLKHCGKDE HRINGKNLEE KMDLEGLCPG QPPLKNLLSL LKAYFALNNE 
       560        570        580        590        600
PTKEELAKIS ESVSLPAEVV KKWFEKMQLG QISMDPSSPQ HEEEQTTPVD 
       610        620        630        640        650
LDGTKGASPK PDLDEQMNSE KQEERECCSP AEGIAASVNG IESVPASPSP 
       660        670        680        690        700
LNLSADGPVP ARTLEEGEGP LDLSLPKSAT TASVASGHAN TVYSAQEEPL 
       710        720        730        740        750
NLTCTKKELL SNASTNAAIY ASQPSANPIN IMTTQLPTLV AITDQGQAQC 
       760        770        780        790        800
LRALTTTKQT ILIPQLTYSY TTTSSSPAGT DTPQKNILHV NGIKEEKQEM 
       810        820        830        840        850
GSEATSILEE QTDSDSGPTK KKMKRTESGL YACDLCDKIF QKSSSLLRHK 
       860        870        880        890        900
YEHTGKRPHE CGICSKAFKH KHHLIEHLRL HSGEKPYQCD KCGKRFSHSG 
       910        920        930        940        950
SYSQHMNHRY SYCKKEAQGQ GLGQGVEEED NPGEEQPQTG STATSPPSHL 
       960        970        980        990       1000
DSDERGSSTR DDESEEEDEM GSGSLVDEDE IQVVKIGEEG DEDDQGADED 
      1010       1020       1030       1040       1050
QERMEEDGDE EGEGETLKVV VMQDECEEDE NEEDEQTSED AMDTSDHTEE 
      1060       1070 
MTERKTPGDN KNIGEHEGNT AAMNGDVK                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ