Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 102 (10 Feb 2021)
Sequence version 2 (07 Mar 2006)
Previous versions | rss
Add a publicationFeedback
Protein

Serine/threonine-protein kinase atr

Gene

atr

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response mechanism.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Kinase activity is activated by topbp1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDNA damage, DNA repair
LigandATP-binding, Manganese, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase atr (EC:2.7.11.1)
Short name:
Xatr
Alternative name(s):
Ataxia telangiectasia and Rad3-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1012725, atr.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002256281 – 2654Serine/threonine-protein kinase atrAdd BLAST2654

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9DE14

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with atrip.

Interacts with topbp1 in the presence of atrip.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
99532, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9DE14, 2 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati814 – 850HEAT 1Add BLAST37
Repeati1344 – 1380HEAT 2Add BLAST37
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1654 – 2196FATPROSITE-ProRule annotationAdd BLAST543
Domaini2331 – 2577PI3K/PI4KPROSITE-ProRule annotationAdd BLAST247
Domaini2622 – 2654FATCPROSITE-ProRule annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family. ATM subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
WMLLPHF

Database of Orthologous Groups

More...
OrthoDBi
80538at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR011990, TPR-like_helical_dom_sf
IPR012993, UME

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF48452, SSF48452, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9DE14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDPGLEMA SMIPALRELA SAGAEEYNTT VQKPRQILCQ FIDRILTDVD
60 70 80 90 100
VVAVELSKNT DSQPSSVMLL DFIQHIMKST PLMFLSANNG DQSAETNQNC
110 120 130 140 150
VAFSNWIISR LLRIGATPSC KALHRKIAEV IRSLLFLFKN KSSFLFGVFT
160 170 180 190 200
KDLLHLFEDL IYIHEQNMEK SVVWPVTISR FLSNASENQT YLRCTQFQLL
210 220 230 240 250
NMQNIEPLES TLLMVLMDNE HDISPVFFQR QNLLLWGIGC SLLDYGSTPL
260 270 280 290 300
KIQALHFLRQ LIKLGGPPEQ GAYFFFIVFF GILTCIKDMD LEEVSLYEMP
310 320 330 340 350
LLKLVKVLFP FESKSYLNIE PVYLNMLLEK LAALFDGGIL SNIQSAPLKE
360 370 380 390 400
ALCYMVHYFL SIVPPGYESA KEVREAHVRC ICRAFVDVLG LQSKQEYLVC
410 420 430 440 450
PLHEALRIEN LVFMQQQRMQ PLSTDSEGGG SSSSDEVQEK RPRLSLTAKP
460 470 480 490 500
LRRNTPSVPA PVDMKTKSIL WKAVSAKFSS ILCKLEGDEV TDEEMVSLLE
510 520 530 540 550
GLNTTVRVAA LNTVHIFTND STDTDQLVSD LSNTSGIQSV EIVPHVFWLS
560 570 580 590 600
PEDILKILKI CRKVLDSAHQ RANINDILMK IIKIFDAILY IHAGNRLNDQ
610 620 630 640 650
TLKDLCSMIS LPWLQNHSNH ASFKVASFDP TLMTISERIG QHYSPEIQSQ
660 670 680 690 700
LVFLLCLFPK MLCPEWRLAV YQWALDSPHE IVRARCIKGF PVLLCNVSQQ
710 720 730 740 750
GYGPIPKILI DCLNDASELV KKELANSVGM FASGLACGFE LQYSPTAPTA
760 770 780 790 800
AESEFLCSSL TVTALPSSKL SRMTASALKP FLALLNRNMP SSVKMAFIEN
810 820 830 840 850
MPMLFAHLSL EKDDLDSRTV IESLLNLMED PDKDVRTAFS GNIKHLLACA
860 870 880 890 900
DCEDGYLKEI VVSRMKKAYT DAKMSRDNEM KDTLILTTGD IGRAAKGELV
910 920 930 940 950
PFALLHLLHC LLSKSPCVAG ASYTEIRSLA AAKSTSLHIF FSQYKKPICQ
960 970 980 990 1000
FLIESLHSSQ AALLTNTPGR SSEMQKQEAT HHREAALDIL SEIANVFDFP
1010 1020 1030 1040 1050
DLNRFLTRTL QLLLPYLAAK ASPTASTLIR TIAKQLNVNR REILINNFKY
1060 1070 1080 1090 1100
IFSHLVCSCT KDELEKSLHY LKNETEIELG SLLRQDYQGL HNELLLRLGE
1110 1120 1130 1140 1150
HYQQVFSGLS ILATYASNDD PYQGPRNFAK PEIMADYLQP KLLGILAFFN
1160 1170 1180 1190 1200
MHLLSSSIGI EDKKMALNSL VSLMKLMGPK HISSVRVKMM TTLRTGLRYK
1210 1220 1230 1240 1250
EEFPGLCCSA WDLFVRCLDQ AYLGPLLSHV IVALLPLLHI QPKETVAVFR
1260 1270 1280 1290 1300
YLIVENRDAV QDFLHEIYFL PDHPELKEIQ KVLQEYRKET TKSTDLQTAM
1310 1320 1330 1340 1350
QLSIRAIQHE NVDVRMHALT SLKETLYKNQ AKLLQYSTDS ETVEPVISQL
1360 1370 1380 1390 1400
VTVLLIGCQD ANPQARLFCG ECLGQLGAID PGRLDFSPSE TQGKGFTFVS
1410 1420 1430 1440 1450
GVEDSDFAYE LLTEQTRAFL AYADNVRAQD SAAYAIQELL SIFECKEGRT
1460 1470 1480 1490 1500
DCPGRRLWRR FPEHVQEILE PHLNTRYKSS RKAVNWSRVK KPIYLSKLGN
1510 1520 1530 1540 1550
NFADWSATWA GYLITKVRHE LARRVFSCCS IMMKHDFKVT IYLLPHILVY
1560 1570 1580 1590 1600
VLLGCNKEDQ QEVYAEIMAV LKHEDPLMRR LQDSASDLSQ LSTQTVFSML
1610 1620 1630 1640 1650
DHLTQWAREK FQALNAEKTN PKPGTRGEPK AVSNEDYGEY QNVTRFLDLI
1660 1670 1680 1690 1700
PQDTLAVASF RSKAYTRALM HFESFIMEKK QEIQEHLGFL QKLYAAMHEP
1710 1720 1730 1740 1750
DGVAGVSAIR KKEASLKEQI LEHESIGLLR DATACYDRAI QLKPEEIIHY
1760 1770 1780 1790 1800
HGVVKSMLGL GQLSTVITQV NGILNSRSEW TAELNTYRVE AAWKLSQWDL
1810 1820 1830 1840 1850
VEEYLSADRK STTWSIRLGQ LLLSAKKGER DMFYETLKVV RAEQIVPLSA
1860 1870 1880 1890 1900
ASFERGSYQR GYEYIVRLHM LCELEHSVKM FLQKPSVEPA VDSLNLPARL
1910 1920 1930 1940 1950
EMTQNSYRAR EPILAVRRAL QTINKRPNHA DMIGECWLQS ARVARKAGHH
1960 1970 1980 1990 2000
QTAYNALLNA GESRLSELNV ERAKWLWSKG DVHQALIVLQ KGAELFLSST
2010 2020 2030 2040 2050
SAPPEQQLIH GRAMLLVGRL MEETANFESN AVMKKYKDVT ALLPEWEDGH
2060 2070 2080 2090 2100
FYLAKYYDKL MPMVTDNKME KQGDLIRYIV LHFGRSLQFG NQYIYQSMPR
2110 2120 2130 2140 2150
MLSLWLDFGA KVYEWEKAGR ADRLQMKNEL MKINKVISDH KNQLAPYQFL
2160 2170 2180 2190 2200
TAFSQLISRI CHSHDEVFAV LMEIVAKVFV AYPQQAMWMM TAVSKSSYPM
2210 2220 2230 2240 2250
RVNRCKEILE KAIHMKPSLG KFIGDATRLT DKLLELCNKP VDGNTSTLSM
2260 2270 2280 2290 2300
NIHFKMLKKL VEETTFSEIL IPLQSVMIPT LPSTAGKRDH ADHDPFPGHW
2310 2320 2330 2340 2350
AYLSGFDDAV EILPSLQKPK KISLKGSDGK SYIMMCKPKD DLRKDCRLME
2360 2370 2380 2390 2400
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGFRNIL
2410 2420 2430 2440 2450
IKLYKEKGIY MGGKELRQCM LPKSAPLQEK LKVFKEALLP RHPPLFHEWF
2460 2470 2480 2490 2500
LRTFPDPTSW YNSRSAYCRS TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC
2510 2520 2530 2540 2550
VHVDFNCLFN KGETFEVPEI VPFRLTHNMV NGMGPMGTEG LFRRACEVIM
2560 2570 2580 2590 2600
RLMREQRESL MSVLKPFLHD PLVEWSKPAR GSSKGQVNET GEVMNEKAKT
2610 2620 2630 2640 2650
HVLDIEQRLQ GVIKTRNRVK GLPLSIEGHV HYLIQEATDE NLLSQMYLGW

APYM
Length:2,654
Mass (Da):301,459
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF88E8A6541E6DD13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191Y → C in AAG34794 (PubMed:11069891).Curated1
Sequence conflicti249P → S in AAG34794 (PubMed:11069891).Curated1
Sequence conflicti434S → SS in AAW78662 (Ref. 3) Curated1
Sequence conflicti520D → N in AAW78662 (Ref. 3) Curated1
Sequence conflicti1047N → S in AAW78662 (Ref. 3) Curated1
Sequence conflicti1543L → P in AAW78662 (Ref. 3) Curated1
Sequence conflicti1785N → S in AAG40002 (PubMed:11137007).Curated1
Sequence conflicti1952T → A in AAW78662 (Ref. 3) Curated1
Sequence conflicti2082H → P in AAG34794 (PubMed:11069891).Curated1
Sequence conflicti2215M → T in AAW78662 (Ref. 3) Curated1
Sequence conflicti2362D → G in AAG34794 (PubMed:11069891).Curated1
Sequence conflicti2424S → N in AAG40002 (PubMed:11137007).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF320125 mRNA Translation: AAG40002.1
AF223644 mRNA Translation: AAG34794.1
AY882989 mRNA Translation: AAW78662.1

NCBI Reference Sequences

More...
RefSeqi
NP_001082049.1, NM_001088580.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
398197

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:398197

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF320125 mRNA Translation: AAG40002.1
AF223644 mRNA Translation: AAG34794.1
AY882989 mRNA Translation: AAW78662.1
RefSeqiNP_001082049.1, NM_001088580.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi99532, 3 interactors
IntActiQ9DE14, 2 interactors

PTM databases

iPTMnetiQ9DE14

Genome annotation databases

GeneIDi398197
KEGGixla:398197

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
398197
XenbaseiXB-GENE-1012725, atr.L

Phylogenomic databases

OMAiWMLLPHF
OrthoDBi80538at2759

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR003152, FATC_dom
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR003151, PIK-rel_kinase_FAT
IPR014009, PIK_FAT
IPR011990, TPR-like_helical_dom_sf
IPR012993, UME
PfamiView protein in Pfam
PF02259, FAT, 1 hit
PF02260, FATC, 1 hit
PF00454, PI3_PI4_kinase, 1 hit
PF08064, UME, 1 hit
SMARTiView protein in SMART
SM01343, FATC, 1 hit
SM00146, PI3Kc, 1 hit
SM00802, UME, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF48452, SSF48452, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51189, FAT, 1 hit
PS51190, FATC, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATR_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9DE14
Secondary accession number(s): Q5EGL8, Q9DDK7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 7, 2006
Last modified: February 10, 2021
This is version 102 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again