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Protein

Runt-related transcription factor

Gene

runx3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Chloride 1UniRule annotation1
Binding sitei113Chloride 1; via amide nitrogenUniRule annotation1
Binding sitei136Chloride 2UniRule annotation1
Binding sitei167Chloride 2; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cartilage development Source: ZFIN
  • chondrocyte differentiation Source: GO_Central
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • hemopoiesis Source: ZFIN
  • neuron differentiation Source: GO_Central
  • ossification Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: UniProtKB-UniRule
  • regulation of cell differentiation Source: GO_Central
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-8941855 RUNX3 regulates CDKN1A transcription
R-DRE-8941856 RUNX3 regulates NOTCH signaling
R-DRE-8941858 Regulation of RUNX3 expression and activity
R-DRE-8951430 RUNX3 regulates WNT signaling
R-DRE-8951671 RUNX3 regulates YAP1-mediated transcription
R-DRE-8951936 RUNX3 regulates p14-ARF

Names & Taxonomyi

Protein namesi
Recommended name:
Runt-related transcription factorUniRule annotation
Gene namesi
Name:runx3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-000605-2 runx3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSDARG00000052826

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000069236

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 175RuntInterPro annotationAdd BLAST129

Phylogenomic databases

eggNOGiKOG3982 Eukaryota
ENOG4111J4Y LUCA
GeneTreeiENSGT00390000016964
HOVERGENiHBG060268
KOiK09279
OMAiGPFQANP
TreeFamiTF321496

Family and domain databases

Gene3Di2.60.40.720, 1 hit
InterProiView protein in InterPro
IPR000040 AML1_Runt
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR013524 Runt_dom
IPR013711 RunxI_C_dom
IPR016554 TF_Runt-rel_RUNX
PANTHERiPTHR11950 PTHR11950, 1 hit
PfamiView protein in Pfam
PF00853 Runt, 1 hit
PF08504 RunxI, 1 hit
PIRSFiPIRSF009374 TF_Runt-rel_RUNX, 1 hit
PRINTSiPR00967 ONCOGENEAML1
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51062 RUNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9DEA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHIPVDPSTS RRFTPPSASF PCAKVTESQS MSAPGPLRSG RPVESRSVVD
60 70 80 90 100
VLADHAGELV RTDSPNFLCS VLPSHWRCNK TLPVAFKVVA LGDVPDGTLV
110 120 130 140 150
TVMAGNDENY SAELRNASAV MKNQVARFND LRFVGRSGRG KSFTLTITVF
160 170 180 190 200
TGPPQVATYH RAIKVTVDGP REPRRHRVKP DDPHKQFSDR LSDIERFQRA
210 220 230 240 250
SLRMNPGNGT TRPHQTHYSP SSTTQIPGLW PDQIDPPTLK TCKVEDDLRW
260 270 280 290 300
TSTDLFQQRT SFPSLSPLTA PRFSDSHMHY PSHFTYSANP SSTGIGGLSV
310 320 330 340 350
AGMPTSSRYH TYLPPPYPGN QNQNSHFQTN SSPYHLYYGT GSGSYQFSMI
360 370 380 390 400
PTGGSGSGGD RSPTRMLTSC TAAGGAAGNT GNNNLINANL GNQSDGVDAD
410 420
GSHSNSPTAM SASTRIDESV WRPY
Length:424
Mass (Da):46,014
Last modified:March 1, 2001 - v1
Checksum:iBE3C03723555AA8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01078996 Genomic DNA No translation available.
CABZ01078997 Genomic DNA No translation available.
CABZ01078998 Genomic DNA No translation available.
CABZ01083958 Genomic DNA No translation available.
CABZ01083959 Genomic DNA No translation available.
CABZ01083960 Genomic DNA No translation available.
CT025744 Genomic DNA No translation available.
AF104037 mRNA Translation: AAG43183.1
BC163552 mRNA Translation: AAI63552.1
BC163560 mRNA Translation: AAI63560.1
AF510734 mRNA Translation: AAO85550.1
RefSeqiNP_571679.2, NM_131604.2
UniGeneiDr.82593

Genome annotation databases

EnsembliENSDART00000161144; ENSDARP00000136974; ENSDARG00000052826
ENSDART00000163556; ENSDARP00000141377; ENSDARG00000052826
GeneIDi58127
KEGGidre:58127

Similar proteinsi

Entry informationi

Entry nameiQ9DEA0_DANRE
AccessioniPrimary (citable) accession number: Q9DEA0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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